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The map label for this gene is hemK [H]

Identifier: 109947073

GI number: 109947073

Start: 421145

End: 421975

Strand: Direct

Name: hemK [H]

Synonym: Hac_0474

Alternate gene names: 109947073

Gene position: 421145-421975 (Clockwise)

Preceding gene: 109947072

Following gene: 109947074

Centisome position: 27.1

GC content: 36.82

Gene sequence:

>831_bases
ATGACCCTTTCACAAGCCCTAAACAAAGCCAAAAAAGGATTATCCCAAAAAGGTTTTAGGGGGGGGTTAGAGTCTGAAAT
TTTGTTAGGCTTTGTTTTGCAAAAAGAGAGGGTTTTTTTGCACACGCATGCACATTTAGAATTAAACCATAGAGAAGAAA
TGCGTTTTTTTGAATTGGTAAAAAAACGCTTGAACGACTACCCCATAGAGTATTTACTAGAAAGCTGCAGTTTTTATGGG
CGCTCTTTTTTTGTGAATGAGCATGTTTTAATCCCACGGCCTGAAACGGAGATTTTAGTTCAAAAAGCGTTGGATATTAT
TTCTCAATACCATTTAAAAGAGGTGGGCGAAATAGGCATAGGGAGCGGTTGCATTTCGGTGAGTTTGGCTTTAGAAAACC
CTAATCTCTCTATTTATGCGAGCGATATTTCACAAAACGCTTTAGAAGTGGCGTCAAAAAATATTGAACGCTTTGACTTG
AAAAAGTGCCTTTTCTTAAAAAAAACGCATCTTTGGGATCATATGCCAACAACACCAATGCTTGTCTCTAACCCACCCTA
TATCGCTAAAGGTTATCCTTTGGATAAATCCGTTTTAAAAGAACCGCATGAAGCCCTTTTTGGTGGGATCAAAGGCGATG
AAATCTTAAAAGAAATCATTTTTTTAGCCGCTGAATTGAAAATCCCTTTTTTGGTTTGTGAAATGGGGTATGATCAGTTG
AAAAGCTTGAAAGAATGCTTGGAATTTTGCGGTTATGATGCAAAGTTTTACAAGGATTTGAGTGGCTTTGATAGAGGGTT
TGTAGGTATTTTAAAAAGTTTTTTAAGATAA

Upstream 100 bases:

>100_bases
AAAATAAGACTTTCCCTTATTCGCACCCCTTCTATGTTTTCTTGCATTTCACACACCCGCCACTTTTAGAGTGCTTGAAA
GCTTTGGATTACAAAATTGA

Downstream 100 bases:

>100_bases
ATGATAAAGAGCTTGATTTAATCAAGCGATAGCTGAGTTTGAAAAATTAAAAATAAAATTTTAACTATCCCTTTTGATGA
GAAAAGCCAAAAGAATTAAA

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: M.AaoHemKP [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAHLELNHREEMRFFELVKKRLNDYPIEYLLESCSFYG
RSFFVNEHVLIPRPETEILVQKALDIISQYHLKEVGEIGIGSGCISVSLALENPNLSIYASDISQNALEVASKNIERFDL
KKCLFLKKTHLWDHMPTTPMLVSNPPYIAKGYPLDKSVLKEPHEALFGGIKGDEILKEIIFLAAELKIPFLVCEMGYDQL
KSLKECLEFCGYDAKFYKDLSGFDRGFVGILKSFLR

Sequences:

>Translated_276_residues
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAHLELNHREEMRFFELVKKRLNDYPIEYLLESCSFYG
RSFFVNEHVLIPRPETEILVQKALDIISQYHLKEVGEIGIGSGCISVSLALENPNLSIYASDISQNALEVASKNIERFDL
KKCLFLKKTHLWDHMPTTPMLVSNPPYIAKGYPLDKSVLKEPHEALFGGIKGDEILKEIIFLAAELKIPFLVCEMGYDQL
KSLKECLEFCGYDAKFYKDLSGFDRGFVGILKSFLR
>Mature_275_residues
TLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAHLELNHREEMRFFELVKKRLNDYPIEYLLESCSFYGR
SFFVNEHVLIPRPETEILVQKALDIISQYHLKEVGEIGIGSGCISVSLALENPNLSIYASDISQNALEVASKNIERFDLK
KCLFLKKTHLWDHMPTTPMLVSNPPYIAKGYPLDKSVLKEPHEALFGGIKGDEILKEIIFLAAELKIPFLVCEMGYDQLK
SLKECLEFCGYDAKFYKDLSGFDRGFVGILKSFLR

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=189, Percent_Identity=33.8624338624339, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1787463, Length=254, Percent_Identity=28.3464566929134, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI87082085, Length=197, Percent_Identity=31.9796954314721, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31481; Mature: 31350

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAHLELNHREEMRFFELV
CCHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEEECCHHHHHHHHHH
KKRLNDYPIEYLLESCSFYGRSFFVNEHVLIPRPETEILVQKALDIISQYHLKEVGEIGI
HHHHCCCCHHHHHHHHHHHCCEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GSGCISVSLALENPNLSIYASDISQNALEVASKNIERFDLKKCLFLKKTHLWDHMPTTPM
CCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCE
LVSNPPYIAKGYPLDKSVLKEPHEALFGGIKGDEILKEIIFLAAELKIPFLVCEMGYDQL
EECCCCCCCCCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECCCHHHH
KSLKECLEFCGYDAKFYKDLSGFDRGFVGILKSFLR
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TLSQALNKAKKGLSQKGFRGGLESEILLGFVLQKERVFLHTHAHLELNHREEMRFFELV
CHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCEEEEEEEEEEEECCHHHHHHHHHH
KKRLNDYPIEYLLESCSFYGRSFFVNEHVLIPRPETEILVQKALDIISQYHLKEVGEIGI
HHHHCCCCHHHHHHHHHHHCCEEEECCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GSGCISVSLALENPNLSIYASDISQNALEVASKNIERFDLKKCLFLKKTHLWDHMPTTPM
CCCEEEEEEEEECCCEEEEECCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCE
LVSNPPYIAKGYPLDKSVLKEPHEALFGGIKGDEILKEIIFLAAELKIPFLVCEMGYDQL
EECCCCCCCCCCCCCHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEECCCHHHH
KSLKECLEFCGYDAKFYKDLSGFDRGFVGILKSFLR
HHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]