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The map label for this gene is hslU

Identifier: 110835106

GI number: 110835106

Start: 2565269

End: 2566606

Strand: Direct

Name: hslU

Synonym: ABO_2245

Alternate gene names: 110835106

Gene position: 2565269-2566606 (Clockwise)

Preceding gene: 110835105

Following gene: 110835107

Centisome position: 82.22

GC content: 58.74

Gene sequence:

>1338_bases
ATGGCTTCCCTGACACCCAAAGACATTGTTTCCGAACTCAATCGCCACATCGTCGGTCAGGACGCGGCCAAGAGAGCCGT
GGCTCTGGCGCTACGCACCCGTTGGCGTCGCATGCAACTGCCCGAAGAAATGCGTGCCGAAGTGGCGCCCAAAAACATTC
TAATGATCGGCCCCACCGGGGTAGGTAAAACTGAAATCGCCCGCCGCTTGGCCAAACTGGCGGATGCCCCCTTCATCAAG
GTAGAAGCCACCAAATTTACTGAGGTGGGCTACGTGGGCCGGGATGTGGAGTCCATTATCCGTGACCTGATGGAAGTAGC
CATCAAGCTGTTGCGCGACAAGGAAATTGCCCGTGTCGGCAGCCAGGCCGATGACGCTGCGGAAGAGCGCATCCTCGACG
CTCTGCTGCCTCCGGCTCGCACCGATGACAGCAGCGCCAACACCGACAACAGCACACGCCAGATCTTCCGCAAGAAGCTG
CGCGAAGGCGAGCTGGACGACAAGGAAATCGACGTGGACGTGGCCAGCAACCCGGCCGGCATCGATATCATGGCGCCCCC
AGGCATGGAAGAAATGACCAGCCAGCTGCAGCAGATGTTTTCCAAAATGGGCAACAACCAGCAGCGCAAGAGCCAGAAAC
TCAAAGTTCGCGAAGCCTATCGCCTGATTCGCGACGAAGAGGCCGCCCGCTTCGTCAACGAAGACGAACTAAAAGTGCAG
GCCATCGACGCGGTGGAAAACAGCGGCATCGTCTTCATCGATGAAATCGACAAGGTGGCCAAACGCGGCGAAGGCGGCGG
TACCGACGTCTCTCGCGAAGGGGTACAGCGCGACCTGCTACCCTTGATCGAAGGCTCCACTGTATCCACAAAATACGGCA
TGGTGAAAACAGATCACATTCTGTTTATCGCCTCCGGCGCCTTCCATCTGTCTCGCCCCAGCGACCTGATCCCCGAGCTG
CAAGGCCGCTTGCCCATCCGCGTAGAGCTAAGCCCGCTGAGCCCGGACGATTTCCAGCGCATCCTCACCGAGCCAAAATG
CTCACTCACCGAACAGTACAAGGCGCTACTGGAAACCGAGGGGCTGAATCTGGAGATCACCGACGATTGCATCCGCCGCA
TTGCGGAAGTGGCTTGGCAGGTCAACGAACGCACCGAGAACATCGGCGCGCGCCGCCTGCACACGGTGCTGGAAAAGCTG
CTGGAAGAAATCAGCTTTGACGCCGACTCTCTCGCCACCCAGTATCACGACAAGCCGCTGGTACTGGACGCAGAGGCTGT
CGACCGTTACCTGGGAGAGCTGGCCGATGACGAAGATCTGAGCCGGTATATTCTGTAA

Upstream 100 bases:

>100_bases
TGCCAGCCCGAGACATCGTCGCCAAGGCGCTCACTATTGCCGGCGATATCTGTATTTACACCAATCACAACCACACCTTC
GAAGAGCTGGACGGTTAATC

Downstream 100 bases:

>100_bases
CCGCAGCAGGCACCACGAATCATGTCGCACCCTTTTTAGCGTGCCAGTGTGATGCGTGGTGCCTGCCGGCGTCTCACTTT
GCTATTATCCGTGCCGGAGG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MASLTPKDIVSELNRHIVGQDAAKRAVALALRTRWRRMQLPEEMRAEVAPKNILMIGPTGVGKTEIARRLAKLADAPFIK
VEATKFTEVGYVGRDVESIIRDLMEVAIKLLRDKEIARVGSQADDAAEERILDALLPPARTDDSSANTDNSTRQIFRKKL
REGELDDKEIDVDVASNPAGIDIMAPPGMEEMTSQLQQMFSKMGNNQQRKSQKLKVREAYRLIRDEEAARFVNEDELKVQ
AIDAVENSGIVFIDEIDKVAKRGEGGGTDVSREGVQRDLLPLIEGSTVSTKYGMVKTDHILFIASGAFHLSRPSDLIPEL
QGRLPIRVELSPLSPDDFQRILTEPKCSLTEQYKALLETEGLNLEITDDCIRRIAEVAWQVNERTENIGARRLHTVLEKL
LEEISFDADSLATQYHDKPLVLDAEAVDRYLGELADDEDLSRYIL

Sequences:

