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The map label for this gene is dnaX [H]

Identifier: 110636381

GI number: 110636381

Start: 4366679

End: 4368481

Strand: Reverse

Name: dnaX [H]

Synonym: Meso_4057

Alternate gene names: 110636381

Gene position: 4368481-4366679 (Counterclockwise)

Preceding gene: 110636383

Following gene: 110636380

Centisome position: 99.0

GC content: 64.45

Gene sequence:

>1803_bases
ATGAACGATGTCGCGCAGACGGCAGAAGGCAAGGCCGCCTACCGCGTGCTCGCACGCAAATATCGCCCGCGCGACTTTTC
CCAGCTCATCGGCCAGGAGCCGATGGTACGCACGCTCACCAACGCATTCGCAGCCGGCCGTATCGCACAAGCCTGGATGC
TGACCGGAGTGCGCGGCGTGGGCAAAACCACCACCGCCCGCATCCTCGCGCGCGCGCTCAATTACAGGACCGAGGCCGTC
GACCGGCCGTCCGTCGACCTTTCCGTGCCCGGCGAGCACTGCGAAGCGATTCTCGAGGGGCGCCATGTCGACGTGATCGA
GATGGACGCGGCCTCGCATACGGGCATCGACGACATCCGCGACATCATCGAGCAGGTGCGCTACGCGCCGGTTTCCGCGC
GTTACAAGGTCTATATCATAGACGAAGTGCACATGCTCTCCAACCAGGCCTTCAACGGCCTGTTGAAGACGCTGGAGGAG
CCGCCGCCGCACGTCAAATTCATCTTCGCAACCACCGAGATCCGCAAGGTCCCGATCACCATCCTCTCCCGCTGCCAGCG
ATTCGATCTGAGACGGATCGATTCTGGCCTCATCAAGCAGCATCTCGCCCATATCGGCGATCTGGAAGGCGTGGATGCCG
ATAGCGACGCGCTGGCGATGATCGCGCGCGCCGCCGAAGGCTCCATGCGCGACGCCCAATCCATCTTCGACCAGGCAATC
GCCCACTCCTCGGGAAAGGTGACGGCTGAGACCGTGCGCGACATGCTGGGGCTTGCGGACCGTGCACGCGTGATCGACCT
TTTCGAGCATCTGATGAAGGGCGATGTAGCGGCAGCGCTCGCCGAATACCGCGCGCAATACGATGCAGGGGCCGATCCGG
CCGCCGTGCTCACCGATCTGGCTGAGTTCAACCATCTTGTCACGCGCATGCGCTTCGTGCCCGATGCGGCGAATGACGGC
TCACTGCCGCAGGAGGAGCGCACGCGAGGACTGGAGTTTTCGAAAAACCTTTCGGTTCGTGTGCTCTCGCGCACCTGGCA
GATGCTGCTGAAGGGCATTCAGGAGGTGCAGGGATCGAGCCGCCCCATCTCGGCGGGCGAAATGGTGCTGATCCGCATCG
CGCATGCGGCGAATTTGCCTACACTGGACGAAGCGCTGAAAACATTGGAGGGGCTGCCCGCGGGGAATGGAAGCGGGCGC
TCCTCAGCCGGCTCTTACGCTCCCTCGCCGCCGGGCAATGGAGGAGCGCAGGCCATATCGAGCCAGCGCATGCCTTCGGG
CGGCGGCGGACAGACTATGCGGCTGATCCAGTCTTCACCGGCCGAATATGCCGCGTCTCCCCAGCCAGCGGAAGCCGAAG
CGCCGAGCGTCCCCGTGAAGTCGCTGGCCGACATCACCGAGCTGGCGGACGCGAATCGCGATATCGCCTTCAAGGTGCAG
TTCAAGCGCTGCGTACGCCTCGTCCAGATCGAGCCGGGCAGGCTTTCGGTCAACCTTACCGAGGACGCGCCGAAGACGCT
TCTGGGGGACCTGACGAATCGCCTGCAGAAATGGACCGGGCGGCGGTGGATCGTCTCGCTTTCCAACGAGCCCGGCAGCA
AGACGCTGGCCGAGGAGGAAAGCGGGCGTCGCGAAACCGCGCTGGCCGATGCACGCGCCGACCCAACTGTGGCCGCGATC
CTGCAAAGCTTTCCCGGCGCGCGTATCCTCGACGTGCGGATACCCGACGCGGCGGCTGAAGAAGAAGCCGAAGGCGCGCC
GCCCGAGCCGGACCTTGGCGACGATGACGATGATGATCTCTGA

Upstream 100 bases:

>100_bases
CTTCCCGCTGCCCATTGACGCGGCTCCCCATCCAAGGGGAAACTCGCCGTCGGGCGAAGACCCGCATCGAGGCCCACATC
ACGGGAGCGTGGACGAGCAG

Downstream 100 bases:

>100_bases
TTGGAGAAGAGAATGCGTGACCTGATGAACCTGATGGGCAAGGCGAAGGAAATGCAGGCCAAGTTCCAGGCCATGCAGGA
GGAGATCGCCCAGTTGGAAT

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MNDVAQTAEGKAAYRVLARKYRPRDFSQLIGQEPMVRTLTNAFAAGRIAQAWMLTGVRGVGKTTTARILARALNYRTEAV
DRPSVDLSVPGEHCEAILEGRHVDVIEMDAASHTGIDDIRDIIEQVRYAPVSARYKVYIIDEVHMLSNQAFNGLLKTLEE
PPPHVKFIFATTEIRKVPITILSRCQRFDLRRIDSGLIKQHLAHIGDLEGVDADSDALAMIARAAEGSMRDAQSIFDQAI
AHSSGKVTAETVRDMLGLADRARVIDLFEHLMKGDVAAALAEYRAQYDAGADPAAVLTDLAEFNHLVTRMRFVPDAANDG
SLPQEERTRGLEFSKNLSVRVLSRTWQMLLKGIQEVQGSSRPISAGEMVLIRIAHAANLPTLDEALKTLEGLPAGNGSGR
SSAGSYAPSPPGNGGAQAISSQRMPSGGGGQTMRLIQSSPAEYAASPQPAEAEAPSVPVKSLADITELADANRDIAFKVQ
FKRCVRLVQIEPGRLSVNLTEDAPKTLLGDLTNRLQKWTGRRWIVSLSNEPGSKTLAEEESGRRETALADARADPTVAAI
LQSFPGARILDVRIPDAAAEEEAEGAPPEPDLGDDDDDDL

Sequences:

>Translated_600_residues
MNDVAQTAEGKAAYRVLARKYRPRDFSQLIGQEPMVRTLTNAFAAGRIAQAWMLTGVRGVGKTTTARILARALNYRTEAV
DRPSVDLSVPGEHCEAILEGRHVDVIEMDAASHTGIDDIRDIIEQVRYAPVSARYKVYIIDEVHMLSNQAFNGLLKTLEE
PPPHVKFIFATTEIRKVPITILSRCQRFDLRRIDSGLIKQHLAHIGDLEGVDADSDALAMIARAAEGSMRDAQSIFDQAI
AHSSGKVTAETVRDMLGLADRARVIDLFEHLMKGDVAAALAEYRAQYDAGADPAAVLTDLAEFNHLVTRMRFVPDAANDG
SLPQEERTRGLEFSKNLSVRVLSRTWQMLLKGIQEVQGSSRPISAGEMVLIRIAHAANLPTLDEALKTLEGLPAGNGSGR
SSAGSYAPSPPGNGGAQAISSQRMPSGGGGQTMRLIQSSPAEYAASPQPAEAEAPSVPVKSLADITELADANRDIAFKVQ
FKRCVRLVQIEPGRLSVNLTEDAPKTLLGDLTNRLQKWTGRRWIVSLSNEPGSKTLAEEESGRRETALADARADPTVAAI
LQSFPGARILDVRIPDAAAEEEAEGAPPEPDLGDDDDDDL
>Mature_600_residues
MNDVAQTAEGKAAYRVLARKYRPRDFSQLIGQEPMVRTLTNAFAAGRIAQAWMLTGVRGVGKTTTARILARALNYRTEAV
DRPSVDLSVPGEHCEAILEGRHVDVIEMDAASHTGIDDIRDIIEQVRYAPVSARYKVYIIDEVHMLSNQAFNGLLKTLEE
PPPHVKFIFATTEIRKVPITILSRCQRFDLRRIDSGLIKQHLAHIGDLEGVDADSDALAMIARAAEGSMRDAQSIFDQAI
AHSSGKVTAETVRDMLGLADRARVIDLFEHLMKGDVAAALAEYRAQYDAGADPAAVLTDLAEFNHLVTRMRFVPDAANDG
SLPQEERTRGLEFSKNLSVRVLSRTWQMLLKGIQEVQGSSRPISAGEMVLIRIAHAANLPTLDEALKTLEGLPAGNGSGR
SSAGSYAPSPPGNGGAQAISSQRMPSGGGGQTMRLIQSSPAEYAASPQPAEAEAPSVPVKSLADITELADANRDIAFKVQ
FKRCVRLVQIEPGRLSVNLTEDAPKTLLGDLTNRLQKWTGRRWIVSLSNEPGSKTLAEEESGRRETALADARADPTVAAI
LQSFPGARILDVRIPDAAAEEEAEGAPPEPDLGDDDDDDL

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=296, Percent_Identity=25, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI194306571, Length=299, Percent_Identity=24.7491638795987, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI194306567, Length=299, Percent_Identity=24.7491638795987, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4506491, Length=265, Percent_Identity=21.8867924528302, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI31881687, Length=265, Percent_Identity=21.8867924528302, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI194306569, Length=211, Percent_Identity=26.5402843601896, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI31563534, Length=284, Percent_Identity=24.2957746478873, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786676, Length=360, Percent_Identity=40.5555555555556, Blast_Score=268, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71986063, Length=298, Percent_Identity=23.8255033557047, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=236, Percent_Identity=26.271186440678, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=313, Percent_Identity=20.7667731629393, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647857, Length=298, Percent_Identity=25.1677852348993, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI18859927, Length=224, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 64969; Mature: 64969

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVAQTAEGKAAYRVLARKYRPRDFSQLIGQEPMVRTLTNAFAAGRIAQAWMLTGVRGV
CCCHHHHHCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKTTTARILARALNYRTEAVDRPSVDLSVPGEHCEAILEGRHVDVIEMDAASHTGIDDIR
CCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
DIIEQVRYAPVSARYKVYIIDEVHMLSNQAFNGLLKTLEEPPPHVKFIFATTEIRKVPIT
HHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHH
ILSRCQRFDLRRIDSGLIKQHLAHIGDLEGVDADSDALAMIARAAEGSMRDAQSIFDQAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
AHSSGKVTAETVRDMLGLADRARVIDLFEHLMKGDVAAALAEYRAQYDAGADPAAVLTDL
HCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AEFNHLVTRMRFVPDAANDGSLPQEERTRGLEFSKNLSVRVLSRTWQMLLKGIQEVQGSS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RPISAGEMVLIRIAHAANLPTLDEALKTLEGLPAGNGSGRSSAGSYAPSPPGNGGAQAIS
CCCCCCCEEEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SQRMPSGGGGQTMRLIQSSPAEYAASPQPAEAEAPSVPVKSLADITELADANRDIAFKVQ
HCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEE
FKRCVRLVQIEPGRLSVNLTEDAPKTLLGDLTNRLQKWTGRRWIVSLSNEPGSKTLAEEE
HHHHHHHHEECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
SGRRETALADARADPTVAAILQSFPGARILDVRIPDAAAEEEAEGAPPEPDLGDDDDDDL
CCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNDVAQTAEGKAAYRVLARKYRPRDFSQLIGQEPMVRTLTNAFAAGRIAQAWMLTGVRGV
CCCHHHHHCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
GKTTTARILARALNYRTEAVDRPSVDLSVPGEHCEAILEGRHVDVIEMDAASHTGIDDIR
CCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCCEEEEECCCCCCCHHHHH
DIIEQVRYAPVSARYKVYIIDEVHMLSNQAFNGLLKTLEEPPPHVKFIFATTEIRKVPIT
HHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHH
ILSRCQRFDLRRIDSGLIKQHLAHIGDLEGVDADSDALAMIARAAEGSMRDAQSIFDQAI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
AHSSGKVTAETVRDMLGLADRARVIDLFEHLMKGDVAAALAEYRAQYDAGADPAAVLTDL
HCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AEFNHLVTRMRFVPDAANDGSLPQEERTRGLEFSKNLSVRVLSRTWQMLLKGIQEVQGSS
HHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RPISAGEMVLIRIAHAANLPTLDEALKTLEGLPAGNGSGRSSAGSYAPSPPGNGGAQAIS
CCCCCCCEEEEEEEHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
SQRMPSGGGGQTMRLIQSSPAEYAASPQPAEAEAPSVPVKSLADITELADANRDIAFKVQ
HCCCCCCCCCHHHHHHHCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEE
FKRCVRLVQIEPGRLSVNLTEDAPKTLLGDLTNRLQKWTGRRWIVSLSNEPGSKTLAEEE
HHHHHHHHEECCCEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHH
SGRRETALADARADPTVAAILQSFPGARILDVRIPDAAAEEEAEGAPPEPDLGDDDDDDL
CCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]