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The map label for this gene is aadR [H]

Identifier: 110636189

GI number: 110636189

Start: 4166117

End: 4166875

Strand: Reverse

Name: aadR [H]

Synonym: Meso_3865

Alternate gene names: 110636189

Gene position: 4166875-4166117 (Counterclockwise)

Preceding gene: 110636192

Following gene: 110636186

Centisome position: 94.43

GC content: 63.64

Gene sequence:

>759_bases
TTGAGCAGGCGCCCAAAGCGCGGGGGCGACGGAAACGACGGCCAGAGCTGGGCTCCGGCTACGGGTCTGCCGCCGTCCAC
AGATGCGTATCGCCTGCTTCCGCGATACCGCAAGGGTGATCGCAAGATCGCGGCCGGCCGAGATCTGTTCAGTATAGGCG
AGACGAACACCGCAATCTTCAACCTGCTGTCCGGATGGGTTGCGATCTACACGCTGTTGGAGGACGGCCGGCGGCAGATC
GTCCATTTCGCACTGCCTGGGGCGGTGATGGGGATGCCGACCTCCAAGGGCGCCCAGGTCAGCTACAGCGCGCAGGCATT
GACCGAGGTGGTCGTCTCCGTCATTCCGAGCACCGTGCTGTCAGCGGCCTCGCGGGACGATCCGGAGATGAGCATGCGGC
TGGCGAGCGCGTTGGCGCGCGACACATCAATGGCCTACGACCATATGACCAGCATCGGACGCCGGACGGCCCGCGAGCGC
GTGGCGCATCTATTGCTGGAGTTGTTTACGCGGTATCGCGCTCAATGGCCGGGCGACCGCATTGAGGAGATGGCGATCCC
TCTCACCCAAGAGCAAATCGGGGACGCGACGGGCCTGACCTTCGTTCATGTGAACCGCGTGCTCGCCACGCTGCGCAAGG
AGAAGATCGTGCATTTCCACTATAGGAGGCTTCGGATACTGGACCCGGATCGGCTCATAGAGGTCGCCGGCGTCGATCCG
CAGACTGCCATGTCGTGGTTTCAGCGACGATCGGTCTGA

Upstream 100 bases:

>100_bases
CGACGAATGGGACGATTTTGAACGCGGACGGAGCAGACCATTTTTTCGAGGATCGGTGACACGGGAAGCGGAACGCCCTC
CGGGCCTTCCGCTCGATGAG

Downstream 100 bases:

>100_bases
ATGGCGGCACCTGTTCGGCATGAGAGATGAACTACGTAGTCGGAGCGATTCGGCTCCGACTGTTTCGTTCAACGATCACG
ACGCCGATGCCCGTAAGAAG

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: Anaerobic aromatic degradation regulator [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSRRPKRGGDGNDGQSWAPATGLPPSTDAYRLLPRYRKGDRKIAAGRDLFSIGETNTAIFNLLSGWVAIYTLLEDGRRQI
VHFALPGAVMGMPTSKGAQVSYSAQALTEVVVSVIPSTVLSAASRDDPEMSMRLASALARDTSMAYDHMTSIGRRTARER
VAHLLLELFTRYRAQWPGDRIEEMAIPLTQEQIGDATGLTFVHVNRVLATLRKEKIVHFHYRRLRILDPDRLIEVAGVDP
QTAMSWFQRRSV

Sequences:

>Translated_252_residues
MSRRPKRGGDGNDGQSWAPATGLPPSTDAYRLLPRYRKGDRKIAAGRDLFSIGETNTAIFNLLSGWVAIYTLLEDGRRQI
VHFALPGAVMGMPTSKGAQVSYSAQALTEVVVSVIPSTVLSAASRDDPEMSMRLASALARDTSMAYDHMTSIGRRTARER
VAHLLLELFTRYRAQWPGDRIEEMAIPLTQEQIGDATGLTFVHVNRVLATLRKEKIVHFHYRRLRILDPDRLIEVAGVDP
QTAMSWFQRRSV
>Mature_251_residues
SRRPKRGGDGNDGQSWAPATGLPPSTDAYRLLPRYRKGDRKIAAGRDLFSIGETNTAIFNLLSGWVAIYTLLEDGRRQIV
HFALPGAVMGMPTSKGAQVSYSAQALTEVVVSVIPSTVLSAASRDDPEMSMRLASALARDTSMAYDHMTSIGRRTARERV
AHLLLELFTRYRAQWPGDRIEEMAIPLTQEQIGDATGLTFVHVNRVLATLRKEKIVHFHYRRLRILDPDRLIEVAGVDPQ
TAMSWFQRRSV

Specific function: Transcriptional activator of anaerobic gene expression. For aromatic acid degradation. Also required for the anaerobic degradation of benzoate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=238, Percent_Identity=24.3697478991597, Blast_Score=71, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 28134; Mature: 28002

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRPKRGGDGNDGQSWAPATGLPPSTDAYRLLPRYRKGDRKIAAGRDLFSIGETNTAIF
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHH
NLLSGWVAIYTLLEDGRRQIVHFALPGAVMGMPTSKGAQVSYSAQALTEVVVSVIPSTVL
HHHHHHHHHHHHHHHHHHHEEHEECCCHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
SAASRDDPEMSMRLASALARDTSMAYDHMTSIGRRTARERVAHLLLELFTRYRAQWPGDR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IEEMAIPLTQEQIGDATGLTFVHVNRVLATLRKEKIVHFHYRRLRILDPDRLIEVAGVDP
HHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHEEEECCCCH
QTAMSWFQRRSV
HHHHHHHHHCCC
>Mature Secondary Structure 
SRRPKRGGDGNDGQSWAPATGLPPSTDAYRLLPRYRKGDRKIAAGRDLFSIGETNTAIF
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHH
NLLSGWVAIYTLLEDGRRQIVHFALPGAVMGMPTSKGAQVSYSAQALTEVVVSVIPSTVL
HHHHHHHHHHHHHHHHHHHEEHEECCCHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
SAASRDDPEMSMRLASALARDTSMAYDHMTSIGRRTARERVAHLLLELFTRYRAQWPGDR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IEEMAIPLTQEQIGDATGLTFVHVNRVLATLRKEKIVHFHYRRLRILDPDRLIEVAGVDP
HHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHEEEECCCCH
QTAMSWFQRRSV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1522059; 10094687 [H]