>Translated_445_residues
MASLTPKDIVSELNRHIVGQDAAKRAVALALRTRWRRMQLPEEMRAEVAPKNILMIGPTGVGKTEIARRLAKLADAPFIK
VEATKFTEVGYVGRDVESIIRDLMEVAIKLLRDKEIARVGSQADDAAEERILDALLPPARTDDSSANTDNSTRQIFRKKL
REGELDDKEIDVDVASNPAGIDIMAPPGMEEMTSQLQQMFSKMGNNQQRKSQKLKVREAYRLIRDEEAARFVNEDELKVQ
AIDAVENSGIVFIDEIDKVAKRGEGGGTDVSREGVQRDLLPLIEGSTVSTKYGMVKTDHILFIASGAFHLSRPSDLIPEL
QGRLPIRVELSPLSPDDFQRILTEPKCSLTEQYKALLETEGLNLEITDDCIRRIAEVAWQVNERTENIGARRLHTVLEKL
LEEISFDADSLATQYHDKPLVLDAEAVDRYLGELADDEDLSRYIL
>Mature_444_residues
ASLTPKDIVSELNRHIVGQDAAKRAVALALRTRWRRMQLPEEMRAEVAPKNILMIGPTGVGKTEIARRLAKLADAPFIKV
EATKFTEVGYVGRDVESIIRDLMEVAIKLLRDKEIARVGSQADDAAEERILDALLPPARTDDSSANTDNSTRQIFRKKLR
EGELDDKEIDVDVASNPAGIDIMAPPGMEEMTSQLQQMFSKMGNNQQRKSQKLKVREAYRLIRDEEAARFVNEDELKVQA
IDAVENSGIVFIDEIDKVAKRGEGGGTDVSREGVQRDLLPLIEGSTVSTKYGMVKTDHILFIASGAFHLSRPSDLIPELQ
GRLPIRVELSPLSPDDFQRILTEPKCSLTEQYKALLETEGLNLEITDDCIRRIAEVAWQVNERTENIGARRLHTVLEKLL
EEISFDADSLATQYHDKPLVLDAEAVDRYLGELADDEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=448, Percent_Identity=66.7410714285714, Blast_Score=611, Evalue=1e-176,
Organism=Escherichia coli, GI1786642, Length=102, Percent_Identity=43.1372549019608, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982905, Length=69, Percent_Identity=43.4782608695652, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71982908, Length=69, Percent_Identity=43.4782608695652, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6319704, Length=127, Percent_Identity=34.6456692913386, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_ALCBS (Q0VMA5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693965.1
- ProteinModelPortal:   Q0VMA5
- SMR:   Q0VMA5
- STRING:   Q0VMA5
- GeneID:   4211335
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2245
- NMPDR:   fig|393595.12.peg.2245
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q0VMA5
- ProtClustDB:   PRK05201
- BioCyc:   ABOR393595:ABO_2245-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 49855; Mature: 49724

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 254-254 BINDING 319-319 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLTPKDIVSELNRHIVGQDAAKRAVALALRTRWRRMQLPEEMRAEVAPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKVEATKFTEVGYVGRDVESIIRDLMEVAIKLLRDKEIARVG
CCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SQADDAAEERILDALLPPARTDDSSANTDNSTRQIFRKKLREGELDDKEIDVDVASNPAG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
IDIMAPPGMEEMTSQLQQMFSKMGNNQQRKSQKLKVREAYRLIRDEEAARFVNEDELKVQ
EEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AIDAVENSGIVFIDEIDKVAKRGEGGGTDVSREGVQRDLLPLIEGSTVSTKYGMVKTDHI
EEHHHCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCE
LFIASGAFHLSRPSDLIPELQGRLPIRVELSPLSPDDFQRILTEPKCSLTEQYKALLETE
EEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHC
GLNLEITDDCIRRIAEVAWQVNERTENIGARRLHTVLEKLLEEISFDADSLATQYHDKPL
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCE
VLDAEAVDRYLGELADDEDLSRYIL
EEEHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure 
ASLTPKDIVSELNRHIVGQDAAKRAVALALRTRWRRMQLPEEMRAEVAPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCC
VGKTEIARRLAKLADAPFIKVEATKFTEVGYVGRDVESIIRDLMEVAIKLLRDKEIARVG
CCHHHHHHHHHHHHCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
SQADDAAEERILDALLPPARTDDSSANTDNSTRQIFRKKLREGELDDKEIDVDVASNPAG
CCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
IDIMAPPGMEEMTSQLQQMFSKMGNNQQRKSQKLKVREAYRLIRDEEAARFVNEDELKVQ
EEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
AIDAVENSGIVFIDEIDKVAKRGEGGGTDVSREGVQRDLLPLIEGSTVSTKYGMVKTDHI
EEHHHCCCCEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEECCE
LFIASGAFHLSRPSDLIPELQGRLPIRVELSPLSPDDFQRILTEPKCSLTEQYKALLETE
EEEECCCCCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHC
GLNLEITDDCIRRIAEVAWQVNERTENIGARRLHTVLEKLLEEISFDADSLATQYHDKPL
CCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCE
VLDAEAVDRYLGELADDEDLSRYIL
EEEHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA