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The map label for this gene is gdhA [H]

Identifier: 110834961

GI number: 110834961

Start: 2405705

End: 2406799

Strand: Direct

Name: gdhA [H]

Synonym: ABO_2100

Alternate gene names: 110834961

Gene position: 2405705-2406799 (Clockwise)

Preceding gene: 110834960

Following gene: 110834964

Centisome position: 77.1

GC content: 52.05

Gene sequence:

>1095_bases
ATGAACAGCGCCATCGGCCCCTACAAAGGCGGGCGACGCTTTCATCCATCGGTTAATCTGGACATCCTGAAGTTTCTCGC
CTTCGAGCAAACCTTTAAAAACTCGCTGACCTCCCTACCTATGGGTTCAGGTAAAGGGGGCGCGGACTTTGACCCCAAAG
ACAAATCTGACGCTGAAATTATGCGTTTTTGCCAGGCGTTTATTACCGAACTCTATCGCCATATTGGTCCCAACCTGGAT
ATTCCTGCCGGCGATATCGGGGTCGGTGCTCGGGAAGTAGGCTATATGTTTGGCATGTATAAAAAGCTCACCAACGAATT
CACCGGCACCTTTACTGGAAAAGGCTTCGCCTTCGGCGGCTCACGAATACGCCCGGAAGCCACCGGATATGGCTGCGTGT
ATTTCGTTGAAGAAATGATGAAAACACGCCATAGCGGGCTAGAAGGGAAAAAAACCCTGATCTCCGGTTCTGGCAATGTC
GCCCAATTTGCTGCCAGGAAAGTACTCGATCTAGGCGGCAAGGTGCTGACTCTTTCTGACTCCAGCGGCACCCTGTTTTT
CCCACAAGGAATGACCGAAGAAGATCTTCTTCATATTACCGAGTTGAAAAATAAGCCCGGAGCGCGTCTCAGCGAAGCGA
CTCAATATTTGAATGCTGAATACTTGGAAAGCCAGCGCCCCTGGCACATCCCCTGTGATATTGCTTTACCATGCGCCACC
CAAAATGAGCTTGACGAGGACAACGCCCGCACCCTGATCAAAAATAATTGTCAGGTTGTTGCCGAAGGGGCGAACATGCC
ATGCACCCTCGCTGCCATAGACATCTTCCGGGATGCCCATATATTGTTTGCGCCCGGCAAAGCCGCCAATGCAGGCGGGG
TATCGGTGTCGGGACTGGAAATGAGCCAGAATAGTTTACGACTAAACTGGACCTCTGGAGAGGTGGACGAGCGACTGCAT
TCTATAATGCAGCGCATTCACCATTCCTGCATTGAGTACGGAACCGTGGACGGCACCACCGGTTATGTCCGGGGTGCAAA
TATCGCTGGGTTTGTCAAAGTGGCAGATGCCATGCTCGCCCAAGGGGTGGTGTAA

Upstream 100 bases:

>100_bases
TACTGGAAAGGCTTGTTGAACCCGAGCGGGTGATTCAATTTAGAATCGCCTAGCAAGATGATAACGGTCAGGTCCAGTCA
ATCGTGGATATCGGGTACAG

Downstream 100 bases:

>100_bases
CCGTTTTTACTCAGCACAATAAAGCAGGCGGGTCGGCACTATCGATCGGCGCGCCCGCTCTTATCTCCCTGCTTAGCTGC
AGGCTCCGGGCGAGCCCAAA

Product: glutamate dehydrogenase

Products: NA

Alternate protein names: GDH; NAD(P)H-utilizing glutamate dehydrogenase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MNSAIGPYKGGRRFHPSVNLDILKFLAFEQTFKNSLTSLPMGSGKGGADFDPKDKSDAEIMRFCQAFITELYRHIGPNLD
IPAGDIGVGAREVGYMFGMYKKLTNEFTGTFTGKGFAFGGSRIRPEATGYGCVYFVEEMMKTRHSGLEGKKTLISGSGNV
AQFAARKVLDLGGKVLTLSDSSGTLFFPQGMTEEDLLHITELKNKPGARLSEATQYLNAEYLESQRPWHIPCDIALPCAT
QNELDEDNARTLIKNNCQVVAEGANMPCTLAAIDIFRDAHILFAPGKAANAGGVSVSGLEMSQNSLRLNWTSGEVDERLH
SIMQRIHHSCIEYGTVDGTTGYVRGANIAGFVKVADAMLAQGVV

Sequences:

>Translated_364_residues
MNSAIGPYKGGRRFHPSVNLDILKFLAFEQTFKNSLTSLPMGSGKGGADFDPKDKSDAEIMRFCQAFITELYRHIGPNLD
IPAGDIGVGAREVGYMFGMYKKLTNEFTGTFTGKGFAFGGSRIRPEATGYGCVYFVEEMMKTRHSGLEGKKTLISGSGNV
AQFAARKVLDLGGKVLTLSDSSGTLFFPQGMTEEDLLHITELKNKPGARLSEATQYLNAEYLESQRPWHIPCDIALPCAT
QNELDEDNARTLIKNNCQVVAEGANMPCTLAAIDIFRDAHILFAPGKAANAGGVSVSGLEMSQNSLRLNWTSGEVDERLH
SIMQRIHHSCIEYGTVDGTTGYVRGANIAGFVKVADAMLAQGVV
>Mature_364_residues
MNSAIGPYKGGRRFHPSVNLDILKFLAFEQTFKNSLTSLPMGSGKGGADFDPKDKSDAEIMRFCQAFITELYRHIGPNLD
IPAGDIGVGAREVGYMFGMYKKLTNEFTGTFTGKGFAFGGSRIRPEATGYGCVYFVEEMMKTRHSGLEGKKTLISGSGNV
AQFAARKVLDLGGKVLTLSDSSGTLFFPQGMTEEDLLHITELKNKPGARLSEATQYLNAEYLESQRPWHIPCDIALPCAT
QNELDEDNARTLIKNNCQVVAEGANMPCTLAAIDIFRDAHILFAPGKAANAGGVSVSGLEMSQNSLRLNWTSGEVDERLH
SIMQRIHHSCIEYGTVDGTTGYVRGANIAGFVKVADAMLAQGVV

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=314, Percent_Identity=30.5732484076433, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI4885281, Length=314, Percent_Identity=30.2547770700637, Blast_Score=134, Evalue=1e-31,
Organism=Escherichia coli, GI1788059, Length=363, Percent_Identity=62.8099173553719, Blast_Score=481, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17544676, Length=317, Percent_Identity=30.9148264984227, Blast_Score=127, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6324951, Length=387, Percent_Identity=50.9043927648579, Blast_Score=353, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319256, Length=390, Percent_Identity=51.5384615384615, Blast_Score=353, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24649283, Length=346, Percent_Identity=31.2138728323699, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45549226, Length=312, Percent_Identity=31.7307692307692, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45553475, Length=312, Percent_Identity=31.7307692307692, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24649460, Length=288, Percent_Identity=30.9027777777778, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.3 [H]

Molecular weight: Translated: 39469; Mature: 39469

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSAIGPYKGGRRFHPSVNLDILKFLAFEQTFKNSLTSLPMGSGKGGADFDPKDKSDAEI
CCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
MRFCQAFITELYRHIGPNLDIPAGDIGVGAREVGYMFGMYKKLTNEFTGTFTGKGFAFGG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCEECCC
SRIRPEATGYGCVYFVEEMMKTRHSGLEGKKTLISGSGNVAQFAARKVLDLGGKVLTLSD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEC
SSGTLFFPQGMTEEDLLHITELKNKPGARLSEATQYLNAEYLESQRPWHIPCDIALPCAT
CCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
QNELDEDNARTLIKNNCQVVAEGANMPCTLAAIDIFRDAHILFAPGKAANAGGVSVSGLE
CCCCCCCHHHHHHHCCCEEEECCCCCCEEHHHHHHHCCCEEEEECCCCCCCCCCEEEEEE
MSQNSLRLNWTSGEVDERLHSIMQRIHHSCIEYGTVDGTTGYVRGANIAGFVKVADAMLA
ECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHH
QGVV
CCCC
>Mature Secondary Structure
MNSAIGPYKGGRRFHPSVNLDILKFLAFEQTFKNSLTSLPMGSGKGGADFDPKDKSDAEI
CCCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHH
MRFCQAFITELYRHIGPNLDIPAGDIGVGAREVGYMFGMYKKLTNEFTGTFTGKGFAFGG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCEECCC
SRIRPEATGYGCVYFVEEMMKTRHSGLEGKKTLISGSGNVAQFAARKVLDLGGKVLTLSD
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEEC
SSGTLFFPQGMTEEDLLHITELKNKPGARLSEATQYLNAEYLESQRPWHIPCDIALPCAT
CCCEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
QNELDEDNARTLIKNNCQVVAEGANMPCTLAAIDIFRDAHILFAPGKAANAGGVSVSGLE
CCCCCCCHHHHHHHCCCEEEECCCCCCEEHHHHHHHCCCEEEEECCCCCCCCCCEEEEEE
MSQNSLRLNWTSGEVDERLHSIMQRIHHSCIEYGTVDGTTGYVRGANIAGFVKVADAMLA
ECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHH
QGVV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8955404; 12663928 [H]