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The map label for this gene is pncB2 [H]

Identifier: 113474205

GI number: 113474205

Start: 492550

End: 493929

Strand: Direct

Name: pncB2 [H]

Synonym: Tery_0318

Alternate gene names: 113474205

Gene position: 492550-493929 (Clockwise)

Preceding gene: 113474200

Following gene: 113474206

Centisome position: 6.36

GC content: 38.84

Gene sequence:

>1380_bases
ATGGTACAAGAATATCTAGAACTTTCTCTATCTCCAGAAGATTACACCTTGTTAACAGACCTCTATCAATTAACAATGAT
AGCTTGCTATGTTGGAGAAAAAATAGACCAACGACAAGCTAGTTTTGAGCTATTTGTGCGAAAACTACCTACAGGTTTTG
GCTATCTCATTGCTATGGGTTTAGCACAAGCATTAGACTATCTCGAGAAATTTAGATTTAGCTCTGAGCAAATTGACGCC
TTAAAGTCAACGGGAATTTTTGCTAATGCCCCTAGTGAATTTTGGTCCTTACTAGCAGAAGCTAAATTCACTGGAAATGT
ATGGGCGGTGAAAGAGGGAACAGCCATTTTTCCAAATCAACCCCTACTGCGGATAGAAGCACCGCTTTGGCAAGGGCAGT
TGGTAGAAACATATCTACTAAATACAATGAATTACCAAACCCTGATAGCAACAAAAGCAGCGAGAATGCGGGATATTGCT
GGAAATAGCACCAAATTACTAGAATTTGGCACAAGACGTGCATTTAGTCCCCAAGCTAGTGTTTTGGCTGCTCGTGCTGC
TTTGGCAGGAGGAATGGATGCTACTTCTAATGTTTTGGCAGCCTTGAAATTAGGTCGGAAACCAGTAGGAACGATGGCTC
ACTCTTTGGTGATGGCAATATCTGCAGTGGAAGGTAGTGAGGAGGATGCTTTTAAAAGTTTTCAGCGATATTTCCCTACA
GCCACTTTATTGATAGATACTTATGATACTTTATCAGCTACTCGTTTATTGGCACGACGAGTTAAACAGGGTGAAATGCA
GATAAGTGGGGTCAGGTTAGATTCTGGAAATTTGGTTGAATTGTCCCAGAAGGTGCGATCGCTACTGCCAAAAGTGAGGA
TTTTTGCTAGTGGAGATATAGATGAGTGGGAAATAGCTAGACTTCAGAAGGAAAATGCTTGTATTGATGGATATGGTATT
GGTACTAAGTTGGTAACTGGTGTTCCTGTGAATGGAGTTTATAAACTGGTAGAAATAGATGGTATTCCTGCGATGAAAAA
TACTACTGGAAAAGTTAGTTATCCTGGTCGAAAACAAATATATAGATATTTGGAAAATGGTCAATTGAAACAAGATTATT
TGGGGTTAATGGCTGAAGATGTATTGAGTCAAACAGAACCTCATACTGATTCTTTTGTAAAATTAATGATACAAGTAGTT
AAAAATGGGGAGATGCTGCAAACATCAGAAAGTCTAGAAGCGATCGCTAAACGTACTGCTATTTCTGTTGCTAGTTTGCC
ACCTGAAACTCGTAGTTTAGAAAATCCTATTTTGCCACCAATGAAAATTTCTCATAAATTACAACAACTTACACAAAAAA
CTCAAGCTAACAGCTCTTAA

Upstream 100 bases:

>100_bases
AACTCAAGTAAAATAGCAAACGAGCCCAAAATTATAAATTGTGCGTTTTTCAGACTTTAACTAAAATACTGCGGGTTTCC
TAACTACCAAGAATTTTTAA

Downstream 100 bases:

>100_bases
AAATTAAGCATTGCATATTTATGGGATGAATGATACGTTAAGAGAGAGAATAAAAGGAAAAAAGTATAAGATGCCCGTAT
GGCTTGTAGTTTTGGGGTTT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB2 [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MVQEYLELSLSPEDYTLLTDLYQLTMIACYVGEKIDQRQASFELFVRKLPTGFGYLIAMGLAQALDYLEKFRFSSEQIDA
LKSTGIFANAPSEFWSLLAEAKFTGNVWAVKEGTAIFPNQPLLRIEAPLWQGQLVETYLLNTMNYQTLIATKAARMRDIA
GNSTKLLEFGTRRAFSPQASVLAARAALAGGMDATSNVLAALKLGRKPVGTMAHSLVMAISAVEGSEEDAFKSFQRYFPT
ATLLIDTYDTLSATRLLARRVKQGEMQISGVRLDSGNLVELSQKVRSLLPKVRIFASGDIDEWEIARLQKENACIDGYGI
GTKLVTGVPVNGVYKLVEIDGIPAMKNTTGKVSYPGRKQIYRYLENGQLKQDYLGLMAEDVLSQTEPHTDSFVKLMIQVV
KNGEMLQTSESLEAIAKRTAISVASLPPETRSLENPILPPMKISHKLQQLTQKTQANSS

Sequences:

>Translated_459_residues
MVQEYLELSLSPEDYTLLTDLYQLTMIACYVGEKIDQRQASFELFVRKLPTGFGYLIAMGLAQALDYLEKFRFSSEQIDA
LKSTGIFANAPSEFWSLLAEAKFTGNVWAVKEGTAIFPNQPLLRIEAPLWQGQLVETYLLNTMNYQTLIATKAARMRDIA
GNSTKLLEFGTRRAFSPQASVLAARAALAGGMDATSNVLAALKLGRKPVGTMAHSLVMAISAVEGSEEDAFKSFQRYFPT
ATLLIDTYDTLSATRLLARRVKQGEMQISGVRLDSGNLVELSQKVRSLLPKVRIFASGDIDEWEIARLQKENACIDGYGI
GTKLVTGVPVNGVYKLVEIDGIPAMKNTTGKVSYPGRKQIYRYLENGQLKQDYLGLMAEDVLSQTEPHTDSFVKLMIQVV
KNGEMLQTSESLEAIAKRTAISVASLPPETRSLENPILPPMKISHKLQQLTQKTQANSS
>Mature_459_residues
MVQEYLELSLSPEDYTLLTDLYQLTMIACYVGEKIDQRQASFELFVRKLPTGFGYLIAMGLAQALDYLEKFRFSSEQIDA
LKSTGIFANAPSEFWSLLAEAKFTGNVWAVKEGTAIFPNQPLLRIEAPLWQGQLVETYLLNTMNYQTLIATKAARMRDIA
GNSTKLLEFGTRRAFSPQASVLAARAALAGGMDATSNVLAALKLGRKPVGTMAHSLVMAISAVEGSEEDAFKSFQRYFPT
ATLLIDTYDTLSATRLLARRVKQGEMQISGVRLDSGNLVELSQKVRSLLPKVRIFASGDIDEWEIARLQKENACIDGYGI
GTKLVTGVPVNGVYKLVEIDGIPAMKNTTGKVSYPGRKQIYRYLENGQLKQDYLGLMAEDVLSQTEPHTDSFVKLMIQVV
KNGEMLQTSESLEAIAKRTAISVASLPPETRSLENPILPPMKISHKLQQLTQKTQANSS

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=527, Percent_Identity=32.8273244781784, Blast_Score=194, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997947, Length=524, Percent_Identity=31.6793893129771, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997952, Length=524, Percent_Identity=31.6793893129771, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71997955, Length=207, Percent_Identity=41.0628019323672, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6324783, Length=384, Percent_Identity=25.2604166666667, Blast_Score=73, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24581587, Length=512, Percent_Identity=33.203125, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161076680, Length=209, Percent_Identity=41.6267942583732, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24581595, Length=209, Percent_Identity=41.6267942583732, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574709, Length=209, Percent_Identity=41.6267942583732, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24581593, Length=209, Percent_Identity=41.6267942583732, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24581591, Length=209, Percent_Identity=41.6267942583732, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 50716; Mature: 50716

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQEYLELSLSPEDYTLLTDLYQLTMIACYVGEKIDQRQASFELFVRKLPTGFGYLIAMG
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAQALDYLEKFRFSSEQIDALKSTGIFANAPSEFWSLLAEAKFTGNVWAVKEGTAIFPNQ
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCC
PLLRIEAPLWQGQLVETYLLNTMNYQTLIATKAARMRDIAGNSTKLLEFGTRRAFSPQAS
CCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHH
VLAARAALAGGMDATSNVLAALKLGRKPVGTMAHSLVMAISAVEGSEEDAFKSFQRYFPT
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
ATLLIDTYDTLSATRLLARRVKQGEMQISGVRLDSGNLVELSQKVRSLLPKVRIFASGDI
EEEEEECHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCC
DEWEIARLQKENACIDGYGIGTKLVTGVPVNGVYKLVEIDGIPAMKNTTGKVSYPGRKQI
CHHHHHHHHHCCCCCCCCCCCHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHH
YRYLENGQLKQDYLGLMAEDVLSQTEPHTDSFVKLMIQVVKNGEMLQTSESLEAIAKRTA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
ISVASLPPETRSLENPILPPMKISHKLQQLTQKTQANSS
HHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVQEYLELSLSPEDYTLLTDLYQLTMIACYVGEKIDQRQASFELFVRKLPTGFGYLIAMG
CCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LAQALDYLEKFRFSSEQIDALKSTGIFANAPSEFWSLLAEAKFTGNVWAVKEGTAIFPNQ
HHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCC
PLLRIEAPLWQGQLVETYLLNTMNYQTLIATKAARMRDIAGNSTKLLEFGTRRAFSPQAS
CCEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCHHH
VLAARAALAGGMDATSNVLAALKLGRKPVGTMAHSLVMAISAVEGSEEDAFKSFQRYFPT
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
ATLLIDTYDTLSATRLLARRVKQGEMQISGVRLDSGNLVELSQKVRSLLPKVRIFASGDI
EEEEEECHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCC
DEWEIARLQKENACIDGYGIGTKLVTGVPVNGVYKLVEIDGIPAMKNTTGKVSYPGRKQI
CHHHHHHHHHCCCCCCCCCCCHHHEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHH
YRYLENGQLKQDYLGLMAEDVLSQTEPHTDSFVKLMIQVVKNGEMLQTSESLEAIAKRTA
HHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHH
ISVASLPPETRSLENPILPPMKISHKLQQLTQKTQANSS
HHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]