Click here to switch to the map view.

The map label for this gene is gcvT

Identifier: 110835455

GI number: 110835455

Start: 2934243

End: 2935322

Strand: Reverse

Name: gcvT

Synonym: ABO_2594

Alternate gene names: 110835455

Gene position: 2935322-2934243 (Counterclockwise)

Preceding gene: 110835456

Following gene: 110835454

Centisome position: 94.08

GC content: 56.67

Gene sequence:

>1080_bases
ATGGCTCATCGCACAGCTTTATACGACGCTCATCTCGCCGCCGGTGGCAAGATGGTGGATTTCGGCGGCTGGGATATGCC
GATTAACTATGGGTCGCAGATCGAAGAACATCACGCCGTGCGCCAAAATGCCGGTGTGTTCGACGTTTCTCATATGACCG
TAGTGGATATCGCCGGCGCCGGCGCCCGTGACTACTTACGCCAGCTGCTGGCAAACGATGTGGACCGCATTGATCCGGGC
CGCGCCCTGTATACCGGGATGCTTAACGATAATGGCGGCGTGATCGATGACCTTATCGTCTACAAACGGGACAATGACTA
CCGTCTGGTGGTAAATTGCGCGACCCGTGAAACCGATCTGGGCTGGATGGAAAAACACGCGGGCGGTTTTGCCGTGGATA
TCCATGAGCGTCCGGAACTGGCCATGTTGGCGATTCAGGGGCCCAAGGCCCGTGACATTCTCGCTGGCCTTTTGAATGGC
AGCCGCGCCGACGCGGTGAAAAGCCTGAAAGTGTTTGCCTTCGCGGAAGACGGTGATTGGATGATTGCCCGCACCGGCTA
CACCGGTGAAGACGGCGTGGAAATCATGCTGCCTAACGCGGATGCGCTGACCCTGTGGGAGCAACTGCTTGAAGCGGGTG
TATCGCCTATTGGCCTGGGGGCACGCGATACGCTGCGCCTGGAAGCGGGCTTGAATCTCTACGGCAACGATATGGATGAG
AGCATTACGCCATGGGAAGCCAACATGGGTTGGACCGTAATGCTCAATGACCGCGAGTTCATCGGTCGCCAGCCCCTGCT
AAACCAGAAAGAAAATGGCCACAGCGAACAGGTGGGTCTGATTTTGGAAGGCAAGGGTGTATTGCGCGCCCATCAGAAAG
TTTTAATGCCGAATGGGGAAGAAGGGGAAATTACCAGCGGTACTTTCTCGCCCACGTTAGGTAAATCCATCGCCCTGGCT
CGTTTGCCTGCCGGCGCCACCGGTAAGGTGGATGTGGAAATTCGCAATAAACGGCAGGTGGCTCAGGTGGTTAAGCCGCC
GTTCGTGCGTAATGGTAACGCGGTGTACAAGGAACAGTAG

Upstream 100 bases:

>100_bases
AACGCAGTGTTCCCGCATTGGGCAGATTACTGGCTCAGCCTATGCCGTTTGGCCCCGTGTCGATATAATTCTCTACTCAC
TCGTTCCATGGTGTTTTTTT

Downstream 100 bases:

>100_bases
CAGCATGCTTTGCGCCGCACGCAACACGCGCGGGGCCTGTTTATTAGGCCGGAAATGCCGATAGCATCTCCGGCAAAACA
TACATTCTGTAGTCGCCATC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MAHRTALYDAHLAAGGKMVDFGGWDMPINYGSQIEEHHAVRQNAGVFDVSHMTVVDIAGAGARDYLRQLLANDVDRIDPG
RALYTGMLNDNGGVIDDLIVYKRDNDYRLVVNCATRETDLGWMEKHAGGFAVDIHERPELAMLAIQGPKARDILAGLLNG
SRADAVKSLKVFAFAEDGDWMIARTGYTGEDGVEIMLPNADALTLWEQLLEAGVSPIGLGARDTLRLEAGLNLYGNDMDE
SITPWEANMGWTVMLNDREFIGRQPLLNQKENGHSEQVGLILEGKGVLRAHQKVLMPNGEEGEITSGTFSPTLGKSIALA
RLPAGATGKVDVEIRNKRQVAQVVKPPFVRNGNAVYKEQ

Sequences:

>Translated_359_residues
MAHRTALYDAHLAAGGKMVDFGGWDMPINYGSQIEEHHAVRQNAGVFDVSHMTVVDIAGAGARDYLRQLLANDVDRIDPG
RALYTGMLNDNGGVIDDLIVYKRDNDYRLVVNCATRETDLGWMEKHAGGFAVDIHERPELAMLAIQGPKARDILAGLLNG
SRADAVKSLKVFAFAEDGDWMIARTGYTGEDGVEIMLPNADALTLWEQLLEAGVSPIGLGARDTLRLEAGLNLYGNDMDE
SITPWEANMGWTVMLNDREFIGRQPLLNQKENGHSEQVGLILEGKGVLRAHQKVLMPNGEEGEITSGTFSPTLGKSIALA
RLPAGATGKVDVEIRNKRQVAQVVKPPFVRNGNAVYKEQ
>Mature_358_residues
AHRTALYDAHLAAGGKMVDFGGWDMPINYGSQIEEHHAVRQNAGVFDVSHMTVVDIAGAGARDYLRQLLANDVDRIDPGR
ALYTGMLNDNGGVIDDLIVYKRDNDYRLVVNCATRETDLGWMEKHAGGFAVDIHERPELAMLAIQGPKARDILAGLLNGS
RADAVKSLKVFAFAEDGDWMIARTGYTGEDGVEIMLPNADALTLWEQLLEAGVSPIGLGARDTLRLEAGLNLYGNDMDES
ITPWEANMGWTVMLNDREFIGRQPLLNQKENGHSEQVGLILEGKGVLRAHQKVLMPNGEEGEITSGTFSPTLGKSIALAR
LPAGATGKVDVEIRNKRQVAQVVKPPFVRNGNAVYKEQ

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=363, Percent_Identity=38.8429752066116, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI257796258, Length=335, Percent_Identity=38.8059701492537, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI257796254, Length=357, Percent_Identity=35.5742296918768, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI257796256, Length=309, Percent_Identity=36.5695792880259, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI24797151, Length=334, Percent_Identity=29.940119760479, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI194306651, Length=310, Percent_Identity=24.8387096774194, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789272, Length=363, Percent_Identity=56.198347107438, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17560118, Length=371, Percent_Identity=36.3881401617251, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71994045, Length=364, Percent_Identity=25.2747252747253, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994052, Length=364, Percent_Identity=25.2747252747253, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI32563613, Length=342, Percent_Identity=25.1461988304094, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320222, Length=379, Percent_Identity=37.9947229551451, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129441, Length=372, Percent_Identity=38.1720430107527, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28571104, Length=256, Percent_Identity=30.078125, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20130091, Length=368, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_ALCBS (Q0VLA6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694314.1
- ProteinModelPortal:   Q0VLA6
- SMR:   Q0VLA6
- STRING:   Q0VLA6
- GeneID:   4211692
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2594
- NMPDR:   fig|393595.12.peg.2598
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- PhylomeDB:   Q0VLA6
- BioCyc:   ABOR393595:ABO_2594-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39187; Mature: 39056

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHRTALYDAHLAAGGKMVDFGGWDMPINYGSQIEEHHAVRQNAGVFDVSHMTVVDIAGA
CCCCCEEEEHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCC
GARDYLRQLLANDVDRIDPGRALYTGMLNDNGGVIDDLIVYKRDNDYRLVVNCATRETDL
CHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCEEEEEEEEEECCCEEEEEEECCCCCCC
GWMEKHAGGFAVDIHERPELAMLAIQGPKARDILAGLLNGSRADAVKSLKVFAFAEDGDW
CHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHEEEEEEEEECCCCE
MIARTGYTGEDGVEIMLPNADALTLWEQLLEAGVSPIGLGARDTLRLEAGLNLYGNDMDE
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEECCCCCCEEEEEECCCEECCCCCC
SITPWEANMGWTVMLNDREFIGRQPLLNQKENGHSEQVGLILEGKGVLRAHQKVLMPNGE
CCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHEEECCCCC
EGEITSGTFSPTLGKSIALARLPAGATGKVDVEIRNKRQVAQVVKPPFVRNGNAVYKEQ
CCCEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHCCCCEECCCEEECCC
>Mature Secondary Structure 
AHRTALYDAHLAAGGKMVDFGGWDMPINYGSQIEEHHAVRQNAGVFDVSHMTVVDIAGA
CCCCEEEEHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEECCEEEEEECCC
GARDYLRQLLANDVDRIDPGRALYTGMLNDNGGVIDDLIVYKRDNDYRLVVNCATRETDL
CHHHHHHHHHHCCHHHCCCCCEEEEEEECCCCCEEEEEEEEEECCCEEEEEEECCCCCCC
GWMEKHAGGFAVDIHERPELAMLAIQGPKARDILAGLLNGSRADAVKSLKVFAFAEDGDW
CHHHHCCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCHHHHHEEEEEEEEECCCCE
MIARTGYTGEDGVEIMLPNADALTLWEQLLEAGVSPIGLGARDTLRLEAGLNLYGNDMDE
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHCCCCEECCCCCCEEEEEECCCEECCCCCC
SITPWEANMGWTVMLNDREFIGRQPLLNQKENGHSEQVGLILEGKGVLRAHQKVLMPNGE
CCCCCCCCCCEEEEECCHHHCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHEEECCCCC
EGEITSGTFSPTLGKSIALARLPAGATGKVDVEIRNKRQVAQVVKPPFVRNGNAVYKEQ
CCCEECCCCCCCCCCCEEEEECCCCCCCEEEEEECCHHHHHHHHCCCCEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA