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The map label for this gene is thrB

Identifier: 110633106

GI number: 110633106

Start: 824576

End: 825544

Strand: Direct

Name: thrB

Synonym: Meso_0749

Alternate gene names: 110633106

Gene position: 824576-825544 (Clockwise)

Preceding gene: 110633105

Following gene: 110633107

Centisome position: 18.69

GC content: 61.61

Gene sequence:

>969_bases
ATGGCCGTCTATACAGATATTTCCGAAGAGGAACTTACCGCATTCCTGCGCCATTATCCGGTTGGCAAGCTTCTGTCCTA
CAAGGGCATCGCGGAAGGGACGGAAAACTCCAATTATCTCCTGCACACGACGGCTGGCGCCTATATCCTGACCCTTTATG
AGCGGCGGGTCGACCGGAGCGATCTGCCCTTCTTCCTCGGCTTGATGGAGCATCTGGCGAGAAAGGGCGTGTCCTGCCCG
CTGCCGGTCAAACGGCTTGACGACGGCCTGATCGGCGAGCTTGCCGGCCGGCCGGCCGCGCTCATTACCTTTCTTGAAGG
GATGTGGATGCGCCGGCCGACCGCCCTGCATTGCGGGCAGGTGGGCAAGGCGCTTGCGGACCTGCACCAGGCCGCGGAGG
ACTTCCCCTTGAAGCGTCCAAACGCGCTCGGCCCGGAAGGGTGGCGGCGGCTTTGGGAGGGCGCAAAAGCGCGCGCGGAT
GAGGTGGAGCCTGGCCTCGCCCGGGAGGTGGATGCCGAGTTTGCCCTCCTGGAGAGAGACTGGCCCAAGGATCTGCCTTC
CGGCGTCATCCATGCTGACCTTTTCCCCGACAATGTCTTCTTCTTGGGAGGCGAGCTTTCCGGGCTGATCGATTTTTATT
TTGCCTGCAACGACCTCCTGGCCTACGACCTTGCCACCTGCCTCAACGCTTGGTGTTTCGAGAAGGACATTTCCTACAAT
CTCACCAAGGGAGCTGCACTTTTGGCAGGCTACCAGGCGGTGCGTCCGCTGACGCGGGAGGAGATCGAGATGCTGCCTCT
GCTGGCGCGCGGATCCGCGCTCCGTTTCATGCTGACGCGTCTTTATGACTGGCTGACGATCCCCGATGGCGCGCTGGTGA
AAAAGCGCGATCCGCTGGAATATCTGCGCCGGCTGCGCTTTCACCGGCAGGTCAGGACCGCCTCTGAATACGGGATCGAA
CTGGCGTGA

Upstream 100 bases:

>100_bases
GTGGCAGCCGATCTCCCCCCTTGAGGGGGAGATGGCCGGCAGGCCAGAGGGGGGTGCAGAATGGCAGAACCCTCTGCACA
GATTTCTCCTGGTACATTAA

Downstream 100 bases:

>100_bases
AGCGGATCGAGATCTTCACCGATGGCGCTTGTTCCGGCAATCCCGGTCCGGGCGGCTGGGGGGCGATTCTGCGCTACAAC
GGCACGGAAAAGGAACTGTA

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAVYTDISEEELTAFLRHYPVGKLLSYKGIAEGTENSNYLLHTTAGAYILTLYERRVDRSDLPFFLGLMEHLARKGVSCP
LPVKRLDDGLIGELAGRPAALITFLEGMWMRRPTALHCGQVGKALADLHQAAEDFPLKRPNALGPEGWRRLWEGAKARAD
EVEPGLAREVDAEFALLERDWPKDLPSGVIHADLFPDNVFFLGGELSGLIDFYFACNDLLAYDLATCLNAWCFEKDISYN
LTKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLYDWLTIPDGALVKKRDPLEYLRRLRFHRQVRTASEYGIE
LA

Sequences:

>Translated_322_residues
MAVYTDISEEELTAFLRHYPVGKLLSYKGIAEGTENSNYLLHTTAGAYILTLYERRVDRSDLPFFLGLMEHLARKGVSCP
LPVKRLDDGLIGELAGRPAALITFLEGMWMRRPTALHCGQVGKALADLHQAAEDFPLKRPNALGPEGWRRLWEGAKARAD
EVEPGLAREVDAEFALLERDWPKDLPSGVIHADLFPDNVFFLGGELSGLIDFYFACNDLLAYDLATCLNAWCFEKDISYN
LTKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLYDWLTIPDGALVKKRDPLEYLRRLRFHRQVRTASEYGIE
LA
>Mature_321_residues
AVYTDISEEELTAFLRHYPVGKLLSYKGIAEGTENSNYLLHTTAGAYILTLYERRVDRSDLPFFLGLMEHLARKGVSCPL
PVKRLDDGLIGELAGRPAALITFLEGMWMRRPTALHCGQVGKALADLHQAAEDFPLKRPNALGPEGWRRLWEGAKARADE
VEPGLAREVDAEFALLERDWPKDLPSGVIHADLFPDNVFFLGGELSGLIDFYFACNDLLAYDLATCLNAWCFEKDISYNL
TKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLYDWLTIPDGALVKKRDPLEYLRRLRFHRQVRTASEYGIEL
A

Specific function: Unknown

COG id: COG2334

COG function: function code R; Putative homoserine kinase type II (protein kinase fold)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pseudomonas-type thrB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KHSE_MESSB (Q11KC6)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673314.1
- ProteinModelPortal:   Q11KC6
- SMR:   Q11KC6
- STRING:   Q11KC6
- GeneID:   4181127
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0749
- NMPDR:   fig|266779.1.peg.2887
- eggNOG:   COG2334
- HOGENOM:   HBG309377
- OMA:   ADLFRDN
- ProtClustDB:   PRK05231
- BioCyc:   MSP266779:MESO_0749-MONOMER
- HAMAP:   MF_00301
- InterPro:   IPR002575
- InterPro:   IPR005280
- InterPro:   IPR011009
- TIGRFAMs:   TIGR00938

Pfam domain/function: PF01636 APH; SSF56112 Kinase_like

EC number: =2.7.1.39

Molecular weight: Translated: 36289; Mature: 36158

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVYTDISEEELTAFLRHYPVGKLLSYKGIAEGTENSNYLLHTTAGAYILTLYERRVDRS
CCEECCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCC
DLPFFLGLMEHLARKGVSCPLPVKRLDDGLIGELAGRPAALITFLEGMWMRRPTALHCGQ
CCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
VGKALADLHQAAEDFPLKRPNALGPEGWRRLWEGAKARADEVEPGLAREVDAEFALLERD
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHCC
WPKDLPSGVIHADLFPDNVFFLGGELSGLIDFYFACNDLLAYDLATCLNAWCFEKDISYN
CCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LTKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLYDWLTIPDGALVKKRDPLE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
YLRRLRFHRQVRTASEYGIELA
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AVYTDISEEELTAFLRHYPVGKLLSYKGIAEGTENSNYLLHTTAGAYILTLYERRVDRS
CEECCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCC
DLPFFLGLMEHLARKGVSCPLPVKRLDDGLIGELAGRPAALITFLEGMWMRRPTALHCGQ
CCCHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
VGKALADLHQAAEDFPLKRPNALGPEGWRRLWEGAKARADEVEPGLAREVDAEFALLERD
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHHHHHCC
WPKDLPSGVIHADLFPDNVFFLGGELSGLIDFYFACNDLLAYDLATCLNAWCFEKDISYN
CCCCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LTKGAALLAGYQAVRPLTREEIEMLPLLARGSALRFMLTRLYDWLTIPDGALVKKRDPLE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
YLRRLRFHRQVRTASEYGIELA
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA