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The map label for this gene is fmt

Identifier: 109947160

GI number: 109947160

Start: 506795

End: 507712

Strand: Direct

Name: fmt

Synonym: Hac_0573

Alternate gene names: 109947160

Gene position: 506795-507712 (Clockwise)

Preceding gene: 109947159

Following gene: 109947161

Centisome position: 32.61

GC content: 39.11

Gene sequence:

>918_bases
ATGCGCATCGTATTTATGGGAACGCCTGGTTTTGCTGAAGTGATCTTAAGGGCGTTAATTGAAAATCAAAACAACAATAT
AGAAGTGGTGGGGCTATTCACTCAAATGGACAAACCTTTTGGGCGTAAAAAGGAATTGAAAGCCCCAGAGACTAAAACAT
ACATTTTAGAAAACCATTCAAATATCCCCATTTTCCAGCCGCAAAGTTTGAAAGAGCCTGAAGTTCAAATTTTAAAAGGT
TTAAAGCCTGATTTTATCGTGGTGGTGGCTTATGGTAAGATTTTGCCCAAAGAGGTTTTAAAAATCGCTCCTTGCATTAA
TGTGCATGCGTCGTTATTGCCTAAATACAGGGGGGCTTCACCCGTTCATGAGATGATACTCAATGACGATACGATTTATG
GCGTAAGCGCCATGCTTATGGATTTGGAATTGGATAGCGGGGATATTTTAGGAAGCGCTTCTTTTTTAAGAGAAGGTTAT
TTGAATTTAGAAACTTTAAGCTTGAAATTAGCGCATATGGGGGCAACTTTACTCCTTTCAACGCTCAAAAATTTCCATTC
AATTACCCCAAAACCTCAAGATCATGCTAGCGCGACTTTTTGTAAAAAAATCACCAAAGCCGATGGTTTAGTGGGTTTTA
AAGACGCTAAAAGCTTGTTTTTAAAATCGCTTGCGTTTAAAACTTGGCCAGAAATCTTTTTAGAAAATAACCTTAAGCTT
TTAGGAGTAGAATTAGTAGAAAATGAAAAAAGCCATAGAGAGGGCGAGATTTTAAGAATTGATGAAAGAGGCGTTCTTGT
GGGTTGCCTAAAGGGCAGTGTGCGTATAGCGCGATTGCAAGCGGTGGGTAAAAAGCCCTTGAAAGCGAAAGATTATTTGA
ATGGCAGGCGTTTGAAAGCAGGCGATATTTTGGCATGA

Upstream 100 bases:

>100_bases
AATTTGCCAGAATAGCTATTAATGCTATGAAAATTTTAAGTCCTTATCAAACACAATCTTATATGAGGAGTGTGGATAAA
AATTGAAAACAAGGAATAAC

Downstream 100 bases:

>100_bases
GAAAATGCGAAAAAAGGGTTTTTGAGAGCTTGCCTTCCACGCAAACCTATCTTTTAGAAAAACTTAAAAACGATGCATTC
AAAGCCCCTATTTTAGTTGT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MRIVFMGTPGFAEVILRALIENQNNNIEVVGLFTQMDKPFGRKKELKAPETKTYILENHSNIPIFQPQSLKEPEVQILKG
LKPDFIVVVAYGKILPKEVLKIAPCINVHASLLPKYRGASPVHEMILNDDTIYGVSAMLMDLELDSGDILGSASFLREGY
LNLETLSLKLAHMGATLLLSTLKNFHSITPKPQDHASATFCKKITKADGLVGFKDAKSLFLKSLAFKTWPEIFLENNLKL
LGVELVENEKSHREGEILRIDERGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGRRLKAGDILA

Sequences:

>Translated_305_residues
MRIVFMGTPGFAEVILRALIENQNNNIEVVGLFTQMDKPFGRKKELKAPETKTYILENHSNIPIFQPQSLKEPEVQILKG
LKPDFIVVVAYGKILPKEVLKIAPCINVHASLLPKYRGASPVHEMILNDDTIYGVSAMLMDLELDSGDILGSASFLREGY
LNLETLSLKLAHMGATLLLSTLKNFHSITPKPQDHASATFCKKITKADGLVGFKDAKSLFLKSLAFKTWPEIFLENNLKL
LGVELVENEKSHREGEILRIDERGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGRRLKAGDILA
>Mature_305_residues
MRIVFMGTPGFAEVILRALIENQNNNIEVVGLFTQMDKPFGRKKELKAPETKTYILENHSNIPIFQPQSLKEPEVQILKG
LKPDFIVVVAYGKILPKEVLKIAPCINVHASLLPKYRGASPVHEMILNDDTIYGVSAMLMDLELDSGDILGSASFLREGY
LNLETLSLKLAHMGATLLLSTLKNFHSITPKPQDHASATFCKKITKADGLVGFKDAKSLFLKSLAFKTWPEIFLENNLKL
LGVELVENEKSHREGEILRIDERGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGRRLKAGDILA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=328, Percent_Identity=26.219512195122, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789683, Length=306, Percent_Identity=37.5816993464052, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1788589, Length=265, Percent_Identity=25.6603773584906, Blast_Score=71, Evalue=8e-14,
Organism=Drosophila melanogaster, GI45550868, Length=309, Percent_Identity=28.8025889967638, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=31.1111111111111, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_HELAH (Q17Y87)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664388.1
- ProteinModelPortal:   Q17Y87
- SMR:   Q17Y87
- STRING:   Q17Y87
- GeneID:   4177507
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0573
- NMPDR:   fig|382638.8.peg.556
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   TYILENH
- ProtClustDB:   PRK00005
- BioCyc:   HACI382638:HAC_0573-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33869; Mature: 33869

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVFMGTPGFAEVILRALIENQNNNIEVVGLFTQMDKPFGRKKELKAPETKTYILENHS
CEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCC
NIPIFQPQSLKEPEVQILKGLKPDFIVVVAYGKILPKEVLKIAPCINVHASLLPKYRGAS
CCCEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCHHHHHHHHCCCCCCCC
PVHEMILNDDTIYGVSAMLMDLELDSGDILGSASFLREGYLNLETLSLKLAHMGATLLLS
HHHHHHCCCCCHHHHEEEEEEEECCCCCCCCCHHHHHHCCCCEEHEEEEHHHHHHHHHHH
TLKNFHSITPKPQDHASATFCKKITKADGLVGFKDAKSLFLKSLAFKTWPEIFLENNLKL
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LGVELVENEKSHREGEILRIDERGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGRRLKA
EEEEEHHCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEHHHCCCCCCHHHCCCCCEECC
GDILA
CCCCC
>Mature Secondary Structure
MRIVFMGTPGFAEVILRALIENQNNNIEVVGLFTQMDKPFGRKKELKAPETKTYILENHS
CEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECCC
NIPIFQPQSLKEPEVQILKGLKPDFIVVVAYGKILPKEVLKIAPCINVHASLLPKYRGAS
CCCEECCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCHHHHHHHHCCCCCCCC
PVHEMILNDDTIYGVSAMLMDLELDSGDILGSASFLREGYLNLETLSLKLAHMGATLLLS
HHHHHHCCCCCHHHHEEEEEEEECCCCCCCCCHHHHHHCCCCEEHEEEEHHHHHHHHHHH
TLKNFHSITPKPQDHASATFCKKITKADGLVGFKDAKSLFLKSLAFKTWPEIFLENNLKL
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
LGVELVENEKSHREGEILRIDERGVLVGCLKGSVRIARLQAVGKKPLKAKDYLNGRRLKA
EEEEEHHCCCCCCCCCEEEEECCCEEEEEECCCEEEEEEHHHCCCCCCHHHCCCCCEECC
GDILA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA