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The map label for this gene is edd [H]

Identifier: 110632519

GI number: 110632519

Start: 191456

End: 193270

Strand: Reverse

Name: edd [H]

Synonym: Meso_0157

Alternate gene names: 110632519

Gene position: 193270-191456 (Counterclockwise)

Preceding gene: 110632520

Following gene: 110632516

Centisome position: 4.38

GC content: 62.98

Gene sequence:

>1815_bases
ATGACCGCAAGGCGAGAAATCGAAGCCGTCACAGCCCGCATCCGCGAGCGCTCGCGCCAGACACGGGAAACCTACCTTGC
CCGCGTGGACGAAGCGGCGGCCAAGGGAGCTCATCGCAGCACGCTCTCCTGCGGAAACCTGGCGCATGGCTTTGCCGCCT
GCGGCCCGCAGGAAAAGCAGGCCCTAGCGGGTGACACCGTTCCCAATCTTGGCATCATCACCGCCTATAACGATATGCTG
TCGGCGCACCAACCCTATGAGACGTTTCCGGCGCTCATCAAGGAGGCAGCGCGGGAAGCAGGTGGTGTGGCGCAAGTGGC
GGCAGGGGTGCCCGCCATGTGCGACGGCGTTACCCAAGGCCAGCCGGGAATGCAGCTTTCGCTTTTCTCGCGCGACGTCA
TCGCGCTCGCCACGGCGGTCGGTCTCTCGCACAACATGTTCGATGCTGCCGTCTATCTCGGCATTTGCGACAAGATCGTT
CCGGGGCTGACCATCGCGGCGCTTACCTTCGGTCACCTGCCGGCCATATTCATCCCCGCTGGCCCCATGACCAGCGGTCT
GCCGAATGACGAGAAGTCGAAGATCCGCCAGCTTTTCGCCGAAGGAAAGATCGGGCGCGAAGCGCTGCTGGATGCCGAAT
CCAAGTCCTATCACGGACCGGGCACCTGCACCTTTTACGGAACGGCCAACTCCAACCAGATGCTGATGGAGATCATGGGC
CTGCACATTCCGGGCTCCTCCTTCGTCAATCCGAACACGCCGCTGCGCGATGCACTTACCAAAGAGGCGGTGAAGCGTGC
GCTCGCCATTACGGCGCTTGGCAACGAGTTCACGCCGGTAGGCCGCATGATCGACGAGCGCTCGGTCGTGAACGGCGTGG
TGGGGCTCAACGCAACGGGCGGCTCCACCAATCACACGATGCATCTCGTGGCCATGGCGGCGGCCGCCGGCATCAAGCTC
ACCTGGGCGGACATCGCCGAGATTTCGGAGCATGTGCCCCTTCTGGCGCGGGTTTATCCGAACGGCCTTGCGGACGTGAA
CCATTTCCATGCCGCGGGCGGGATCGGCTTTCTTGTCCGCGAGCTCCTCGATGCCGGTCTTCTGCATGAGGATGTGCAGA
CCGTCTGGGGAGCGGGCCTGCGGCAATATGCGATTGAAGCAAAGCTCGGCCCTGACGGTTCAGTGACGCGCGAAATAGCG
CCTAACGAAAGCGGGGATGAGAAGGTGCTCGTGCCTGTCGCGAAAGCGTTTCAGCCGACCGGCGGCATACGCGTGCTCAA
GGGCAATCTCGGGCAGGCCATCATCAAGACCTCTGCCGTAAAGCCCCAGCACAGGATTATAGAGGCGCCGGCTATTATCT
TCCACGCACAGGGAGAATTGCAAGCGGCTTTCAAGGCGGGCGAGCTCGACCGCGATTTTATCGCCGTCATCCGTTTTCAA
GGGCCGAAGGCGAATGGCATGCCGGAGCTGCACAAGCTTACGCCGGTGCTCGGCGTGCTGCAGGACCGGGGTTACAAGGT
CGCGTTGCTTACGGACGGGCGGATGTCCGGCGCCTCTGGCAAGGTGCCTGCCGCAATCCATGTCACGCCGGAGGCCGCCG
ACGGCGGCGCAATCGCAAAGCTCAGGGATGGAGACCTGGTGCGGCTGGACGCGGAAGCCGGAACGGTCGAGGCTCTGGTC
GACGCGGAGGAATTTTCCGCCCGCGCTCCCGCATCGGCCGATCTCTCCTATGAACATTACGGCATGGGGCGCGAGCTCTT
CGCAAGCTTCCGTCAGATCGTTTCACCGGCAGATCAGGGCGCGGCGGTGTTTTGA

Upstream 100 bases:

>100_bases
GGCACCGGGAGCGGCAAGCGCCTCGGGCAAGCGCCCCTGACATCTTGAATATTATCGAGACCGAAGCCACTCGGACTCGA
CCATGACAGGATATGAAGCC

Downstream 100 bases:

>100_bases
GGCACACTCCCCTAGGAAGCGCTATTTCGCGGTCGCGAAATAGATGTGCCGCTTACCTCCCTTGAGCGGTTCCTCCGCTT
GGATGTCGAAGTGAGCCGAC

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 604; Mature: 603

Protein sequence:

>604_residues
MTARREIEAVTARIRERSRQTRETYLARVDEAAAKGAHRSTLSCGNLAHGFAACGPQEKQALAGDTVPNLGIITAYNDML
SAHQPYETFPALIKEAAREAGGVAQVAAGVPAMCDGVTQGQPGMQLSLFSRDVIALATAVGLSHNMFDAAVYLGICDKIV
PGLTIAALTFGHLPAIFIPAGPMTSGLPNDEKSKIRQLFAEGKIGREALLDAESKSYHGPGTCTFYGTANSNQMLMEIMG
LHIPGSSFVNPNTPLRDALTKEAVKRALAITALGNEFTPVGRMIDERSVVNGVVGLNATGGSTNHTMHLVAMAAAAGIKL
TWADIAEISEHVPLLARVYPNGLADVNHFHAAGGIGFLVRELLDAGLLHEDVQTVWGAGLRQYAIEAKLGPDGSVTREIA
PNESGDEKVLVPVAKAFQPTGGIRVLKGNLGQAIIKTSAVKPQHRIIEAPAIIFHAQGELQAAFKAGELDRDFIAVIRFQ
GPKANGMPELHKLTPVLGVLQDRGYKVALLTDGRMSGASGKVPAAIHVTPEAADGGAIAKLRDGDLVRLDAEAGTVEALV
DAEEFSARAPASADLSYEHYGMGRELFASFRQIVSPADQGAAVF

Sequences:

>Translated_604_residues
MTARREIEAVTARIRERSRQTRETYLARVDEAAAKGAHRSTLSCGNLAHGFAACGPQEKQALAGDTVPNLGIITAYNDML
SAHQPYETFPALIKEAAREAGGVAQVAAGVPAMCDGVTQGQPGMQLSLFSRDVIALATAVGLSHNMFDAAVYLGICDKIV
PGLTIAALTFGHLPAIFIPAGPMTSGLPNDEKSKIRQLFAEGKIGREALLDAESKSYHGPGTCTFYGTANSNQMLMEIMG
LHIPGSSFVNPNTPLRDALTKEAVKRALAITALGNEFTPVGRMIDERSVVNGVVGLNATGGSTNHTMHLVAMAAAAGIKL
TWADIAEISEHVPLLARVYPNGLADVNHFHAAGGIGFLVRELLDAGLLHEDVQTVWGAGLRQYAIEAKLGPDGSVTREIA
PNESGDEKVLVPVAKAFQPTGGIRVLKGNLGQAIIKTSAVKPQHRIIEAPAIIFHAQGELQAAFKAGELDRDFIAVIRFQ
GPKANGMPELHKLTPVLGVLQDRGYKVALLTDGRMSGASGKVPAAIHVTPEAADGGAIAKLRDGDLVRLDAEAGTVEALV
DAEEFSARAPASADLSYEHYGMGRELFASFRQIVSPADQGAAVF
>Mature_603_residues
TARREIEAVTARIRERSRQTRETYLARVDEAAAKGAHRSTLSCGNLAHGFAACGPQEKQALAGDTVPNLGIITAYNDMLS
AHQPYETFPALIKEAAREAGGVAQVAAGVPAMCDGVTQGQPGMQLSLFSRDVIALATAVGLSHNMFDAAVYLGICDKIVP
GLTIAALTFGHLPAIFIPAGPMTSGLPNDEKSKIRQLFAEGKIGREALLDAESKSYHGPGTCTFYGTANSNQMLMEIMGL
HIPGSSFVNPNTPLRDALTKEAVKRALAITALGNEFTPVGRMIDERSVVNGVVGLNATGGSTNHTMHLVAMAAAAGIKLT
WADIAEISEHVPLLARVYPNGLADVNHFHAAGGIGFLVRELLDAGLLHEDVQTVWGAGLRQYAIEAKLGPDGSVTREIAP
NESGDEKVLVPVAKAFQPTGGIRVLKGNLGQAIIKTSAVKPQHRIIEAPAIIFHAQGELQAAFKAGELDRDFIAVIRFQG
PKANGMPELHKLTPVLGVLQDRGYKVALLTDGRMSGASGKVPAAIHVTPEAADGGAIAKLRDGDLVRLDAEAGTVEALVD
AEEFSARAPASADLSYEHYGMGRELFASFRQIVSPADQGAAVF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=595, Percent_Identity=61.1764705882353, Blast_Score=768, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=577, Percent_Identity=29.2894280762565, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI2367371, Length=497, Percent_Identity=30.784708249497, Blast_Score=149, Evalue=7e-37,
Organism=Escherichia coli, GI1786464, Length=501, Percent_Identity=29.5409181636727, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322476, Length=491, Percent_Identity=29.5315682281059, Blast_Score=177, Evalue=3e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63670; Mature: 63538

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARREIEAVTARIRERSRQTRETYLARVDEAAAKGAHRSTLSCGNLAHGFAACGPQEKQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHH
ALAGDTVPNLGIITAYNDMLSAHQPYETFPALIKEAAREAGGVAQVAAGVPAMCDGVTQG
HHCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMQLSLFSRDVIALATAVGLSHNMFDAAVYLGICDKIVPGLTIAALTFGHLPAIFIPA
CCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEHHHHCCCCEEEECC
GPMTSGLPNDEKSKIRQLFAEGKIGREALLDAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
LHIPGSSFVNPNTPLRDALTKEAVKRALAITALGNEFTPVGRMIDERSVVNGVVGLNATG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEEECCCC
GSTNHTMHLVAMAAAAGIKLTWADIAEISEHVPLLARVYPNGLADVNHFHAAGGIGFLVR
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCHHHHHH
ELLDAGLLHEDVQTVWGAGLRQYAIEAKLGPDGSVTREIAPNESGDEKVLVPVAKAFQPT
HHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCCEEEECCCCCCCCEEEEEEHHHCCCC
GGIRVLKGNLGQAIIKTSAVKPQHRIIEAPAIIFHAQGELQAAFKAGELDRDFIAVIRFQ
CCEEEEECCCCHHHHHHCCCCCHHHHEECCEEEEECCCCHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTPVLGVLQDRGYKVALLTDGRMSGASGKVPAAIHVTPEAADGGAIAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
LRDGDLVRLDAEAGTVEALVDAEEFSARAPASADLSYEHYGMGRELFASFRQIVSPADQG
ECCCCEEEEECCCCCCHHHCCHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCC
AAVF
CCCC
>Mature Secondary Structure 
TARREIEAVTARIRERSRQTRETYLARVDEAAAKGAHRSTLSCGNLAHGFAACGPQEKQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCHHH
ALAGDTVPNLGIITAYNDMLSAHQPYETFPALIKEAAREAGGVAQVAAGVPAMCDGVTQG
HHCCCCCCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHCCCCCC
QPGMQLSLFSRDVIALATAVGLSHNMFDAAVYLGICDKIVPGLTIAALTFGHLPAIFIPA
CCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEHHHHCCCCEEEECC
GPMTSGLPNDEKSKIRQLFAEGKIGREALLDAESKSYHGPGTCTFYGTANSNQMLMEIMG
CCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHH
LHIPGSSFVNPNTPLRDALTKEAVKRALAITALGNEFTPVGRMIDERSVVNGVVGLNATG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHEEEECCCC
GSTNHTMHLVAMAAAAGIKLTWADIAEISEHVPLLARVYPNGLADVNHFHAAGGIGFLVR
CCCCCHHHHHHHHHHCCCEEEHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHCCCHHHHHH
ELLDAGLLHEDVQTVWGAGLRQYAIEAKLGPDGSVTREIAPNESGDEKVLVPVAKAFQPT
HHHHHHHHHHHHHHHHHCCHHHHEEEEECCCCCCCEEEECCCCCCCCEEEEEEHHHCCCC
GGIRVLKGNLGQAIIKTSAVKPQHRIIEAPAIIFHAQGELQAAFKAGELDRDFIAVIRFQ
CCEEEEECCCCHHHHHHCCCCCHHHHEECCEEEEECCCCHHHHHHCCCCCCCEEEEEEEC
GPKANGMPELHKLTPVLGVLQDRGYKVALLTDGRMSGASGKVPAAIHVTPEAADGGAIAK
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEE
LRDGDLVRLDAEAGTVEALVDAEEFSARAPASADLSYEHYGMGRELFASFRQIVSPADQG
ECCCCEEEEECCCCCCHHHCCHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCC
AAVF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]