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The map label for this gene is ubiE [H]

Identifier: 110835107

GI number: 110835107

Start: 2567333

End: 2568163

Strand: Direct

Name: ubiE [H]

Synonym: ABO_2246

Alternate gene names: 110835107

Gene position: 2567333-2568163 (Clockwise)

Preceding gene: 110835106

Following gene: 110835108

Centisome position: 82.28

GC content: 56.32

Gene sequence:

>831_bases
TTGAACAGCTGGCCGCCCGGGAAGAAGCCATTATGGGAAAGGTTTTCGCCTGTCACCCATCGCCTTTCGAGAATTGATAT
GTCCGACGATAACAAGGTCACACACTTCGGCTACCAACAAGTGCCATGGCAGGAAAAGCAACAGAAAGTGGCAGGCGTAT
TTCGCTCGGTGGCGGGCAAATACGATGTCATGAATGACCTGATCTCCATGGGTAGCCACCGCATTCTCAAGCGCATGACC
ATTGAGCTCGCGGGCATTCGTCCGGGCCACAAAGTGCTCGACCTTGCTGGCGGCACCGGCGATCTAGCGATCAAATTTTC
CCGGCTGGTTGGCGAAACCGGCCAAGTGGTGCTGGCTGATATCAACGACGCGATGCTAGACGTGGGCCGCGACCGCCTGT
TCGATGCTGGCTGCAGCCACAACACTCAAGTCACTCAGGTTAACGGCGAGTGCCTGCCGTTCGAAGACAACAGTTTCCAC
TGCATCACCATTGCCTTCGGCCTGCGCAACATCACCGATAAAGACGCCGCCCTGCGTTCCATGTTGCGGGTCCTGAAACC
CGGCGGGCGCCTGCTGGTGCTGGAGTTTTCCACCCCCACCAATAAGCACCTAGCCAAAGCCTACGAGGCCTATTCCTTTG
CTGTCTGGCCCAAACTGGGCAAGCTCATCGTCAACGACCCCGACAGCTACCAGTACCTAGCCGAATCCATTCGCATGCAC
CCAGACCAAGATACCCTACAGGGCATGATGGACAACGCTGGCTTTGCCCGCACCGAATACTTCAACATGATTGGCGGCAT
CGTGGCCCTGCACAGAGGATTCAAATTTTGA

Upstream 100 bases:

>100_bases
GTCCGCAAACCGGCCCATGCGGCAGGCTTTGCGAACCTGTATGATTTCATGGATCGCAGTTTCCGAGTGATGAAACCCGT
CCCCAGCGTGGGGCTGCTGC

Downstream 100 bases:

>100_bases
GCCTGAAAGACCAGTCACGCTCTCCCGGGCTGCTCTCTACCACCGCCCTGGCCACCGTGGAGCGAGCCATCAACACGGCC
CTGCGATCTGACCCCGCCAG

Product: methyltransferase, ubiquinone biosynthesis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNSWPPGKKPLWERFSPVTHRLSRIDMSDDNKVTHFGYQQVPWQEKQQKVAGVFRSVAGKYDVMNDLISMGSHRILKRMT
IELAGIRPGHKVLDLAGGTGDLAIKFSRLVGETGQVVLADINDAMLDVGRDRLFDAGCSHNTQVTQVNGECLPFEDNSFH
CITIAFGLRNITDKDAALRSMLRVLKPGGRLLVLEFSTPTNKHLAKAYEAYSFAVWPKLGKLIVNDPDSYQYLAESIRMH
PDQDTLQGMMDNAGFARTEYFNMIGGIVALHRGFKF

Sequences:

>Translated_276_residues
MNSWPPGKKPLWERFSPVTHRLSRIDMSDDNKVTHFGYQQVPWQEKQQKVAGVFRSVAGKYDVMNDLISMGSHRILKRMT
IELAGIRPGHKVLDLAGGTGDLAIKFSRLVGETGQVVLADINDAMLDVGRDRLFDAGCSHNTQVTQVNGECLPFEDNSFH
CITIAFGLRNITDKDAALRSMLRVLKPGGRLLVLEFSTPTNKHLAKAYEAYSFAVWPKLGKLIVNDPDSYQYLAESIRMH
PDQDTLQGMMDNAGFARTEYFNMIGGIVALHRGFKF
>Mature_276_residues
MNSWPPGKKPLWERFSPVTHRLSRIDMSDDNKVTHFGYQQVPWQEKQQKVAGVFRSVAGKYDVMNDLISMGSHRILKRMT
IELAGIRPGHKVLDLAGGTGDLAIKFSRLVGETGQVVLADINDAMLDVGRDRLFDAGCSHNTQVTQVNGECLPFEDNSFH
CITIAFGLRNITDKDAALRSMLRVLKPGGRLLVLEFSTPTNKHLAKAYEAYSFAVWPKLGKLIVNDPDSYQYLAESIRMH
PDQDTLQGMMDNAGFARTEYFNMIGGIVALHRGFKF

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=276, Percent_Identity=41.6666666666667, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=64.6341463414634, Blast_Score=338, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17557039, Length=253, Percent_Identity=43.0830039525692, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323526, Length=273, Percent_Identity=38.4615384615385, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24641702, Length=264, Percent_Identity=42.8030303030303, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 30946; Mature: 30946

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSWPPGKKPLWERFSPVTHRLSRIDMSDDNKVTHFGYQQVPWQEKQQKVAGVFRSVAGK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCH
YDVMNDLISMGSHRILKRMTIELAGIRPGHKVLDLAGGTGDLAIKFSRLVGETGQVVLAD
HHHHHHHHHHCHHHHHHHHHHHEECCCCCCCEEEECCCCCCCEEEEHHHHCCCCCEEEEE
INDAMLDVGRDRLFDAGCSHNTQVTQVNGECLPFEDNSFHCITIAFGLRNITDKDAALRS
CCHHHHHHCHHHHHCCCCCCCCEEEEECCCEECCCCCCEEEEEEEECCCCCCCHHHHHHH
MLRVLKPGGRLLVLEFSTPTNKHLAKAYEAYSFAVWPKLGKLIVNDPDSYQYLAESIRMH
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEECHHHCCEEECCCHHHHHHHHHHCCC
PDQDTLQGMMDNAGFARTEYFNMIGGIVALHRGFKF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNSWPPGKKPLWERFSPVTHRLSRIDMSDDNKVTHFGYQQVPWQEKQQKVAGVFRSVAGK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCH
YDVMNDLISMGSHRILKRMTIELAGIRPGHKVLDLAGGTGDLAIKFSRLVGETGQVVLAD
HHHHHHHHHHCHHHHHHHHHHHEECCCCCCCEEEECCCCCCCEEEEHHHHCCCCCEEEEE
INDAMLDVGRDRLFDAGCSHNTQVTQVNGECLPFEDNSFHCITIAFGLRNITDKDAALRS
CCHHHHHHCHHHHHCCCCCCCCEEEEECCCEECCCCCCEEEEEEEECCCCCCCHHHHHHH
MLRVLKPGGRLLVLEFSTPTNKHLAKAYEAYSFAVWPKLGKLIVNDPDSYQYLAESIRMH
HHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHEEECHHHCCEEECCCHHHHHHHHHHCCC
PDQDTLQGMMDNAGFARTEYFNMIGGIVALHRGFKF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA