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The map label for this gene is pyrH

Identifier: 109947214

GI number: 109947214

Start: 558272

End: 558994

Strand: Direct

Name: pyrH

Synonym: Hac_0636

Alternate gene names: 109947214

Gene position: 558272-558994 (Clockwise)

Preceding gene: 109947213

Following gene: 109947215

Centisome position: 35.93

GC content: 40.53

Gene sequence:

>723_bases
ATGCAAACAAAGATAAAAAACAAACGGGTTTTGGTGAAATTTTCTGGGGAAGCGTTAGCTGGGGACAACCAGTTTGGGAT
TGACATTCATGTGTTAGATCACATCGCTAAAGAGATCAGAAGTTTAGTGGAAAACGATATTGAAGTGGGTATTGTGATAG
GTGGAGGCAATATCATTAGGGGGGTTAGTGCGGCTCAAGGGGGGATCATTAGGCGCACTAGTGGGGATTATATGGGCATG
TTAGCCACTGTGATTAATGCAGTAGCGATGCAAGAAGCTTTAGAGCATATTGGTCTGGATACAAGAGTCCAGAGCGCGAT
TGAGATTAAAGAGATTTGTGAAAGTTATATTTACAGAAAGGCGATCAGGCATTTAGAAAAGGGTAGGGTGGTGATTTTTG
GTGCAGGCACTGGAAACCCATTTTTCACTACCGATACGGCCGCCACTTTAAGAGCGATTGAAATTGGATCGGATCTGATC
ATTAAAGCGACTAAAGTGGATGGCATTTATGACAAAGACCCTAACAAGTTTAAAGACGCTAAAAAATTAGACACTTTAAG
CTATAACGATGCCTTGATAGGGGATATTGAAGTGATGGATGACACGGCAATTTCTTTAGCGAAAGACAATAAACTCCCCA
TTGTGGTGTGTAACATGTTTAAAAAAGGGAATTTATTGCAAGTGATTAAGCACCAACAAGGCGTATTTTCTATGGTAAAA
TAA

Upstream 100 bases:

>100_bases
TAGTGGAAGTGATTAATGAATTAAAAACCCTAGAAAGTGTTTTTAAGCAAGATTAGGTTACAATCGCAATTTTTATAATA
ATAATAATTGAGAAGGGATC

Downstream 100 bases:

>100_bases
GCCCTTTAAAATTTGATAGTTTAAAATAAAAGGATAAGTTTGAAAAAAGAAAGAACAGAGAGTTTAGTCGCTCAAGCCTT
AAAAAATATTGGGAACGACC

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIRGVSAAQGGIIRRTSGDYMGM
LATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRKAIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLI
IKATKVDGIYDKDPNKFKDAKKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK

Sequences:

>Translated_240_residues
MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIRGVSAAQGGIIRRTSGDYMGM
LATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRKAIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLI
IKATKVDGIYDKDPNKFKDAKKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK
>Mature_240_residues
MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIRGVSAAQGGIIRRTSGDYMGM
LATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRKAIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLI
IKATKVDGIYDKDPNKFKDAKKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=226, Percent_Identity=50.8849557522124, Blast_Score=229, Evalue=1e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_HELAH (Q17Y33)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664442.1
- ProteinModelPortal:   Q17Y33
- SMR:   Q17Y33
- STRING:   Q17Y33
- GeneID:   4177062
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0636
- NMPDR:   fig|382638.8.peg.618
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   HACI382638:HAC_0636-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26231; Mature: 26231

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: NA

Important sites: BINDING 55-55 BINDING 56-56 BINDING 60-60 BINDING 76-76 BINDING 164-164 BINDING 170-170 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIR
CCCCCCCCEEEEEECCCEECCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEECCHHEE
GVSAAQGGIIRRTSGDYMGMLATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRK
CCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLIIKATKVDGIYDKDPNKFKDA
HHHHHHCCCEEEEECCCCCCCEECCHHHHEEEEECCCCEEEEEEEECCCCCCCCHHHHHH
KKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK
HHHCCCCCCCCEEEEEEEECCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTKIKNKRVLVKFSGEALAGDNQFGIDIHVLDHIAKEIRSLVENDIEVGIVIGGGNIIR
CCCCCCCCEEEEEECCCEECCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEEEECCHHEE
GVSAAQGGIIRRTSGDYMGMLATVINAVAMQEALEHIGLDTRVQSAIEIKEICESYIYRK
CCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
AIRHLEKGRVVIFGAGTGNPFFTTDTAATLRAIEIGSDLIIKATKVDGIYDKDPNKFKDA
HHHHHHCCCEEEEECCCCCCCEECCHHHHEEEEECCCCEEEEEEEECCCCCCCCHHHHHH
KKLDTLSYNDALIGDIEVMDDTAISLAKDNKLPIVVCNMFKKGNLLQVIKHQQGVFSMVK
HHHCCCCCCCCEEEEEEEECCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA