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The map label for this gene is udg [H]

Identifier: 110632845

GI number: 110632845

Start: 534590

End: 535930

Strand: Direct

Name: udg [H]

Synonym: Meso_0484

Alternate gene names: 110632845

Gene position: 534590-535930 (Clockwise)

Preceding gene: 110632844

Following gene: 110632852

Centisome position: 12.12

GC content: 56.23

Gene sequence:

>1341_bases
ATGAAAGTCACTGTATTCGGTGTGGGTCATGTGGGGTTGGTGCAAGCTGCTGCTCTTGCGGAAGTCGGAAATGACGTTCT
GTGTATCGATGTAGATGAGAAAAAGGTGGAGCAGCTCCAACATGGAGTCATACCGATCTATGAGCCCGGGCTAGAGAGGC
TGGTGAACGAGAACTGCGCCGCTGGTAGATTGCACTTTACCACCGATGCTGCAGCGGGCATCAATCACGGCAAGGTCATT
ATTATCGCCGTTGGTACGCCACCCGAAGAAGACGGCTCAGCTGACCTGAAGCACGTTTTGGCGGTCGCAAGCACAATCGG
CCAGAACATGGCCGCAGACAAGGTTATCATCAGCAAGTCGACAGTGCCCGTGGGCACGTGTGACAGGATAAGGGAGACGA
TCAGCGCGGCGCTGTCCGACAGGGGCCTCGAGCGCATCGCCTTCCATGTTGTGTCGAACCCGGAATTCCTGAAGGAGGGC
TCCGCTGTCTCCGACTGCATGAAGCCCGATCGAATTATCGTTGGCACTAACAGCCCGGAAGCTGAGGCGGTCATGCGTGA
ACTCTACGCGCCGTTCAACCGCAACCATGAAAAGATGATCTTGATGGATGTGCGGAGTGCCGAACTCACAAAATATGCCG
CCAATTGCATGCTGGCGACAAAGATCAGCTTTATGAACGAAATGGCGAATATTGCCCATCGGTTGGGGGCTGACATCGAG
CAGGTGCGGCTTGGGATCGGCAGCGATCCACGTATCGGCTACGACTTCATCTATCCCGGTATCGGTTATGGCGGCTCGTG
CTTTCCTAAAGATGTGCGGGCGCTGATCCGCACGGCCGAGCAGGCGGAGTTGGAGCCGAAGATACTTCGGGCGGTGAGCG
ACCGAAATGAGCGGCAGAAATGGGTGCTGTTCGAGCGCATACGGGATTATTTCGGCCGGGATCTTTCGGGGCGCGTCATC
GCGCTATGGGGACTCGCCTATAAACCGAATACCAATGACATGCGTGAAGCACCCTCACGCGTGCTCATGGAAGCGCTATG
GGATGCCGGAGCCCAAGTGCAGGCATATGATCCACACGCAATGGGAGAGTGTCGGAAGATCTACGGCGAACGACAAGGTT
TGACTTTCTGTGAGACAAAAGAAGCTACATTGGAGGGGGCTGACGCGCTAGCGATCGCCACCGAATGGAAAAGCTTCCGC
GCACCTGACTTCGCTCTCATCCGGCGGAAGCTGAAGGCACCCGTCATTTTCGACGGAAGAAATCTATACGACCCGCGCAT
GGTGGCAAGGTACGGCCTGGAATACTGCAGCATCGGCCGAACGACTGGAAACGCGAGCTAG

Upstream 100 bases:

>100_bases
CCAGTGCTTCCCATCGTCTGGGGCGCCCGAAATACCCGCGCTTGATAATGGGGATCATCAATGCTGGATGGTATTGAACC
TTGAAGAATAGGATGGTTGG

Downstream 100 bases:

>100_bases
AGACGCCGCGTCAGGCTGGTGCACTCTCCCCCAGCTCGCCCTTCAGCGTGCATGTTCTCGGGCCGCGCGTGCCGCGCAAG
GAGATCTCCCCGCTCGCGAT

Product: UDP-glucose/GDP-mannose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKVTVFGVGHVGLVQAAALAEVGNDVLCIDVDEKKVEQLQHGVIPIYEPGLERLVNENCAAGRLHFTTDAAAGINHGKVI
IIAVGTPPEEDGSADLKHVLAVASTIGQNMAADKVIISKSTVPVGTCDRIRETISAALSDRGLERIAFHVVSNPEFLKEG
SAVSDCMKPDRIIVGTNSPEAEAVMRELYAPFNRNHEKMILMDVRSAELTKYAANCMLATKISFMNEMANIAHRLGADIE
QVRLGIGSDPRIGYDFIYPGIGYGGSCFPKDVRALIRTAEQAELEPKILRAVSDRNERQKWVLFERIRDYFGRDLSGRVI
ALWGLAYKPNTNDMREAPSRVLMEALWDAGAQVQAYDPHAMGECRKIYGERQGLTFCETKEATLEGADALAIATEWKSFR
APDFALIRRKLKAPVIFDGRNLYDPRMVARYGLEYCSIGRTTGNAS

Sequences:

>Translated_446_residues
MKVTVFGVGHVGLVQAAALAEVGNDVLCIDVDEKKVEQLQHGVIPIYEPGLERLVNENCAAGRLHFTTDAAAGINHGKVI
IIAVGTPPEEDGSADLKHVLAVASTIGQNMAADKVIISKSTVPVGTCDRIRETISAALSDRGLERIAFHVVSNPEFLKEG
SAVSDCMKPDRIIVGTNSPEAEAVMRELYAPFNRNHEKMILMDVRSAELTKYAANCMLATKISFMNEMANIAHRLGADIE
QVRLGIGSDPRIGYDFIYPGIGYGGSCFPKDVRALIRTAEQAELEPKILRAVSDRNERQKWVLFERIRDYFGRDLSGRVI
ALWGLAYKPNTNDMREAPSRVLMEALWDAGAQVQAYDPHAMGECRKIYGERQGLTFCETKEATLEGADALAIATEWKSFR
APDFALIRRKLKAPVIFDGRNLYDPRMVARYGLEYCSIGRTTGNAS
>Mature_446_residues
MKVTVFGVGHVGLVQAAALAEVGNDVLCIDVDEKKVEQLQHGVIPIYEPGLERLVNENCAAGRLHFTTDAAAGINHGKVI
IIAVGTPPEEDGSADLKHVLAVASTIGQNMAADKVIISKSTVPVGTCDRIRETISAALSDRGLERIAFHVVSNPEFLKEG
SAVSDCMKPDRIIVGTNSPEAEAVMRELYAPFNRNHEKMILMDVRSAELTKYAANCMLATKISFMNEMANIAHRLGADIE
QVRLGIGSDPRIGYDFIYPGIGYGGSCFPKDVRALIRTAEQAELEPKILRAVSDRNERQKWVLFERIRDYFGRDLSGRVI
ALWGLAYKPNTNDMREAPSRVLMEALWDAGAQVQAYDPHAMGECRKIYGERQGLTFCETKEATLEGADALAIATEWKSFR
APDFALIRRKLKAPVIFDGRNLYDPRMVARYGLEYCSIGRTTGNAS

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=447, Percent_Identity=34.2281879194631, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI296040438, Length=349, Percent_Identity=35.5300859598854, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI296040443, Length=296, Percent_Identity=35.472972972973, Blast_Score=169, Evalue=3e-42,
Organism=Escherichia coli, GI1788340, Length=363, Percent_Identity=28.6501377410468, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI48994968, Length=413, Percent_Identity=26.3922518159806, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17560350, Length=473, Percent_Identity=31.7124735729387, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=32.3340471092077, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 49060; Mature: 49060

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTVFGVGHVGLVQAAALAEVGNDVLCIDVDEKKVEQLQHGVIPIYEPGLERLVNENCA
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCEECHHHHHHHCCCCC
AGRLHFTTDAAAGINHGKVIIIAVGTPPEEDGSADLKHVLAVASTIGQNMAADKVIISKS
CCEEEEECCHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECC
TVPVGTCDRIRETISAALSDRGLERIAFHVVSNPEFLKEGSAVSDCMKPDRIIVGTNSPE
CCCCCCHHHHHHHHHHHHHHCCHHHHHEEECCCHHHHHCCCHHHHHCCCCEEEEECCCCH
AEAVMRELYAPFNRNHEKMILMDVRSAELTKYAANCMLATKISFMNEMANIAHRLGADIE
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVRLGIGSDPRIGYDFIYPGIGYGGSCFPKDVRALIRTAEQAELEPKILRAVSDRNERQK
HHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHH
WVLFERIRDYFGRDLSGRVIALWGLAYKPNTNDMREAPSRVLMEALWDAGAQVQAYDPHA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHH
MGECRKIYGERQGLTFCETKEATLEGADALAIATEWKSFRAPDFALIRRKLKAPVIFDGR
HHHHHHHHCCCCCCEEECCCCHHHCCCCEEEEEECHHHCCCCCHHHHHHHHCCCEEECCC
NLYDPRMVARYGLEYCSIGRTTGNAS
CCCCHHHHHHHCCHHHHCCCCCCCCC
>Mature Secondary Structure
MKVTVFGVGHVGLVQAAALAEVGNDVLCIDVDEKKVEQLQHGVIPIYEPGLERLVNENCA
CEEEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCEECHHHHHHHCCCCC
AGRLHFTTDAAAGINHGKVIIIAVGTPPEEDGSADLKHVLAVASTIGQNMAADKVIISKS
CCEEEEECCHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECC
TVPVGTCDRIRETISAALSDRGLERIAFHVVSNPEFLKEGSAVSDCMKPDRIIVGTNSPE
CCCCCCHHHHHHHHHHHHHHCCHHHHHEEECCCHHHHHCCCHHHHHCCCCEEEEECCCCH
AEAVMRELYAPFNRNHEKMILMDVRSAELTKYAANCMLATKISFMNEMANIAHRLGADIE
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
QVRLGIGSDPRIGYDFIYPGIGYGGSCFPKDVRALIRTAEQAELEPKILRAVSDRNERQK
HHHCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHH
WVLFERIRDYFGRDLSGRVIALWGLAYKPNTNDMREAPSRVLMEALWDAGAQVQAYDPHA
HHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEECCCHH
MGECRKIYGERQGLTFCETKEATLEGADALAIATEWKSFRAPDFALIRRKLKAPVIFDGR
HHHHHHHHCCCCCCEEECCCCHHHCCCCEEEEEECHHHCCCCCHHHHHHHHCCCEEECCC
NLYDPRMVARYGLEYCSIGRTTGNAS
CCCCHHHHHHHCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]