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The map label for this gene is fabI1 [H]

Identifier: 110633084

GI number: 110633084

Start: 802116

End: 802934

Strand: Direct

Name: fabI1 [H]

Synonym: Meso_0727

Alternate gene names: 110633084

Gene position: 802116-802934 (Clockwise)

Preceding gene: 110633083

Following gene: 110633085

Centisome position: 18.18

GC content: 60.2

Gene sequence:

>819_bases
ATGGCAGGTGGGAATGGCCTGATGGCCGGCAAACGGGGGCTCGTTCTCGGCGTTGCAAACAACCGCTCGATTGCCTGGGG
CATTTGCAAGGCATGCGCCACAGAGGGCGCAGAGCTAGCGCTCACCTACCAGGGCGATGCACTGAAAAAGAGGGTGGAGC
CGCTGGCCGCCGAGCTCGGCGCCATAGTCGTCGGCCATTGCGACGTCACCGATCCGGCGTCGATCGATGCGGTCTTTGCC
GAGGTGGAGAAGCGCTGGGGCAAGCTGGACTTCCTCGTTCACGCTGTAGCCTTTTCCGACAAGGACGAACTGACCGGCCG
TTATGTCGAGACCACGCGGGAGAATTTCCTGCGCACAATGGATATTTCCGTTTATTCGCTGACCGCCGTCGCAAAGCGAG
CCGAACCTCTCATGACGGATGGCGGGTCCATCATCACGCTCACCTATTATGGTGCGGAGAAGGTCATGCCGCACTACAAC
GTGATGGGTGTGGCGAAAGCCGCGCTTGAGGCAAGCGTCCGCTATCTGGCGGTTGACCTCGGCGGCAGCAACATTCGCGT
CAATGCGATTTCGGCCGGGCCGATCAAGACACTCGCCGCCTCGGGCATCGGCGACTTCCGCTACATCCTGCGCTGGAACG
AATACAATTCACCGTTGAAGCGCGTGGTGACTATCGAGGAGGTGGGCGATACCGCGCTTTACCTGCTGTCACATCTTTCG
CGCGCCGTGACAGGTGAGGTGCTGCATGCCGATTCCGGTTATCACGTGGTTGGTATGAAGGCGGTGGATGCGCCCGATAT
CACGGTGAACGGTGACTAA

Upstream 100 bases:

>100_bases
CGAGCAAAACCTCACGGCAGGCTTTCCCGGTCGCGCGCTTGATGCAATTCTGCCACTGTGCGATACGGCGTCCGCCGCAA
TTTGAGTTCGGAGAATCGAT

Downstream 100 bases:

>100_bases
CGCATCGAAACCTGGGCGCTGGATTCAATAATTTACAACGCCCTTGGTGCGTTCTAAAGGACGCTCGGCGCTGTAGTCCG
AATTTGGCGGGGCGCCCTAT

Product: enoyl-(acyl carrier protein) reductase

Products: NA

Alternate protein names: NADH-dependent enoyl-ACP reductase 1 [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAGGNGLMAGKRGLVLGVANNRSIAWGICKACATEGAELALTYQGDALKKRVEPLAAELGAIVVGHCDVTDPASIDAVFA
EVEKRWGKLDFLVHAVAFSDKDELTGRYVETTRENFLRTMDISVYSLTAVAKRAEPLMTDGGSIITLTYYGAEKVMPHYN
VMGVAKAALEASVRYLAVDLGGSNIRVNAISAGPIKTLAASGIGDFRYILRWNEYNSPLKRVVTIEEVGDTALYLLSHLS
RAVTGEVLHADSGYHVVGMKAVDAPDITVNGD

Sequences:

>Translated_272_residues
MAGGNGLMAGKRGLVLGVANNRSIAWGICKACATEGAELALTYQGDALKKRVEPLAAELGAIVVGHCDVTDPASIDAVFA
EVEKRWGKLDFLVHAVAFSDKDELTGRYVETTRENFLRTMDISVYSLTAVAKRAEPLMTDGGSIITLTYYGAEKVMPHYN
VMGVAKAALEASVRYLAVDLGGSNIRVNAISAGPIKTLAASGIGDFRYILRWNEYNSPLKRVVTIEEVGDTALYLLSHLS
RAVTGEVLHADSGYHVVGMKAVDAPDITVNGD
>Mature_271_residues
AGGNGLMAGKRGLVLGVANNRSIAWGICKACATEGAELALTYQGDALKKRVEPLAAELGAIVVGHCDVTDPASIDAVFAE
VEKRWGKLDFLVHAVAFSDKDELTGRYVETTRENFLRTMDISVYSLTAVAKRAEPLMTDGGSIITLTYYGAEKVMPHYNV
MGVAKAALEASVRYLAVDLGGSNIRVNAISAGPIKTLAASGIGDFRYILRWNEYNSPLKRVVTIEEVGDTALYLLSHLSR
AVTGEVLHADSGYHVVGMKAVDAPDITVNGD

Specific function: Fatty acid biosynthesis pathway; second reduction step. [C]

COG id: COG0623

COG function: function code I; Enoyl-[acyl-carrier-protein] reductase (NADH)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=193, Percent_Identity=31.6062176165803, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=27.7533039647577, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=52.1235521235521, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=30.4182509505703, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=28.2352941176471, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367365, Length=253, Percent_Identity=30.0395256916996, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787905, Length=224, Percent_Identity=26.3392857142857, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24644337, Length=196, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=26.7924528301887, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR014358
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.9 [H]

Molecular weight: Translated: 29035; Mature: 28903

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGNGLMAGKRGLVLGVANNRSIAWGICKACATEGAELALTYQGDALKKRVEPLAAELG
CCCCCCCEECCCEEEEEECCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCC
AIVVGHCDVTDPASIDAVFAEVEKRWGKLDFLVHAVAFSDKDELTGRYVETTRENFLRTM
EEEEEECCCCCCCHHHHHHHHHHHHHCHHHHEEEEECCCCCHHHCCHHHHHHHHHHHHHH
DISVYSLTAVAKRAEPLMTDGGSIITLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL
CCHHHHHHHHHHHCCCCEECCCCEEEEEEECCHHCCCCCCHHHHHHHHHHCCEEEEEEEE
GGSNIRVNAISAGPIKTLAASGIGDFRYILRWNEYNSPLKRVVTIEEVGDTALYLLSHLS
CCCEEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCHHHEEEHHHHCCHHHHHHHHHH
RAVTGEVLHADSGYHVVGMKAVDAPDITVNGD
HHHCCCEEECCCCEEEEEEEEECCCCEEECCC
>Mature Secondary Structure 
AGGNGLMAGKRGLVLGVANNRSIAWGICKACATEGAELALTYQGDALKKRVEPLAAELG
CCCCCCEECCCEEEEEECCCCEEHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCC
AIVVGHCDVTDPASIDAVFAEVEKRWGKLDFLVHAVAFSDKDELTGRYVETTRENFLRTM
EEEEEECCCCCCCHHHHHHHHHHHHHCHHHHEEEEECCCCCHHHCCHHHHHHHHHHHHHH
DISVYSLTAVAKRAEPLMTDGGSIITLTYYGAEKVMPHYNVMGVAKAALEASVRYLAVDL
CCHHHHHHHHHHHCCCCEECCCCEEEEEEECCHHCCCCCCHHHHHHHHHHCCEEEEEEEE
GGSNIRVNAISAGPIKTLAASGIGDFRYILRWNEYNSPLKRVVTIEEVGDTALYLLSHLS
CCCEEEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCCHHHEEEHHHHCCHHHHHHHHHH
RAVTGEVLHADSGYHVVGMKAVDAPDITVNGD
HHHCCCEEECCCCEEEEEEEEECCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]