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The map label for this gene is nhaC [H]

Identifier: 110835190

GI number: 110835190

Start: 2656382

End: 2657857

Strand: Reverse

Name: nhaC [H]

Synonym: ABO_2329

Alternate gene names: 110835190

Gene position: 2657857-2656382 (Counterclockwise)

Preceding gene: 110835191

Following gene: 110835187

Centisome position: 85.18

GC content: 56.78

Gene sequence:

>1476_bases
ATGACCGAATCCCGATACCGCCGCCCCTCCTTGCTGGATGCTCTGCTGCCGATCGTAGTACTGGTGGTGTTACTGGCGTC
GGCGGTTTATTTGTACGGCGATAGTGCCTCCTCCGGTCCCAACCAGATTGCCTTGCTGATCTGTGCCGGCCTTGCCTCAT
TAATCGCATTTAAAAATGGCCTGACTTGGCGGGAAATCGAAACCGCCATGATTAAGGGTATTTCGGTGGCGTTGGGTGCG
GTGCTGATTCTACTCAGTGTGGGGGCCCTGATCGGTACCTGGCGGTTGGCAGGCATCGTGCCTTCGCTCATTTATTTTGG
TCTTGAGTTGATGAATCCGGCCCTGTTTTATGCGGCCGCCTGTTTGATCTGCGCGATTATCGCCCTGAGTATCGGCTCCA
GTTGGACTGTGGCGGCCACCGTGGGGGTGGCGTTGATCGGGGTGGCCAGCGGGCTGGGGTTGTCGTTGCCGGTGGCGGCC
GGTGCGGTGGTCTCCGGTGCCTACTTTGGTGACAAGATTTCTCCGTTGTCTGAGACCACTAACCTAGCTCCGGCGGTGGC
GGGTTCGGAACTGTTTGAGCATATTCGCCTGATGTTGTGGACCACGGTGCCCTCCATTGTCATCGCCTTGCTGATTTTTT
TGGTGATGGGGCTGAATACGGACGTTGCCGGCGACACAGTGGACCGAATTACCCCGCTGCTACAGGGGCTGGAAAGCCAG
TTTGATATTTCCTTGCTGCACCTGATTCCATTGCTGGTGTTGTTGGTGCTGGCGCTCAAGCGGATGCCGGCCTTACCGGC
GATTTTTCTGGGCGCGTTATTGGGTGGGATCTGGGCTCTGATGTTTCAGCCGCAGGCGATTGCGGTGCAAGCTGGCGAGC
CGGCACCCGGCTGGGTGGCGTCTTTGAAAGTGGTTTGGCAGACCTTTTACCAGGGCATCACCGTGGAAACCGGCGATGCG
ACGTTGAATAACCTGCTGTCTGGCGGCGGCATGGCGTCCATGCTCAATACCGTGTGGCTGATTATCTGTGCGATGACCTT
TGGTGCGGTGATGGAGCACGCAGGGTTTCTTGCTCGCTTAATCGAAGGGCTGCTGGGGGCGGTTAAGGGCGCAGCGGGGT
TGATCGCCGCCACATTGGCCACCTGTTTTGGCAGCAATATTCTTACTGCTGACCAGTACATTTCTATCATTATGCCTGGC
CGGATGTTCCGTGAAGCCTATGCAAAACAGGGCCTGGCGCCAGTGAATCTGTCCCGTGCGCTAGAAGATGGTGGCACTAT
CACCAGCCCGCTTATCCCTTGGAACACCTGCGGTGCCTACATGCAATCGGTATTGCTGGTGCCGGTGACCGATTATCTTT
TCTACGCGTTCTTTAATCTGATCAACCCGGTGTTGGCGTTGGTTTATGCCTGGCTGGGGGTCAAGGTGCTGCGGTTAGCG
CCCCCTCAAGAGGTGTATAAAACCGGATCACTATGA

Upstream 100 bases:

>100_bases
GCCAGCATCGCCGGCTAGCGCCGCTTTCTGCCTCGATGATATGTGCTTACTGGTGGCCTGTCGGGTATAACGGAAAGCTC
AGCCGCTGAATGTTGCCGCT

Downstream 100 bases:

>100_bases
ACAAAAAGAAAAGGCGGCCTGGCCGCCTTTTCTTTTAAACCCTTTGCGCATGAAACGTGCTGCGTTTACTGCTATGGCAG
TAACGATTCCAGTTTCAATT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTESRYRRPSLLDALLPIVVLVVLLASAVYLYGDSASSGPNQIALLICAGLASLIAFKNGLTWREIETAMIKGISVALGA
VLILLSVGALIGTWRLAGIVPSLIYFGLELMNPALFYAAACLICAIIALSIGSSWTVAATVGVALIGVASGLGLSLPVAA
GAVVSGAYFGDKISPLSETTNLAPAVAGSELFEHIRLMLWTTVPSIVIALLIFLVMGLNTDVAGDTVDRITPLLQGLESQ
FDISLLHLIPLLVLLVLALKRMPALPAIFLGALLGGIWALMFQPQAIAVQAGEPAPGWVASLKVVWQTFYQGITVETGDA
TLNNLLSGGGMASMLNTVWLIICAMTFGAVMEHAGFLARLIEGLLGAVKGAAGLIAATLATCFGSNILTADQYISIIMPG
RMFREAYAKQGLAPVNLSRALEDGGTITSPLIPWNTCGAYMQSVLLVPVTDYLFYAFFNLINPVLALVYAWLGVKVLRLA
PPQEVYKTGSL

Sequences:

>Translated_491_residues
MTESRYRRPSLLDALLPIVVLVVLLASAVYLYGDSASSGPNQIALLICAGLASLIAFKNGLTWREIETAMIKGISVALGA
VLILLSVGALIGTWRLAGIVPSLIYFGLELMNPALFYAAACLICAIIALSIGSSWTVAATVGVALIGVASGLGLSLPVAA
GAVVSGAYFGDKISPLSETTNLAPAVAGSELFEHIRLMLWTTVPSIVIALLIFLVMGLNTDVAGDTVDRITPLLQGLESQ
FDISLLHLIPLLVLLVLALKRMPALPAIFLGALLGGIWALMFQPQAIAVQAGEPAPGWVASLKVVWQTFYQGITVETGDA
TLNNLLSGGGMASMLNTVWLIICAMTFGAVMEHAGFLARLIEGLLGAVKGAAGLIAATLATCFGSNILTADQYISIIMPG
RMFREAYAKQGLAPVNLSRALEDGGTITSPLIPWNTCGAYMQSVLLVPVTDYLFYAFFNLINPVLALVYAWLGVKVLRLA
PPQEVYKTGSL
>Mature_490_residues
TESRYRRPSLLDALLPIVVLVVLLASAVYLYGDSASSGPNQIALLICAGLASLIAFKNGLTWREIETAMIKGISVALGAV
LILLSVGALIGTWRLAGIVPSLIYFGLELMNPALFYAAACLICAIIALSIGSSWTVAATVGVALIGVASGLGLSLPVAAG
AVVSGAYFGDKISPLSETTNLAPAVAGSELFEHIRLMLWTTVPSIVIALLIFLVMGLNTDVAGDTVDRITPLLQGLESQF
DISLLHLIPLLVLLVLALKRMPALPAIFLGALLGGIWALMFQPQAIAVQAGEPAPGWVASLKVVWQTFYQGITVETGDAT
LNNLLSGGGMASMLNTVWLIICAMTFGAVMEHAGFLARLIEGLLGAVKGAAGLIAATLATCFGSNILTADQYISIIMPGR
MFREAYAKQGLAPVNLSRALEDGGTITSPLIPWNTCGAYMQSVLLVPVTDYLFYAFFNLINPVLALVYAWLGVKVLRLAP
PQEVYKTGSL

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 51632; Mature: 51501

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESRYRRPSLLDALLPIVVLVVLLASAVYLYGDSASSGPNQIALLICAGLASLIAFKNG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LTWREIETAMIKGISVALGAVLILLSVGALIGTWRLAGIVPSLIYFGLELMNPALFYAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLICAIIALSIGSSWTVAATVGVALIGVASGLGLSLPVAAGAVVSGAYFGDKISPLSETT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
NLAPAVAGSELFEHIRLMLWTTVPSIVIALLIFLVMGLNTDVAGDTVDRITPLLQGLESQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
FDISLLHLIPLLVLLVLALKRMPALPAIFLGALLGGIWALMFQPQAIAVQAGEPAPGWVA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
SLKVVWQTFYQGITVETGDATLNNLLSGGGMASMLNTVWLIICAMTFGAVMEHAGFLARL
HHHHHHHHHHCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGLLGAVKGAAGLIAATLATCFGSNILTADQYISIIMPGRMFREAYAKQGLAPVNLSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
LEDGGTITSPLIPWNTCGAYMQSVLLVPVTDYLFYAFFNLINPVLALVYAWLGVKVLRLA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPQEVYKTGSL
CHHHHHCCCCC
>Mature Secondary Structure 
TESRYRRPSLLDALLPIVVLVVLLASAVYLYGDSASSGPNQIALLICAGLASLIAFKNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
LTWREIETAMIKGISVALGAVLILLSVGALIGTWRLAGIVPSLIYFGLELMNPALFYAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CLICAIIALSIGSSWTVAATVGVALIGVASGLGLSLPVAAGAVVSGAYFGDKISPLSETT
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHH
NLAPAVAGSELFEHIRLMLWTTVPSIVIALLIFLVMGLNTDVAGDTVDRITPLLQGLESQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
FDISLLHLIPLLVLLVLALKRMPALPAIFLGALLGGIWALMFQPQAIAVQAGEPAPGWVA
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHH
SLKVVWQTFYQGITVETGDATLNNLLSGGGMASMLNTVWLIICAMTFGAVMEHAGFLARL
HHHHHHHHHHCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEGLLGAVKGAAGLIAATLATCFGSNILTADQYISIIMPGRMFREAYAKQGLAPVNLSRA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
LEDGGTITSPLIPWNTCGAYMQSVLLVPVTDYLFYAFFNLINPVLALVYAWLGVKVLRLA
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPQEVYKTGSL
CHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]