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The map label for this gene is cysJ [H]

Identifier: 110834985

GI number: 110834985

Start: 2428371

End: 2429837

Strand: Direct

Name: cysJ [H]

Synonym: ABO_2124

Alternate gene names: 110834985

Gene position: 2428371-2429837 (Clockwise)

Preceding gene: 110834981

Following gene: 110834986

Centisome position: 77.83

GC content: 61.01

Gene sequence:

>1467_bases
ATGGTAATAACCAGAGCGCCCCATTCCATGACGCCCCCGCAAACGACAACCCCCTTTTCCGCCCCTCAGTGGCAACAGGT
TCAACAACTGCTAGGCCTATTGGATCAACGCCAAGCCCTCTGGCTCAGTGGCTACTTGGCCGCCGGCGCGCCGGCGGCCG
CTCCACAGGTTGCCCCCACCCCAAGTAATGCCGCGCTTATCGCCTACGGGGGCGAAACCGGCAACAGTGAGAGCATCGCC
CAAGCGCTGGCCGAACAGGCACTCCAGCAAGGCATTCGCGTGGACGTGCAAGACTTGGCCAAATTGCGGACACGACAACT
CAGCAAACGCAAACACCTATTGCTTATTTGCAGCACCCACGGCGATGGAGACCCTCCCGAACCCGTGGTGCCTTTTTACG
ACGCCTTGATGGCCGATAATGCACCGCGCCTGGAAGGCCTGCAGTTCTCGGTACTGGCACTGGGCGACAGCAGCTACGAG
CACTTTTGTGTCACCGGCCAGCAGCTGGATGAGCGACTGGAAGCGCTGGGCGGCACGCGCTTGCACCCGCGTCAGGAGTG
CGACGTAGACTTTGACGAACCCGCTGCCCGCTGGGGTAAAGCCGTACGCGAGCAGCTGCCCCGTAGCGATCAGCGTGGAG
CCACATCCACGATAACGAGTGCGCCCGCCCACTCCGCACTGACCTACAGCAAAAGGCATCCGCTCAGTGTCGAGGTACTG
GAAAACCTAAACTTGAGCCACCCGCAGCGGACCACGCCGATCCATCATCTGGAGCTGGCGTTGAAATCCCCGGACTTCTC
CCTCGCCCCTGGGGATGCGGTCGGGGTACTCGCCGACAACCCACCGGCATTGGTCGCCGCCGTGCTGGATGCCTGCCATC
TATCTGGAGAGGCGCCGGTCATTGTTCAGGACGAATCCATGCCATTGGTGCAAGCACTCCGCCAGCATCAAGACCTGACC
ATCCCCAGCACCCGTTTTTTGGAACAGTGGGCGCAGCCGAGTGATAGCCCGATTCTGAAACAGCAATTGAAAGCCCCCAG
CAAGGCACAGCGGCAATACTTGAAAACCGTCCAGGTACTGGATCTGCTACGTCAGGCGCCCGCCACACCGGACCCGCAAG
CCCTGGTCGATGCCCTGCGCCCGCTGCAACCGCGCTTGTACGATGTGGCCAACAGCCTGGAGCACATCGACGATGAGCTG
CACTTGAACGTGAAAGCGTATCGCTACGACATTGCCGGTCGGCAGGAAAGCGGCATTGCCTCCCAATACCTGCTCACTCT
GGAACCCGGTGACACCGTGCGCATTTATCCGCACCGCAACGCCCGCTTCCATTTGCCCGATGACCCGCACATTCCGGTCA
TCCTGATTGCCGAGGGCAGCGGCATCTTGAAAATGGCCGTGTCGATGGCGCCCTGCGAGATCAACTGGGAGGGTTTTTCC
AGCAGTTCGGCGGACGTATCCGCATGA

Upstream 100 bases:

>100_bases
CCTCACACAAGCTCAAACCAAACTTATATCAACATCTTCGATATTAAATCCCCTTATATTTCATTATTTCCTATAAAAAA
GAGCCTTCATACTCATTGTC

Downstream 100 bases:

