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The map label for this gene is yfhA [H]

Identifier: 110632497

GI number: 110632497

Start: 165211

End: 166281

Strand: Direct

Name: yfhA [H]

Synonym: Meso_0135

Alternate gene names: 110632497

Gene position: 165211-166281 (Clockwise)

Preceding gene: 110632496

Following gene: 110632498

Centisome position: 3.74

GC content: 66.11

Gene sequence:

>1071_bases
ATGATGGGCGAGGCGGCGAAGCTTTCCCGCAGCGGGCCCGCGCTTGGCGGCATCGCACGCGATCGTGCGCGGGCGGTCAC
GGTCCTCTTGATCCTCCTCATCGTTACACTTCTGGTGGTGCTTGCCAGCACGGCCTTCGGCTCCACCTGGGTGCCGCTGG
AAAAAATCGTCGCGGTTCTTACCGGAGGCGGGGAGCGCACGGAACGGCTGATCGTTCTGCAACTGCGGCTGCCGCGCGTG
CTGCTTGCCGCGCTCGCTGGCGGCGCTATGGCAGTGGCCGGCTTCCTGCTTCAGAAGGTGACGCGCAACGACCTTGCCTC
GCCAAGCGTGCTTGGGGTGGTTGATGGAGCCGCCCTCGGCGTCGTCATCTTCCTTGCTCTGCTCTCCGATGAGAGCAATG
CGCTGATAGTCAGCATCGCCTGGCAGCCCCTCGCGGCGGTGCTCGGGGCCTGTGCGGCCGTGGCGCTGGTTTTCGCCTTG
AGCGGGCGGCAAGCCTCCTCGGCGGTGCGGCTCCTGCTCTTCGGCATCGCTGCCGCCGCGGCGGCCAAGTCCGTCATCAT
GGTACTGCTGCTGACGGGGCCGATCTATCGCACGACGCAGGCGACCCGCTGGATCGCCGGCGCCGTCAACGAAACCAATT
GGGGCGAGGTGCAGATGACCGCGGAGCTTCTCCTGCCGGTGCTCCTTCTGGCGCTTCTCGCCGCGAGACGTCTGCCGCCG
AGCGATTTGGACGACGTTTCCGCCCAGTCGGTGGGGCTCAACCTTCCCGTCTTTCGCCTGGCGGTCTTCGCGCTCGCCGC
TGCGCTAACCTCCGTCTCGGTGGCCTTTGCGGGCGGGGTGAGCTTTATCGGTCTTCTTGCACCGCATATTGCGCGGCTTC
TGATAGGCCGTTCTGCCGTCGCGGGGATGCTTGCGAGCGCTCTTTGCGGCGCGGTGATCCTGATGGGGGCGGACCTCGTC
GTGCGGGTGCTCTTTGCCCCAACCGAAGTTCCGGCAGGCGCCATCACGGCGGTGATCGGCGCTCCCTATTTCCTCTATCT
TCTTTTGCGGAAGGACCGCCTCAATGGATAA

Upstream 100 bases:

>100_bases
TGGCCCGCTTCGTGATCTATCCCACTGAAGCGCCGGTAGGCGCGATTACGGCCGTTGTGGGCGCCGGCCTTCTTCTCGTT
CTCCTGCGCCGGCGGGCCGC

Downstream 100 bases:

>100_bases
GGCGCTCAGCGGATTAAAGGTCGACACGCTTTCGGTAGCCTATGGCGCGCATCTCGCCGTCGATGCCATTTCGCTTACCA
TCCCGAAGGGCAAGATCACG

Product: transport system permease protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MMGEAAKLSRSGPALGGIARDRARAVTVLLILLIVTLLVVLASTAFGSTWVPLEKIVAVLTGGGERTERLIVLQLRLPRV
LLAALAGGAMAVAGFLLQKVTRNDLASPSVLGVVDGAALGVVIFLALLSDESNALIVSIAWQPLAAVLGACAAVALVFAL
SGRQASSAVRLLLFGIAAAAAAKSVIMVLLLTGPIYRTTQATRWIAGAVNETNWGEVQMTAELLLPVLLLALLAARRLPP
SDLDDVSAQSVGLNLPVFRLAVFALAAALTSVSVAFAGGVSFIGLLAPHIARLLIGRSAVAGMLASALCGAVILMGADLV
VRVLFAPTEVPAGAITAVIGAPYFLYLLLRKDRLNG

Sequences:

>Translated_356_residues
MMGEAAKLSRSGPALGGIARDRARAVTVLLILLIVTLLVVLASTAFGSTWVPLEKIVAVLTGGGERTERLIVLQLRLPRV
LLAALAGGAMAVAGFLLQKVTRNDLASPSVLGVVDGAALGVVIFLALLSDESNALIVSIAWQPLAAVLGACAAVALVFAL
SGRQASSAVRLLLFGIAAAAAAKSVIMVLLLTGPIYRTTQATRWIAGAVNETNWGEVQMTAELLLPVLLLALLAARRLPP
SDLDDVSAQSVGLNLPVFRLAVFALAAALTSVSVAFAGGVSFIGLLAPHIARLLIGRSAVAGMLASALCGAVILMGADLV
VRVLFAPTEVPAGAITAVIGAPYFLYLLLRKDRLNG
>Mature_356_residues
MMGEAAKLSRSGPALGGIARDRARAVTVLLILLIVTLLVVLASTAFGSTWVPLEKIVAVLTGGGERTERLIVLQLRLPRV
LLAALAGGAMAVAGFLLQKVTRNDLASPSVLGVVDGAALGVVIFLALLSDESNALIVSIAWQPLAAVLGACAAVALVFAL
SGRQASSAVRLLLFGIAAAAAAKSVIMVLLLTGPIYRTTQATRWIAGAVNETNWGEVQMTAELLLPVLLLALLAARRLPP
SDLDDVSAQSVGLNLPVFRLAVFALAAALTSVSVAFAGGVSFIGLLAPHIARLLIGRSAVAGMLASALCGAVILMGADLV
VRVLFAPTEVPAGAITAVIGAPYFLYLLLRKDRLNG

Specific function: Part of the ABC transporter complex yfiYZ/yfhA/yusV involved in import of the iron-hydroxamate siderophores schizokinen, arthrobactin and corprogen (Probable) [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=278, Percent_Identity=36.3309352517986, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790740, Length=310, Percent_Identity=35.4838709677419, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1786804, Length=329, Percent_Identity=33.1306990881459, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790741, Length=295, Percent_Identity=35.2542372881356, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1788004, Length=290, Percent_Identity=34.1379310344828, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786805, Length=314, Percent_Identity=32.484076433121, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36527; Mature: 36527

Theoretical pI: Translated: 10.72; Mature: 10.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGEAAKLSRSGPALGGIARDRARAVTVLLILLIVTLLVVLASTAFGSTWVPLEKIVAVL
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TGGGERTERLIVLQLRLPRVLLAALAGGAMAVAGFLLQKVTRNDLASPSVLGVVDGAALG
CCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
VVIFLALLSDESNALIVSIAWQPLAAVLGACAAVALVFALSGRQASSAVRLLLFGIAAAA
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AAKSVIMVLLLTGPIYRTTQATRWIAGAVNETNWGEVQMTAELLLPVLLLALLAARRLPP
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SDLDDVSAQSVGLNLPVFRLAVFALAAALTSVSVAFAGGVSFIGLLAPHIARLLIGRSAV
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMLASALCGAVILMGADLVVRVLFAPTEVPAGAITAVIGAPYFLYLLLRKDRLNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MMGEAAKLSRSGPALGGIARDRARAVTVLLILLIVTLLVVLASTAFGSTWVPLEKIVAVL
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
TGGGERTERLIVLQLRLPRVLLAALAGGAMAVAGFLLQKVTRNDLASPSVLGVVDGAALG
CCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
VVIFLALLSDESNALIVSIAWQPLAAVLGACAAVALVFALSGRQASSAVRLLLFGIAAAA
HHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
AAKSVIMVLLLTGPIYRTTQATRWIAGAVNETNWGEVQMTAELLLPVLLLALLAARRLPP
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SDLDDVSAQSVGLNLPVFRLAVFALAAALTSVSVAFAGGVSFIGLLAPHIARLLIGRSAV
CCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGMLASALCGAVILMGADLVVRVLFAPTEVPAGAITAVIGAPYFLYLLLRKDRLNG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]