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The map label for this gene is ctaD [H]

Identifier: 110633099

GI number: 110633099

Start: 818113

End: 819765

Strand: Direct

Name: ctaD [H]

Synonym: Meso_0742

Alternate gene names: 110633099

Gene position: 818113-819765 (Clockwise)

Preceding gene: 110633098

Following gene: 110633100

Centisome position: 18.54

GC content: 61.1

Gene sequence:

>1653_bases
ATGGCAGGCGCTGCAGCGATTAGCGACCACGACGACCACAAGCCGAGAGGCTGGGTCCGCTGGGTCTACTCCACCAATCA
TAAGGATATCGGCACGCTTTACCTGATCTTCGCGATCATTGCGGGCATCATCGGCGGCTTTCTGTCGGTGATGATGCGCT
GGGAGCTCGCGGAGCCCGGAATCCAGATTTTCCATGGCCTCGCTTCAATGGTCTATGGATATGAGGGCGCGGCCGCCGTC
GATGCCGGCAAGGAGATGTACAACGTCTTCACCACCGGCCACGGCCTCATCATGATCTTCTTCATGGTCATGCCGGCGCT
CATCGGCGGGTTCGCCAACTGGATGGTACCGATCATGATCGGCGCGCCGGACATGGCGTTTCCGCGCATGAACAACATTT
CGTTCTGGCTCCTGCCGCCAGCCTTCATTCTGCTGCTCTTGTCCATGTTCGTGCCGGGCGCTCCGGGCGGCTATGGCGCC
GGCACCGGCTGGACCATCTATCCGCCTCTGTCGACCGTCGGTCACCCTGGCCCCGCCGTGGATCTTGGAATCCTGGCGCT
GCACATCGCGGGTGCCTCGTCGATCCTTGGCGCCATCAACTTCATCACCACCATCTTCAACATGCGCGCGCCGGGCATGA
CGCTGCATAAGATGCCGCTCTTTGCCTGGTCGGTGCTCATCACGGCGTTCCTGCTGCTCCTCTCCCTGCCGGTCCTGGCG
GGCGGCATCACCATGCTTCTGACCGACCGGAATTTCGGCACGACCTTCTTCGCGCCGGATGGCGGCGGTGACCCCATCCT
GTTCCAGCATCTGTTCTGGTTCTTCGGTCACCCTGAGGTTTATATTCTGATCCTGCCCGGCTTCGGCATCGTCAGCCACA
TCGTATCGACCTTCTCGCGCAAGCCGGTCTTCGGCTACCTCGGAATGGCCTATGCGATGGTAGCCATCGGCGCGATCGGC
TTCGTCGTGTGGGCGCACCACATGTACACCACCGGCCTCTCGCTAGACACGCAGCGCTACTTCGTCTTCGCCACCATGGT
GATCGCGGTTCCGACGGGCGTGAAGATCTTCTCCTGGATCGCCACCATGTGGGGCGGTTCGATCTCCTTCCGCGTGCCGA
TGCTGTGGGCGATCGCCTTCATCTTCCTGTTCACCGTCGGCGGCGTGACCGGCGTTCAGCTCGCCAATGCCGGCCTGGAC
CGGGCCATGCACGACACCTACTATGTCGTGGCGCACTTCCATTACGTGCTTTCGATGGGTGCGGTGTTCGCCATCTTCGC
CGCCTGGTACTACTGGTTCCCGAAGATGACGGGCTACATGTACAACTCCTTCATCGCCCGGCTGCATTTCTGGATCACCT
TCATCGGCGTGAACCTGATCTTCTTCCCGCAGCATTTCCTGGGCCTTTCCGGCATGCCCCGCCGCTATATTGACTACCCG
GATGCCTTCGCGGGTTGGAACCAGGTTTCTTCCTACGGTTCCTATCTGGCGGCCATTGGCGTGCTGGTATTCCTCTATGG
CGTGATGGAGGCCTTCGCGAAGAAGCGTGTCGCAGGCGCCAATCCCTGGGGTGAAGGTGCAACCACGCTCGAATGGCAGC
TTCCCTCGCCGCCGCCCTTCCACCAATGGGAAGAGCTGCCGAGAATCCGCTAA

Upstream 100 bases:

>100_bases
CGCCAATCGCGCTTTGATGGCGGCAATCGAAAACGGCAAGGACAAGATCGCCGCCGCCCAGTAGCGGCAGAGCGACCAAA
GGATAATGGAGCGGTAGGAT

Downstream 100 bases:

>100_bases
GGAGCATCGCGCGGCCTGGATAGATCCCGGGCCGCGCTAGTTATAGGCGACAGAAAAGCATGGCACTGGTCGAGCGCGAG
CATATGAAGGAAGACGCGGG

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MAGAAAISDHDDHKPRGWVRWVYSTNHKDIGTLYLIFAIIAGIIGGFLSVMMRWELAEPGIQIFHGLASMVYGYEGAAAV
DAGKEMYNVFTTGHGLIMIFFMVMPALIGGFANWMVPIMIGAPDMAFPRMNNISFWLLPPAFILLLLSMFVPGAPGGYGA
GTGWTIYPPLSTVGHPGPAVDLGILALHIAGASSILGAINFITTIFNMRAPGMTLHKMPLFAWSVLITAFLLLLSLPVLA
GGITMLLTDRNFGTTFFAPDGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIVSTFSRKPVFGYLGMAYAMVAIGAIG
FVVWAHHMYTTGLSLDTQRYFVFATMVIAVPTGVKIFSWIATMWGGSISFRVPMLWAIAFIFLFTVGGVTGVQLANAGLD
RAMHDTYYVVAHFHYVLSMGAVFAIFAAWYYWFPKMTGYMYNSFIARLHFWITFIGVNLIFFPQHFLGLSGMPRRYIDYP
DAFAGWNQVSSYGSYLAAIGVLVFLYGVMEAFAKKRVAGANPWGEGATTLEWQLPSPPPFHQWEELPRIR

Sequences:

>Translated_550_residues
MAGAAAISDHDDHKPRGWVRWVYSTNHKDIGTLYLIFAIIAGIIGGFLSVMMRWELAEPGIQIFHGLASMVYGYEGAAAV
DAGKEMYNVFTTGHGLIMIFFMVMPALIGGFANWMVPIMIGAPDMAFPRMNNISFWLLPPAFILLLLSMFVPGAPGGYGA
GTGWTIYPPLSTVGHPGPAVDLGILALHIAGASSILGAINFITTIFNMRAPGMTLHKMPLFAWSVLITAFLLLLSLPVLA
GGITMLLTDRNFGTTFFAPDGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIVSTFSRKPVFGYLGMAYAMVAIGAIG
FVVWAHHMYTTGLSLDTQRYFVFATMVIAVPTGVKIFSWIATMWGGSISFRVPMLWAIAFIFLFTVGGVTGVQLANAGLD
RAMHDTYYVVAHFHYVLSMGAVFAIFAAWYYWFPKMTGYMYNSFIARLHFWITFIGVNLIFFPQHFLGLSGMPRRYIDYP
DAFAGWNQVSSYGSYLAAIGVLVFLYGVMEAFAKKRVAGANPWGEGATTLEWQLPSPPPFHQWEELPRIR
>Mature_549_residues
AGAAAISDHDDHKPRGWVRWVYSTNHKDIGTLYLIFAIIAGIIGGFLSVMMRWELAEPGIQIFHGLASMVYGYEGAAAVD
AGKEMYNVFTTGHGLIMIFFMVMPALIGGFANWMVPIMIGAPDMAFPRMNNISFWLLPPAFILLLLSMFVPGAPGGYGAG
TGWTIYPPLSTVGHPGPAVDLGILALHIAGASSILGAINFITTIFNMRAPGMTLHKMPLFAWSVLITAFLLLLSLPVLAG
GITMLLTDRNFGTTFFAPDGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIVSTFSRKPVFGYLGMAYAMVAIGAIGF
VVWAHHMYTTGLSLDTQRYFVFATMVIAVPTGVKIFSWIATMWGGSISFRVPMLWAIAFIFLFTVGGVTGVQLANAGLDR
AMHDTYYVVAHFHYVLSMGAVFAIFAAWYYWFPKMTGYMYNSFIARLHFWITFIGVNLIFFPQHFLGLSGMPRRYIDYPD
AFAGWNQVSSYGSYLAAIGVLVFLYGVMEAFAKKRVAGANPWGEGATTLEWQLPSPPPFHQWEELPRIR

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=528, Percent_Identity=60.6060606060606, Blast_Score=592, Evalue=1e-169,
Organism=Escherichia coli, GI1786634, Length=541, Percent_Identity=41.0351201478743, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=547, Percent_Identity=56.672760511883, Blast_Score=603, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6226524, Length=342, Percent_Identity=59.9415204678363, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6226523, Length=267, Percent_Identity=53.9325842696629, Blast_Score=267, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6226522, Length=94, Percent_Identity=39.3617021276596, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6226521, Length=81, Percent_Identity=39.5061728395062, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 60665; Mature: 60534

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGAAAISDHDDHKPRGWVRWVYSTNHKDIGTLYLIFAIIAGIIGGFLSVMMRWELAEPG
CCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IQIFHGLASMVYGYEGAAAVDAGKEMYNVFTTGHGLIMIFFMVMPALIGGFANWMVPIMI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEE
GAPDMAFPRMNNISFWLLPPAFILLLLSMFVPGAPGGYGAGTGWTIYPPLSTVGHPGPAV
CCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHCCCCCCHH
DLGILALHIAGASSILGAINFITTIFNMRAPGMTLHKMPLFAWSVLITAFLLLLSLPVLA
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GGITMLLTDRNFGTTFFAPDGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIVSTFSR
CCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCC
KPVFGYLGMAYAMVAIGAIGFVVWAHHMYTTGLSLDTQRYFVFATMVIAVPTGVKIFSWI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ATMWGGSISFRVPMLWAIAFIFLFTVGGVTGVQLANAGLDRAMHDTYYVVAHFHYVLSMG
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFAIFAAWYYWFPKMTGYMYNSFIARLHFWITFIGVNLIFFPQHFLGLSGMPRRYIDYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCC
DAFAGWNQVSSYGSYLAAIGVLVFLYGVMEAFAKKRVAGANPWGEGATTLEWQLPSPPPF
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCC
HQWEELPRIR
HHHHHCCCCC
>Mature Secondary Structure 
AGAAAISDHDDHKPRGWVRWVYSTNHKDIGTLYLIFAIIAGIIGGFLSVMMRWELAEPG
CCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
IQIFHGLASMVYGYEGAAAVDAGKEMYNVFTTGHGLIMIFFMVMPALIGGFANWMVPIMI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEE
GAPDMAFPRMNNISFWLLPPAFILLLLSMFVPGAPGGYGAGTGWTIYPPLSTVGHPGPAV
CCCCCCCCCCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCEEECCHHHCCCCCCHH
DLGILALHIAGASSILGAINFITTIFNMRAPGMTLHKMPLFAWSVLITAFLLLLSLPVLA
HHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GGITMLLTDRNFGTTFFAPDGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIVSTFSR
CCEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCC
KPVFGYLGMAYAMVAIGAIGFVVWAHHMYTTGLSLDTQRYFVFATMVIAVPTGVKIFSWI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ATMWGGSISFRVPMLWAIAFIFLFTVGGVTGVQLANAGLDRAMHDTYYVVAHFHYVLSMG
HHHHCCCCEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVFAIFAAWYYWFPKMTGYMYNSFIARLHFWITFIGVNLIFFPQHFLGLSGMPRRYIDYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCC
DAFAGWNQVSSYGSYLAAIGVLVFLYGVMEAFAKKRVAGANPWGEGATTLEWQLPSPPPF
CHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCC
HQWEELPRIR
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]