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The map label for this gene is fabG [C]

Identifier: 110834973

GI number: 110834973

Start: 2417992

End: 2418825

Strand: Direct

Name: fabG [C]

Synonym: ABO_2112

Alternate gene names: 110834973

Gene position: 2417992-2418825 (Clockwise)

Preceding gene: 110834972

Following gene: 110834976

Centisome position: 77.5

GC content: 53.72

Gene sequence:

>834_bases
ATGAGCAAACGCGTACTCATCACCGGCGGTAATTCCGGCATTGGTTTCTGCACGGCAGAACAACTCGTCGCGCGCGGCGC
AGAGGTCATCCTCGCCTGCCGCGACCAAACGAAAGGCCAAGCCGCCATTGCCAAAATCAAGAATGCTCATCCGCAGGCAA
AAATACGCTTATTTCCGTTGGATCTGGCAGATCTTGAACAAGTCCGTGATTGCGCGGCTCAGCTCTATCAAGAACTGGGA
CACATTGATGTTTTGATCAACAATGCCGGCGTGGTCCCGACCCGGCAGGAATTCACCAAAGACGGATATGAAATGCAGTT
CGGAGTGAATTATCTCGCTCCAGTACTGTTCACCCACCTAATGCTGCCGCTGTTAAAAAAAGGCACCGCACCGCGCATCC
TCCATGTGGCTTCTGTGGCTCATTGGCTAGGCCGCATCAATAAGAAAACGTGGAAGGGCCGCAAACCCTATCTGATTATG
GATGCTTACGGGCAGTCCAAACTGGCCAACATCCTGTTCAGCAATGTGCTTGCAGACCGTCTGAAAGAAATTGGCATTAC
CAGCAACGCTCTGCACCCCGGCGGCGTGGACACCCCGATTTTTCGCCACGTCCCCAACGCCATTATGGCGCTCATTCGCC
CTACGCTCACCACCCCGGAAAAAGCCGCTTCGCTTCCGGTAAGCCTGGCCTTAGACAAACAATACGTAGGCATCACCGGG
GAATATTTCGCTAACCATAAAACGGCTCTTCGCTCGCCCCGGGCGCGCAATAGCAGCTTGGCTGATGAGTTGTATTACGA
CACCATGGCCGAGTTGGGTATACCTGCGTTATAA

Upstream 100 bases:

>100_bases
CCACAGAAAAACACAAAAAATGGCCTGACCGGCTCCACCCCCGCCCTGTGAGGCCTGTTAAGCTGGCAACACACCAACAG
GAAAAAGGGCATCCATAGCC

Downstream 100 bases:

>100_bases
GCCAAGGGGAGTTGCCAACGACAAGCTGCAACACGCAAGAGAGCAAAAAGCTCTGAAACAGAAGGGCAGCGTCCGAAGTC
TTGGCGCAGCCCTTTTGTTG

Product: dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 276

Protein sequence:

>277_residues
MSKRVLITGGNSGIGFCTAEQLVARGAEVILACRDQTKGQAAIAKIKNAHPQAKIRLFPLDLADLEQVRDCAAQLYQELG
HIDVLINNAGVVPTRQEFTKDGYEMQFGVNYLAPVLFTHLMLPLLKKGTAPRILHVASVAHWLGRINKKTWKGRKPYLIM
DAYGQSKLANILFSNVLADRLKEIGITSNALHPGGVDTPIFRHVPNAIMALIRPTLTTPEKAASLPVSLALDKQYVGITG
EYFANHKTALRSPRARNSSLADELYYDTMAELGIPAL

Sequences:

>Translated_277_residues
MSKRVLITGGNSGIGFCTAEQLVARGAEVILACRDQTKGQAAIAKIKNAHPQAKIRLFPLDLADLEQVRDCAAQLYQELG
HIDVLINNAGVVPTRQEFTKDGYEMQFGVNYLAPVLFTHLMLPLLKKGTAPRILHVASVAHWLGRINKKTWKGRKPYLIM
DAYGQSKLANILFSNVLADRLKEIGITSNALHPGGVDTPIFRHVPNAIMALIRPTLTTPEKAASLPVSLALDKQYVGITG
EYFANHKTALRSPRARNSSLADELYYDTMAELGIPAL
>Mature_276_residues
SKRVLITGGNSGIGFCTAEQLVARGAEVILACRDQTKGQAAIAKIKNAHPQAKIRLFPLDLADLEQVRDCAAQLYQELGH
IDVLINNAGVVPTRQEFTKDGYEMQFGVNYLAPVLFTHLMLPLLKKGTAPRILHVASVAHWLGRINKKTWKGRKPYLIMD
AYGQSKLANILFSNVLADRLKEIGITSNALHPGGVDTPIFRHVPNAIMALIRPTLTTPEKAASLPVSLALDKQYVGITGE
YFANHKTALRSPRARNSSLADELYYDTMAELGIPAL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=275, Percent_Identity=39.6363636363636, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI186928839, Length=274, Percent_Identity=38.3211678832117, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI225579078, Length=284, Percent_Identity=38.3802816901408, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI10190746, Length=284, Percent_Identity=37.6760563380282, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI146231950, Length=275, Percent_Identity=36.3636363636364, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI7706523, Length=274, Percent_Identity=35.036496350365, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI19923931, Length=249, Percent_Identity=36.144578313253, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI193804850, Length=280, Percent_Identity=31.7857142857143, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI142976729, Length=241, Percent_Identity=29.4605809128631, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI7705421, Length=253, Percent_Identity=25.6916996047431, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI13375997, Length=165, Percent_Identity=31.5151515151515, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI72534732, Length=161, Percent_Identity=31.6770186335404, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI20149619, Length=200, Percent_Identity=27.5, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI31542939, Length=207, Percent_Identity=28.5024154589372, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4503817, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4504503, Length=204, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787335, Length=214, Percent_Identity=27.1028037383178, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789378, Length=231, Percent_Identity=26.4069264069264, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17558006, Length=282, Percent_Identity=34.7517730496454, Blast_Score=157, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71992402, Length=280, Percent_Identity=28.9285714285714, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17532791, Length=282, Percent_Identity=29.4326241134752, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17505416, Length=246, Percent_Identity=29.6747967479675, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532805, Length=278, Percent_Identity=27.3381294964029, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI193207620, Length=278, Percent_Identity=25.8992805755396, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17535059, Length=278, Percent_Identity=30.5755395683453, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32565532, Length=202, Percent_Identity=29.7029702970297, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI72001364, Length=205, Percent_Identity=30.2439024390244, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324820, Length=229, Percent_Identity=32.3144104803493, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323882, Length=203, Percent_Identity=31.0344827586207, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586328, Length=271, Percent_Identity=39.1143911439114, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45554248, Length=273, Percent_Identity=40.6593406593407, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24640117, Length=273, Percent_Identity=40.6593406593407, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI22024069, Length=283, Percent_Identity=37.8091872791519, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI28573296, Length=277, Percent_Identity=36.4620938628159, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI19921754, Length=282, Percent_Identity=35.8156028368794, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI45553409, Length=252, Percent_Identity=36.5079365079365, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24647948, Length=252, Percent_Identity=36.5079365079365, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24647946, Length=252, Percent_Identity=36.5079365079365, Blast_Score=148, Evalue=5e-36,
Organism=Drosophila melanogaster, GI161076371, Length=271, Percent_Identity=35.7933579335793, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI20129347, Length=274, Percent_Identity=32.1167883211679, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24647931, Length=301, Percent_Identity=36.2126245847176, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24656154, Length=268, Percent_Identity=34.7014925373134, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI19922628, Length=268, Percent_Identity=34.7014925373134, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI23397609, Length=206, Percent_Identity=29.126213592233, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356301, Length=208, Percent_Identity=26.4423076923077, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 30364; Mature: 30233

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRVLITGGNSGIGFCTAEQLVARGAEVILACRDQTKGQAAIAKIKNAHPQAKIRLFPL
CCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEC
DLADLEQVRDCAAQLYQELGHIDVLINNAGVVPTRQEFTKDGYEMQFGVNYLAPVLFTHL
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCEEEECHHHHHHHHHHHH
MLPLLKKGTAPRILHVASVAHWLGRINKKTWKGRKPYLIMDAYGQSKLANILFSNVLADR
HHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
LKEIGITSNALHPGGVDTPIFRHVPNAIMALIRPTLTTPEKAASLPVSLALDKQYVGITG
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCEEECCCH
EYFANHKTALRSPRARNSSLADELYYDTMAELGIPAL
HHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKRVLITGGNSGIGFCTAEQLVARGAEVILACRDQTKGQAAIAKIKNAHPQAKIRLFPL
CCEEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEC
DLADLEQVRDCAAQLYQELGHIDVLINNAGVVPTRQEFTKDGYEMQFGVNYLAPVLFTHL
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHCCCCCEEEECHHHHHHHHHHHH
MLPLLKKGTAPRILHVASVAHWLGRINKKTWKGRKPYLIMDAYGQSKLANILFSNVLADR
HHHHHHCCCCCHHHHHHHHHHHHHHHCHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
LKEIGITSNALHPGGVDTPIFRHVPNAIMALIRPTLTTPEKAASLPVSLALDKQYVGITG
HHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCEEECCCH
EYFANHKTALRSPRARNSSLADELYYDTMAELGIPAL
HHHHCCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]