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The map label for this gene is fumC [H]

Identifier: 110632716

GI number: 110632716

Start: 397121

End: 398512

Strand: Reverse

Name: fumC [H]

Synonym: Meso_0355

Alternate gene names: 110632716

Gene position: 398512-397121 (Counterclockwise)

Preceding gene: 110632717

Following gene: 110632715

Centisome position: 9.03

GC content: 61.49

Gene sequence:

>1392_bases
ATGACGAAGACCCGCACCGAAACCGATACTTTTGGCCCGATCGACGTCGCCGCCGATCGTTACTGGGGCGCGCAGACCCA
GCGCTCTTTGACCAATTTCCGCATCGGCGTGGAAAAGATGCCTGTTCCACTGGTGCGCGCCTTTGGCATCGTCAAGCTTG
CCGCCGCGGAGGTGAATACGAACCTTGGAAAGCTTGATCCCAAGCTTGGCGAAGCGATCGTTGCGGCGGCACGCGAGGTG
GTGGACGGGAAACTGGACGCGCACTTCCCGCTCGCCGTCTGGCAGACCGGTTCCGGCACACAGTCGAACATGAACGCCAA
TGAGGTGATCTCCAATCGGGCAATCGAAATGCTCGGCGGTGAGATGGGTTCAAAAAAGCCCATCCATCCAAACGATCACG
TCAATATGAGCCAGTCGTCGAATGACAGCTTCCCCACCGCCATGCACATCGCGGCCGCCCGCGAGGCGGCGGAAGAGCTG
TTGCCGGCGCTGGACCACCTGACCGCCACGCTGGAGGAAAAGGAACGGGCTTTCGGCGATATCGTCAAGATCGGCCGCAC
CCATACGCAGGACGCGACGCCTCTCACACTCGGCCAGGAATTTTCCGGCTATGTGGCAGCGCTGAGGCTCGGGCGAAAGC
GTATCGAGGATGCGCTGCATGACGTGCATGCGCTGGCCCAGGGAGGCACTGCCGTTGGCACTGGCTTGAATGCGCCCAAG
GGTTTCGACAGGGCCTTTGCGGATCGCGTCGCAGCCATCACCGGCCTGCCCTTCCGCACTGCTGAAAACAAATTCGAGGC
CTTGGCGAGCCACGGAGCGCTGAACGCCCTGCACGGCACGCTCAACGCGCTTGCCGGCGATCTCTTCAAGATCGCGAATG
ATATCCGCTTCCTGGGTTCCGGTCCGCGCTCCGGGCTGGGCGAACTCAAGCTTCCCGAAAACGAACCCGGATCCTCGATC
ATGCCCGGCAAGGTGAACCCGACCCAGGCGGAAGCTCTTACCATGGTGGCCACGCAGATCATGGGCAATCAGACCACGGT
CTCGATCGCCGCCAGTCAGGGGCATTTCGAGCTCAATGTCTTCAAGCCTGTAATCGCAAACGCCGTGCTGCAGTCAATTC
GCCTGCTTTCCGACGCGATGCGCTCCTTCGCCGACAATTGCGTCAAGGGCATAGAGGCGGACGAAGTGCGCATTGCGGAG
TTGATGCAGCGCTCGCTCATGCTGGTGACGGCCCTGGCGCCCGTGATCGGCTACGACAACGCGGCCAAGATCGCCAAGAC
GGCACACAAGAACGGAACGACGCTGCGCGAGGAAGCGCTGAGGACCGGCCTTGTGACGGAAGAGGAATACGACCGCATCG
TGCGGCCGGAAAACATGATCTCACCGGGATAG

Upstream 100 bases:

>100_bases
GATTTTAATCGATCCAACAGGCTGGAGAAGTCGCCGCGGGGTTTGCAAAAGAAGTGCCTTTGGCGCATATGGCCCCAGGA
CTGATGGGAGCAACATTTCA

Downstream 100 bases:

>100_bases
CCCGCCACGCAAAGCATCTCTCTGGAAACACAGTGTCAACGGCCAGGCGGTAGTCCCGGCCGCGTGTTGACCTTATCTAG
CCGGTTCGCTTTCTCGCTAA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTKTRTETDTFGPIDVAADRYWGAQTQRSLTNFRIGVEKMPVPLVRAFGIVKLAAAEVNTNLGKLDPKLGEAIVAAAREV
VDGKLDAHFPLAVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAMHIAAAREAAEEL
LPALDHLTATLEEKERAFGDIVKIGRTHTQDATPLTLGQEFSGYVAALRLGRKRIEDALHDVHALAQGGTAVGTGLNAPK
GFDRAFADRVAAITGLPFRTAENKFEALASHGALNALHGTLNALAGDLFKIANDIRFLGSGPRSGLGELKLPENEPGSSI
MPGKVNPTQAEALTMVATQIMGNQTTVSIAASQGHFELNVFKPVIANAVLQSIRLLSDAMRSFADNCVKGIEADEVRIAE
LMQRSLMLVTALAPVIGYDNAAKIAKTAHKNGTTLREEALRTGLVTEEEYDRIVRPENMISPG

