Click here to switch to the map view.

The map label for this gene is aqpZ [H]

Identifier: 110632827

GI number: 110632827

Start: 513956

End: 514660

Strand: Direct

Name: aqpZ [H]

Synonym: Meso_0466

Alternate gene names: 110632827

Gene position: 513956-514660 (Clockwise)

Preceding gene: 110632826

Following gene: 110632830

Centisome position: 11.65

GC content: 59.72

Gene sequence:

>705_bases
ATGAAAGCCTACATAGCGGAAGTATTTGGCACATTCTGCCTTGTATTTATCGGGTGCGGAAGTGTGGTGCTCGGCGGCTT
CGGGCCGCTGATTCCTACGGGGGGAGCGCTGGGCATCGCGGTTGCCTTTGGTGTGGCCGTCTTGGCAATGGCTTACGCGA
TTGGCCCGGTCTCGGGTGCGCATCTCAATCCCGCTGTAACGTTGGGTGCTTTTCTTGCCGGGCGATTGCCGGCGAAGGAC
GTCGCACCATACATGATTGCACAGGTCGCGGGCGGCATTCTCGGCGCTCTGGTGCTCTGGATCATTGCCTCGGGCAAAAC
GGGTGGCGCGCCCGCCAATCTCGCCGCGAATGGCTGGAGCGAATATACGACAAGTGCTGCTTTCCTTGGTGAAGTCGTGG
CCACCTTCATATTCGTGATGGTGATCCTGGGCGCGACCTCCGAGCGTCACACGACGGTAATGGCAGGCGCTGTTATCGGT
CTGACACTCACCGCGATCCATATCTGTTTCATCGCCGTCACCGGTACCTCGGTCAATCCGGCCCGATCGATCGGACCGGC
TCTGTTCTCGGGCGGCGCGGCGATCTCTAAGCTGTGGCTTTTTATCGTCGCTCCGCTGATCGGCGGTGCTCTGGCCGGGC
TCGTCTACAAGTCGCATGCGCTTGAAAATACGCAGGCGGACCTTTTGAAGAAGGCAAAGGCCTGA

Upstream 100 bases:

>100_bases
GAATTGCGGTGAGCCTCTCCGCCAAGAGCCCAAAAACTTGCTTTCAAAAATAAATTGTAGGATGATTCATCGCTTTTACA
ATTGTGGGGATGATTCGATT

Downstream 100 bases:

>100_bases
TCTAGCAAATATCCAGAAATAAAAACGCCCGGCTTGCCGGGCGTTTTTTGTCTTACCTTCCAGGGTTCTATTGTCTCATG
ACGCGCCCGGATAGTTCGGG

Product: MIP family channel protein

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKAYIAEVFGTFCLVFIGCGSVVLGGFGPLIPTGGALGIAVAFGVAVLAMAYAIGPVSGAHLNPAVTLGAFLAGRLPAKD
VAPYMIAQVAGGILGALVLWIIASGKTGGAPANLAANGWSEYTTSAAFLGEVVATFIFVMVILGATSERHTTVMAGAVIG
LTLTAIHICFIAVTGTSVNPARSIGPALFSGGAAISKLWLFIVAPLIGGALAGLVYKSHALENTQADLLKKAKA

Sequences:

>Translated_234_residues
MKAYIAEVFGTFCLVFIGCGSVVLGGFGPLIPTGGALGIAVAFGVAVLAMAYAIGPVSGAHLNPAVTLGAFLAGRLPAKD
VAPYMIAQVAGGILGALVLWIIASGKTGGAPANLAANGWSEYTTSAAFLGEVVATFIFVMVILGATSERHTTVMAGAVIG
LTLTAIHICFIAVTGTSVNPARSIGPALFSGGAAISKLWLFIVAPLIGGALAGLVYKSHALENTQADLLKKAKA
>Mature_234_residues
MKAYIAEVFGTFCLVFIGCGSVVLGGFGPLIPTGGALGIAVAFGVAVLAMAYAIGPVSGAHLNPAVTLGAFLAGRLPAKD
VAPYMIAQVAGGILGALVLWIIASGKTGGAPANLAANGWSEYTTSAAFLGEVVATFIFVMVILGATSERHTTVMAGAVIG
LTLTAIHICFIAVTGTSVNPARSIGPALFSGGAAISKLWLFIVAPLIGGALAGLVYKSHALENTQADLLKKAKA

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=242, Percent_Identity=35.1239669421488, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502183, Length=218, Percent_Identity=36.2385321100917, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI6912506, Length=219, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4502179, Length=219, Percent_Identity=33.7899543378995, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4755125, Length=220, Percent_Identity=31.3636363636364, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502181, Length=220, Percent_Identity=31.3636363636364, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI157266307, Length=249, Percent_Identity=31.3253012048193, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI86792455, Length=226, Percent_Identity=32.7433628318584, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI4826645, Length=244, Percent_Identity=31.1475409836066, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI45446752, Length=194, Percent_Identity=30.4123711340206, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22538420, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787101, Length=208, Percent_Identity=49.5192307692308, Blast_Score=164, Evalue=6e-42,
Organism=Escherichia coli, GI1790362, Length=257, Percent_Identity=28.0155642023346, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71993722, Length=238, Percent_Identity=28.9915966386555, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17558372, Length=220, Percent_Identity=32.2727272727273, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531429, Length=252, Percent_Identity=28.1746031746032, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=252, Percent_Identity=28.1746031746032, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992966, Length=244, Percent_Identity=29.0983606557377, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71994009, Length=243, Percent_Identity=27.9835390946502, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17533613, Length=254, Percent_Identity=27.5590551181102, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6321054, Length=207, Percent_Identity=28.9855072463768, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24652747, Length=219, Percent_Identity=35.1598173515982, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45551084, Length=219, Percent_Identity=35.1598173515982, Blast_Score=110, Evalue=6e-25,
Organism=Drosophila melanogaster, GI24762346, Length=237, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24762348, Length=237, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI20130305, Length=237, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24762344, Length=237, Percent_Identity=31.6455696202532, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24762342, Length=239, Percent_Identity=30.1255230125523, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550503, Length=236, Percent_Identity=26.6949152542373, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17136672, Length=238, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24652751, Length=220, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922038, Length=220, Percent_Identity=30, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23399; Mature: 23399

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAYIAEVFGTFCLVFIGCGSVVLGGFGPLIPTGGALGIAVAFGVAVLAMAYAIGPVSGA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
HLNPAVTLGAFLAGRLPAKDVAPYMIAQVAGGILGALVLWIIASGKTGGAPANLAANGWS
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EYTTSAAFLGEVVATFIFVMVILGATSERHTTVMAGAVIGLTLTAIHICFIAVTGTSVNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ARSIGPALFSGGAAISKLWLFIVAPLIGGALAGLVYKSHALENTQADLLKKAKA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MKAYIAEVFGTFCLVFIGCGSVVLGGFGPLIPTGGALGIAVAFGVAVLAMAYAIGPVSGA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
HLNPAVTLGAFLAGRLPAKDVAPYMIAQVAGGILGALVLWIIASGKTGGAPANLAANGWS
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
EYTTSAAFLGEVVATFIFVMVILGATSERHTTVMAGAVIGLTLTAIHICFIAVTGTSVNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ARSIGPALFSGGAAISKLWLFIVAPLIGGALAGLVYKSHALENTQADLLKKAKA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]