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The map label for this gene is pepP [H]

Identifier: 110835461

GI number: 110835461

Start: 2944387

End: 2945658

Strand: Reverse

Name: pepP [H]

Synonym: ABO_2600

Alternate gene names: 110835461

Gene position: 2945658-2944387 (Counterclockwise)

Preceding gene: 110835462

Following gene: 110835460

Centisome position: 94.41

GC content: 57.0

Gene sequence:

>1272_bases
ATGTCGATCATGGGGCCTAACAGCATCGCCATTCTGCCCGCCGCCCCGGAACGCACCCGCAACCGGGATGTGGAGTATCC
CTACCGGCAGGACAGTGATTTCTGGTACCTCACCGGCTTTGCGGAACCCGAGGCGGTGATGGTGTTGCTGCCGGGGCGCG
AGCACGGTGAGTATGTGCTGTTCTGTCGCGATCGCGACCGCACCATGGAAATTTGGAACGGTTACCGTGCCGGGCCGGAA
GGGGCGGTGTCTGAATACGATGCGGACGATGCGTTTCCGATCAGCGATATTGATGAAATTCTGCCGGGCCTGATCGAAGG
CAGCGAGCGGGTCTATTACGACCTTGGCCACGATAGTGAATTCGACCGCCGCCTGATGGGCTGGGTGAACAGCATCCGCG
AGCGGGTGCGTAGCGGGGCGCATCCGCCCGGTGAATTTGTGGCCTTGGCGCATCATCTGCACGACCAGCGACTGTTCAAA
TCTGCGGCGGAAGGCAAAATCATGCGTAAGGCGGCCAGCATTTCCGCTGGCGCCCATGTGCGGGCCATGCAGGCGGTGAA
GCCAGGCATGATGGAATATCAGCTGGAAGCGGAATACATCCACGAGTTCATGCGCCATGGGGCGCGCAGCCCAGCCTACC
CGAGTATTGTCGGCGGTGGCCCGAATAGCTGCATTCTTCACTACATTGAAAATACCGGGAAACTGAAGGACGGTGACCTG
GTGTTAGTGGATGCGGGTTGCGAGCTGGACTACTACGCCTCGGATATCACCCGGACTTTTCCGGTGAATGGTACATTCAG
CAAGCCACAGCAAGCCTTGTATGAGCTGGTGTTAGCCAGTCAGTACGCAGCCATCGAAGCCACACATCCGGACAATCACT
GGAACGTGCCCCACGAACAGGTGGTGAACATTCTTACCCAGGGTTTGATGGACCTGGGCCTGCTAAAAGGCGAGTTTAAC
GAGCTGGTGGAAACTGAAGGTTATCGATCCTTTTTCATGCATCGCACCGGCCATTGGTTGGGGCTTGATGTGCATGATGT
CGGTGACTACCGCATTCAGGAGCAATGGCGTCAGCTTGAGCCGGGTATGGTTCTGACTGTGGAGCCGGGGTTGTATGTGG
CGCCGGATGATACTTCCGTGGATGAGCAATGGCGTGGTATTGGCATTCGTATTGAAGATGATGTGCTGGTAACTAAAGCC
GGGTGCGAAGTCCTTAGCCACGAGGTGCCCAAGGACGTGGCGGATATCGAAAAGATAATGAAAGGCAATTGA

Upstream 100 bases:

>100_bases
GCCTGACGCTACACGTGAAAATCGATAAGCGACTCGTGCCCGCTAAGGAGTAGTTTTGAGTATCAGCCGTGAGGAATTCG
CCAGTCGTCGTCAGGAATTG

Downstream 100 bases:

>100_bases
ACGCTTAACCTTGACGCGTCAAGAGTGCGTTGTGCCGAGCAGGGAAGTAAGTTGTCGCGGGTACGGCTTTGAAGAGCCTG
TAGCCCCTGGTTTTTACTTT

Product: aminopeptidase P II

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSIMGPNSIAILPAAPERTRNRDVEYPYRQDSDFWYLTGFAEPEAVMVLLPGREHGEYVLFCRDRDRTMEIWNGYRAGPE
GAVSEYDADDAFPISDIDEILPGLIEGSERVYYDLGHDSEFDRRLMGWVNSIRERVRSGAHPPGEFVALAHHLHDQRLFK
SAAEGKIMRKAASISAGAHVRAMQAVKPGMMEYQLEAEYIHEFMRHGARSPAYPSIVGGGPNSCILHYIENTGKLKDGDL
VLVDAGCELDYYASDITRTFPVNGTFSKPQQALYELVLASQYAAIEATHPDNHWNVPHEQVVNILTQGLMDLGLLKGEFN
ELVETEGYRSFFMHRTGHWLGLDVHDVGDYRIQEQWRQLEPGMVLTVEPGLYVAPDDTSVDEQWRGIGIRIEDDVLVTKA
GCEVLSHEVPKDVADIEKIMKGN

Sequences:

>Translated_423_residues
MSIMGPNSIAILPAAPERTRNRDVEYPYRQDSDFWYLTGFAEPEAVMVLLPGREHGEYVLFCRDRDRTMEIWNGYRAGPE
GAVSEYDADDAFPISDIDEILPGLIEGSERVYYDLGHDSEFDRRLMGWVNSIRERVRSGAHPPGEFVALAHHLHDQRLFK
SAAEGKIMRKAASISAGAHVRAMQAVKPGMMEYQLEAEYIHEFMRHGARSPAYPSIVGGGPNSCILHYIENTGKLKDGDL
VLVDAGCELDYYASDITRTFPVNGTFSKPQQALYELVLASQYAAIEATHPDNHWNVPHEQVVNILTQGLMDLGLLKGEFN
ELVETEGYRSFFMHRTGHWLGLDVHDVGDYRIQEQWRQLEPGMVLTVEPGLYVAPDDTSVDEQWRGIGIRIEDDVLVTKA
GCEVLSHEVPKDVADIEKIMKGN
>Mature_422_residues
SIMGPNSIAILPAAPERTRNRDVEYPYRQDSDFWYLTGFAEPEAVMVLLPGREHGEYVLFCRDRDRTMEIWNGYRAGPEG
AVSEYDADDAFPISDIDEILPGLIEGSERVYYDLGHDSEFDRRLMGWVNSIRERVRSGAHPPGEFVALAHHLHDQRLFKS
AAEGKIMRKAASISAGAHVRAMQAVKPGMMEYQLEAEYIHEFMRHGARSPAYPSIVGGGPNSCILHYIENTGKLKDGDLV
LVDAGCELDYYASDITRTFPVNGTFSKPQQALYELVLASQYAAIEATHPDNHWNVPHEQVVNILTQGLMDLGLLKGEFNE
LVETEGYRSFFMHRTGHWLGLDVHDVGDYRIQEQWRQLEPGMVLTVEPGLYVAPDDTSVDEQWRGIGIRIEDDVLVTKAG
CEVLSHEVPKDVADIEKIMKGN

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=419, Percent_Identity=34.8448687350835, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI149589008, Length=456, Percent_Identity=33.7719298245614, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI260593665, Length=299, Percent_Identity=39.7993311036789, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI260593663, Length=252, Percent_Identity=39.2857142857143, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1789275, Length=418, Percent_Identity=49.5215311004785, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788728, Length=264, Percent_Identity=31.4393939393939, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790282, Length=326, Percent_Identity=27.3006134969325, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508215, Length=454, Percent_Identity=31.7180616740088, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71989583, Length=368, Percent_Identity=29.3478260869565, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320922, Length=432, Percent_Identity=31.25, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321118, Length=446, Percent_Identity=30.9417040358744, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19920384, Length=419, Percent_Identity=33.6515513126492, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21357079, Length=452, Percent_Identity=32.5221238938053, Blast_Score=191, Evalue=6e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 47622; Mature: 47491

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIMGPNSIAILPAAPERTRNRDVEYPYRQDSDFWYLTGFAEPEAVMVLLPGREHGEYVL
CCCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEE
FCRDRDRTMEIWNGYRAGPEGAVSEYDADDAFPISDIDEILPGLIEGSERVYYDLGHDSE
EECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCH
FDRRLMGWVNSIRERVRSGAHPPGEFVALAHHLHDQRLFKSAAEGKIMRKAASISAGAHV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHH
RAMQAVKPGMMEYQLEAEYIHEFMRHGARSPAYPSIVGGGPNSCILHYIENTGKLKDGDL
HHHHHHCCCHHEEEECHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCE
VLVDAGCELDYYASDITRTFPVNGTFSKPQQALYELVLASQYAAIEATHPDNHWNVPHEQ
EEEECCCCCEEHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHH
VVNILTQGLMDLGLLKGEFNELVETEGYRSFFMHRTGHWLGLDVHDVGDYRIQEQWRQLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEHHCCCCHHHHHHHHHCC
PGMVLTVEPGLYVAPDDTSVDEQWRGIGIRIEDDVLVTKAGCEVLSHEVPKDVADIEKIM
CCEEEEECCCEEECCCCCCCHHHHCCCCEEEECCEEEEHHHHHHHHHHCCHHHHHHHHHH
KGN
CCC
>Mature Secondary Structure 
SIMGPNSIAILPAAPERTRNRDVEYPYRQDSDFWYLTGFAEPEAVMVLLPGREHGEYVL
CCCCCCCEEEEECCCCHHCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEE
FCRDRDRTMEIWNGYRAGPEGAVSEYDADDAFPISDIDEILPGLIEGSERVYYDLGHDSE
EECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCH
FDRRLMGWVNSIRERVRSGAHPPGEFVALAHHLHDQRLFKSAAEGKIMRKAASISAGAHV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHH
RAMQAVKPGMMEYQLEAEYIHEFMRHGARSPAYPSIVGGGPNSCILHYIENTGKLKDGDL
HHHHHHCCCHHEEEECHHHHHHHHHCCCCCCCCCCEECCCCCCEEEEEECCCCCCCCCCE
VLVDAGCELDYYASDITRTFPVNGTFSKPQQALYELVLASQYAAIEATHPDNHWNVPHEQ
EEEECCCCCEEHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCHHH
VVNILTQGLMDLGLLKGEFNELVETEGYRSFFMHRTGHWLGLDVHDVGDYRIQEQWRQLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEHHCCCCHHHHHHHHHCC
PGMVLTVEPGLYVAPDDTSVDEQWRGIGIRIEDDVLVTKAGCEVLSHEVPKDVADIEKIM
CCEEEEECCCEEECCCCCCCHHHHCCCCEEEECCEEEEHHHHHHHHHHCCHHHHHHHHHH
KGN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]