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The map label for this gene is rnhA

Identifier: 110633107

GI number: 110633107

Start: 825541

End: 826029

Strand: Direct

Name: rnhA

Synonym: Meso_0750

Alternate gene names: 110633107

Gene position: 825541-826029 (Clockwise)

Preceding gene: 110633106

Following gene: 110633110

Centisome position: 18.71

GC content: 65.64

Gene sequence:

>489_bases
GTGAAGCGGATCGAGATCTTCACCGATGGCGCTTGTTCCGGCAATCCCGGTCCGGGCGGCTGGGGGGCGATTCTGCGCTA
CAACGGCACGGAAAAGGAACTGTACGGCGGCGAGGCGGACACCACCAACAATCGAATGGAGCTGACCGCAGCGATCGAGG
CTCTGGAAGCCTTGAAGGAGCCCTGCGAGGTCGACCTTCACACGGACAGCAACTACCTGCGCGACGGCATTTCCGGTTGG
ATCGAGGGCTGGAAGCGCAATGGCTGGCGGACGGCCGACAGGAAGCCGGTGAAGAATGCAGAGCTTTGGCAGGCTCTGGA
TGAGGCTCGCCGGCGCCACAAGGTGCACTGGCACTGGGTGCGCGGCCATGCCGGGCACCCGGAGAACGAGCGCGCCGATG
CCTTGGCCCGCGCCGGCATGGCCCCGTTCAAGAAGAAAAAGGGGGGCGACACGGCCTCTTCCGAGGAAGGAAGCGCGCGC
CGCCGCTAG

Upstream 100 bases:

>100_bases
ATGGCGCGCTGGTGAAAAAGCGCGATCCGCTGGAATATCTGCGCCGGCTGCGCTTTCACCGGCAGGTCAGGACCGCCTCT
GAATACGGGATCGAACTGGC

Downstream 100 bases:

>100_bases
AGCATGAGGTTGATCAAAGCTGCTCCAGAATGCGGGCCGCGCCGCTCGTCACCGCCTGGCCGGGAACTTCCTCGACGTTG
ATCGCCTTCACGATGCCATC

Product: ribonuclease H

Products: NA

Alternate protein names: RNase H

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKEPCEVDLHTDSNYLRDGISGW
IEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWVRGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSAR
RR

Sequences:

>Translated_162_residues
MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKEPCEVDLHTDSNYLRDGISGW
IEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWVRGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSAR
RR
>Mature_162_residues
MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKEPCEVDLHTDSNYLRDGISGW
IEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWVRGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSAR
RR

Specific function: Endonuclease that specifically degrades the RNA of RNA- DNA hybrids

COG id: COG0328

COG function: function code L; Ribonuclease HI

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase H domain

Homologues:

Organism=Homo sapiens, GI21359816, Length=141, Percent_Identity=37.5886524822695, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786408, Length=149, Percent_Identity=64.4295302013423, Blast_Score=201, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI115532542, Length=146, Percent_Identity=39.7260273972603, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137476, Length=155, Percent_Identity=34.1935483870968, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45552509, Length=155, Percent_Identity=34.1935483870968, Blast_Score=89, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNH_MESSB (Q11KC5)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673315.1
- ProteinModelPortal:   Q11KC5
- SMR:   Q11KC5
- STRING:   Q11KC5
- GeneID:   4181128
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0750
- NMPDR:   fig|266779.1.peg.2888
- eggNOG:   COG0328
- HOGENOM:   HBG742437
- OMA:   NGWRTAD
- PhylomeDB:   Q11KC5
- ProtClustDB:   PRK00203
- BioCyc:   MSP266779:MESO_0750-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00042
- InterPro:   IPR022892
- InterPro:   IPR012337
- InterPro:   IPR002156

Pfam domain/function: PF00075 RnaseH; SSF53098 RNaseH_fold

EC number: =3.1.26.4

Molecular weight: Translated: 18135; Mature: 18135

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS50879 RNASE_H

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKE
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
PCEVDLHTDSNYLRDGISGWIEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWV
CCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
RGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSARRR
CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRIEIFTDGACSGNPGPGGWGAILRYNGTEKELYGGEADTTNNRMELTAAIEALEALKE
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
PCEVDLHTDSNYLRDGISGWIEGWKRNGWRTADRKPVKNAELWQALDEARRRHKVHWHWV
CCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
RGHAGHPENERADALARAGMAPFKKKKGGDTASSEEGSARRR
CCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA