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The map label for this gene is cobD [H]

Identifier: 110835238

GI number: 110835238

Start: 2701878

End: 2702807

Strand: Reverse

Name: cobD [H]

Synonym: ABO_2377

Alternate gene names: 110835238

Gene position: 2702807-2701878 (Counterclockwise)

Preceding gene: 110835241

Following gene: 110835237

Centisome position: 86.62

GC content: 63.23

Gene sequence:

>930_bases
ATGCTTTCTGTTTCCCTGATAAGTGCTGCTGTGGCAGCGATTGTGCTGGATTTTTTGCTGGGCGAGCCGCGTCGCTGGCA
TCCGCTGGTGGGGTTTGGTCGGCTGGCCGGGTGGTTAGAGCAGCGTTGGAATGCGGCTGCGCCGGGTAGTGTGTTCAAGG
GGGCCGGAGCGGTGCTGGTCTTGGTGCTACCGGTGGTGCTGTTGGCTGTGCTGATGTTGTCGACCCTGCCAGGGTGGGCC
TGCTGGCTGTTGCAGGTGGTGGGCTTGTGGCTGGTGATGGGCGCGCGCAGTTTGGCCGACCATGGCCGTGCGGTGGCCGC
ACCGTTACGGGCGCAGAATGTGCCTGAGGCCAGAGAACAGGTAGCGAGAATTGTTAGCCGTGACACACAGGCACTGGATG
CCAACGGGGTGGCACGGGCCGCCACCGAATCCGTATTGGAAAATGGGGCCGATGCGGTGTTTGCCAGCCTGTTTTGGTTT
GTGGTGGCGGGGCTGCCCGGTGCGATATTACATCGGTTGGTGAATACGCTGGATGCCATGTGGGGTTATCGCACCGCTCG
TTTCGAACGCTTCGGTAAGGCTGCCGCGCGGCTGGATGACGGCCTTGCTTGGTTGCCTTCGAGACTGACCGCGCTGAGTT
ATGCGCTAGTGGGCGGGTTGCACGGCCGCTTCTGGACCGCGTTGCGCTGCTGGCGGCAGCAAGCCAAGGGCTGCGATAGC
CCCAATGCGGGGCCGGTGATGGCCGCCGGCGCAGGTGCGCTGGGGGTGCAAGTGGGCGGCGGCGCCCCGTACCACGGTGG
CTGGAAAAATAAGCCGTTGTTAGGAGAGGGCCGGCCCGCGGATGCGGACAGCATCGACGCGGCCATTGTACTGGTGTGGC
GTAGCGTATTGTTGTGGTTACTGGTCTTTATAGCGGGAGCGTTGGTGTGA

Upstream 100 bases:

>100_bases
TGGGGCGGCGCAGGGCCGGAAAGCGGCAAATCCTCTGCCCCGCAACCGGGAGTGTCAAGTACACTGCCCGCCATCGATAC
CGGACAATGACGGCAAAATC

Downstream 100 bases:

>100_bases
GCGTGGCAAAGCTGGACCATGGTGGCGGGGTGCATAACGCGGCGAGACGTTGGGGAATTCCCCCGCACCACTGGCTGGAT
TTGTCCACGGGGATTAGCCC

Product: cobalamin biosynthesis protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MLSVSLISAAVAAIVLDFLLGEPRRWHPLVGFGRLAGWLEQRWNAAAPGSVFKGAGAVLVLVLPVVLLAVLMLSTLPGWA
CWLLQVVGLWLVMGARSLADHGRAVAAPLRAQNVPEAREQVARIVSRDTQALDANGVARAATESVLENGADAVFASLFWF
VVAGLPGAILHRLVNTLDAMWGYRTARFERFGKAAARLDDGLAWLPSRLTALSYALVGGLHGRFWTALRCWRQQAKGCDS
PNAGPVMAAGAGALGVQVGGGAPYHGGWKNKPLLGEGRPADADSIDAAIVLVWRSVLLWLLVFIAGALV

Sequences:

>Translated_309_residues
MLSVSLISAAVAAIVLDFLLGEPRRWHPLVGFGRLAGWLEQRWNAAAPGSVFKGAGAVLVLVLPVVLLAVLMLSTLPGWA
CWLLQVVGLWLVMGARSLADHGRAVAAPLRAQNVPEAREQVARIVSRDTQALDANGVARAATESVLENGADAVFASLFWF
VVAGLPGAILHRLVNTLDAMWGYRTARFERFGKAAARLDDGLAWLPSRLTALSYALVGGLHGRFWTALRCWRQQAKGCDS
PNAGPVMAAGAGALGVQVGGGAPYHGGWKNKPLLGEGRPADADSIDAAIVLVWRSVLLWLLVFIAGALV
>Mature_309_residues
MLSVSLISAAVAAIVLDFLLGEPRRWHPLVGFGRLAGWLEQRWNAAAPGSVFKGAGAVLVLVLPVVLLAVLMLSTLPGWA
CWLLQVVGLWLVMGARSLADHGRAVAAPLRAQNVPEAREQVARIVSRDTQALDANGVARAATESVLENGADAVFASLFWF
VVAGLPGAILHRLVNTLDAMWGYRTARFERFGKAAARLDDGLAWLPSRLTALSYALVGGLHGRFWTALRCWRQQAKGCDS
PNAGPVMAAGAGALGVQVGGGAPYHGGWKNKPLLGEGRPADADSIDAAIVLVWRSVLLWLLVFIAGALV

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 32744; Mature: 32744

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVSLISAAVAAIVLDFLLGEPRRWHPLVGFGRLAGWLEQRWNAAAPGSVFKGAGAVLV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LVLPVVLLAVLMLSTLPGWACWLLQVVGLWLVMGARSLADHGRAVAAPLRAQNVPEAREQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCHHHHH
VARIVSRDTQALDANGVARAATESVLENGADAVFASLFWFVVAGLPGAILHRLVNTLDAM
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WGYRTARFERFGKAAARLDDGLAWLPSRLTALSYALVGGLHGRFWTALRCWRQQAKGCDS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
PNAGPVMAAGAGALGVQVGGGAPYHGGWKNKPLLGEGRPADADSIDAAIVLVWRSVLLWL
CCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVFIAGALV
HHHHHHHCC
>Mature Secondary Structure
MLSVSLISAAVAAIVLDFLLGEPRRWHPLVGFGRLAGWLEQRWNAAAPGSVFKGAGAVLV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LVLPVVLLAVLMLSTLPGWACWLLQVVGLWLVMGARSLADHGRAVAAPLRAQNVPEAREQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHCCCCHHHHH
VARIVSRDTQALDANGVARAATESVLENGADAVFASLFWFVVAGLPGAILHRLVNTLDAM
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WGYRTARFERFGKAAARLDDGLAWLPSRLTALSYALVGGLHGRFWTALRCWRQQAKGCDS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
PNAGPVMAAGAGALGVQVGGGAPYHGGWKNKPLLGEGRPADADSIDAAIVLVWRSVLLWL
CCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVFIAGALV
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA