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The map label for this gene is def

Identifier: 110632755

GI number: 110632755

Start: 433016

End: 433549

Strand: Reverse

Name: def

Synonym: Meso_0394

Alternate gene names: 110632755

Gene position: 433549-433016 (Counterclockwise)

Preceding gene: 110632756

Following gene: 110632754

Centisome position: 9.83

GC content: 58.99

Gene sequence:

>534_bases
ATGGCTATTCGACCGCTCGTCACTCTTCCCGATCCGCTTCTGCGCCAGGTTTCAAAACCCGTCGAGCGCGTGGACGAAAG
CTTGCGTAAATTCGCCGGCGACATGCTCGAGACCATGTATGACGCGCCGGGGATCGGGCTTGCCGCCATCCAGGTGGGAG
AGCCTTTGCGCATGCTGGTGCTGGACGTGGCGGAGAAGGACGAGCCCAAAAATCCACAGGTTTTCATCAATCCGGAGATC
GTATCGCGCTCCGATGTGCCGAGCTTCCACGAGGAAGGCTGCCTTTCCATTCCCGACTATTACGCGGAGGTGGAGCGTCC
GGCCGAGGTGACGGTGAAATACGTAGACCTCGACGGCAAGGAGCAGATCGTGGAAGCCAAAGGCATCCTCGCAACTTGCC
TACAGCACGAGATCGACCACCTTAACGGCGTGCTCTTCATTGACTATCTGTCGAAGCTCAAGCGCGACATGGTGGTGCGC
AAATTCAGGAAGCTTGCCAAGGACCGTCCCCCGCCTGCGCGAATGGTGGGCTGA

Upstream 100 bases:

>100_bases
ATCTGTGTATGCCAAAGGCTGCCGCCGAAAGGGCGATCAGCCGTCATGGCCGCTGCCGTTCCATATTGACGCTCTCACGC
CAAGCCATTACCTGACAGCC

Downstream 100 bases:

>100_bases
GCACGTCACCGCCGCCGGGGAGGCGCCATGACCTTACGCCTCGTCTTTATGGGAACGCCGGAATTTTCCGTGCCCACACT
GCGTGCATTGGCGGGCGCTG

Product: peptide deformylase

Products: NA

Alternate protein names: PDF; Polypeptide deformylase

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MAIRPLVTLPDPLLRQVSKPVERVDESLRKFAGDMLETMYDAPGIGLAAIQVGEPLRMLVLDVAEKDEPKNPQVFINPEI
VSRSDVPSFHEEGCLSIPDYYAEVERPAEVTVKYVDLDGKEQIVEAKGILATCLQHEIDHLNGVLFIDYLSKLKRDMVVR
KFRKLAKDRPPPARMVG

Sequences:

>Translated_177_residues
MAIRPLVTLPDPLLRQVSKPVERVDESLRKFAGDMLETMYDAPGIGLAAIQVGEPLRMLVLDVAEKDEPKNPQVFINPEI
VSRSDVPSFHEEGCLSIPDYYAEVERPAEVTVKYVDLDGKEQIVEAKGILATCLQHEIDHLNGVLFIDYLSKLKRDMVVR
KFRKLAKDRPPPARMVG
>Mature_176_residues
AIRPLVTLPDPLLRQVSKPVERVDESLRKFAGDMLETMYDAPGIGLAAIQVGEPLRMLVLDVAEKDEPKNPQVFINPEIV
SRSDVPSFHEEGCLSIPDYYAEVERPAEVTVKYVDLDGKEQIVEAKGILATCLQHEIDHLNGVLFIDYLSKLKRDMVVRK
FRKLAKDRPPPARMVG

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family

Homologues:

Organism=Homo sapiens, GI11641243, Length=158, Percent_Identity=33.5443037974684, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1789682, Length=165, Percent_Identity=46.0606060606061, Blast_Score=138, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24645728, Length=164, Percent_Identity=34.1463414634146, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24645726, Length=164, Percent_Identity=26.8292682926829, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DEF_MESSB (Q11LC7)

Other databases:

- EMBL:   CP000390
- RefSeq:   YP_672963.1
- ProteinModelPortal:   Q11LC7
- SMR:   Q11LC7
- STRING:   Q11LC7
- GeneID:   4182226
- GenomeReviews:   CP000390_GR
- KEGG:   mes:Meso_0394
- NMPDR:   fig|266779.1.peg.4192
- eggNOG:   COG0242
- HOGENOM:   HBG665227
- OMA:   AADMAET
- PhylomeDB:   Q11LC7
- ProtClustDB:   PRK00150
- BioCyc:   MSP266779:MESO_0394-MONOMER
- GO:   GO:0006412
- HAMAP:   MF_00163
- InterPro:   IPR000181
- Gene3D:   G3DSA:3.90.45.10
- PANTHER:   PTHR10458
- PIRSF:   PIRSF004749
- PRINTS:   PR01576
- TIGRFAMs:   TIGR00079

Pfam domain/function: PF01327 Pep_deformylase; SSF56420 Fmet_deformylase

EC number: =3.5.1.88

Molecular weight: Translated: 19920; Mature: 19789

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 137-137

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRPLVTLPDPLLRQVSKPVERVDESLRKFAGDMLETMYDAPGIGLAAIQVGEPLRMLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
LDVAEKDEPKNPQVFINPEIVSRSDVPSFHEEGCLSIPDYYAEVERPAEVTVKYVDLDGK
HHHHHCCCCCCCEEEECCCHHCCCCCCCHHHCCCCCCCHHHHHHCCCCCEEEEEECCCCH
EQIVEAKGILATCLQHEIDHLNGVLFIDYLSKLKRDMVVRKFRKLAKDRPPPARMVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AIRPLVTLPDPLLRQVSKPVERVDESLRKFAGDMLETMYDAPGIGLAAIQVGEPLRMLV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHH
LDVAEKDEPKNPQVFINPEIVSRSDVPSFHEEGCLSIPDYYAEVERPAEVTVKYVDLDGK
HHHHHCCCCCCCEEEECCCHHCCCCCCCHHHCCCCCCCHHHHHHCCCCCEEEEEECCCCH
EQIVEAKGILATCLQHEIDHLNGVLFIDYLSKLKRDMVVRKFRKLAKDRPPPARMVG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA