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The map label for this gene is pqqL [C]

Identifier: 110835426

GI number: 110835426

Start: 2906362

End: 2907714

Strand: Reverse

Name: pqqL [C]

Synonym: ABO_2565

Alternate gene names: 110835426

Gene position: 2907714-2906362 (Counterclockwise)

Preceding gene: 110835435

Following gene: 110835425

Centisome position: 93.19

GC content: 56.91

Gene sequence:

>1353_bases
ATGAAAAAACTGATAACGGTACTGGCGTTGGGCCTGTGGTCGCTGACTAGCCAGGCGTCACTGCCAACCCATGCCTTTAC
GCTGGATAACGGCCTGAAAGTGTTAGTGCGCGAAGATCATCGGGCGCCAGTAGTCACGGTAATGATGTGGTACAAGGCTG
GCAGTATCGACGAAGCTCCCTACGAAACCGGCTTGGCTCATGTGTTGGAACACATGATGTTTAAGGGCACCGAGAGGCTC
GGCCCTGGTGATTTTTCCAAGTTTGTCTCCCGATATGGTGGTAGCGATAATGCTTTTACCAGCTACGACTACACTGCCTA
CTTTCAGCAATACGAAGTGTCACGCCTGCCTCTGGCGCTGGAGCTGGAGGCCGAGCGGTTGGGGCACTTAGACATTGATG
ATGAAGAGTTTGCCCGTGAGCTAAAGGTGGTGATGGAAGAGCGGCGCATGCGAACCGACGATAACCCGAATGCGTTGGCC
TGGGAGAAATTTCAGGCGGTGGCCCGCCCGGGTACCGGTTATGCCCACCCGATTATTGGTTGGCGTTCCTTATTGTCCCA
GTTACAGCCGGAGCAAGCCCGCAGCTGGTATCAACGATTTTATGTGCCGGGTAACGCTACATTGGTGATTGCTGGGGATG
TAACCCGTGATCAGGTTGAACCGCTGGTGGAAAAATTCTTTGCTGATCTGCCTGCCGGGCAGACGCCGCCGCGGCCCAAG
CAAACGGTGAACCCGCCAGCAGGCGAACGTCGGCTGGCGCTGAATTTGCCGGTAAAAGTCCCCTTGTTGTACATGATGTA
CAACGTTCCTTCGCTGGTAACGCTGGAAGACAAAAAAGATTTCTATGCCCTGACCATGCTGGCTGGGGTGCTGGATGGCG
GCATGAGCGCGCGAATCGAAACGGATCTGGTCCGCGGTCAGCGGCTAGTGGCCGGTGCTGGCGCCAGTTATAGCGGCATT
CAGCGAGGCGATGGGACCTTTACATTGACTGCGGCACCGAACCCTGGTGTGACGTTGGCTGACGTGGAGAAAGCGCTGCT
GGCACAGATCGAAACCCTGCAGACCACCTTGCCCACTGACGCGGAAATGGCGCGGGTGCGGGCCGGGGTGTTGGCGGGTC
AGGTGTATGAGAAAGACTCGGTGATGGGCCAGGCCATGGAGCTGGGCATGCTTAGTACCTTAGGGTTGGATATTGACCTG
TCCACTCGTTTTGCCGAACACCTGGAGGCGGTGACCGCTGAAGATGTACGACGTGTGGCACAGCAATGGCTGGTGCCGGA
GCGTTTGACCGTGGGTATGGTGAAGCCGACAGCGCCCACCTCTGATGAACAGAAAGCGGAGCCGCAACCATGA

Upstream 100 bases:

>100_bases
TTGCAGAGTTGCCGTTCGCGGTGCGAACGCGCCGCTATCCTACCATTATGGGGAGAGGGGAGCAGCTTTGGGTTTGCGGT
CCCCAAAATAGAGGTATTTC

Downstream 100 bases:

>100_bases
AGATAAATACTTTCCGGCTGGCCTTCCTGCTCGGCCTGAGCGTGGTGCTGAGTGCCTGCGCGGGCCCCTTTTCTGGCTCT
TTCCCCTCTACTGAAGCGCA

Product: zinc protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MKKLITVLALGLWSLTSQASLPTHAFTLDNGLKVLVREDHRAPVVTVMMWYKAGSIDEAPYETGLAHVLEHMMFKGTERL
GPGDFSKFVSRYGGSDNAFTSYDYTAYFQQYEVSRLPLALELEAERLGHLDIDDEEFARELKVVMEERRMRTDDNPNALA
WEKFQAVARPGTGYAHPIIGWRSLLSQLQPEQARSWYQRFYVPGNATLVIAGDVTRDQVEPLVEKFFADLPAGQTPPRPK
QTVNPPAGERRLALNLPVKVPLLYMMYNVPSLVTLEDKKDFYALTMLAGVLDGGMSARIETDLVRGQRLVAGAGASYSGI
QRGDGTFTLTAAPNPGVTLADVEKALLAQIETLQTTLPTDAEMARVRAGVLAGQVYEKDSVMGQAMELGMLSTLGLDIDL
STRFAEHLEAVTAEDVRRVAQQWLVPERLTVGMVKPTAPTSDEQKAEPQP

Sequences:

>Translated_450_residues
MKKLITVLALGLWSLTSQASLPTHAFTLDNGLKVLVREDHRAPVVTVMMWYKAGSIDEAPYETGLAHVLEHMMFKGTERL
GPGDFSKFVSRYGGSDNAFTSYDYTAYFQQYEVSRLPLALELEAERLGHLDIDDEEFARELKVVMEERRMRTDDNPNALA
WEKFQAVARPGTGYAHPIIGWRSLLSQLQPEQARSWYQRFYVPGNATLVIAGDVTRDQVEPLVEKFFADLPAGQTPPRPK
QTVNPPAGERRLALNLPVKVPLLYMMYNVPSLVTLEDKKDFYALTMLAGVLDGGMSARIETDLVRGQRLVAGAGASYSGI
QRGDGTFTLTAAPNPGVTLADVEKALLAQIETLQTTLPTDAEMARVRAGVLAGQVYEKDSVMGQAMELGMLSTLGLDIDL
STRFAEHLEAVTAEDVRRVAQQWLVPERLTVGMVKPTAPTSDEQKAEPQP
>Mature_450_residues
MKKLITVLALGLWSLTSQASLPTHAFTLDNGLKVLVREDHRAPVVTVMMWYKAGSIDEAPYETGLAHVLEHMMFKGTERL
GPGDFSKFVSRYGGSDNAFTSYDYTAYFQQYEVSRLPLALELEAERLGHLDIDDEEFARELKVVMEERRMRTDDNPNALA
WEKFQAVARPGTGYAHPIIGWRSLLSQLQPEQARSWYQRFYVPGNATLVIAGDVTRDQVEPLVEKFFADLPAGQTPPRPK
QTVNPPAGERRLALNLPVKVPLLYMMYNVPSLVTLEDKKDFYALTMLAGVLDGGMSARIETDLVRGQRLVAGAGASYSGI
QRGDGTFTLTAAPNPGVTLADVEKALLAQIETLQTTLPTDAEMARVRAGVLAGQVYEKDSVMGQAMELGMLSTLGLDIDL
STRFAEHLEAVTAEDVRRVAQQWLVPERLTVGMVKPTAPTSDEQKAEPQP

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=220, Percent_Identity=27.7272727272727, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI46593007, Length=209, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI155969707, Length=260, Percent_Identity=26.1538461538462, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787770, Length=296, Percent_Identity=28.0405405405405, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71999683, Length=209, Percent_Identity=25.8373205741627, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17553678, Length=206, Percent_Identity=26.6990291262136, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=226, Percent_Identity=23.0088495575221, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357875, Length=221, Percent_Identity=30.316742081448, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24646943, Length=221, Percent_Identity=30.316742081448, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 49742; Mature: 49742

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLITVLALGLWSLTSQASLPTHAFTLDNGLKVLVREDHRAPVVTVMMWYKAGSIDEAP
CHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCCCC
YETGLAHVLEHMMFKGTERLGPGDFSKFVSRYGGSDNAFTSYDYTAYFQQYEVSRLPLAL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHCCEEE
ELEAERLGHLDIDDEEFARELKVVMEERRMRTDDNPNALAWEKFQAVARPGTGYAHPIIG
EECHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
WRSLLSQLQPEQARSWYQRFYVPGNATLVIAGDVTRDQVEPLVEKFFADLPAGQTPPRPK
HHHHHHHCCHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC
QTVNPPAGERRLALNLPVKVPLLYMMYNVPSLVTLEDKKDFYALTMLAGVLDGGMSARIE
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHH
TDLVRGQRLVAGAGASYSGIQRGDGTFTLTAAPNPGVTLADVEKALLAQIETLQTTLPTD
HHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCC
AEMARVRAGVLAGQVYEKDSVMGQAMELGMLSTLGLDIDLSTRFAEHLEAVTAEDVRRVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHH
QQWLVPERLTVGMVKPTAPTSDEQKAEPQP
HHCCCCCHHEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLITVLALGLWSLTSQASLPTHAFTLDNGLKVLVREDHRAPVVTVMMWYKAGSIDEAP
CHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCCCCEEEEEEECCCCCCCCCC
YETGLAHVLEHMMFKGTERLGPGDFSKFVSRYGGSDNAFTSYDYTAYFQQYEVSRLPLAL
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHCCEEE
ELEAERLGHLDIDDEEFARELKVVMEERRMRTDDNPNALAWEKFQAVARPGTGYAHPIIG
EECHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHH
WRSLLSQLQPEQARSWYQRFYVPGNATLVIAGDVTRDQVEPLVEKFFADLPAGQTPPRPK
HHHHHHHCCHHHHHHHHHHEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCC
QTVNPPAGERRLALNLPVKVPLLYMMYNVPSLVTLEDKKDFYALTMLAGVLDGGMSARIE
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHH
TDLVRGQRLVAGAGASYSGIQRGDGTFTLTAAPNPGVTLADVEKALLAQIETLQTTLPTD
HHHHCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCC
AEMARVRAGVLAGQVYEKDSVMGQAMELGMLSTLGLDIDLSTRFAEHLEAVTAEDVRRVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHH
QQWLVPERLTVGMVKPTAPTSDEQKAEPQP
HHCCCCCHHEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]