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The map label for this gene is mutM

Identifier: 110835444

GI number: 110835444

Start: 2922999

End: 2923808

Strand: Reverse

Name: mutM

Synonym: ABO_2583

Alternate gene names: 110835444

Gene position: 2923808-2922999 (Counterclockwise)

Preceding gene: 110835447

Following gene: 110835443

Centisome position: 93.71

GC content: 59.38

Gene sequence:

>810_bases
ATGCCTGAATTACCTGAAGTGGAAACCACCCTGCGTGGCATTCGCCCGCATTTACAGGGGCGGATTTTGAAATCGGTAAC
GGTGCGCGAACCGCGGTTGCGCTGGCCGGTGAGTGAGGCGATTTATGCGCTGCGTGACTGCCCGGTGGTGGCGTTGCGTC
GGCGGGCCAAATATCTGCTGATTGAGCTGGAGCATGGGCAGCTGCTCATTCATCTGGGGATGTCCGGCACTTTGCGGGTG
GTGGATATGGACCTGCCATTACGCAAGCACGACCATGTGGATTTGTTGCTCGATAGTGGCAAGGTGCTGCGTTTTAACGA
CCCGCGCCGCTTTGGCTCTGTGTTGTTCCAGGGCGGTGACCAGCCGCACAGCCTGCTGCAGTCGCTGGGGCCGGAACCGC
TCAGCGATAGTTTTAATGGCCAGTGGTTGTTTGCTCGCTCTCGTGGCCGAAAGGTGGCAGTGAAAAGCTTTATTATGGAT
AACGCCACGGTGGTGGGAGTGGGCAATATTTACGCTCAGGAAAGCCTCTTTATGGCGGGTATCCACCCCTCCCGGGCGGC
GGGCCGCATTTCCCTGGCGCGTTATCAGGCACTGGCAGAGGCAATTAAGCGGGTGCTGGCCCAGGCGATTGAGGCGGGCG
GCACCACGCTGAAGGATTTCACCCGGGCGGATGGTCAGCCAGGGTATTTTGCTCAGTCCCTCAATGTGTATGGCCGTGCG
GGCCAGCCTTGCGTGCAATGCGACGCCATATTGAAGGCGGATCGTCATGGCCAGCGGAGCACGGCTTATTGCCCACAATG
CCAGCGGTGA

Upstream 100 bases:

>100_bases
GCAGCAAGGTAACATAGCTAGCGCCAGCGCGCTCTTCGGGACCGCGCAATGAGTTTTTAGCTGTTCAATTGTCCATTATC
AATCACGAACTGACTTTCCT

Downstream 100 bases:

>100_bases
AGGGGAAGGAAATCGATTACCGGATGGGACAGCAAGTGGTGTGGGCGGGAAATGCGTTGCGACGGGGTTGATCAGGCTTT
GCTTTTTTGCACTATTGCTG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVETTLRGIRPHLQGRILKSVTVREPRLRWPVSEAIYALRDCPVVALRRRAKYLLIELEHGQLLIHLGMSGTLRV
VDMDLPLRKHDHVDLLLDSGKVLRFNDPRRFGSVLFQGGDQPHSLLQSLGPEPLSDSFNGQWLFARSRGRKVAVKSFIMD
NATVVGVGNIYAQESLFMAGIHPSRAAGRISLARYQALAEAIKRVLAQAIEAGGTTLKDFTRADGQPGYFAQSLNVYGRA
GQPCVQCDAILKADRHGQRSTAYCPQCQR

Sequences:

>Translated_269_residues
MPELPEVETTLRGIRPHLQGRILKSVTVREPRLRWPVSEAIYALRDCPVVALRRRAKYLLIELEHGQLLIHLGMSGTLRV
VDMDLPLRKHDHVDLLLDSGKVLRFNDPRRFGSVLFQGGDQPHSLLQSLGPEPLSDSFNGQWLFARSRGRKVAVKSFIMD
NATVVGVGNIYAQESLFMAGIHPSRAAGRISLARYQALAEAIKRVLAQAIEAGGTTLKDFTRADGQPGYFAQSLNVYGRA
GQPCVQCDAILKADRHGQRSTAYCPQCQR
>Mature_268_residues
PELPEVETTLRGIRPHLQGRILKSVTVREPRLRWPVSEAIYALRDCPVVALRRRAKYLLIELEHGQLLIHLGMSGTLRVV
DMDLPLRKHDHVDLLLDSGKVLRFNDPRRFGSVLFQGGDQPHSLLQSLGPEPLSDSFNGQWLFARSRGRKVAVKSFIMDN
ATVVGVGNIYAQESLFMAGIHPSRAAGRISLARYQALAEAIKRVLAQAIEAGGTTLKDFTRADGQPGYFAQSLNVYGRAG
QPCVQCDAILKADRHGQRSTAYCPQCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=269, Percent_Identity=58.7360594795539, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1786932, Length=284, Percent_Identity=25, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_ALCBS (Q0VLB7)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_694303.1
- ProteinModelPortal:   Q0VLB7
- SMR:   Q0VLB7
- STRING:   Q0VLB7
- GeneID:   4211249
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2583
- NMPDR:   fig|393595.12.peg.2590
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- PhylomeDB:   Q0VLB7
- BioCyc:   ABOR393595:ABO_2583-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 29903; Mature: 29772

Theoretical pI: Translated: 10.11; Mature: 10.11

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 57-57 ACT_SITE 259-259 BINDING 90-90 BINDING 109-109 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETTLRGIRPHLQGRILKSVTVREPRLRWPVSEAIYALRDCPVVALRRRAKYLL
CCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHCCEEEE
IELEHGQLLIHLGMSGTLRVVDMDLPLRKHDHVDLLLDSGKVLRFNDPRRFGSVLFQGGD
EEEECCEEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHCCCC
QPHSLLQSLGPEPLSDSFNGQWLFARSRGRKVAVKSFIMDNATVVGVGNIYAQESLFMAG
CHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHCCCEEEEECCHHHHCCEEEEC
IHPSRAAGRISLARYQALAEAIKRVLAQAIEAGGTTLKDFTRADGQPGYFAQSLNVYGRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEHHCCCCCCC
GQPCVQCDAILKADRHGQRSTAYCPQCQR
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETTLRGIRPHLQGRILKSVTVREPRLRWPVSEAIYALRDCPVVALRRRAKYLL
CCCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHCCEEEE
IELEHGQLLIHLGMSGTLRVVDMDLPLRKHDHVDLLLDSGKVLRFNDPRRFGSVLFQGGD
EEEECCEEEEEECCCCEEEEEEECCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHCCCC
QPHSLLQSLGPEPLSDSFNGQWLFARSRGRKVAVKSFIMDNATVVGVGNIYAQESLFMAG
CHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEHHHHHHCCCEEEEECCHHHHCCEEEEC
IHPSRAAGRISLARYQALAEAIKRVLAQAIEAGGTTLKDFTRADGQPGYFAQSLNVYGRA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEEHHCCCCCCC
GQPCVQCDAILKADRHGQRSTAYCPQCQR
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA