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The map label for this gene is ribBA [H]

Identifier: 110633088

GI number: 110633088

Start: 805236

End: 806342

Strand: Direct

Name: ribBA [H]

Synonym: Meso_0731

Alternate gene names: 110633088

Gene position: 805236-806342 (Clockwise)

Preceding gene: 110633087

Following gene: 110633089

Centisome position: 18.25

GC content: 63.14

Gene sequence:

>1107_bases
TTGCTCAGAACGGAAACCTATATGCCTTATGATCAGAAACATGTCGTCGAGGCCCTGCGTGCTTTCGAGCGCGGCGAGAT
CGTCGTCGTCATGGACGATGATGGACGCGAGAATGAAGGCGACCTGATCGTTTCCGCGGTGCACTGCACGCCCGAGAAGA
TGGCCTTCATCGTCCGCCACACCTCCGGCATCGTCTGCGCGCCCATGCCGCGCGAGGAAGCACGCCGGCTGAACCTGGCG
CCCATGGTTGCCGAGAACGATGCGCCTCATCAGACCGCCTTCACCGTCAGCGTTGACTTCAGGCACGGCACGACAACGGG
CATTTCCGCGGAGGACCGGACGCTCACCGTGCGGAATCTCGCAAACCCCAATGTCGGCGCGCAGGATTTTGTGCGGCCGG
GCCATATCTTCCCGCTGGTGGCGCGGGAGGGCGGCGTACTCATGCGCTCCGGCCATACGGAAGCGGCGGTGGATCTTTGC
CGCCTGGCCGGTCTGCCGCCGGTCGGTGTCATCTGCGAGTTGGTGAACGACGACGGCACGGTGATGCGCGGCCCTCAGGT
AACGGCCTTCGCCGAAAAGCACGGGCTCAAGCAGGTTTCCGTCGCCGATCTCATAGCCTATCGCCAGCGGAAGGAGACGC
TTGTCGAGCGTGTAGCGTCTTTCCCGGTCAGCACTGCCGCGGGCCAGGCGACGGCCTATGCCTACACCCTGCCTTGGGAG
GTGATGCAGCATCTGGCGATCGTCTTCGGCGACATCCGCGACGGGCAGGATGTGCCGGTCCGGCTGCATACCGAGAATGT
CGTCCAGGATGTCTTCGGCATGGAAAGACGGTTGCAGCAGATCATGGAGCGCATGGGAAGCCGCGGAGTCCTGGTCTATT
TGCGGGCGGGATCGGTTGGCGTGGCCCATCAGCAGCGCCGGCTGGCTGGCGGGGAAGATCACGAAGAGGCAGTGCGGCGT
GAGAACGAATGGCGTGAAATTGGCCTGGGCGCCCAGATCCTGAAGGATCTCGGTATCACGTCGATCCGGCTGCTCGCTTC
CCGTGAACGCCACTATGTGGGCCTCGAGGGTTTTGGGATCGAGATCGCATCCACCGAAATCCTCTGA

Upstream 100 bases:

>100_bases
CGATCATTATCTGCGCCACAGGGGGCAGACGGGGAAAGGATGAGCGAACGGGGAGGAGTAACCTTGCCGGACTTTCCATT
CGCTGCTCCCTATTCGCTAC

Downstream 100 bases:

>100_bases
TGAGCCACGTGTCTGTCTAACGGTGCGGCTCGTCAGTTGATGGACGTACGGCGCTGCAGGCTCTTGAGGGCGCTTTGCTC
AGCGTGGCCAAGCGCCGCTT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MLRTETYMPYDQKHVVEALRAFERGEIVVVMDDDGRENEGDLIVSAVHCTPEKMAFIVRHTSGIVCAPMPREEARRLNLA
PMVAENDAPHQTAFTVSVDFRHGTTTGISAEDRTLTVRNLANPNVGAQDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLC
RLAGLPPVGVICELVNDDGTVMRGPQVTAFAEKHGLKQVSVADLIAYRQRKETLVERVASFPVSTAAGQATAYAYTLPWE
VMQHLAIVFGDIRDGQDVPVRLHTENVVQDVFGMERRLQQIMERMGSRGVLVYLRAGSVGVAHQQRRLAGGEDHEEAVRR
ENEWREIGLGAQILKDLGITSIRLLASRERHYVGLEGFGIEIASTEIL

Sequences:

>Translated_368_residues
MLRTETYMPYDQKHVVEALRAFERGEIVVVMDDDGRENEGDLIVSAVHCTPEKMAFIVRHTSGIVCAPMPREEARRLNLA
PMVAENDAPHQTAFTVSVDFRHGTTTGISAEDRTLTVRNLANPNVGAQDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLC
RLAGLPPVGVICELVNDDGTVMRGPQVTAFAEKHGLKQVSVADLIAYRQRKETLVERVASFPVSTAAGQATAYAYTLPWE
VMQHLAIVFGDIRDGQDVPVRLHTENVVQDVFGMERRLQQIMERMGSRGVLVYLRAGSVGVAHQQRRLAGGEDHEEAVRR
ENEWREIGLGAQILKDLGITSIRLLASRERHYVGLEGFGIEIASTEIL
>Mature_368_residues
MLRTETYMPYDQKHVVEALRAFERGEIVVVMDDDGRENEGDLIVSAVHCTPEKMAFIVRHTSGIVCAPMPREEARRLNLA
PMVAENDAPHQTAFTVSVDFRHGTTTGISAEDRTLTVRNLANPNVGAQDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLC
RLAGLPPVGVICELVNDDGTVMRGPQVTAFAEKHGLKQVSVADLIAYRQRKETLVERVASFPVSTAAGQATAYAYTLPWE
VMQHLAIVFGDIRDGQDVPVRLHTENVVQDVFGMERRLQQIMERMGSRGVLVYLRAGSVGVAHQQRRLAGGEDHEEAVRR
ENEWREIGLGAQILKDLGITSIRLLASRERHYVGLEGFGIEIASTEIL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=204, Percent_Identity=48.0392156862745, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320695, Length=213, Percent_Identity=49.7652582159624, Blast_Score=205, Evalue=9e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 40661; Mature: 40661

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRTETYMPYDQKHVVEALRAFERGEIVVVMDDDGRENEGDLIVSAVHCTPEKMAFIVRH
CCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHEEEEEE
TSGIVCAPMPREEARRLNLAPMVAENDAPHQTAFTVSVDFRHGTTTGISAEDRTLTVRNL
CCCEEECCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEC
ANPNVGAQDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICELVNDDGT
CCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHEEEECCCCC
VMRGPQVTAFAEKHGLKQVSVADLIAYRQRKETLVERVASFPVSTAAGQATAYAYTLPWE
EEECCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHH
VMQHLAIVFGDIRDGQDVPVRLHTENVVQDVFGMERRLQQIMERMGSRGVLVYLRAGSVG
HHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VAHQQRRLAGGEDHEEAVRRENEWREIGLGAQILKDLGITSIRLLASRERHYVGLEGFGI
CHHHHHHCCCCCCHHHHHHHCCHHHHHCCHHHHHHHCCCHHEEHHHHCCCCEEEECCCCE
EIASTEIL
EEECCCCC
>Mature Secondary Structure
MLRTETYMPYDQKHVVEALRAFERGEIVVVMDDDGRENEGDLIVSAVHCTPEKMAFIVRH
CCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEECCHHHHEEEEEE
TSGIVCAPMPREEARRLNLAPMVAENDAPHQTAFTVSVDFRHGTTTGISAEDRTLTVRNL
CCCEEECCCCHHHHHHCCCCCEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCEEEEEEC
ANPNVGAQDFVRPGHIFPLVAREGGVLMRSGHTEAAVDLCRLAGLPPVGVICELVNDDGT
CCCCCCHHHCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCCCHHHHEEEECCCCC
VMRGPQVTAFAEKHGLKQVSVADLIAYRQRKETLVERVASFPVSTAAGQATAYAYTLPWE
EEECCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCHH
VMQHLAIVFGDIRDGQDVPVRLHTENVVQDVFGMERRLQQIMERMGSRGVLVYLRAGSVG
HHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
VAHQQRRLAGGEDHEEAVRRENEWREIGLGAQILKDLGITSIRLLASRERHYVGLEGFGI
CHHHHHHCCCCCCHHHHHHHCCHHHHHCCHHHHHHHCCCHHEEHHHHCCCCEEEECCCCE
EIASTEIL
EEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA