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The map label for this gene is dxs

Identifier: 110633092

GI number: 110633092

Start: 808705

End: 810657

Strand: Direct

Name: dxs

Synonym: Meso_0735

Alternate gene names: 110633092

Gene position: 808705-810657 (Clockwise)

Preceding gene: 110633091

Following gene: 110633093

Centisome position: 18.33

GC content: 63.44

Gene sequence:

>1953_bases
ATGTCCAAGATAAAAAACGATAAGCGAGAAACGGGCCATTTGAAGTCGCCGCCCGAAACGCCTCTGTTAAACCGTGTCCG
GTTCCCTTCGGATCTGAAGCAGATTCCCGAGGAGGATCTGCCGCAGCTCGCCGAGGAGTTGCGGGCGGAGATGATCGATG
CGGTTTCGCAGACGGGCGGGCATCTGGGCGCTGGCCTGGGCGTCGTCGAGCTTACGGTCGCGCTGCACTACATTTTTGAT
ACGCCGCATGACCGGCTGATCTGGGATGTCGGCCATCAGGCCTACCCGCACAAGATTCTCACCGGCCGGCGCGACCGCAT
CCGCACCCTGCGTCAGGAGGACGGGCTTTCCGGCTTCACCAAGCGTTCGGAGAGCGAATACGATCCTTTCGGCGCAGCCC
ATTCCTCCACGTCGATCTCCGCCGGGCTCGGCATGGCCGTGGCGAGGGAGCTTTCCGGCGGCCAGCGCCACGTGATCGCC
GTCATCGGCGATGGAGCGCTTTCGGCGGGCATGGCCTATGAGGCCATGAACAATGCCGGCGCGCTTGATGCGCGGCTGAT
CGTCATCCTGAACGACAACGATATGTCCATTGCGCCGCCCACGGGTGCGATGAGCACTTATCTGGCGCGCCTTGCCTCAG
GCCGCGCTTATCGGGGAATCCGTGACGTCGGCAAAAAACTCACCTCCCATTTGGGCAAGTCGTTTGACCGCGCCATCACC
CGCGCCGTGGAGCACGCGCGCGGTTTTGTGACGGGCGGCACTCTGTTCGAGGAGATGGGCTTCTTCCACATCGGCCCGAT
CGACGGCCACGATCTGGAGGCGCTCGTGCCGGTGCTCCGCAATGTGCGCGACAATGGCACGGGCCCGGTGCTGATCCACG
TGGTTACCCAAAAGGGCAAGGGCTATCCGCCGGCGGAAGCTGCGGCGGATAAGTATCACGGCGTCGCAAAGTTCGACGTG
ATCACCGGCGCTCAGGCCAAATCACCTGCGGGCGCGCCGAGCTACACGAAAGTGTTCGCCCAGGCGCTTGTCCAGGAGGC
GCGGGAGGATAAACGGATCGTGGCCATCACGGCGGCCATGCCCTCGGGCACGGGTCTTGATCTGTTCGAAAAGGAGTTTC
CGGACCGCAGCTTCGATGTCGGCATTGCCGAGCAGCACGCGGTGACCTTCGCCGCCGGCCTCGCCACCGAGGGCTATCGG
CCCTTTGCGGCGATCTATTCCACCTTTTTGCAGCGCGCCTATGACCAGGTGGTGCATGACGTGGCGATCCAAAACCTGCC
CGTCCGCTTCGCCATCGATCGCGCGGGCTTCGTCGGCGCCGATGGCGCCACCCATTGCGGTGCTTTCGATGTCGCCTATC
TCGCCACACTGCCCAATATGGTCGTCATGGCGGCCGCGGATGAGGCCGAGCTGAAGCACATGGTTCGCACCGCTGCTGAC
CATGACGAAGGTCCCATCGCATTCCGTTATCCCCGCGGAGAGGGCACAGGCGTTCCGCTGCCTCAGCGCGGCGAGATCCT
GAAAATCGGCAAGGGCCGTATCGTCCGCGAGGGCAGCAAGATCGCGCTCCTCTCGCTCGGCACACGCCTTGCTGACTGCA
TGATTGCGGCCGAAGAGCTTGAGGCGGCGGGTCTTTCCACCACCGTTGCCGATGCTCGCTTTGCAAAGCCGCTCGATGCG
GACCTTATCCGCCGGCTTGCGCGCGAGCATGAGGTTCTTGTCACCGTCGAGGAAGGCTCCATCGGCGGCTTCGGTGCGCA
TGTGCTGCACTTCCTGGCGCATGAGGGCCTTCTCGAAAATGGGCTCAAGGTTCGCCCGCTCGTAATGCCGGACATCTTCA
TGGATCAGGCGAAGCCGGAAAAGATGTATGCCAAGGCTGGGCTCGACGCGGCGGGCATCGTGAAGACGGTTTTCGCCGCG
CTCGGCCAGGCGGAGCAGGCGGCAAGGGCTTGA

Upstream 100 bases:

>100_bases
TCGACACCGTTCCCGGTGACGAAGAGGAGTTCACCCCCTTGCCGGAGAAGTAAGGCAGAGCAAATAACGCGCCACGGCCG
CACGCAGCGAACGAGATCTT

Downstream 100 bases:

>100_bases
GTGGGTTTGAATTGGCGGGATTAGGTGCCCTTTCGCGCCCTCCCTTTGGCCTCCCGGCCAGAGGGGGGGGCGTGAAGGGG
CGCGGCATTTCCGGTTTCGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSKIKNDKRETGHLKSPPETPLLNRVRFPSDLKQIPEEDLPQLAEELRAEMIDAVSQTGGHLGAGLGVVELTVALHYIFD
TPHDRLIWDVGHQAYPHKILTGRRDRIRTLRQEDGLSGFTKRSESEYDPFGAAHSSTSISAGLGMAVARELSGGQRHVIA
VIGDGALSAGMAYEAMNNAGALDARLIVILNDNDMSIAPPTGAMSTYLARLASGRAYRGIRDVGKKLTSHLGKSFDRAIT
RAVEHARGFVTGGTLFEEMGFFHIGPIDGHDLEALVPVLRNVRDNGTGPVLIHVVTQKGKGYPPAEAAADKYHGVAKFDV
ITGAQAKSPAGAPSYTKVFAQALVQEAREDKRIVAITAAMPSGTGLDLFEKEFPDRSFDVGIAEQHAVTFAAGLATEGYR
PFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAIDRAGFVGADGATHCGAFDVAYLATLPNMVVMAAADEAELKHMVRTAAD
HDEGPIAFRYPRGEGTGVPLPQRGEILKIGKGRIVREGSKIALLSLGTRLADCMIAAEELEAAGLSTTVADARFAKPLDA
DLIRRLAREHEVLVTVEEGSIGGFGAHVLHFLAHEGLLENGLKVRPLVMPDIFMDQAKPEKMYAKAGLDAAGIVKTVFAA
LGQAEQAARA

Sequences:

>Translated_650_residues
MSKIKNDKRETGHLKSPPETPLLNRVRFPSDLKQIPEEDLPQLAEELRAEMIDAVSQTGGHLGAGLGVVELTVALHYIFD
TPHDRLIWDVGHQAYPHKILTGRRDRIRTLRQEDGLSGFTKRSESEYDPFGAAHSSTSISAGLGMAVARELSGGQRHVIA
VIGDGALSAGMAYEAMNNAGALDARLIVILNDNDMSIAPPTGAMSTYLARLASGRAYRGIRDVGKKLTSHLGKSFDRAIT
RAVEHARGFVTGGTLFEEMGFFHIGPIDGHDLEALVPVLRNVRDNGTGPVLIHVVTQKGKGYPPAEAAADKYHGVAKFDV
ITGAQAKSPAGAPSYTKVFAQALVQEAREDKRIVAITAAMPSGTGLDLFEKEFPDRSFDVGIAEQHAVTFAAGLATEGYR
PFAAIYSTFLQRAYDQVVHDVAIQNLPVRFAIDRAGFVGADGATHCGAFDVAYLATLPNMVVMAAADEAELKHMVRTAAD
HDEGPIAFRYPRGEGTGVPLPQRGEILKIGKGRIVREGSKIALLSLGTRLADCMIAAEELEAAGLSTTVADARFAKPLDA
DLIRRLAREHEVLVTVEEGSIGGFGAHVLHFLAHEGLLENGLKVRPLVMPDIFMDQAKPEKMYAKAGLDAAGIVKTVFAA
LGQAEQAARA
>Mature_649_residues
SKIKNDKRETGHLKSPPETPLLNRVRFPSDLKQIPEEDLPQLAEELRAEMIDAVSQTGGHLGAGLGVVELTVALHYIFDT
PHDRLIWDVGHQAYPHKILTGRRDRIRTLRQEDGLSGFTKRSESEYDPFGAAHSSTSISAGLGMAVARELSGGQRHVIAV
IGDGALSAGMAYEAMNNAGALDARLIVILNDNDMSIAPPTGAMSTYLARLASGRAYRGIRDVGKKLTSHLGKSFDRAITR
AVEHARGFVTGGTLFEEMGFFHIGPIDGHDLEALVPVLRNVRDNGTGPVLIHVVTQKGKGYPPAEAAADKYHGVAKFDVI
TGAQAKSPAGAPSYTKVFAQALVQEAREDKRIVAITAAMPSGTGLDLFEKEFPDRSFDVGIAEQHAVTFAAGLATEGYRP
FAAIYSTFLQRAYDQVVHDVAIQNLPVRFAIDRAGFVGADGATHCGAFDVAYLATLPNMVVMAAADEAELKHMVRTAADH
DEGPIAFRYPRGEGTGVPLPQRGEILKIGKGRIVREGSKIALLSLGTRLADCMIAAEELEAAGLSTTVADARFAKPLDAD
LIRRLAREHEVLVTVEEGSIGGFGAHVLHFLAHEGLLENGLKVRPLVMPDIFMDQAKPEKMYAKAGLDAAGIVKTVFAAL
GQAEQAARA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=473, Percent_Identity=26.6384778012685, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI4507521, Length=473, Percent_Identity=26.6384778012685, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI133778974, Length=364, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=6e-19,
Organism=Homo sapiens, GI225637461, Length=391, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI225637459, Length=391, Percent_Identity=26.0869565217391, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI225637463, Length=391, Percent_Identity=26.0869565217391, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=52.4879614767255, Blast_Score=627, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=621, Percent_Identity=23.6714975845411, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45551847, Length=643, Percent_Identity=25.9720062208398, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45550715, Length=643, Percent_Identity=25.9720062208398, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24645119, Length=508, Percent_Identity=26.5748031496063, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=29.5454545454545, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_MESSB (Q11KE0)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_673300.1
- ProteinModelPortal:   Q11KE0
- SMR:   Q11KE0
- STRING:   Q11KE0
- GeneID:   4180213
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0735
- NMPDR:   fig|266779.1.peg.2873
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q11KE0
- ProtClustDB:   PRK05444
- BioCyc:   MSP266779:MESO_0735-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69703; Mature: 69572

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIKNDKRETGHLKSPPETPLLNRVRFPSDLKQIPEEDLPQLAEELRAEMIDAVSQTGG
CCCCCCCCHHCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
HLGAGLGVVELTVALHYIFDTPHDRLIWDVGHQAYPHKILTGRRDRIRTLRQEDGLSGFT
CCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCHHH
KRSESEYDPFGAAHSSTSISAGLGMAVARELSGGQRHVIAVIGDGALSAGMAYEAMNNAG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCHHHHHHCCCC
ALDARLIVILNDNDMSIAPPTGAMSTYLARLASGRAYRGIRDVGKKLTSHLGKSFDRAIT
CCCEEEEEEECCCCCEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAVEHARGFVTGGTLFEEMGFFHIGPIDGHDLEALVPVLRNVRDNGTGPVLIHVVTQKGK
HHHHHHCCEEECCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GYPPAEAAADKYHGVAKFDVITGAQAKSPAGAPSYTKVFAQALVQEAREDKRIVAITAAM
CCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
PSGTGLDLFEKEFPDRSFDVGIAEQHAVTFAAGLATEGYRPFAAIYSTFLQRAYDQVVHD
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VAIQNLPVRFAIDRAGFVGADGATHCGAFDVAYLATLPNMVVMAAADEAELKHMVRTAAD
HHHHCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCC
HDEGPIAFRYPRGEGTGVPLPQRGEILKIGKGRIVREGSKIALLSLGTRLADCMIAAEEL
CCCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHH
EAAGLSTTVADARFAKPLDADLIRRLAREHEVLVTVEEGSIGGFGAHVLHFLAHEGLLEN
HHCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
GLKVRPLVMPDIFMDQAKPEKMYAKAGLDAAGIVKTVFAALGQAEQAARA
CCEEEEEECCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
SKIKNDKRETGHLKSPPETPLLNRVRFPSDLKQIPEEDLPQLAEELRAEMIDAVSQTGG
CCCCCCCHHCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
HLGAGLGVVELTVALHYIFDTPHDRLIWDVGHQAYPHKILTGRRDRIRTLRQEDGLSGFT
CCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCHHH
KRSESEYDPFGAAHSSTSISAGLGMAVARELSGGQRHVIAVIGDGALSAGMAYEAMNNAG
HCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHCHHHHHHCCCC
ALDARLIVILNDNDMSIAPPTGAMSTYLARLASGRAYRGIRDVGKKLTSHLGKSFDRAIT
CCCEEEEEEECCCCCEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAVEHARGFVTGGTLFEEMGFFHIGPIDGHDLEALVPVLRNVRDNGTGPVLIHVVTQKGK
HHHHHHCCEEECCHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCC
GYPPAEAAADKYHGVAKFDVITGAQAKSPAGAPSYTKVFAQALVQEAREDKRIVAITAAM
CCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
PSGTGLDLFEKEFPDRSFDVGIAEQHAVTFAAGLATEGYRPFAAIYSTFLQRAYDQVVHD
CCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
VAIQNLPVRFAIDRAGFVGADGATHCGAFDVAYLATLPNMVVMAAADEAELKHMVRTAAD
HHHHCCCEEEEEECCCEECCCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCC
HDEGPIAFRYPRGEGTGVPLPQRGEILKIGKGRIVREGSKIALLSLGTRLADCMIAAEEL
CCCCCEEEEECCCCCCCCCCCCCCCEEEECCCEEEECCCCEEEEEHHHHHHHHHHHHHHH
EAAGLSTTVADARFAKPLDADLIRRLAREHEVLVTVEEGSIGGFGAHVLHFLAHEGLLEN
HHCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHC
GLKVRPLVMPDIFMDQAKPEKMYAKAGLDAAGIVKTVFAALGQAEQAARA
CCEEEEEECCHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA