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The map label for this gene is hprA [C]

Identifier: 110835252

GI number: 110835252

Start: 2713661

End: 2714614

Strand: Reverse

Name: hprA [C]

Synonym: ABO_2391

Alternate gene names: 110835252

Gene position: 2714614-2713661 (Counterclockwise)

Preceding gene: 110835254

Following gene: 110835251

Centisome position: 87.0

GC content: 60.59

Gene sequence:

>954_bases
ATGCAAGGCGTTTTTCTGGATACCGATACCCTGGTTCCCAGTGAGCTGGACTTCAGCACCTTCGACACTTTGTTGTCGTG
GGCGTGCTACCCGCAGACCCGTGCCGACCAGTGTGCGGCTAGGCTGGAAGGTGCGCAGGTGGTGGTGACCAACAAGGTCG
TTTTGGATGCCGCCACGCTGAAAGCCTGTCCTTCCCTTAAGCTTATCTGCATTTGCGCCACTGGTACCAATAATGTGGAT
TTGGCTGCGGCCTCTGCCCTGGGCATCACGGTTTGCAATGTGACGGGCTATGCGCGCGCCTCGGTGGCACAGCATACGAT
GGCCCTGCTGTTGTCGCTGGCGGCTCGGCTGGTTCCCTACCATGAAGCGGTGCGTAGCGGGGAGTGGAGCCGTGCCTCGC
AGTTCTGCCTGCTTGACCATCCAATGATGGAGCTGTCGGGTAAAACGTTCGGGGTTATCGGTTATGGCGATTTGGGCCGC
GAAGTTGCCCGGCTGGCAAAGGCGTTTGGCATGCAGGTGCTGGTTGCCGAATCGTTTCAGGCCCAGGGCAATCAGCCCGG
CCGGGTACCGATGGCGGAGCTGTTGCCGGCGGCGGATGTGATTAGCCTGCATTGCCCGCTAACAGCGCAGACCGACAAGC
TAGTGGACGCGGCGTTTTTGTCGCAGATGAAACCCGGCGCAGTGTTGCTGAACACCGCCCGCGGCGGGTTGATTGATGAG
CCTGCATTGGCGCAAGCGTTGCGCAGTGGGCAACTTGGCGGGGCCGGGTTGGATGTGCTCAGCAGCGAGCCGCCTTCGAT
GGCGCATCCGTTGCTGGCGGACGGTATCCCCAACCTGTTGATTACCCCCCACAATGCCTGGGGCACCCGCGAATCCCGGC
AACGGTTGCTTAATGGTGTGGTGGAGAATATTCGCCAATGGCAGGCGGGTACGCCAATGAACGTGGTGTGTTGA

Upstream 100 bases:

>100_bases
ATGGGTTTTTGCCACTCCTGCTGCGGCAGGTCGAAGCCCATTTTTTCCAATAAATCCGTTAGCATGGCAGGCCTCCCTTC
TTCCCCAACGGTGACAGGTT

Downstream 100 bases:

>100_bases
TCTGTCGCTGATCCCCGCAGCCTCGGCATGGATGCCACTGACGGCACCGATAAGTACAATGGTTTGGCCTTTAGGTTTTA
TGCATGCCTGTGAATGCTGT

Product: glycerate dehydrogenase

Products: hydroxypyruvate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MQGVFLDTDTLVPSELDFSTFDTLLSWACYPQTRADQCAARLEGAQVVVTNKVVLDAATLKACPSLKLICICATGTNNVD
LAAASALGITVCNVTGYARASVAQHTMALLLSLAARLVPYHEAVRSGEWSRASQFCLLDHPMMELSGKTFGVIGYGDLGR
EVARLAKAFGMQVLVAESFQAQGNQPGRVPMAELLPAADVISLHCPLTAQTDKLVDAAFLSQMKPGAVLLNTARGGLIDE
PALAQALRSGQLGGAGLDVLSSEPPSMAHPLLADGIPNLLITPHNAWGTRESRQRLLNGVVENIRQWQAGTPMNVVC

Sequences:

>Translated_317_residues
MQGVFLDTDTLVPSELDFSTFDTLLSWACYPQTRADQCAARLEGAQVVVTNKVVLDAATLKACPSLKLICICATGTNNVD
LAAASALGITVCNVTGYARASVAQHTMALLLSLAARLVPYHEAVRSGEWSRASQFCLLDHPMMELSGKTFGVIGYGDLGR
EVARLAKAFGMQVLVAESFQAQGNQPGRVPMAELLPAADVISLHCPLTAQTDKLVDAAFLSQMKPGAVLLNTARGGLIDE
PALAQALRSGQLGGAGLDVLSSEPPSMAHPLLADGIPNLLITPHNAWGTRESRQRLLNGVVENIRQWQAGTPMNVVC
>Mature_317_residues
MQGVFLDTDTLVPSELDFSTFDTLLSWACYPQTRADQCAARLEGAQVVVTNKVVLDAATLKACPSLKLICICATGTNNVD
LAAASALGITVCNVTGYARASVAQHTMALLLSLAARLVPYHEAVRSGEWSRASQFCLLDHPMMELSGKTFGVIGYGDLGR
EVARLAKAFGMQVLVAESFQAQGNQPGRVPMAELLPAADVISLHCPLTAQTDKLVDAAFLSQMKPGAVLLNTARGGLIDE
PALAQALRSGQLGGAGLDVLSSEPPSMAHPLLADGIPNLLITPHNAWGTRESRQRLLNGVVENIRQWQAGTPMNVVC

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI61743967, Length=274, Percent_Identity=35.036496350365, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4557497, Length=274, Percent_Identity=35.036496350365, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI145580578, Length=274, Percent_Identity=35.4014598540146, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI4557499, Length=274, Percent_Identity=35.4014598540146, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=35.5555555555556, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI23308577, Length=262, Percent_Identity=34.7328244274809, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI6912396, Length=268, Percent_Identity=31.3432835820896, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=32.8185328185328, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI87082289, Length=284, Percent_Identity=31.6901408450704, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789279, Length=232, Percent_Identity=36.2068965517241, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788660, Length=230, Percent_Identity=27.8260869565217, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=34.0996168582375, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=274, Percent_Identity=32.8467153284672, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=261, Percent_Identity=32.5670498084291, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=30.9090909090909, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=284, Percent_Identity=30.9859154929577, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=295, Percent_Identity=29.1525423728814, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=134, Percent_Identity=34.3283582089552, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=154, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=35.3571428571429, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=35.3571428571429, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=35.3571428571429, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=35.3571428571429, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=35.3571428571429, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19921140, Length=252, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574286, Length=297, Percent_Identity=28.956228956229, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571528, Length=268, Percent_Identity=30.2238805970149, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=26.1992619926199, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=26.1992619926199, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=26.1992619926199, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=26.1992619926199, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=26.9372693726937, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585516, Length=266, Percent_Identity=24.812030075188, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: 1.1.1.29

Molecular weight: Translated: 33574; Mature: 33574

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGVFLDTDTLVPSELDFSTFDTLLSWACYPQTRADQCAARLEGAQVVVTNKVVLDAATL
CCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEEEEHHHH
KACPSLKLICICATGTNNVDLAAASALGITVCNVTGYARASVAQHTMALLLSLAARLVPY
HCCCCCEEEEEEECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
HEAVRSGEWSRASQFCLLDHPMMELSGKTFGVIGYGDLGREVARLAKAFGMQVLVAESFQ
HHHHHCCCCCHHCCEEEECCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEHHHH
AQGNQPGRVPMAELLPAADVISLHCPLTAQTDKLVDAAFLSQMKPGAVLLNTARGGLIDE
HCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
PALAQALRSGQLGGAGLDVLSSEPPSMAHPLLADGIPNLLITPHNAWGTRESRQRLLNGV
HHHHHHHHCCCCCCCCCHHHCCCCCCHHCCHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
VENIRQWQAGTPMNVVC
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQGVFLDTDTLVPSELDFSTFDTLLSWACYPQTRADQCAARLEGAQVVVTNKVVLDAATL
CCCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEEEEHHHH
KACPSLKLICICATGTNNVDLAAASALGITVCNVTGYARASVAQHTMALLLSLAARLVPY
HCCCCCEEEEEEECCCCCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
HEAVRSGEWSRASQFCLLDHPMMELSGKTFGVIGYGDLGREVARLAKAFGMQVLVAESFQ
HHHHHCCCCCHHCCEEEECCCHHHHCCCEEEEEECCHHHHHHHHHHHHHCCEEEEEHHHH
AQGNQPGRVPMAELLPAADVISLHCPLTAQTDKLVDAAFLSQMKPGAVLLNTARGGLIDE
HCCCCCCCCCHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
PALAQALRSGQLGGAGLDVLSSEPPSMAHPLLADGIPNLLITPHNAWGTRESRQRLLNGV
HHHHHHHHCCCCCCCCCHHHCCCCCCHHCCHHHCCCCCEEEECCCCCCCHHHHHHHHHHH
VENIRQWQAGTPMNVVC
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-glycerate; NAD+

Specific reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]