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The map label for this gene is hisE

Identifier: 110835110

GI number: 110835110

Start: 2570541

End: 2570876

Strand: Direct

Name: hisE

Synonym: ABO_2249

Alternate gene names: 110835110

Gene position: 2570541-2570876 (Clockwise)

Preceding gene: 110835109

Following gene: 110835111

Centisome position: 82.39

GC content: 54.76

Gene sequence:

>336_bases
ATGTCAGACATACTCAGTGAGCTGCATCAGGTTCTGGAGTCACGCAAGGGCGCCAATCCGGACAGCTCCTATGTGGCCAG
CCTGTATGCCAAGGGCCTCAACAAAATCCTGGAAAAAGTCGGCGAAGAAGCGATAGAAACCATCCTTGCGGCCCGAGATG
CGGAAGTCAGCGGCGAGCATCAGGCACTGATCAGCGAAACTGCCGATTTATGGTTCCACTCCCTGGTAATGTTGGCCAAA
CTGGGCGAACACCCAGACAAAGTCCTGGCAGAACTACAACGACGTTTTGGCCTGTCCGGCCATGATGAGAAAGCCGCACG
CAGCGGTAAGCACTAA

Upstream 100 bases:

>100_bases
GCGCCGCTAGCAACAACACATCAGAAAAAAGAGCCTATGGCCCTTTTACGCACCCTGATAAACTCATCCCCCTGCCGGGT
TGGGCAATAAGGAATACACT

Downstream 100 bases:

>100_bases
CGTAGCTAACGCGGCCCTTAACTTTTTCGGAGAGAAATTCCATGTTTTCCGGTATCAGCATTTGGCAGCTATTGATTCTC
CTGGCCATCGTGGTCCTGTT

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 111; Mature: 110

Protein sequence:

>111_residues
MSDILSELHQVLESRKGANPDSSYVASLYAKGLNKILEKVGEEAIETILAARDAEVSGEHQALISETADLWFHSLVMLAK
LGEHPDKVLAELQRRFGLSGHDEKAARSGKH

Sequences:

>Translated_111_residues
MSDILSELHQVLESRKGANPDSSYVASLYAKGLNKILEKVGEEAIETILAARDAEVSGEHQALISETADLWFHSLVMLAK
LGEHPDKVLAELQRRFGLSGHDEKAARSGKH
>Mature_110_residues
SDILSELHQVLESRKGANPDSSYVASLYAKGLNKILEKVGEEAIETILAARDAEVSGEHQALISETADLWFHSLVMLAKL
GEHPDKVLAELQRRFGLSGHDEKAARSGKH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=92, Percent_Identity=41.304347826087, Blast_Score=67, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_ALCBS (Q0VMA1)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693969.1
- ProteinModelPortal:   Q0VMA1
- SMR:   Q0VMA1
- STRING:   Q0VMA1
- GeneID:   4212201
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2249
- NMPDR:   fig|393595.12.peg.2250
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   ABOR393595:ABO_2249-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12162; Mature: 12031

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILSELHQVLESRKGANPDSSYVASLYAKGLNKILEKVGEEAIETILAARDAEVSGEH
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QALISETADLWFHSLVMLAKLGEHPDKVLAELQRRFGLSGHDEKAARSGKH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCC
>Mature Secondary Structure 
SDILSELHQVLESRKGANPDSSYVASLYAKGLNKILEKVGEEAIETILAARDAEVSGEH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QALISETADLWFHSLVMLAKLGEHPDKVLAELQRRFGLSGHDEKAARSGKH
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA