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The map label for this gene is mro [H]

Identifier: 110632812

GI number: 110632812

Start: 497665

End: 498675

Strand: Direct

Name: mro [H]

Synonym: Meso_0451

Alternate gene names: 110632812

Gene position: 497665-498675 (Clockwise)

Preceding gene: 110632811

Following gene: 110632815

Centisome position: 11.28

GC content: 60.34

Gene sequence:

>1011_bases
ATGGCGGGCGGGCCGAGGAAGATTGCCGTTTACGAAGGACGTGAAGTCTTCGAGGCGACGCTGACAAGCAGCACGGGCGT
GAAGGTGTCGGTCATCAGCTACGGCGCCGTCATCCGCGACTGGCAAGTGCCGGTTCCTGGCGGCATGCGCAGCGTGGTAT
TGGGTTTCGAACATTTCGAAGAATATACCAAATACAGCGGCTATTTCGGAGCAATCGCCGGTCGCGTCGCAAATCGCATC
TCCGGCGCGCGCTTCATGCTGAATGGCAAGGAATACCGGCTCCAGCCGAACGAAGGCGCCAACCATCTGCACGGCGGGAA
AAGGGGGCTGAGCCGTCAGGTCTGGGACATGGAGGTGCTTTCGGAAAATGCGGTTCGTCTTAGCCTGACCAGCCCTGACG
GAGAGATGGGCTATCCGGGACGGCTGGATGTCTCGGTTACTTACCGGCTTGAAGGGAATGCCCTTGAGCTCGACTGCACG
GCAACCACCGATGCACCCACGCCGGTCAATATCGTGCAGCATAACTACTTCAATCTGATGGGCGAGGGCGATATCCGAAA
CCACGTGCTTTGGCTCGCGGCCAATGCCTATACGGTGCGGGATTTCGACCTCATCCCGACAGGTGGAATCGAGCCGGTGG
CCGGCACGCATTTCGATTTCCGCAAACCGCGCCCTCTTTGTGACGCCCAGGGCGAGCCGATCGCCTATGACAACAACCTG
GTTCTTGATACCGGCCGCGATCCCTCCTCGCCCGTGGCTATTCTCAAGGCGCCGGACGGCTCCCTTACGCTCGCGCTCAA
GACGGATCAGCCAGGACTGCAGCTCTATACGGGCAGCAAGATCAACCTTCCTGTCCCCGGCCTGGGCGGGCGGCACTATC
CCCGCTTCGCCGGGCTATGCCTTGAAGACCAGAACTTCCCCGATGCAATCAATCACCCGCATTTCCCCAACTGCGTCGTG
ACCCCGGAGCGGCCATATAGGCACTGGTGCGAGATAGAGATCGGGCAGTAG

Upstream 100 bases:

>100_bases
CAAATGCCATGCACGACGGCTTTGCAGCTTTGCATTTTTAGGAATTGACGATAGGTGCCTTCTTGCCGAAGGCTCTGAAG
CGTGAAACAGGAGGAGACGT

Downstream 100 bases:

>100_bases
CCGCTCACCCCTTCGCGAACACCACCGTCTTCAGACCGTTGAGCACTACCCTGCTTTCGAGGTGAAGCTTGACCGCCCTC
GCCAGGACACGGCTCTCGAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAGGPRKIAVYEGREVFEATLTSSTGVKVSVISYGAVIRDWQVPVPGGMRSVVLGFEHFEEYTKYSGYFGAIAGRVANRI
SGARFMLNGKEYRLQPNEGANHLHGGKRGLSRQVWDMEVLSENAVRLSLTSPDGEMGYPGRLDVSVTYRLEGNALELDCT
ATTDAPTPVNIVQHNYFNLMGEGDIRNHVLWLAANAYTVRDFDLIPTGGIEPVAGTHFDFRKPRPLCDAQGEPIAYDNNL
VLDTGRDPSSPVAILKAPDGSLTLALKTDQPGLQLYTGSKINLPVPGLGGRHYPRFAGLCLEDQNFPDAINHPHFPNCVV
TPERPYRHWCEIEIGQ

Sequences:

>Translated_336_residues
MAGGPRKIAVYEGREVFEATLTSSTGVKVSVISYGAVIRDWQVPVPGGMRSVVLGFEHFEEYTKYSGYFGAIAGRVANRI
SGARFMLNGKEYRLQPNEGANHLHGGKRGLSRQVWDMEVLSENAVRLSLTSPDGEMGYPGRLDVSVTYRLEGNALELDCT
ATTDAPTPVNIVQHNYFNLMGEGDIRNHVLWLAANAYTVRDFDLIPTGGIEPVAGTHFDFRKPRPLCDAQGEPIAYDNNL
VLDTGRDPSSPVAILKAPDGSLTLALKTDQPGLQLYTGSKINLPVPGLGGRHYPRFAGLCLEDQNFPDAINHPHFPNCVV
TPERPYRHWCEIEIGQ
>Mature_335_residues
AGGPRKIAVYEGREVFEATLTSSTGVKVSVISYGAVIRDWQVPVPGGMRSVVLGFEHFEEYTKYSGYFGAIAGRVANRIS
GARFMLNGKEYRLQPNEGANHLHGGKRGLSRQVWDMEVLSENAVRLSLTSPDGEMGYPGRLDVSVTYRLEGNALELDCTA
TTDAPTPVNIVQHNYFNLMGEGDIRNHVLWLAANAYTVRDFDLIPTGGIEPVAGTHFDFRKPRPLCDAQGEPIAYDNNLV
LDTGRDPSSPVAILKAPDGSLTLALKTDQPGLQLYTGSKINLPVPGLGGRHYPRFAGLCLEDQNFPDAINHPHFPNCVVT
PERPYRHWCEIEIGQ

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=315, Percent_Identity=41.2698412698413, Blast_Score=224, Evalue=9e-59,
Organism=Escherichia coli, GI1786971, Length=326, Percent_Identity=34.6625766871166, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17557428, Length=318, Percent_Identity=31.1320754716981, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI115533334, Length=318, Percent_Identity=31.1320754716981, Blast_Score=157, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6319493, Length=331, Percent_Identity=28.7009063444109, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324399, Length=329, Percent_Identity=26.7477203647416, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=329, Percent_Identity=26.4437689969605, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24659048, Length=334, Percent_Identity=35.0299401197605, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24668278, Length=333, Percent_Identity=34.5345345345345, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24668282, Length=335, Percent_Identity=33.4328358208955, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583720, Length=342, Percent_Identity=34.5029239766082, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641876, Length=331, Percent_Identity=30.8157099697885, Blast_Score=141, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 36895; Mature: 36764

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGGPRKIAVYEGREVFEATLTSSTGVKVSVISYGAVIRDWQVPVPGGMRSVVLGFEHFE
CCCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEECCCCCCCCHHHHHCCHHHHH
EYTKYSGYFGAIAGRVANRISGARFMLNGKEYRLQPNEGANHLHGGKRGLSRQVWDMEVL
HHHHCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCHHCCCCHHHHHHHH
SENAVRLSLTSPDGEMGYPGRLDVSVTYRLEGNALELDCTATTDAPTPVNIVQHNYFNLM
CCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCEEEEEECEEEEE
GEGDIRNHVLWLAANAYTVRDFDLIPTGGIEPVAGTHFDFRKPRPLCDAQGEPIAYDNNL
ECCCCCCEEEEEEECEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCE
VLDTGRDPSSPVAILKAPDGSLTLALKTDQPGLQLYTGSKINLPVPGLGGRHYPRFAGLC
EEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEECCEEECCCCCCCCCCCCHHEEEE
LEDQNFPDAINHPHFPNCVVTPERPYRHWCEIEIGQ
EECCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECC
>Mature Secondary Structure 
AGGPRKIAVYEGREVFEATLTSSTGVKVSVISYGAVIRDWQVPVPGGMRSVVLGFEHFE
CCCCEEEEEECCCEEEEEEECCCCCCEEEEEECCEEEEECCCCCCCCHHHHHCCHHHHH
EYTKYSGYFGAIAGRVANRISGARFMLNGKEYRLQPNEGANHLHGGKRGLSRQVWDMEVL
HHHHCCCHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCCCCCCCHHCCCCHHHHHHHH
SENAVRLSLTSPDGEMGYPGRLDVSVTYRLEGNALELDCTATTDAPTPVNIVQHNYFNLM
CCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCEEEEEECEEEEE
GEGDIRNHVLWLAANAYTVRDFDLIPTGGIEPVAGTHFDFRKPRPLCDAQGEPIAYDNNL
ECCCCCCEEEEEEECEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCE
VLDTGRDPSSPVAILKAPDGSLTLALKTDQPGLQLYTGSKINLPVPGLGGRHYPRFAGLC
EEECCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEECCEEECCCCCCCCCCCCHHEEEE
LEDQNFPDAINHPHFPNCVVTPERPYRHWCEIEIGQ
EECCCCCCCCCCCCCCCEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]