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The map label for this gene is ubiB [H]

Identifier: 110835109

GI number: 110835109

Start: 2568864

End: 2570450

Strand: Direct

Name: ubiB [H]

Synonym: ABO_2248

Alternate gene names: 110835109

Gene position: 2568864-2570450 (Clockwise)

Preceding gene: 110835108

Following gene: 110835110

Centisome position: 82.33

GC content: 59.99

Gene sequence:

>1587_bases
ATGCTGGTGGTGATCCATGTGATCTGCCGCTACCGGCTAATATCCTTGCTTCCCCCACACCCCACCAAGGGGTTATTGCT
TATTCTCCAATATCTGGTGCCTGCTAGCTGGCTCGGCACCGGCCACCTAAGCGAAGGGGAGCGTCTACAGAAAGCCCTGG
AGCAACTAGGCCCGATTTTCATCAAATTCGGCCAACTGCTGGCCACCCGGCAAGACATGCTGCCGCCGGAGTGGGTCGCC
GCCCTTGCCCGTCTGCAAGATCAGGTTGCCCCATTCGACGGCGAGCAGGCCAGGGCCCTGGTGGAAGCCAGCCTGCACCA
ACCGCTGGATGAAGTATTCCGTGACTTTGATAGTACGCCTATAGCCGCAGCCTCGGTCGCGCAGGTACACGCCGCCACCC
TGCACAACGGCCAGCAAGTGGTTGCCAAAGTGCTGCGCCCTACAATCCGCCCGGTGGTGGAAAGGGATCTGAAAGTCATG
GCATTCGGTGCACGCTGGCTGGAACGCCTATGGCGTGATGCTCGCTATTTCCGCCCGGTCCGAGTGGTGCAGGACTACCG
AGAGATCCTCCTTGGCGAGCTAGATCTGGCCGCCGAAGCGCGCAACAGCGAAACCATGCGCCGGCATTTTCTGTTCAGCC
CACTGCTGCACATCCCGGCCATACATCTGGAACTGTCCAGCCCGACCGTAATCATCATGGATCGCATCCATGGTATTCCG
GTGAATGATATCGAGCGCATTAAGGCCGCGGGTATCGACCCAAAAGTGCTGGCCGAACGGGGCGTGGAGATTTTCTTCGC
CCAGGTATTCCGCTTCAATTTCTTCCACGCAGACATGCACCCGGGAAATATTTTCGTCAACCCGGAACATCCTGAATCGC
CCCAGTACATGGCAATAGACGCTGCCATCGCTGGGCGCTTGTCCAAAGACGATTTGAACATCCTCGGGCGCATGGTGTTG
GCGGTAATGCGCGAAGACTACAGCGCCCTAGTCGATGCGGTTATTCGCGCCGGCTGGAATACCGCCCCCATCGACCGCTC
CCGGTTCGAACGGGCGGTAATCGACATCGTCGAGCCGGTTCGCTCTGCCCAGCTTGACCAGCTGGAATTCGCGCCCCTAG
TAATGAAGCTGTTTGATATGGCGCGTACCTACCATATCGAAATGCCGGTGCAGTACATCCTTCTGATGAAAACCTTGGTG
CATATCGAAGGGCTGGGGCGCAGCATCTACCCGCAGCTGGATATCTGGAGCACCGGGCGCCCACTGCTGGAAGCGTGGAT
GCTGGCCGAGTACGGCCCCAGCGCCACCCTGAAGAAACTACAAAACCGCCTACCGGAATGGTCCGCTCAACTTCCAGACA
TGCCCGACCTGCTGCGCGACGGGCTGGAAAGCCTGCGAAACCTGCCCTACCAGCAAGATCGCCAGGAAGCCCGTTTCGAG
CAGCAGCTAGTGCGTCACCGTCAAAAGCTGTTTGCCGGCCTCGTCGCGCTGGGCTGTGCCGGCGCGGCCCTATGGCTGGC
CAACCCCTACAGCTGGGCCTTGGGCGGTGCTGCGGCCATTCTGGGCAGCTGGAGCTGGCGCCGCTAG

Upstream 100 bases:

>100_bases
ACGCTCGCATTCAACGGTTAAGAAGCCGCTCGACTTCCTCATCACCCTCCTCGCCACAGGATTCCGGGAGCTCACCACAC
TAATGCCGCCGATTACCCGT

Downstream 100 bases:

>100_bases
CAACAACACATCAGAAAAAAGAGCCTATGGCCCTTTTACGCACCCTGATAAACTCATCCCCCTGCCGGGTTGGGCAATAA
GGAATACACTATGTCAGACA

Product: ubiquinone biosynthesis protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MLVVIHVICRYRLISLLPPHPTKGLLLILQYLVPASWLGTGHLSEGERLQKALEQLGPIFIKFGQLLATRQDMLPPEWVA
ALARLQDQVAPFDGEQARALVEASLHQPLDEVFRDFDSTPIAAASVAQVHAATLHNGQQVVAKVLRPTIRPVVERDLKVM
AFGARWLERLWRDARYFRPVRVVQDYREILLGELDLAAEARNSETMRRHFLFSPLLHIPAIHLELSSPTVIIMDRIHGIP
VNDIERIKAAGIDPKVLAERGVEIFFAQVFRFNFFHADMHPGNIFVNPEHPESPQYMAIDAAIAGRLSKDDLNILGRMVL
AVMREDYSALVDAVIRAGWNTAPIDRSRFERAVIDIVEPVRSAQLDQLEFAPLVMKLFDMARTYHIEMPVQYILLMKTLV
HIEGLGRSIYPQLDIWSTGRPLLEAWMLAEYGPSATLKKLQNRLPEWSAQLPDMPDLLRDGLESLRNLPYQQDRQEARFE
QQLVRHRQKLFAGLVALGCAGAALWLANPYSWALGGAAAILGSWSWRR

Sequences:

>Translated_528_residues
MLVVIHVICRYRLISLLPPHPTKGLLLILQYLVPASWLGTGHLSEGERLQKALEQLGPIFIKFGQLLATRQDMLPPEWVA
ALARLQDQVAPFDGEQARALVEASLHQPLDEVFRDFDSTPIAAASVAQVHAATLHNGQQVVAKVLRPTIRPVVERDLKVM
AFGARWLERLWRDARYFRPVRVVQDYREILLGELDLAAEARNSETMRRHFLFSPLLHIPAIHLELSSPTVIIMDRIHGIP
VNDIERIKAAGIDPKVLAERGVEIFFAQVFRFNFFHADMHPGNIFVNPEHPESPQYMAIDAAIAGRLSKDDLNILGRMVL
AVMREDYSALVDAVIRAGWNTAPIDRSRFERAVIDIVEPVRSAQLDQLEFAPLVMKLFDMARTYHIEMPVQYILLMKTLV
HIEGLGRSIYPQLDIWSTGRPLLEAWMLAEYGPSATLKKLQNRLPEWSAQLPDMPDLLRDGLESLRNLPYQQDRQEARFE
QQLVRHRQKLFAGLVALGCAGAALWLANPYSWALGGAAAILGSWSWRR
>Mature_528_residues
MLVVIHVICRYRLISLLPPHPTKGLLLILQYLVPASWLGTGHLSEGERLQKALEQLGPIFIKFGQLLATRQDMLPPEWVA
ALARLQDQVAPFDGEQARALVEASLHQPLDEVFRDFDSTPIAAASVAQVHAATLHNGQQVVAKVLRPTIRPVVERDLKVM
AFGARWLERLWRDARYFRPVRVVQDYREILLGELDLAAEARNSETMRRHFLFSPLLHIPAIHLELSSPTVIIMDRIHGIP
VNDIERIKAAGIDPKVLAERGVEIFFAQVFRFNFFHADMHPGNIFVNPEHPESPQYMAIDAAIAGRLSKDDLNILGRMVL
AVMREDYSALVDAVIRAGWNTAPIDRSRFERAVIDIVEPVRSAQLDQLEFAPLVMKLFDMARTYHIEMPVQYILLMKTLV
HIEGLGRSIYPQLDIWSTGRPLLEAWMLAEYGPSATLKKLQNRLPEWSAQLPDMPDLLRDGLESLRNLPYQQDRQEARFE
QQLVRHRQKLFAGLVALGCAGAALWLANPYSWALGGAAAILGSWSWRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=282, Percent_Identity=29.7872340425532, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI40254938, Length=253, Percent_Identity=32.0158102766798, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI217035081, Length=190, Percent_Identity=33.6842105263158, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=24.1791044776119, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI2367309, Length=537, Percent_Identity=39.4785847299814, Blast_Score=398, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17559152, Length=387, Percent_Identity=24.8062015503876, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=309, Percent_Identity=22.6537216828479, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=490, Percent_Identity=25.1020408163265, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323282, Length=249, Percent_Identity=28.9156626506024, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=246, Percent_Identity=25.2032520325203, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22024280, Length=272, Percent_Identity=28.6764705882353, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24662575, Length=245, Percent_Identity=30.2040816326531, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59853; Mature: 59853

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVIHVICRYRLISLLPPHPTKGLLLILQYLVPASWLGTGHLSEGERLQKALEQLGPIF
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHH
IKFGQLLATRQDMLPPEWVAALARLQDQVAPFDGEQARALVEASLHQPLDEVFRDFDSTP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCC
IAAASVAQVHAATLHNGQQVVAKVLRPTIRPVVERDLKVMAFGARWLERLWRDARYFRPV
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVVQDYREILLGELDLAAEARNSETMRRHFLFSPLLHIPAIHLELSSPTVIIMDRIHGIP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCC
VNDIERIKAAGIDPKVLAERGVEIFFAQVFRFNFFHADMHPGNIFVNPEHPESPQYMAID
CHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCCEEEEH
AAIAGRLSKDDLNILGRMVLAVMREDYSALVDAVIRAGWNTAPIDRSRFERAVIDIVEPV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RSAQLDQLEFAPLVMKLFDMARTYHIEMPVQYILLMKTLVHIEGLGRSIYPQLDIWSTGR
HHCCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
PLLEAWMLAEYGPSATLKKLQNRLPEWSAQLPDMPDLLRDGLESLRNLPYQQDRQEARFE
HHHHHHHHHHCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
QQLVRHRQKLFAGLVALGCAGAALWLANPYSWALGGAAAILGSWSWRR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLVVIHVICRYRLISLLPPHPTKGLLLILQYLVPASWLGTGHLSEGERLQKALEQLGPIF
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHH
IKFGQLLATRQDMLPPEWVAALARLQDQVAPFDGEQARALVEASLHQPLDEVFRDFDSTP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCC
IAAASVAQVHAATLHNGQQVVAKVLRPTIRPVVERDLKVMAFGARWLERLWRDARYFRPV
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVVQDYREILLGELDLAAEARNSETMRRHFLFSPLLHIPAIHLELSSPTVIIMDRIHGIP
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCC
VNDIERIKAAGIDPKVLAERGVEIFFAQVFRFNFFHADMHPGNIFVNPEHPESPQYMAID
CHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHEECCCCCCEEEECCCCCCCCCEEEEH
AAIAGRLSKDDLNILGRMVLAVMREDYSALVDAVIRAGWNTAPIDRSRFERAVIDIVEPV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
RSAQLDQLEFAPLVMKLFDMARTYHIEMPVQYILLMKTLVHIEGLGRSIYPQLDIWSTGR
HHCCHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
PLLEAWMLAEYGPSATLKKLQNRLPEWSAQLPDMPDLLRDGLESLRNLPYQQDRQEARFE
HHHHHHHHHHCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
QQLVRHRQKLFAGLVALGCAGAALWLANPYSWALGGAAAILGSWSWRR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA