Click here to switch to the map view.

The map label for this gene is lysA [H]

Identifier: 109947141

GI number: 109947141

Start: 481935

End: 483152

Strand: Direct

Name: lysA [H]

Synonym: Hac_0550

Alternate gene names: 109947141

Gene position: 481935-483152 (Clockwise)

Preceding gene: 109947140

Following gene: 109947142

Centisome position: 31.01

GC content: 39.24

Gene sequence:

>1218_bases
ATGTTCAATTATGAAGAGCTGTTTCAAACTTACAAAACCCCTTTTTATTTCTATGATTTTGACAAAATCAAACAGGCTTT
TTTAAGCTATAAAGAGGCGTTTAAGGGGCGTAAATCGTTGATTTGTTACGCTTTAAAGGCGAATTCTAATTTGAGCATCC
TTTCTTTATTGGCAAGTTTAGAAAGTGGGGCGGATTGCGTTTCTTTGGGCGAGATACAAAGGGCTTTAAAAGCGGGCATT
AAGCCTTATAGGATCGTGTTTAGCGGGGTGGGTAAGAGTGCATTTGAAATAGAACAAGCCCTAAAACTCAACATTTTATT
TTTGAATGTAGAGAGTTTTATGGAATTACAAACGATTGAAAAAATCGCTCAATCTTTAGGAATTAAGGCTCGCATTTCCA
TTAGAATCAACCCCAATATTGACGCTAAAACGCACCCTTATATTTCTACCGGCTTGAAAGAAAACAAGTTTGGCGTAGAG
GAAAAAGAAGCTTTAGAAATGTTTCTTTGGGCTAAAAAAAGCGCGTTTTTAGAGCCTATTAGCGTGCATTTTCATATTGG
ATCGCAGCTTTTAGATTTAGAGCCTATTATAGAAGCGAGCCAAAAGGTGGCTAAAACCGCTAAATCTTTGATAGCTTTAG
GCATAGATTTACGCTTTTTTGATGTGGGCGGAGGCATTGGCGTGAGCTATGAAAATGAAGAGACGATTAAGCTTTATGAT
TACGCGCAAGGGATTTTAGACTCGCTTCAAGGCTTGGATTTGACTATCATTTGTGAGCCAGGTCGATCTATTGTGGCTGA
AAGTGGGGAATTGATCACGCAGGTTTTGTATGAAAAAAAGGCTCAAAACAAGCGCTTTGTGATCGTGGATGCGGGCATGA
ATGATTTTTTACGCCCCAGTTTATATCATGCTAAACATGAAATAAGAGTCATAACGCCTCGTAAGGGTGGTAAGGTTTCG
CCTTGCGATGTGGTGGGACCTGTGTGTGAGAGCAGCGATACTTTTTTAAAGGAAGTCAATTTGCCAGAATTAAAGCCGGG
CGATAAATTAGCCATAGAAAAGGTTGGGGCTTATGGCTCTAGCATGGCTAGTCAATACAATTCGCGCCCCAAACTTTTAG
AATTAGCCCTAGAAGATCACAAAATTAGAGTGATAAGAAAAAAAGAAAGTTTGGAAGATTTATGGCGTTTAGAAGAGGAA
GGCTTAAAAGGAGTTTGA

Upstream 100 bases:

>100_bases
AATATCAAGATATTAATATAACCGGGAATGTGGGCATGCGAGTGGTGTTTTAGCTTTTTTGCTACAATGCTTCGTTCAAA
TTTTATGGTTAGGTTTTTCT

Downstream 100 bases:

>100_bases
TTAGATGCAAAAAAGGAGTCTTTTAGAAAATTTAAGGGCTGAGATTGATGTTTTAGACAATGAATTGAGCGATCTTTTAG
ACAAACGCTTAGAAGTGGCT

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MFNYEELFQTYKTPFYFYDFDKIKQAFLSYKEAFKGRKSLICYALKANSNLSILSLLASLESGADCVSLGEIQRALKAGI
KPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVE
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKTAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQGILDSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHEIRVITPRKGGKVS
PCDVVGPVCESSDTFLKEVNLPELKPGDKLAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKKESLEDLWRLEEE
GLKGV

Sequences:

>Translated_405_residues
MFNYEELFQTYKTPFYFYDFDKIKQAFLSYKEAFKGRKSLICYALKANSNLSILSLLASLESGADCVSLGEIQRALKAGI
KPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVE
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKTAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQGILDSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHEIRVITPRKGGKVS
PCDVVGPVCESSDTFLKEVNLPELKPGDKLAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKKESLEDLWRLEEE
GLKGV
>Mature_405_residues
MFNYEELFQTYKTPFYFYDFDKIKQAFLSYKEAFKGRKSLICYALKANSNLSILSLLASLESGADCVSLGEIQRALKAGI
KPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELQTIEKIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVE
EKEALEMFLWAKKSAFLEPISVHFHIGSQLLDLEPIIEASQKVAKTAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
YAQGILDSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPSLYHAKHEIRVITPRKGGKVS
PCDVVGPVCESSDTFLKEVNLPELKPGDKLAIEKVGAYGSSMASQYNSRPKLLELALEDHKIRVIRKKESLEDLWRLEEE
GLKGV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=388, Percent_Identity=25, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI22538418, Length=413, Percent_Identity=23.0024213075061, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI21361583, Length=413, Percent_Identity=23.0024213075061, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI16506287, Length=344, Percent_Identity=25.2906976744186, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=30.4136253041363, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789307, Length=277, Percent_Identity=25.9927797833935, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562780, Length=382, Percent_Identity=23.8219895287958, Blast_Score=88, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=380, Percent_Identity=28.4210526315789, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24586472, Length=337, Percent_Identity=24.3323442136499, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24586474, Length=346, Percent_Identity=25.1445086705202, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45363; Mature: 45363

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNYEELFQTYKTPFYFYDFDKIKQAFLSYKEAFKGRKSLICYALKANSNLSILSLLASL
CCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ESGADCVSLGEIQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELQTIE
HCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVEEKEALEMFLWAKKSAFLEPI
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKTAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEHHH
YAQGILDSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCH
LYHAKHEIRVITPRKGGKVSPCDVVGPVCESSDTFLKEVNLPELKPGDKLAIEKVGAYGS
HHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCHH
SMASQYNSRPKLLELALEDHKIRVIRKKESLEDLWRLEEEGLKGV
HHHHHHCCCCCEEHEECCCCEEEEEECHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFNYEELFQTYKTPFYFYDFDKIKQAFLSYKEAFKGRKSLICYALKANSNLSILSLLASL
CCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHH
ESGADCVSLGEIQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELQTIE
HCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHEEEEEEEEHHHHHHHHHHH
KIAQSLGIKARISIRINPNIDAKTHPYISTGLKENKFGVEEKEALEMFLWAKKSAFLEPI
HHHHHCCCEEEEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEE
SVHFHIGSQLLDLEPIIEASQKVAKTAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYD
EEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEEHHH
YAQGILDSLQGLDLTIICEPGRSIVAESGELITQVLYEKKAQNKRFVIVDAGMNDFLRPS
HHHHHHHHHCCCCEEEEECCCCHHHHCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHCCH
LYHAKHEIRVITPRKGGKVSPCDVVGPVCESSDTFLKEVNLPELKPGDKLAIEKVGAYGS
HHHCCCEEEEEECCCCCCCCCHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHCCCHH
SMASQYNSRPKLLELALEDHKIRVIRKKESLEDLWRLEEEGLKGV
HHHHHHCCCCCEEHEECCCCEEEEEECHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]