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The map label for this gene is pgl [H]

Identifier: 110632520

GI number: 110632520

Start: 193331

End: 194059

Strand: Reverse

Name: pgl [H]

Synonym: Meso_0158

Alternate gene names: 110632520

Gene position: 194059-193331 (Counterclockwise)

Preceding gene: 110632521

Following gene: 110632519

Centisome position: 4.4

GC content: 64.06

Gene sequence:

>729_bases
ATGGCCAAGGCAGTCTGGCATGAATTCGCCGCGAGCGAGGCTCTCGCGGAAGCCCTCGCCGAAGCGGTGGCGCAGCACCT
TGCGGCGGCTCTGGAAAAGCGCGGCATGGCGAGCATCGCCGTTTCCGGCGGCAGCACTCCAGCTCCATTCTTCCGCGCTC
TGTCGCGAAAGAAGATCGATTGGGCCCGCATTATCGTCACGCTTGTAGACGAGCGCTTCGTTCCTCCCTCTTCCGAGCGG
TCGAATGCTGCTCTGGCTTCGCGTTATTTGCTGCAGAACGATGCGGCGCGAGCGAGCTTCGTACCGCTTTACCAGCCGGT
CGAAACGGTCGAGGAGGCTGCCGAGAAGGCAGACGAGGAAATCGGCAGGCTCCCGCTGCCTCTCGATGTCGTCGTGCTCG
GCATGGGGCTCGACGGGCACACGGCATCTTTCTTTCCGGATGCGGAAGATATCGCGCTCAAGCTGCAGGTGGAAAATCGC
CGCGTGCTGCCCATTCACGCAAGGAGCGCCGGAGAACCGCGCCTGACGCTATCCATGCCCCTTCTTTGCCAGGCACGGCT
CATGGTGCTCCATATCGAAGGGCAGGAGAAGCGCCGGCTGCTCGAAGCCGCACTTGCCGAAGAGACCGGTGCGAAGCTGC
CCGTGCGGATCGCCGTGGAACAAGCCGCGGCCCCAGTCGCTATCTATTGGGCACCGGGAGCGGCAAGCGCCTCGGGCAAG
CGCCCCTGA

Upstream 100 bases:

>100_bases
GTAGCCAGTCGGTGCAGCCCTATACCGCAGGCACTTGGGGCCCCTCAGCGTCGATCGCCCTCATCGAACGTGACGGTCGC
ACCTGGCATGAGAGCTTCTG

Downstream 100 bases:

>100_bases
CATCTTGAATATTATCGAGACCGAAGCCACTCGGACTCGACCATGACAGGATATGAAGCCATGACCGCAAGGCGAGAAAT
CGAAGCCGTCACAGCCCGCA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAKAVWHEFAASEALAEALAEAVAQHLAAALEKRGMASIAVSGGSTPAPFFRALSRKKIDWARIIVTLVDERFVPPSSER
SNAALASRYLLQNDAARASFVPLYQPVETVEEAAEKADEEIGRLPLPLDVVVLGMGLDGHTASFFPDAEDIALKLQVENR
RVLPIHARSAGEPRLTLSMPLLCQARLMVLHIEGQEKRRLLEAALAEETGAKLPVRIAVEQAAAPVAIYWAPGAASASGK
RP

Sequences:

>Translated_242_residues
MAKAVWHEFAASEALAEALAEAVAQHLAAALEKRGMASIAVSGGSTPAPFFRALSRKKIDWARIIVTLVDERFVPPSSER
SNAALASRYLLQNDAARASFVPLYQPVETVEEAAEKADEEIGRLPLPLDVVVLGMGLDGHTASFFPDAEDIALKLQVENR
RVLPIHARSAGEPRLTLSMPLLCQARLMVLHIEGQEKRRLLEAALAEETGAKLPVRIAVEQAAAPVAIYWAPGAASASGK
RP
>Mature_241_residues
AKAVWHEFAASEALAEALAEAVAQHLAAALEKRGMASIAVSGGSTPAPFFRALSRKKIDWARIIVTLVDERFVPPSSERS
NAALASRYLLQNDAARASFVPLYQPVETVEEAAEKADEEIGRLPLPLDVVVLGMGLDGHTASFFPDAEDIALKLQVENRR
VLPIHARSAGEPRLTLSMPLLCQARLMVLHIEGQEKRRLLEAALAEETGAKLPVRIAVEQAAAPVAIYWAPGAASASGKR
P

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=205, Percent_Identity=32.6829268292683, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI6912586, Length=219, Percent_Identity=31.9634703196347, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI115533060, Length=192, Percent_Identity=31.7708333333333, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115533058, Length=192, Percent_Identity=31.7708333333333, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321957, Length=204, Percent_Identity=27.9411764705882, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6324362, Length=210, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6319918, Length=213, Percent_Identity=30.9859154929577, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321687, Length=237, Percent_Identity=23.2067510548523, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641119, Length=206, Percent_Identity=29.126213592233, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900 [H]

Pfam domain/function: NA

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26012; Mature: 25881

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKAVWHEFAASEALAEALAEAVAQHLAAALEKRGMASIAVSGGSTPAPFFRALSRKKID
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCH
WARIIVTLVDERFVPPSSERSNAALASRYLLQNDAARASFVPLYQPVETVEEAAEKADEE
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGRLPLPLDVVVLGMGLDGHTASFFPDAEDIALKLQVENRRVLPIHARSAGEPRLTLSMP
HCCCCCCHHHEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEEEECC
LLCQARLMVLHIEGQEKRRLLEAALAEETGAKLPVRIAVEQAAAPVAIYWAPGAASASGK
HHHCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC
RP
CC
>Mature Secondary Structure 
AKAVWHEFAASEALAEALAEAVAQHLAAALEKRGMASIAVSGGSTPAPFFRALSRKKID
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHCCCH
WARIIVTLVDERFVPPSSERSNAALASRYLLQNDAARASFVPLYQPVETVEEAAEKADEE
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGRLPLPLDVVVLGMGLDGHTASFFPDAEDIALKLQVENRRVLPIHARSAGEPRLTLSMP
HCCCCCCHHHEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEEEECC
LLCQARLMVLHIEGQEKRRLLEAALAEETGAKLPVRIAVEQAAAPVAIYWAPGAASASGK
HHHCEEEEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEEEECCCCCCCCCC
RP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]