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The map label for this gene is fmt

Identifier: 110632754

GI number: 110632754

Start: 432053

End: 432988

Strand: Reverse

Name: fmt

Synonym: Meso_0393

Alternate gene names: 110632754

Gene position: 432988-432053 (Counterclockwise)

Preceding gene: 110632755

Following gene: 110632753

Centisome position: 9.81

GC content: 65.49

Gene sequence:

>936_bases
ATGACCTTACGCCTCGTCTTTATGGGAACGCCGGAATTTTCCGTGCCCACACTGCGTGCATTGGCGGGCGCTGGACACGA
GATCACGGCCATTTACACCCAGCCGCCACGCCCCGCCGGCCGGCGCGGGCTGGAGCTGACCAGATCTCCAGTGCATCAGG
CCGCCGAAGAGCTGGATCTTTACGTACGCACGCCGCAATCCCTCAAAAGCGAGGAGGAACAGCAGGTTTTCCGGGAGCTT
GAGGCCGATGCCGCGGTCGTGGTCGCCTATGGGCTGCTTCTACCCAGAGCGATCCTTGAGGGCACGCGCCTCGGCGCCTT
CAACGGCCATGCCTCGCTCCTGCCGCGCTGGCGGGGCGCGGCACCCATCCAGCGTGCCATCATGGCCGGCGACCGGGAGA
CCGGGATGATGGTGATGAAGATGGACGAGGGGCTGGACACCGGCCCCATCGCGATGACGGAGAAGATTGCCATCGGGCCG
GATATGACCGCTGGCGAATTGCACGATGTCATGAAATTAGCCGGCGCGGGCCTCATGGTGGCTGCCATAGCGGCGCTAGA
GCAGGGCGAACTTGCGCTTACGCCGCAGCCCGCGACAGGGGTCACCTACGCGAAAAAGATCATCAAGGAGGAGACGCGCG
TCGACTGGTCGCGGCCGGCAGAGGAGGTGCATAATCACATCCGCGGGCTATCGCCATTGCCCGGCGCCTGGTGCGAGATG
CCGGCGGGCGACAAGGCGGAACGCGTAAAGCTTCTGCGCTCAACGCTCTCTGAGGGGAGCGGCGCGCCGGGCGAAGTTAT
CGACGAGGGGCTTGCCATAGCCTGCGGCCAAGGCGCGGTGCGGCTCTTGGAGCTCCAGAGGGCCGGCGGCAAGCCGGTGT
CAGCGGCGGATTTCCAGCGCGGCTCCAAGCTTGGCAGAGGAACGAGGCTCACATGA

Upstream 100 bases:

>100_bases
GCGCGACATGGTGGTGCGCAAATTCAGGAAGCTTGCCAAGGACCGTCCCCCGCCTGCGCGAATGGTGGGCTGAGCACGTC
ACCGCCGCCGGGGAGGCGCC

Downstream 100 bases:

>100_bases
GCGCAGTGATTATCCGTCCGGAAGAAGTCGGAGACGAGACCGCGATCCGTCTCCTCCTCGTCAACGCCTTTGGCGGCGAG
GCTGAAGCAAGGCTTGTGGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTLRLVFMGTPEFSVPTLRALAGAGHEITAIYTQPPRPAGRRGLELTRSPVHQAAEELDLYVRTPQSLKSEEEQQVFREL
EADAAVVVAYGLLLPRAILEGTRLGAFNGHASLLPRWRGAAPIQRAIMAGDRETGMMVMKMDEGLDTGPIAMTEKIAIGP
DMTAGELHDVMKLAGAGLMVAAIAALEQGELALTPQPATGVTYAKKIIKEETRVDWSRPAEEVHNHIRGLSPLPGAWCEM
PAGDKAERVKLLRSTLSEGSGAPGEVIDEGLAIACGQGAVRLLELQRAGGKPVSAADFQRGSKLGRGTRLT

Sequences:

>Translated_311_residues
MTLRLVFMGTPEFSVPTLRALAGAGHEITAIYTQPPRPAGRRGLELTRSPVHQAAEELDLYVRTPQSLKSEEEQQVFREL
EADAAVVVAYGLLLPRAILEGTRLGAFNGHASLLPRWRGAAPIQRAIMAGDRETGMMVMKMDEGLDTGPIAMTEKIAIGP
DMTAGELHDVMKLAGAGLMVAAIAALEQGELALTPQPATGVTYAKKIIKEETRVDWSRPAEEVHNHIRGLSPLPGAWCEM
PAGDKAERVKLLRSTLSEGSGAPGEVIDEGLAIACGQGAVRLLELQRAGGKPVSAADFQRGSKLGRGTRLT
>Mature_310_residues
TLRLVFMGTPEFSVPTLRALAGAGHEITAIYTQPPRPAGRRGLELTRSPVHQAAEELDLYVRTPQSLKSEEEQQVFRELE
ADAAVVVAYGLLLPRAILEGTRLGAFNGHASLLPRWRGAAPIQRAIMAGDRETGMMVMKMDEGLDTGPIAMTEKIAIGPD
MTAGELHDVMKLAGAGLMVAAIAALEQGELALTPQPATGVTYAKKIIKEETRVDWSRPAEEVHNHIRGLSPLPGAWCEMP
AGDKAERVKLLRSTLSEGSGAPGEVIDEGLAIACGQGAVRLLELQRAGGKPVSAADFQRGSKLGRGTRLT

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=310, Percent_Identity=28.3870967741935, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI21614513, Length=319, Percent_Identity=27.8996865203762, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI164663775, Length=328, Percent_Identity=28.9634146341463, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789683, Length=302, Percent_Identity=44.0397350993377, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1788589, Length=296, Percent_Identity=29.3918918918919, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI133930964, Length=326, Percent_Identity=25.1533742331288, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6319458, Length=301, Percent_Identity=28.5714285714286, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45550868, Length=315, Percent_Identity=31.7460317460317, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571984, Length=231, Percent_Identity=35.9307359307359, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24585660, Length=318, Percent_Identity=25.1572327044025, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_MESSB (Q11LC8)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672962.1
- ProteinModelPortal:   Q11LC8
- SMR:   Q11LC8
- STRING:   Q11LC8
- GeneID:   4182225
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0393
- NMPDR:   fig|266779.1.peg.4191
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   QIRACTP
- PhylomeDB:   Q11LC8
- ProtClustDB:   PRK00005
- BioCyc:   MSP266779:MESO_0393-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33209; Mature: 33078

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRLVFMGTPEFSVPTLRALAGAGHEITAIYTQPPRPAGRRGLELTRSPVHQAAEELDL
CEEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHE
YVRTPQSLKSEEEQQVFRELEADAAVVVAYGLLLPRAILEGTRLGAFNGHASLLPRWRGA
EEECCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
APIQRAIMAGDRETGMMVMKMDEGLDTGPIAMTEKIAIGPDMTAGELHDVMKLAGAGLMV
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECEEECCCCCCHHHHHHHHHHHCCHHHH
AAIAALEQGELALTPQPATGVTYAKKIIKEETRVDWSRPAEEVHNHIRGLSPLPGAWCEM
HHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHCC
PAGDKAERVKLLRSTLSEGSGAPGEVIDEGLAIACGQGAVRLLELQRAGGKPVSAADFQR
CCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHH
GSKLGRGTRLT
HHHCCCCCCCC
>Mature Secondary Structure 
TLRLVFMGTPEFSVPTLRALAGAGHEITAIYTQPPRPAGRRGLELTRSPVHQAAEELDL
EEEEEEECCCCCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHE
YVRTPQSLKSEEEQQVFRELEADAAVVVAYGLLLPRAILEGTRLGAFNGHASLLPRWRGA
EEECCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCC
APIQRAIMAGDRETGMMVMKMDEGLDTGPIAMTEKIAIGPDMTAGELHDVMKLAGAGLMV
HHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEECEEECCCCCCHHHHHHHHHHHCCHHHH
AAIAALEQGELALTPQPATGVTYAKKIIKEETRVDWSRPAEEVHNHIRGLSPLPGAWCEM
HHHHHHCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHCC
PAGDKAERVKLLRSTLSEGSGAPGEVIDEGLAIACGQGAVRLLELQRAGGKPVSAADFQR
CCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEECCCHHHHHHHHHCCCCCCCHHHHHH
GSKLGRGTRLT
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA