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The map label for this gene is proC [H]

Identifier: 110632513

GI number: 110632513

Start: 184420

End: 185229

Strand: Reverse

Name: proC [H]

Synonym: Meso_0151

Alternate gene names: 110632513

Gene position: 185229-184420 (Counterclockwise)

Preceding gene: 110632515

Following gene: 110632512

Centisome position: 4.2

GC content: 61.11

Gene sequence:

>810_bases
ATGGGCAAGCGAGTCGTTCTCGTCGGTTGCGGCAATATGGGTTATGCCATGATGAAGGGCTGGCTCGCGGCGGGAAAGCT
TTCCGCGGCCGATATCAGCGTCGTTGAACCAAACGACGAGCTGCGTGCCCGTGCCGCCGATTGTGGGGTGAGCGTCGCAG
CTCAACCAGATGCGTTGCCCTGGAGGGAGGCGGATCTCGTCATCTTTGCCGTGAAGCCGCAGATGGTTCATCAGGTGGTG
CCCGATTATCGCTTCTTCGCGCCAGGCGCCACCTTTCTGAGCGTCGCCGCAGGCGCGGGGATTTCCCTCTTCGAAGAGCT
GTTGGGACATAACGCAGCCGTTGTCCGCTGCATGCCGAATACGCCCGCTGCAATCGGGAAGGGCATGCTGGTGATTGTCT
CGAATGGGAATGTCCGCCCGCAGACAAAGGAATTCGTCAACGAACTCCTGGCCACCAACGGAGCGGTCGCCACAATCGAG
GATGAGAGCCTCATGGACACCGTAACAGCTGTTTCGGGCTCAGGTCCCGCCTATGTCTTCCACTTCATCGAATGCCTCAC
GGCGGCGGGCGAGCAAGCCGGCCTGCCCTCTCAAACGGCAAAGCAGCTGGCCATGCAGACGGTCTATGGCGCGGCAGTTC
TTGCCAAGGAAAGCGGCGAGGAGCCAGGGATGCTTAGAGAGCAGGTCACAAGCCCCAACGGAACGACCGCGGCCGCACTG
AAGGTTCTGATGGGCGAAGAGCGGCTGCAAAGACTCCTGGGCGAGGCCGTGGAAGCGGCCCGGCAGCGTTCCATAGAGCT
TGGAAAGTAA

Upstream 100 bases:

>100_bases
TTCAACAAGCCTGTGGCGGCGGGAGGGATGCGAGTTTCCATCGAAATGGTTGCATCGCGCGGCCCGACGCGCCATTGCTT
GAGCAGCATAGGAGGTGTTG

Downstream 100 bases:

>100_bases
TCTCCCGGGGAGAAGAGCCAATGCCAGAAAGCTTGCTCGAACGGCTCAATCGCGCTGATGGCTCGATCGCCGCGCGGGCT
GGCCCACCGGTCGAGGTCGG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MGKRVVLVGCGNMGYAMMKGWLAAGKLSAADISVVEPNDELRARAADCGVSVAAQPDALPWREADLVIFAVKPQMVHQVV
PDYRFFAPGATFLSVAAGAGISLFEELLGHNAAVVRCMPNTPAAIGKGMLVIVSNGNVRPQTKEFVNELLATNGAVATIE
DESLMDTVTAVSGSGPAYVFHFIECLTAAGEQAGLPSQTAKQLAMQTVYGAAVLAKESGEEPGMLREQVTSPNGTTAAAL
KVLMGEERLQRLLGEAVEAARQRSIELGK

Sequences:

>Translated_269_residues
MGKRVVLVGCGNMGYAMMKGWLAAGKLSAADISVVEPNDELRARAADCGVSVAAQPDALPWREADLVIFAVKPQMVHQVV
PDYRFFAPGATFLSVAAGAGISLFEELLGHNAAVVRCMPNTPAAIGKGMLVIVSNGNVRPQTKEFVNELLATNGAVATIE
DESLMDTVTAVSGSGPAYVFHFIECLTAAGEQAGLPSQTAKQLAMQTVYGAAVLAKESGEEPGMLREQVTSPNGTTAAAL
KVLMGEERLQRLLGEAVEAARQRSIELGK
>Mature_268_residues
GKRVVLVGCGNMGYAMMKGWLAAGKLSAADISVVEPNDELRARAADCGVSVAAQPDALPWREADLVIFAVKPQMVHQVVP
DYRFFAPGATFLSVAAGAGISLFEELLGHNAAVVRCMPNTPAAIGKGMLVIVSNGNVRPQTKEFVNELLATNGAVATIED
ESLMDTVTAVSGSGPAYVFHFIECLTAAGEQAGLPSQTAKQLAMQTVYGAAVLAKESGEEPGMLREQVTSPNGTTAAALK
VLMGEERLQRLLGEAVEAARQRSIELGK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=33.210332103321, Blast_Score=121, Evalue=5e-28,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=33.210332103321, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI198041662, Length=273, Percent_Identity=33.6996336996337, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=33.0882352941176, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=33.9483394833948, Blast_Score=140, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=32.4723247232472, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=27.8571428571429, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=29.5138888888889, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21358587, Length=243, Percent_Identity=39.917695473251, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24648116, Length=279, Percent_Identity=32.9749103942652, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24647700, Length=146, Percent_Identity=43.1506849315069, Blast_Score=109, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28200; Mature: 28069

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRVVLVGCGNMGYAMMKGWLAAGKLSAADISVVEPNDELRARAADCGVSVAAQPDALP
CCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCCCCC
WREADLVIFAVKPQMVHQVVPDYRFFAPGATFLSVAAGAGISLFEELLGHNAAVVRCMPN
CCCCCEEEEEECHHHHHHHCCCCEEECCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
TPAAIGKGMLVIVSNGNVRPQTKEFVNELLATNGAVATIEDESLMDTVTAVSGSGPAYVF
CCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHHH
HFIECLTAAGEQAGLPSQTAKQLAMQTVYGAAVLAKESGEEPGMLREQVTSPNGTTAAAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCCHHHHHH
KVLMGEERLQRLLGEAVEAARQRSIELGK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GKRVVLVGCGNMGYAMMKGWLAAGKLSAADISVVEPNDELRARAADCGVSVAAQPDALP
CCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCCCCC
WREADLVIFAVKPQMVHQVVPDYRFFAPGATFLSVAAGAGISLFEELLGHNAAVVRCMPN
CCCCCEEEEEECHHHHHHHCCCCEEECCCHHHHHHHHCCCHHHHHHHHCCCCEEEEECCC
TPAAIGKGMLVIVSNGNVRPQTKEFVNELLATNGAVATIEDESLMDTVTAVSGSGPAYVF
CCHHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCHHHHH
HFIECLTAAGEQAGLPSQTAKQLAMQTVYGAAVLAKESGEEPGMLREQVTSPNGTTAAAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHCCCCCHHHHHH
KVLMGEERLQRLLGEAVEAARQRSIELGK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]