Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 110633100

GI number: 110633100

Start: 819825

End: 820757

Strand: Direct

Name: ctaB

Synonym: Meso_0743

Alternate gene names: 110633100

Gene position: 819825-820757 (Clockwise)

Preceding gene: 110633099

Following gene: 110633101

Centisome position: 18.58

GC content: 64.31

Gene sequence:

>933_bases
ATGGCACTGGTCGAGCGCGAGCATATGAAGGAAGACGCGGGCCGCCTCTCCGAGGCGACTGCCGGCGACTTCATCGCGCT
TTTGAAGCCGCGCGTCATGTCGCTCGTCGTCTTCACCGCCTTTGTGGGCATGGTGCTGGCGCCCGCAAATCCTCACCCGT
TCCTCGCGCTGATTTCCATCCTGGCCATTGCCGTGGGCGCGGGGGCGTCGGGCGCGCTCAACATGTGGTACGATGCCGAT
ATCGATGCCGTGATGGCGCGCACGGCCGGAAGACCGGTGCCCGCTGGCCGCATCGCCCCCGGCGAGGCGCTGGGCTTCGG
TCTTTTTCTTTCGGCCTTCTCCGTCGGCACACTCGGGCTGATGGCCAATTGGCTCGCCGCGAGCCTGCTTGCCTTCACCA
TCTTCTTCTATGTGGTGATCTACACGATGTGGCTGAAGCGCTCGACGGCGCAGAACATCGTGATCGGCGGGGCCGCGGGC
GCGCTGCCCCCGGTTGTCGGCTGGGCGGCCATGACCGGAAGCGTCAGTTTGGAAAGCCTGGTGCTTTTCCTGATCATCTT
CCTTTGGACCCCGCCGCATTTCTGGGCGCTCGCTCTCTTCAAGGAAGGCGATTATGAGCGGGCGGGTGTCCCGATGATGC
CCAATGTCGCGGGTGCCGCTTCGACGCGCAGGCAAATTTTTGCCTATTCTGTTCTGGTGGCAGTGAGCGGCGTTCTGCCC
ACGGCCATGGGGTTCGCGAGCCTGTCTTACGGTGCTGTTGCCGCGGCGCTCGGCGTCGCTTTTGTCTGGTATTCCTGGCG
CGTGCTGGCGGCCAAGGGGCAGGACCCGGCGCTGCGGCCCGAAAAGGCGCTTTTCGGCTATTCGGTTCTCTACCTCTTCG
CCATCTTCGCTGCGCTGCTGTGTGACGGCCTTGTCGAGCGGTTCGGAGCCTGA

Upstream 100 bases:

>100_bases
CGCCCTTCCACCAATGGGAAGAGCTGCCGAGAATCCGCTAAGGAGCATCGCGCGGCCTGGATAGATCCCGGGCCGCGCTA
GTTATAGGCGACAGAAAAGC

Downstream 100 bases:

>100_bases
GATGCCGGACAAGGATCGCGTGAAGCCGACGGAGGCTCAGTTGAAGGCCCGACGCAGCCGGTCGATTGCGATCGCTCTTG
CGCTGATCGCCTTCGTGGTC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MALVEREHMKEDAGRLSEATAGDFIALLKPRVMSLVVFTAFVGMVLAPANPHPFLALISILAIAVGAGASGALNMWYDAD
IDAVMARTAGRPVPAGRIAPGEALGFGLFLSAFSVGTLGLMANWLAASLLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAG
ALPPVVGWAAMTGSVSLESLVLFLIIFLWTPPHFWALALFKEGDYERAGVPMMPNVAGAASTRRQIFAYSVLVAVSGVLP
TAMGFASLSYGAVAAALGVAFVWYSWRVLAAKGQDPALRPEKALFGYSVLYLFAIFAALLCDGLVERFGA

Sequences:

>Translated_310_residues
MALVEREHMKEDAGRLSEATAGDFIALLKPRVMSLVVFTAFVGMVLAPANPHPFLALISILAIAVGAGASGALNMWYDAD
IDAVMARTAGRPVPAGRIAPGEALGFGLFLSAFSVGTLGLMANWLAASLLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAG
ALPPVVGWAAMTGSVSLESLVLFLIIFLWTPPHFWALALFKEGDYERAGVPMMPNVAGAASTRRQIFAYSVLVAVSGVLP
TAMGFASLSYGAVAAALGVAFVWYSWRVLAAKGQDPALRPEKALFGYSVLYLFAIFAALLCDGLVERFGA
>Mature_309_residues
ALVEREHMKEDAGRLSEATAGDFIALLKPRVMSLVVFTAFVGMVLAPANPHPFLALISILAIAVGAGASGALNMWYDADI
DAVMARTAGRPVPAGRIAPGEALGFGLFLSAFSVGTLGLMANWLAASLLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGA
LPPVVGWAAMTGSVSLESLVLFLIIFLWTPPHFWALALFKEGDYERAGVPMMPNVAGAASTRRQIFAYSVLVAVSGVLPT
AMGFASLSYGAVAAALGVAFVWYSWRVLAAKGQDPALRPEKALFGYSVLYLFAIFAALLCDGLVERFGA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=190, Percent_Identity=35.7894736842105, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786631, Length=291, Percent_Identity=28.5223367697594, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71998235, Length=291, Percent_Identity=29.2096219931272, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=193, Percent_Identity=31.6062176165803, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921064, Length=222, Percent_Identity=32.4324324324324, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_MESSB (Q11KD2)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673308.1
- STRING:   Q11KD2
- GeneID:   4180221
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0743
- NMPDR:   fig|266779.1.peg.2881
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q11KD2
- ProtClustDB:   PRK04375
- BioCyc:   MSP266779:MESO_0743-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 32792; Mature: 32661

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17b8d78c)-; HASH(0x12bd5860)-; HASH(0x130e00a8)-; HASH(0x127f3d84)-; HASH(0x13a53cf0)-; HASH(0x1370d4e8)-; HASH(0x176c6794)-; HASH(0x12b611cc)-; HASH(0x132cc1c4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVEREHMKEDAGRLSEATAGDFIALLKPRVMSLVVFTAFVGMVLAPANPHPFLALISI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAIAVGAGASGALNMWYDADIDAVMARTAGRPVPAGRIAPGEALGFGLFLSAFSVGTLGL
HHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MANWLAASLLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGALPPVVGWAAMTGSVSLESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHH
VLFLIIFLWTPPHFWALALFKEGDYERAGVPMMPNVAGAASTRRQIFAYSVLVAVSGVLP
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TAMGFASLSYGAVAAALGVAFVWYSWRVLAAKGQDPALRPEKALFGYSVLYLFAIFAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
CDGLVERFGA
HHHHHHHHCH
>Mature Secondary Structure 
ALVEREHMKEDAGRLSEATAGDFIALLKPRVMSLVVFTAFVGMVLAPANPHPFLALISI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LAIAVGAGASGALNMWYDADIDAVMARTAGRPVPAGRIAPGEALGFGLFLSAFSVGTLGL
HHHHHCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
MANWLAASLLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGALPPVVGWAAMTGSVSLESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCHHHH
VLFLIIFLWTPPHFWALALFKEGDYERAGVPMMPNVAGAASTRRQIFAYSVLVAVSGVLP
HHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TAMGFASLSYGAVAAALGVAFVWYSWRVLAAKGQDPALRPEKALFGYSVLYLFAIFAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
CDGLVERFGA
HHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA