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The map label for this gene is lysA [H]

Identifier: 110835189

GI number: 110835189

Start: 2655069

End: 2656310

Strand: Direct

Name: lysA [H]

Synonym: ABO_2328

Alternate gene names: 110835189

Gene position: 2655069-2656310 (Clockwise)

Preceding gene: 110835188

Following gene: 110835193

Centisome position: 85.09

GC content: 58.86

Gene sequence:

>1242_bases
ATGGATCATTTTCAGTACCGCGACGGAGAATTGTTTGCCGAAGAGCTGCCGGTAGAGCAACTGGCGGACCGCTTCGGCAC
GCCGCTCTATCTGTATTCCCGGGCGGCGTTGGAACGTCACTACTTGGCGTTCGACGAAGCGTTCGGTGATCATCCTCATC
AGGTGTGCTATGCGGTAAAAGCCAACTCCAATCTGGCCGTGCTGAATGTACTAGCCCGGGTCGGCGCGGGTTTCGACATT
GTTTCCGGTGGCGAACTGGAACGCGTGCTGCGTGCCGGCGGCGACCCAGACAAAATTGTTTTCTCCGGAGTCGGCAAAAC
CGCCAACGAAATGGCCGCCGCCCTGAAAGCCAACATCCACTGTTTCAACGTGGAATCCGCCGCGGAACTGGAATTGCTGA
ACCTGGTGGCCGGCGAGCTGGACCGGGAGGCGCCGATCGCCATCCGCGTGAACCCGGATGTGGACGCCCAGACCCACCCC
TATATTTCCACCGGTTTGAAAGACAACAAGTTCGGCGTGGACATCACTAAAGCCCCCGCCTTGTATCAACGAGCCGCTGA
GTTACCGCACATCAAGATACTGGGCATCGATTGCCATATCGGCAGCCAGCTCACCAAACTCGATCCATTCGAAGCGGCCT
TGGAGCGGGTATTGAAACTGCTGGCCCAACTGCAAGAGCACGGCATCGAGATTCATCATTTGGATTTGGGTGGCGGCCTA
GGCGTGACCTACGACGACGAAACGCCCCCGGATCGCTCGGACTATGTGCAGGCCTTGCTCAAGCACATTCCCGGCGAGCT
TCCCGTGCACATCGAACCAGGGCGCTCCATTGCTGCCAATGCCGGAATTTTTGTTACTCAAGTGCTGTTTCTGAAGCCCA
CCGAGCACAAAAATTTCGCCATCGTCGACGGCGCCATGAACGATCTGATTCGCCCCAGCCTCTACTCCGCCTGGCAGAAC
ATTGTGCCGGTAAAACCCCACGAGGCGGACTGCCGCAACTGGGATATTGTCGGGCCAGTGTGCGAAACCGGCGACTTCCT
GGGCAAGGACCGGGCCCTGGCACTGGAGACCGGCGACCTGCTGGCCGTGCGCAGTGCCGGCGCCTACGGCTTCGCCATGG
CCAGCAACTACAACAGCCGCAACCGCCCCGCCGAAGTCATGGTGGATGGCGACCAGGCCTTTGTCGTGCGGCAAAGGGAA
ACCTATGACGAGCAATTGAAACTGGAATCGTTACTGCCATAG

Upstream 100 bases:

>100_bases
CGTCAACGCCGGCCAGCAACGCCGAGCCGTCGCAAACCAACGCAGACAGTGACGACACACAAGACAAAGAGGACGCTGAC
GCGTCAGCACAGGACTAATC

Downstream 100 bases:

>100_bases
CAGTAAACGCAGCACGTTTCATGCGCAAAGGGTTTAAAAGAAAAGGCGGCCAGGCCGCCTTTTCTTTTTGTTCATAGTGA
TCCGGTTTTATACACCTCTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MDHFQYRDGELFAEELPVEQLADRFGTPLYLYSRAALERHYLAFDEAFGDHPHQVCYAVKANSNLAVLNVLARVGAGFDI
VSGGELERVLRAGGDPDKIVFSGVGKTANEMAAALKANIHCFNVESAAELELLNLVAGELDREAPIAIRVNPDVDAQTHP
YISTGLKDNKFGVDITKAPALYQRAAELPHIKILGIDCHIGSQLTKLDPFEAALERVLKLLAQLQEHGIEIHHLDLGGGL
GVTYDDETPPDRSDYVQALLKHIPGELPVHIEPGRSIAANAGIFVTQVLFLKPTEHKNFAIVDGAMNDLIRPSLYSAWQN
IVPVKPHEADCRNWDIVGPVCETGDFLGKDRALALETGDLLAVRSAGAYGFAMASNYNSRNRPAEVMVDGDQAFVVRQRE
TYDEQLKLESLLP

Sequences:

>Translated_413_residues
MDHFQYRDGELFAEELPVEQLADRFGTPLYLYSRAALERHYLAFDEAFGDHPHQVCYAVKANSNLAVLNVLARVGAGFDI
VSGGELERVLRAGGDPDKIVFSGVGKTANEMAAALKANIHCFNVESAAELELLNLVAGELDREAPIAIRVNPDVDAQTHP
YISTGLKDNKFGVDITKAPALYQRAAELPHIKILGIDCHIGSQLTKLDPFEAALERVLKLLAQLQEHGIEIHHLDLGGGL
GVTYDDETPPDRSDYVQALLKHIPGELPVHIEPGRSIAANAGIFVTQVLFLKPTEHKNFAIVDGAMNDLIRPSLYSAWQN
IVPVKPHEADCRNWDIVGPVCETGDFLGKDRALALETGDLLAVRSAGAYGFAMASNYNSRNRPAEVMVDGDQAFVVRQRE
TYDEQLKLESLLP
>Mature_413_residues
MDHFQYRDGELFAEELPVEQLADRFGTPLYLYSRAALERHYLAFDEAFGDHPHQVCYAVKANSNLAVLNVLARVGAGFDI
VSGGELERVLRAGGDPDKIVFSGVGKTANEMAAALKANIHCFNVESAAELELLNLVAGELDREAPIAIRVNPDVDAQTHP
YISTGLKDNKFGVDITKAPALYQRAAELPHIKILGIDCHIGSQLTKLDPFEAALERVLKLLAQLQEHGIEIHHLDLGGGL
GVTYDDETPPDRSDYVQALLKHIPGELPVHIEPGRSIAANAGIFVTQVLFLKPTEHKNFAIVDGAMNDLIRPSLYSAWQN
IVPVKPHEADCRNWDIVGPVCETGDFLGKDRALALETGDLLAVRSAGAYGFAMASNYNSRNRPAEVMVDGDQAFVVRQRE
TYDEQLKLESLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=368, Percent_Identity=25.5434782608696, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI16506287, Length=184, Percent_Identity=28.2608695652174, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1789203, Length=425, Percent_Identity=30.3529411764706, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=359, Percent_Identity=25.9052924791086, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=24.0331491712707, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586472, Length=341, Percent_Identity=26.3929618768328, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586474, Length=393, Percent_Identity=25.1908396946565, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45291; Mature: 45291

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFQYRDGELFAEELPVEQLADRFGTPLYLYSRAALERHYLAFDEAFGDHPHQVCYAVK
CCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEE
ANSNLAVLNVLARVGAGFDIVSGGELERVLRAGGDPDKIVFSGVGKTANEMAAALKANIH
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCEE
CFNVESAAELELLNLVAGELDREAPIAIRVNPDVDAQTHPYISTGLKDNKFGVDITKAPA
EEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCEEECCHH
LYQRAAELPHIKILGIDCHIGSQLTKLDPFEAALERVLKLLAQLQEHGIEIHHLDLGGGL
HHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDDETPPDRSDYVQALLKHIPGELPVHIEPGRSIAANAGIFVTQVLFLKPTEHKNFA
CEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCEECCCCEEEEEEEEECCCCCCCEE
IVDGAMNDLIRPSLYSAWQNIVPVKPHEADCRNWDIVGPVCETGDFLGKDRALALETGDL
EECCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCE
LAVRSAGAYGFAMASNYNSRNRPAEVMVDGDQAFVVRQRETYDEQLKLESLLP
EEEECCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDHFQYRDGELFAEELPVEQLADRFGTPLYLYSRAALERHYLAFDEAFGDHPHQVCYAVK
CCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEE
ANSNLAVLNVLARVGAGFDIVSGGELERVLRAGGDPDKIVFSGVGKTANEMAAALKANIH
CCCCHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCEE
CFNVESAAELELLNLVAGELDREAPIAIRVNPDVDAQTHPYISTGLKDNKFGVDITKAPA
EEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEECCCCCCCCCCEEECCHH
LYQRAAELPHIKILGIDCHIGSQLTKLDPFEAALERVLKLLAQLQEHGIEIHHLDLGGGL
HHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVTYDDETPPDRSDYVQALLKHIPGELPVHIEPGRSIAANAGIFVTQVLFLKPTEHKNFA
CEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCEECCCCEEEEEEEEECCCCCCCEE
IVDGAMNDLIRPSLYSAWQNIVPVKPHEADCRNWDIVGPVCETGDFLGKDRALALETGDL
EECCHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEECCCE
LAVRSAGAYGFAMASNYNSRNRPAEVMVDGDQAFVVRQRETYDEQLKLESLLP
EEEECCCCCEEEEECCCCCCCCCCEEEEECCCEEEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]