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The map label for this gene is bioA [H]

Identifier: 109947213

GI number: 109947213

Start: 556896

End: 558227

Strand: Direct

Name: bioA [H]

Synonym: Hac_0635

Alternate gene names: 109947213

Gene position: 556896-558227 (Clockwise)

Preceding gene: 109947209

Following gene: 109947214

Centisome position: 35.84

GC content: 37.09

Gene sequence:

>1332_bases
ATGAATTTTCAAGAAAATTTGGCCGCTTTGGATTTAGAATACCTTTGGCACCCTTGCTCGCAAATGCAAGAGCATCAAAA
TTTCCCCATTATCCCTATTAAAAAGGCTCAAGGGATCTATCTCTATGATTTCAACAATAACGCTTACATGGATTTAATCA
GCTCATGGTGGGTGAATCTTTTTGGGCATAATAACGCCTATATTAGCCAGCAGCTCAAACATCAAATTGACAATTTAGAG
CATGTCCTTTTGGCTTCCTTTAGCCATAAGCCCATTATCACGCTCTCTAAAAGGCTCTGCCAGCTTACCCACATGGATAA
ATGCTTTTATGCGGATAACGGTTCATCTTGCATTGAAATCGCTTTAAAAATGAGCTATCATGTCCATTTTTTAGAAAACC
AGACGCACCAAAAAAAGCTTTTTTTATCGCTCTCTAATTCCTATCATGGCGAGACTTTGGGAGCGTTAAGCGTGGGCGAT
GTGAAACTTTATAAAGACACTTACACCCCCTTATTACTCAAAAATCTCACTACACCTGTGCCTAAAAATGATAGCGAGAT
AGAAAACGCCCTAAACGCTTTAAAGCGCTTGTTAGATGCACATGCTAAAGAAATTTGTGCCTTTATTGTAGAGCCTCTTT
TGCAATGTGCAGGGAATATGCATATCTATAGTGCAAAATATTTAAAACAAGCCGTTTTATTGTGTAAGCAAAGAAACATC
CACATTATTTTTGATGAAATCGCTACAGGGTTTGGGCGCACAGGAAGCATGTTTGCTTATGAGCAATGTGCAATCAAACC
TGATTTTTTATGCTTGTCTAAAGGGATTAGTGGGGGGTATTTGCCTTTAAGCGTGTTGTTAACCCATAATGAAATTTATA
ACCAATTTTACGCCCCCTATGAAGACAATAAAGCGTTTTTACATTCGCACAGCTATACAGGAAACGCCCTAGCATGTGCA
TGTGCAAACGCTACGCTAGATATTTTTGAAAAAGAAAATGTTATTGAAAAAAACAAGGTTTTAAGCGAGTTTGTTTTCAG
CACTCTCCAAAACGCATTAAAAGACTTGATAGATCAACAAGTGGTGCGTCATTTAAGGCATTTAGGCATGGTTTTTGCCT
TTGAAGTTTTTATCTCAACTAAAGAGCGTTTGAGTTTGGCGATTTTTAAAAAGGCCTTAATTAAAGGCTTATTACTACGA
CCTTTAAACAACACTATCTATTTCATGCCTCCTTATATTATCACGCATGAAGAAATTAAAAAAGCGATCATAGGGATAGT
GGAAGTGATTAATGAATTAAAAACCCTAGAAAGTGTTTTTAAGCAAGATTAG

Upstream 100 bases:

>100_bases
AAAATATGAAATTCAAGTTTAAACAACCTTATAGTAAAATCAAATAACCTTATTCTAACCAAAGGTTATTAAAATTATCC
TTATTTAGAGAGTTTTTAGC

Downstream 100 bases:

>100_bases
GTTACAATCGCAATTTTTATAATAATAATAATTGAGAAGGGATCATGCAAACAAAGATAAAAAACAAACGGGTTTTGGTG
AAATTTTCTGGGGAAGCGTT

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNNNAYMDLISSWWVNLFGHNNAYISQQLKHQIDNLE
HVLLASFSHKPIITLSKRLCQLTHMDKCFYADNGSSCIEIALKMSYHVHFLENQTHQKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDSEIENALNALKRLLDAHAKEICAFIVEPLLQCAGNMHIYSAKYLKQAVLLCKQRNI
HIIFDEIATGFGRTGSMFAYEQCAIKPDFLCLSKGISGGYLPLSVLLTHNEIYNQFYAPYEDNKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKVLSEFVFSTLQNALKDLIDQQVVRHLRHLGMVFAFEVFISTKERLSLAIFKKALIKGLLLR
PLNNTIYFMPPYIITHEEIKKAIIGIVEVINELKTLESVFKQD

Sequences:

>Translated_443_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNNNAYMDLISSWWVNLFGHNNAYISQQLKHQIDNLE
HVLLASFSHKPIITLSKRLCQLTHMDKCFYADNGSSCIEIALKMSYHVHFLENQTHQKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDSEIENALNALKRLLDAHAKEICAFIVEPLLQCAGNMHIYSAKYLKQAVLLCKQRNI
HIIFDEIATGFGRTGSMFAYEQCAIKPDFLCLSKGISGGYLPLSVLLTHNEIYNQFYAPYEDNKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKVLSEFVFSTLQNALKDLIDQQVVRHLRHLGMVFAFEVFISTKERLSLAIFKKALIKGLLLR
PLNNTIYFMPPYIITHEEIKKAIIGIVEVINELKTLESVFKQD
>Mature_443_residues
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNNNAYMDLISSWWVNLFGHNNAYISQQLKHQIDNLE
HVLLASFSHKPIITLSKRLCQLTHMDKCFYADNGSSCIEIALKMSYHVHFLENQTHQKKLFLSLSNSYHGETLGALSVGD
VKLYKDTYTPLLLKNLTTPVPKNDSEIENALNALKRLLDAHAKEICAFIVEPLLQCAGNMHIYSAKYLKQAVLLCKQRNI
HIIFDEIATGFGRTGSMFAYEQCAIKPDFLCLSKGISGGYLPLSVLLTHNEIYNQFYAPYEDNKAFLHSHSYTGNALACA
CANATLDIFEKENVIEKNKVLSEFVFSTLQNALKDLIDQQVVRHLRHLGMVFAFEVFISTKERLSLAIFKKALIKGLLLR
PLNNTIYFMPPYIITHEEIKKAIIGIVEVINELKTLESVFKQD

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=405, Percent_Identity=28.641975308642, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI284507298, Length=320, Percent_Identity=30, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI13994255, Length=368, Percent_Identity=24.4565217391304, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=24.7058823529412, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=24.4705882352941, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24119277, Length=444, Percent_Identity=22.5225225225225, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442709, Length=366, Percent_Identity=24.0437158469945, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786991, Length=445, Percent_Identity=33.7078651685393, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=27.8481012658228, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI145693181, Length=390, Percent_Identity=27.9487179487179, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=25.1870324189526, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=25.1798561151079, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787560, Length=406, Percent_Identity=26.8472906403941, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=412, Percent_Identity=24.5145631067961, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=26.3513513513513, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=27.9310344827586, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=22.883295194508, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=471, Percent_Identity=31.4225053078556, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6323470, Length=429, Percent_Identity=24.9417249417249, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=24.8138957816377, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357415, Length=409, Percent_Identity=26.4058679706601, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=23.2558139534884, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=25.4464285714286, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28574759, Length=443, Percent_Identity=25.5079006772009, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50618; Mature: 50618

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNNNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKHQIDNLEHVLLASFSHKPIITLSKRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHVHFLENQTHQKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
EEHHHHEEEEECCCCCHHHEEEEECCCCCCCEECCEEECCEEEECCCCCHHHHHHCCCCC
PKNDSEIENALNALKRLLDAHAKEICAFIVEPLLQCAGNMHIYSAKYLKQAVLLCKQRNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCAIKPDFLCLSKGISGGYLPLSVLLTHNEIYNQFYAPY
EEEEHHHHCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCCCHHHHEEHHHHHHHHHCCCC
EDNKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKVLSEFVFSTLQNALKDLIDQQ
CCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRHLRHLGMVFAFEVFISTKERLSLAIFKKALIKGLLLRPLNNTIYFMPPYIITHEEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEHHHHH
KAIIGIVEVINELKTLESVFKQD
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNFQENLAALDLEYLWHPCSQMQEHQNFPIIPIKKAQGIYLYDFNNNAYMDLISSWWVNL
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHH
FGHNNAYISQQLKHQIDNLEHVLLASFSHKPIITLSKRLCQLTHMDKCFYADNGSSCIEI
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCHHHHH
ALKMSYHVHFLENQTHQKKLFLSLSNSYHGETLGALSVGDVKLYKDTYTPLLLKNLTTPV
EEHHHHEEEEECCCCCHHHEEEEECCCCCCCEECCEEECCEEEECCCCCHHHHHHCCCCC
PKNDSEIENALNALKRLLDAHAKEICAFIVEPLLQCAGNMHIYSAKYLKQAVLLCKQRNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCC
HIIFDEIATGFGRTGSMFAYEQCAIKPDFLCLSKGISGGYLPLSVLLTHNEIYNQFYAPY
EEEEHHHHCCCCCCCCCCHHHHHCCCCCHHHHHCCCCCCCCHHHHEEHHHHHHHHHCCCC
EDNKAFLHSHSYTGNALACACANATLDIFEKENVIEKNKVLSEFVFSTLQNALKDLIDQQ
CCCCEEEEECCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVRHLRHLGMVFAFEVFISTKERLSLAIFKKALIKGLLLRPLNNTIYFMPPYIITHEEIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEHHHHH
KAIIGIVEVINELKTLESVFKQD
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]