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The map label for this gene is cobC [H]

Identifier: 110835237

GI number: 110835237

Start: 2700892

End: 2701881

Strand: Reverse

Name: cobC [H]

Synonym: ABO_2376

Alternate gene names: 110835237

Gene position: 2701881-2700892 (Counterclockwise)

Preceding gene: 110835238

Following gene: 110835233

Centisome position: 86.59

GC content: 60.71

Gene sequence:

>990_bases
GTGAGCGTGGCAAAGCTGGACCATGGTGGCGGGGTGCATAACGCGGCGAGACGTTGGGGAATTCCCCCGCACCACTGGCT
GGATTTGTCCACGGGGATTAGCCCTTGGTCCTGGCCTGTACCGGCGGTGCCGGAGCATGTTTGGCGGCGCTTGCCGGAAG
ATGACGATGGCCTGGTGGATATTTGTCGTGAGGTGCTGGCGCTACCCAGCAATGCCGATTGCTTGCCGGTGCCGGGGAGC
CAGGCGGCATTGCAAACCTTGCCTTTATTGCGGCCCCGTTGCCGTGTGGGTGTGCCTGCGGTGGGGTATGCGGAACATGC
GCAGGCTTGGGCGCGAGCAGGCCATGAGGTCATACCGCTGGCCTACGACCGCATTGAGGCCACCTTGGCGACGCTCGATG
TGCTGGTGTGTATTAATCCCAATAACCCCACAGGGAAGCTCACGGACAGTGAAACGCTGTTGGGCTGGCATCAGCAGTTG
CTGAAGCGAGGTGGCTGGCTGGTGGTGGATGAAGCGTTTTTGGACGCGACTGAGGGGCAGTCTTTGGCGCCGCTGAGTGA
TCGAGCTGGATTGATTGTGCTGCGTTCGCTGGGCAAGTTTTATGGTTTGGCCGGTTTGCGTGCGGGGCTCGTCACGGCGA
CGCCGGATTTGTGTTCTCAAATGGCTCAGCGGTTAGGGCCCTGGGCGGTGAATCACCCGGCCCGTTTTGTGATGGCTAAG
GCGCTAACCGATGCTGATTGGAAACAGCGTCAATATCAGCGGATTACAACGGCGCACCAACGGCTGCTGACGGTGCTGAG
TGACGCAGGCCTGCAAGCAGAAGGCGATTGTGGATTATTTGCTTGGTGCAAGACCGATAAGGCCAACGCCCTCGCCGAGG
CACTGGCCCGGCAGGGCGTGTTGGTTCGGCTTTTCCCCGATGTGCCCGCATTGCGTTTTGGTTTGCCTGGGCACGATCGG
GGATGGACGCAATTGGCCGCGGCGCTTTAA

Upstream 100 bases:

>100_bases
AGGGCCGGCCCGCGGATGCGGACAGCATCGACGCGGCCATTGTACTGGTGTGGCGTAGCGTATTGTTGTGGTTACTGGTC
TTTATAGCGGGAGCGTTGGT

Downstream 100 bases:

>100_bases
TGATGACCGCGCAGCCCCGTTTTGCTAGACCATAAGGTTTCTTTCCAGACAATTCCCAGGTTCCAGCGATGCTCTTTTTC
GGGCAGGGACTCGTCCTGAA

Product: cobalamin biosynthesis protein CobC

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSVAKLDHGGGVHNAARRWGIPPHHWLDLSTGISPWSWPVPAVPEHVWRRLPEDDDGLVDICREVLALPSNADCLPVPGS
QAALQTLPLLRPRCRVGVPAVGYAEHAQAWARAGHEVIPLAYDRIEATLATLDVLVCINPNNPTGKLTDSETLLGWHQQL
LKRGGWLVVDEAFLDATEGQSLAPLSDRAGLIVLRSLGKFYGLAGLRAGLVTATPDLCSQMAQRLGPWAVNHPARFVMAK
ALTDADWKQRQYQRITTAHQRLLTVLSDAGLQAEGDCGLFAWCKTDKANALAEALARQGVLVRLFPDVPALRFGLPGHDR
GWTQLAAAL

Sequences:

>Translated_329_residues
MSVAKLDHGGGVHNAARRWGIPPHHWLDLSTGISPWSWPVPAVPEHVWRRLPEDDDGLVDICREVLALPSNADCLPVPGS
QAALQTLPLLRPRCRVGVPAVGYAEHAQAWARAGHEVIPLAYDRIEATLATLDVLVCINPNNPTGKLTDSETLLGWHQQL
LKRGGWLVVDEAFLDATEGQSLAPLSDRAGLIVLRSLGKFYGLAGLRAGLVTATPDLCSQMAQRLGPWAVNHPARFVMAK
ALTDADWKQRQYQRITTAHQRLLTVLSDAGLQAEGDCGLFAWCKTDKANALAEALARQGVLVRLFPDVPALRFGLPGHDR
GWTQLAAAL
>Mature_328_residues
SVAKLDHGGGVHNAARRWGIPPHHWLDLSTGISPWSWPVPAVPEHVWRRLPEDDDGLVDICREVLALPSNADCLPVPGSQ
AALQTLPLLRPRCRVGVPAVGYAEHAQAWARAGHEVIPLAYDRIEATLATLDVLVCINPNNPTGKLTDSETLLGWHQQLL
KRGGWLVVDEAFLDATEGQSLAPLSDRAGLIVLRSLGKFYGLAGLRAGLVTATPDLCSQMAQRLGPWAVNHPARFVMAKA
LTDADWKQRQYQRITTAHQRLLTVLSDAGLQAEGDCGLFAWCKTDKANALAEALARQGVLVRLFPDVPALRFGLPGHDRG
WTQLAAAL

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35741; Mature: 35610

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVAKLDHGGGVHNAARRWGIPPHHWLDLSTGISPWSWPVPAVPEHVWRRLPEDDDGLVD
CCCCCCCCCCCCCHHHHHCCCCCHHEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
ICREVLALPSNADCLPVPGSQAALQTLPLLRPRCRVGVPAVGYAEHAQAWARAGHEVIPL
HHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEHH
AYDRIEATLATLDVLVCINPNNPTGKLTDSETLLGWHQQLLKRGGWLVVDEAFLDATEGQ
HHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
SLAPLSDRAGLIVLRSLGKFYGLAGLRAGLVTATPDLCSQMAQRLGPWAVNHPARFVMAK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ALTDADWKQRQYQRITTAHQRLLTVLSDAGLQAEGDCGLFAWCKTDKANALAEALARQGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCE
LVRLFPDVPALRFGLPGHDRGWTQLAAAL
EEEECCCCCCEEECCCCCCCCHHHHHHCC
>Mature Secondary Structure 
SVAKLDHGGGVHNAARRWGIPPHHWLDLSTGISPWSWPVPAVPEHVWRRLPEDDDGLVD
CCCCCCCCCCCCHHHHHCCCCCHHEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCHHH
ICREVLALPSNADCLPVPGSQAALQTLPLLRPRCRVGVPAVGYAEHAQAWARAGHEVIPL
HHHHHHCCCCCCCEECCCCCHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHHHCCCCEEHH
AYDRIEATLATLDVLVCINPNNPTGKLTDSETLLGWHQQLLKRGGWLVVDEAFLDATEGQ
HHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHCCCCCC
SLAPLSDRAGLIVLRSLGKFYGLAGLRAGLVTATPDLCSQMAQRLGPWAVNHPARFVMAK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
ALTDADWKQRQYQRITTAHQRLLTVLSDAGLQAEGDCGLFAWCKTDKANALAEALARQGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCE
LVRLFPDVPALRFGLPGHDRGWTQLAAAL
EEEECCCCCCEEECCCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]