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The map label for this gene is ggt [H]

Identifier: 109947183

GI number: 109947183

Start: 525497

End: 527200

Strand: Direct

Name: ggt [H]

Synonym: Hac_0598

Alternate gene names: 109947183

Gene position: 525497-527200 (Clockwise)

Preceding gene: 109947182

Following gene: 109947184

Centisome position: 33.82

GC content: 43.72

Gene sequence:

>1704_bases
ATGAGACGGAGTTTTTTAAAAACGATTGGCTTATGCACGATAGCATTCTCTTTGGGTTTGTTAAACCCTTTGAGTGCAGC
GAGTTACCCACCCATTCAAAACACTAAAGTAGGGTTAGCCCTTTCTAGCCATCCGCTAGCTACTGAAATCGGGCAAAAGG
TTTTAGAAGATGGGGGCAATGCGATTGATGCGGCCGTAGCGATTGGCTTTGCTTTAGCGGTCGTCCATCCTGTGGCAGGC
AATATTGGTGGAGGGGGTTTTGCGGTTATCCATTTAGCCAATGGGGAAAATGTGACCTTAGATTTTAGAGAAAAAGCCCC
CCTAAAAGCCACTAGAGACATGTTTTTAGACAAGCAAGGCAATGTGATCCCCAAACTCAGTCAAGATGGCTATTTAGCCG
TTGGTGTTCCTGGAACGGTGGCTGGCATGGAAGCGATGCTAAAAAAGTACGGCACTAAAAAATTGTCGCAACTTATTGAG
CCTGCGATTAAATTAGCTGAGCATGGTTACCCTATTTCAAAAAGGCAAGCAGAGACTTTAAAGGACGCTAGGGAGCGGTT
TTTAAAATACAATTCTAGTAAAAAATATTTTTTGAAAAAGGGGCATCTTGATTACCAAGAGGGGGATTTGTTTGTCCAAA
AGGATTTGGCCAAAACTTTGACTCAAATCAAAACGCTAGGTGCTAAAGGCTTTTATCAAGGGCAAGTGGCTGATTTGATT
GAAAAAGACATGAAAAAAAATGGAGGGATTATCACCAAAGAGGATCTCGCTAGTTATAGCGTGAAATGGCGCAAACCGGT
GGTGGGGAATTATCGCGGATATAAGATCATTTCTATGGCACCACCGAGTTCGGGAGGTACGCATTTGATCCAAATTTTGA
ATGTCATGGAAAATGCGGATTTGAGCGCTCTTGGGTATGGGGCTTCTAAAAATATCCATATCGTTGCAGAAGCGATGCGC
CAAGCTTATGCGGATAGATCGGTTTATATGGGAGACGCTGATTTTGTTTCAGTGCCGGTGGATAAACTCATCAATAAAGC
GTATGCTAAAAAGATTTTTGATGCTATCCAACCAGATACGGTCACGCCAAGCTCTCAAATCAAACCGGGAATGGGGCAAT
TGCATGAGGGGAATAACACGACGCATTATTCTGTGGCGGACAGGTGGGGGAATGCGGTGAGTATCACTTACACGATCAAC
GATTATTATGGGAGTGCTGCGAGCGTTGATGGGGCAGGATTTTTGTTGAATAATGAAATGGATGATTTTTCCATTAAGCC
AGGAAACCCTAATCTCTATGGTTTGGTAGGGGGCGATGCAAATGCGATTGAAGCCAATAAGCGCCCTTTAAGCTCCATGA
CGCCCACGATCGTGTTGAAAAACAATAAGGTTTTTATGGTGGTGGGGAGTCCTGGAGGCGCTAGGATTATCACCACGGTG
TCGCAAGTGATTTCTAATGTGATTGATTACAACATGGATATTTCTGAAGCGGTTTCAGCCCCTAGGTTTCACATGCAATG
GCTCCCTGATGAATTAAGGATTGAAAAATTTGGCATGCCCGCTGATGTGAAGGATAATCTCACTAAAATGGGCTATCAAA
TTGTCACTAAGCCGGTGATGGGCGATGTGAATGCGATCCATATTTTACCTCAAGTGAAAGGGCGTATCTTTTATGGATCA
ACAGATCCAAGGAAAGAGTTTTGA

Upstream 100 bases:

>100_bases
AGTTAATAACATAGAAGCTGCAAGCGAGAGAGCGTTTTATAAAACTTGTGTTATAATAAGGGAAATTTTAAGCGTCATTG
CTTATGGAAAGGAAAATTAG

Downstream 100 bases:

>100_bases
TTTTTATCAAATATTAGGCTCTTTAGTCCTATTTTACCCTATTTTTGGGGGGGGGGGACTTTTTAGCTAAAAAAGTTTTA
AACTTAGTCTTAAAATTCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MRRSFLKTIGLCTIAFSLGLLNPLSAASYPPIQNTKVGLALSSHPLATEIGQKVLEDGGNAIDAAVAIGFALAVVHPVAG
NIGGGGFAVIHLANGENVTLDFREKAPLKATRDMFLDKQGNVIPKLSQDGYLAVGVPGTVAGMEAMLKKYGTKKLSQLIE
PAIKLAEHGYPISKRQAETLKDARERFLKYNSSKKYFLKKGHLDYQEGDLFVQKDLAKTLTQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYSVKWRKPVVGNYRGYKIISMAPPSSGGTHLIQILNVMENADLSALGYGASKNIHIVAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGNNTTHYSVADRWGNAVSITYTIN
DYYGSAASVDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMTPTIVLKNNKVFMVVGSPGGARIITTV
SQVISNVIDYNMDISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIHILPQVKGRIFYGS
TDPRKEF

Sequences:

>Translated_567_residues
MRRSFLKTIGLCTIAFSLGLLNPLSAASYPPIQNTKVGLALSSHPLATEIGQKVLEDGGNAIDAAVAIGFALAVVHPVAG
NIGGGGFAVIHLANGENVTLDFREKAPLKATRDMFLDKQGNVIPKLSQDGYLAVGVPGTVAGMEAMLKKYGTKKLSQLIE
PAIKLAEHGYPISKRQAETLKDARERFLKYNSSKKYFLKKGHLDYQEGDLFVQKDLAKTLTQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYSVKWRKPVVGNYRGYKIISMAPPSSGGTHLIQILNVMENADLSALGYGASKNIHIVAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGNNTTHYSVADRWGNAVSITYTIN
DYYGSAASVDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMTPTIVLKNNKVFMVVGSPGGARIITTV
SQVISNVIDYNMDISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIHILPQVKGRIFYGS
TDPRKEF
>Mature_567_residues
MRRSFLKTIGLCTIAFSLGLLNPLSAASYPPIQNTKVGLALSSHPLATEIGQKVLEDGGNAIDAAVAIGFALAVVHPVAG
NIGGGGFAVIHLANGENVTLDFREKAPLKATRDMFLDKQGNVIPKLSQDGYLAVGVPGTVAGMEAMLKKYGTKKLSQLIE
PAIKLAEHGYPISKRQAETLKDARERFLKYNSSKKYFLKKGHLDYQEGDLFVQKDLAKTLTQIKTLGAKGFYQGQVADLI
EKDMKKNGGIITKEDLASYSVKWRKPVVGNYRGYKIISMAPPSSGGTHLIQILNVMENADLSALGYGASKNIHIVAEAMR
QAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDTVTPSSQIKPGMGQLHEGNNTTHYSVADRWGNAVSITYTIN
DYYGSAASVDGAGFLLNNEMDDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMTPTIVLKNNKVFMVVGSPGGARIITTV
SQVISNVIDYNMDISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVMGDVNAIHILPQVKGRIFYGS
TDPRKEF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=478, Percent_Identity=33.2635983263598, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI73915090, Length=478, Percent_Identity=33.2635983263598, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI73915096, Length=478, Percent_Identity=33.2635983263598, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI73915094, Length=478, Percent_Identity=33.2635983263598, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI113429324, Length=476, Percent_Identity=31.7226890756302, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI113429326, Length=481, Percent_Identity=31.6008316008316, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI109148539, Length=471, Percent_Identity=29.723991507431, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=25.3211009174312, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=25.6410256410256, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI30581157, Length=175, Percent_Identity=38.2857142857143, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI30581155, Length=175, Percent_Identity=38.2857142857143, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI218505805, Length=174, Percent_Identity=35.632183908046, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI310124095, Length=174, Percent_Identity=32.183908045977, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789856, Length=537, Percent_Identity=51.5828677839851, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI212646519, Length=493, Percent_Identity=35.6997971602434, Blast_Score=256, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI72000294, Length=498, Percent_Identity=35.3413654618474, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17506189, Length=591, Percent_Identity=30.9644670050761, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI193208245, Length=521, Percent_Identity=33.3973128598848, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI193208247, Length=521, Percent_Identity=33.3973128598848, Blast_Score=225, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=497, Percent_Identity=33.1991951710262, Blast_Score=205, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI72001497, Length=228, Percent_Identity=31.5789473684211, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI72001495, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17564448, Length=430, Percent_Identity=25.5813953488372, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=519, Percent_Identity=31.2138728323699, Blast_Score=186, Evalue=8e-48,
Organism=Drosophila melanogaster, GI161077496, Length=546, Percent_Identity=32.4175824175824, Blast_Score=229, Evalue=5e-60,
Organism=Drosophila melanogaster, GI18859893, Length=519, Percent_Identity=32.9479768786127, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI45551474, Length=506, Percent_Identity=30.0395256916996, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24642670, Length=506, Percent_Identity=30.0395256916996, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24642666, Length=506, Percent_Identity=30.0395256916996, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161077878, Length=506, Percent_Identity=30.0395256916996, Blast_Score=210, Evalue=3e-54,
Organism=Drosophila melanogaster, GI161077880, Length=506, Percent_Identity=30.0395256916996, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI18859741, Length=530, Percent_Identity=28.4905660377358, Blast_Score=172, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61542; Mature: 61542

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS00462 G_GLU_TRANSPEPTIDASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSFLKTIGLCTIAFSLGLLNPLSAASYPPIQNTKVGLALSSHPLATEIGQKVLEDGGN
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPVAGNIGGGGFAVIHLANGENVTLDFREKAPLKATRDMFLDKQG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHCCCC
NVIPKLSQDGYLAVGVPGTVAGMEAMLKKYGTKKLSQLIEPAIKLAEHGYPISKRQAETL
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KDARERFLKYNSSKKYFLKKGHLDYQEGDLFVQKDLAKTLTQIKTLGAKGFYQGQVADLI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EKDMKKNGGIITKEDLASYSVKWRKPVVGNYRGYKIISMAPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIVAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDT
CCEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGNNTTHYSVADRWGNAVSITYTINDYYGSAASVDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMTPTIVLKNNKVFMVVGSPGGARIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCHHHHHH
SQVISNVIDYNMDISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIHILPQVKGRIFYGSTDPRKEF
CCCCEEEEEECCCCEEEECCCCCCCCC
>Mature Secondary Structure
MRRSFLKTIGLCTIAFSLGLLNPLSAASYPPIQNTKVGLALSSHPLATEIGQKVLEDGGN
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
AIDAAVAIGFALAVVHPVAGNIGGGGFAVIHLANGENVTLDFREKAPLKATRDMFLDKQG
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCCCCCHHHHHHHHCCCC
NVIPKLSQDGYLAVGVPGTVAGMEAMLKKYGTKKLSQLIEPAIKLAEHGYPISKRQAETL
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
KDARERFLKYNSSKKYFLKKGHLDYQEGDLFVQKDLAKTLTQIKTLGAKGFYQGQVADLI
HHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHH
EKDMKKNGGIITKEDLASYSVKWRKPVVGNYRGYKIISMAPPSSGGTHLIQILNVMENAD
HHHHHHCCCEEEHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCC
LSALGYGASKNIHIVAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDAIQPDT
CCEECCCCCCCHHHHHHHHHHHHCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHCCCCC
VTPSSQIKPGMGQLHEGNNTTHYSVADRWGNAVSITYTINDYYGSAASVDGAGFLLNNEM
CCCHHCCCCCCCCCCCCCCCEEEEHHHHCCCEEEEEEEEECCCCCCCCCCCCEEEECCCC
DDFSIKPGNPNLYGLVGGDANAIEANKRPLSSMTPTIVLKNNKVFMVVGSPGGARIITTV
CCCEECCCCCCEEEEECCCCCEECCCCCCCCCCCCEEEEECCEEEEEEECCCCCHHHHHH
SQVISNVIDYNMDISEAVSAPRFHMQWLPDELRIEKFGMPADVKDNLTKMGYQIVTKPVM
HHHHHHHHHCCCCHHHHHCCCCEEEECCCHHHHHHHCCCCCCHHHHHHHHCHHHEECCCC
GDVNAIHILPQVKGRIFYGSTDPRKEF
CCCCEEEEEECCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]