>100_bases
CCACCAACCAGAACCTGCAGCTGACCCACGTGGAAGAACACGAACGGGAACAGATCAGCTGGCGACTGGACGATTTAGGT
CTGAGCCAGCGGCTCAAGCC

Product: NADPH-sulfite reductase

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MVITRAPHSMTPPQTTTPFSAPQWQQVQQLLGLLDQRQALWLSGYLAAGAPAAAPQVAPTPSNAALIAYGGETGNSESIA
QALAEQALQQGIRVDVQDLAKLRTRQLSKRKHLLLICSTHGDGDPPEPVVPFYDALMADNAPRLEGLQFSVLALGDSSYE
HFCVTGQQLDERLEALGGTRLHPRQECDVDFDEPAARWGKAVREQLPRSDQRGATSTITSAPAHSALTYSKRHPLSVEVL
ENLNLSHPQRTTPIHHLELALKSPDFSLAPGDAVGVLADNPPALVAAVLDACHLSGEAPVIVQDESMPLVQALRQHQDLT
IPSTRFLEQWAQPSDSPILKQQLKAPSKAQRQYLKTVQVLDLLRQAPATPDPQALVDALRPLQPRLYDVANSLEHIDDEL
HLNVKAYRYDIAGRQESGIASQYLLTLEPGDTVRIYPHRNARFHLPDDPHIPVILIAEGSGILKMAVSMAPCEINWEGFS
SSSADVSA

Sequences:

>Translated_488_residues
MVITRAPHSMTPPQTTTPFSAPQWQQVQQLLGLLDQRQALWLSGYLAAGAPAAAPQVAPTPSNAALIAYGGETGNSESIA
QALAEQALQQGIRVDVQDLAKLRTRQLSKRKHLLLICSTHGDGDPPEPVVPFYDALMADNAPRLEGLQFSVLALGDSSYE
HFCVTGQQLDERLEALGGTRLHPRQECDVDFDEPAARWGKAVREQLPRSDQRGATSTITSAPAHSALTYSKRHPLSVEVL
ENLNLSHPQRTTPIHHLELALKSPDFSLAPGDAVGVLADNPPALVAAVLDACHLSGEAPVIVQDESMPLVQALRQHQDLT
IPSTRFLEQWAQPSDSPILKQQLKAPSKAQRQYLKTVQVLDLLRQAPATPDPQALVDALRPLQPRLYDVANSLEHIDDEL
HLNVKAYRYDIAGRQESGIASQYLLTLEPGDTVRIYPHRNARFHLPDDPHIPVILIAEGSGILKMAVSMAPCEINWEGFS
SSSADVSA
>Mature_488_residues
MVITRAPHSMTPPQTTTPFSAPQWQQVQQLLGLLDQRQALWLSGYLAAGAPAAAPQVAPTPSNAALIAYGGETGNSESIA
QALAEQALQQGIRVDVQDLAKLRTRQLSKRKHLLLICSTHGDGDPPEPVVPFYDALMADNAPRLEGLQFSVLALGDSSYE
HFCVTGQQLDERLEALGGTRLHPRQECDVDFDEPAARWGKAVREQLPRSDQRGATSTITSAPAHSALTYSKRHPLSVEVL
ENLNLSHPQRTTPIHHLELALKSPDFSLAPGDAVGVLADNPPALVAAVLDACHLSGEAPVIVQDESMPLVQALRQHQDLT
IPSTRFLEQWAQPSDSPILKQQLKAPSKAQRQYLKTVQVLDLLRQAPATPDPQALVDALRPLQPRLYDVANSLEHIDDEL
HLNVKAYRYDIAGRQESGIASQYLLTLEPGDTVRIYPHRNARFHLPDDPHIPVILIAEGSGILKMAVSMAPCEINWEGFS
SSSADVSA

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI24041029, Length=449, Percent_Identity=27.3942093541203, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI127139033, Length=462, Percent_Identity=25.974025974026, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI10835173, Length=500, Percent_Identity=24.4, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40254422, Length=502, Percent_Identity=27.2908366533865, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI221316707, Length=430, Percent_Identity=25.1162790697674, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI221316705, Length=465, Percent_Identity=24.3010752688172, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI7657393, Length=465, Percent_Identity=24.3010752688172, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI221316709, Length=464, Percent_Identity=23.9224137931034, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI169790956, Length=120, Percent_Identity=30, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI169790958, Length=126, Percent_Identity=29.3650793650794, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1789123, Length=469, Percent_Identity=32.8358208955224, Blast_Score=256, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17554134, Length=457, Percent_Identity=23.1947483588621, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17566446, Length=462, Percent_Identity=22.9437229437229, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17531441, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32563863, Length=126, Percent_Identity=32.5396825396825, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24660907, Length=455, Percent_Identity=25.9340659340659, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24660903, Length=455, Percent_Identity=25.9340659340659, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17137192, Length=459, Percent_Identity=23.7472766884532, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24583543, Length=416, Percent_Identity=26.4423076923077, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78706876, Length=416, Percent_Identity=26.4423076923077, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI78706872, Length=416, Percent_Identity=26.4423076923077, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 53193; Mature: 53193

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS50902 FLAVODOXIN_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVITRAPHSMTPPQTTTPFSAPQWQQVQQLLGLLDQRQALWLSGYLAAGAPAAAPQVAPT
CEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PSNAALIAYGGETGNSESIAQALAEQALQQGIRVDVQDLAKLRTRQLSKRKHLLLICSTH
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
GDGDPPEPVVPFYDALMADNAPRLEGLQFSVLALGDSSYEHFCVTGQQLDERLEALGGTR
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHCCCC
LHPRQECDVDFDEPAARWGKAVREQLPRSDQRGATSTITSAPAHSALTYSKRHPLSVEVL
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHEECCCCCCHHHHH
ENLNLSHPQRTTPIHHLELALKSPDFSLAPGDAVGVLADNPPALVAAVLDACHLSGEAPV
HCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCE
IVQDESMPLVQALRQHQDLTIPSTRFLEQWAQPSDSPILKQQLKAPSKAQRQYLKTVQVL
EEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
DLLRQAPATPDPQALVDALRPLQPRLYDVANSLEHIDDELHLNVKAYRYDIAGRQESGIA
HHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHEEEEEEEEEEECCCCCCCCC
SQYLLTLEPGDTVRIYPHRNARFHLPDDPHIPVILIAEGSGILKMAVSMAPCEINWEGFS
EEEEEEECCCCEEEEEECCCCEEECCCCCCCCEEEEECCCCEEHHHHHHCCEEEECCCCC
SSSADVSA
CCCCCCCC
>Mature Secondary Structure
MVITRAPHSMTPPQTTTPFSAPQWQQVQQLLGLLDQRQALWLSGYLAAGAPAAAPQVAPT
CEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PSNAALIAYGGETGNSESIAQALAEQALQQGIRVDVQDLAKLRTRQLSKRKHLLLICSTH
CCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
GDGDPPEPVVPFYDALMADNAPRLEGLQFSVLALGDSSYEHFCVTGQQLDERLEALGGTR
CCCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEEEECHHHHHHHHHHHCCCC
LHPRQECDVDFDEPAARWGKAVREQLPRSDQRGATSTITSAPAHSALTYSKRHPLSVEVL
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCHHHEECCCCCCHHHHH
ENLNLSHPQRTTPIHHLELALKSPDFSLAPGDAVGVLADNPPALVAAVLDACHLSGEAPV
HCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCE
IVQDESMPLVQALRQHQDLTIPSTRFLEQWAQPSDSPILKQQLKAPSKAQRQYLKTVQVL
EEECCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHH
DLLRQAPATPDPQALVDALRPLQPRLYDVANSLEHIDDELHLNVKAYRYDIAGRQESGIA
HHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHEEEEEEEEEEECCCCCCCCC
SQYLLTLEPGDTVRIYPHRNARFHLPDDPHIPVILIAEGSGILKMAVSMAPCEINWEGFS
EEEEEEECCCCEEEEEECCCCEEECCCCCCCCEEEEECCCCEEHHHHHHCCEEEECCCCC
SSSADVSA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]