Sequences:

>Translated_463_residues
MTKTRTETDTFGPIDVAADRYWGAQTQRSLTNFRIGVEKMPVPLVRAFGIVKLAAAEVNTNLGKLDPKLGEAIVAAAREV
VDGKLDAHFPLAVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAMHIAAAREAAEEL
LPALDHLTATLEEKERAFGDIVKIGRTHTQDATPLTLGQEFSGYVAALRLGRKRIEDALHDVHALAQGGTAVGTGLNAPK
GFDRAFADRVAAITGLPFRTAENKFEALASHGALNALHGTLNALAGDLFKIANDIRFLGSGPRSGLGELKLPENEPGSSI
MPGKVNPTQAEALTMVATQIMGNQTTVSIAASQGHFELNVFKPVIANAVLQSIRLLSDAMRSFADNCVKGIEADEVRIAE
LMQRSLMLVTALAPVIGYDNAAKIAKTAHKNGTTLREEALRTGLVTEEEYDRIVRPENMISPG
>Mature_462_residues
TKTRTETDTFGPIDVAADRYWGAQTQRSLTNFRIGVEKMPVPLVRAFGIVKLAAAEVNTNLGKLDPKLGEAIVAAAREVV
DGKLDAHFPLAVWQTGSGTQSNMNANEVISNRAIEMLGGEMGSKKPIHPNDHVNMSQSSNDSFPTAMHIAAAREAAEELL
PALDHLTATLEEKERAFGDIVKIGRTHTQDATPLTLGQEFSGYVAALRLGRKRIEDALHDVHALAQGGTAVGTGLNAPKG
FDRAFADRVAAITGLPFRTAENKFEALASHGALNALHGTLNALAGDLFKIANDIRFLGSGPRSGLGELKLPENEPGSSIM
PGKVNPTQAEALTMVATQIMGNQTTVSIAASQGHFELNVFKPVIANAVLQSIRLLSDAMRSFADNCVKGIEADEVRIAEL
MQRSLMLVTALAPVIGYDNAAKIAKTAHKNGTTLREEALRTGLVTEEEYDRIVRPENMISPG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=65.2173913043478, Blast_Score=597, Evalue=1e-171,
Organism=Homo sapiens, GI266458395, Length=59, Percent_Identity=52.5423728813559, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=58.9130434782609, Blast_Score=533, Evalue=1e-152,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=40.3470715835141, Blast_Score=336, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=66.8103448275862, Blast_Score=627, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=65.4434250764526, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324993, Length=460, Percent_Identity=63.4782608695652, Blast_Score=590, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=63.9913232104121, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=63.9913232104121, Blast_Score=595, Evalue=1e-170,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=60.8225108225108, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24662684, Length=464, Percent_Identity=60.1293103448276, Blast_Score=566, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583245, Length=463, Percent_Identity=51.8358531317495, Blast_Score=487, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49539; Mature: 49408

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTRTETDTFGPIDVAADRYWGAQTQRSLTNFRIGVEKMPVPLVRAFGIVKLAAAEVNT
CCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCC
NLGKLDPKLGEAIVAAAREVVDGKLDAHFPLAVWQTGSGTQSNMNANEVISNRAIEMLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPIHPNDHVNMSQSSNDSFPTAMHIAAAREAAEELLPALDHLTATLEEKERAFGD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHTQDATPLTLGQEFSGYVAALRLGRKRIEDALHDVHALAQGGTAVGTGLNAPK
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFDRAFADRVAAITGLPFRTAENKFEALASHGALNALHGTLNALAGDLFKIANDIRFLGS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELKLPENEPGSSIMPGKVNPTQAEALTMVATQIMGNQTTVSIAASQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEH
FKPVIANAVLQSIRLLSDAMRSFADNCVKGIEADEVRIAELMQRSLMLVTALAPVIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AAKIAKTAHKNGTTLREEALRTGLVTEEEYDRIVRPENMISPG
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TKTRTETDTFGPIDVAADRYWGAQTQRSLTNFRIGVEKMPVPLVRAFGIVKLAAAEVNT
CCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHCC
NLGKLDPKLGEAIVAAAREVVDGKLDAHFPLAVWQTGSGTQSNMNANEVISNRAIEMLGG
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCC
EMGSKKPIHPNDHVNMSQSSNDSFPTAMHIAAAREAAEELLPALDHLTATLEEKERAFGD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVKIGRTHTQDATPLTLGQEFSGYVAALRLGRKRIEDALHDVHALAQGGTAVGTGLNAPK
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GFDRAFADRVAAITGLPFRTAENKFEALASHGALNALHGTLNALAGDLFKIANDIRFLGS
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRSGLGELKLPENEPGSSIMPGKVNPTQAEALTMVATQIMGNQTTVSIAASQGHFELNV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEH
FKPVIANAVLQSIRLLSDAMRSFADNCVKGIEADEVRIAELMQRSLMLVTALAPVIGYDN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
AAKIAKTAHKNGTTLREEALRTGLVTEEEYDRIVRPENMISPG
HHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]