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The map label for this gene is aroP [H]

Identifier: 108812540

GI number: 108812540

Start: 2662618

End: 2663991

Strand: Reverse

Name: aroP [H]

Synonym: YPN_2379

Alternate gene names: 108812540

Gene position: 2663991-2662618 (Counterclockwise)

Preceding gene: 108812541

Following gene: 108812538

Centisome position: 58.75

GC content: 46.65

Gene sequence:

>1374_bases
ATGGAACAGCAGTTACAGAACTCATCGTTAAAACGCGGTTTAAAAAATAGACATATTCAACTAATAGCTTTGGGTGGCGC
AATCGGAACCGGGTTATTTCTCGGGATTGCCCAAACCATCAATATGGCCGGCCCCTCAGTAATATTGGGGTATGCAATAG
GCGGGTTTATTGCTTTTCTGATTATGCGTCAATTAGGTGAAATGGTCGTCGAAGAGCCTGTTGCTGGCTCATTCAGCCAC
TTTGCCTATAAGTATTGGGGCGATTTTGCTGGTTTTCTATCGGGCTGGAACTACTGGGCCATGTTTATTCTGGTCGGTAT
GGCTGAATTGACTGCGGTAGGCATATATATTCAGTATTGGTGGCCTGAGATACCGACATGGGTTTCAGCAGCAGTATTCT
TTATCATAATCAACGCTATCAACTTAGTTAACGTACGTCTGTATGGCGAAACGGAGTTTTGGTTTGCCATCATTAAAGTG
GCTGCAATTATCGGTATGATTGTGTTCGGTGCTTATCTACTGGCATCGGGATCTGGTGGGCCAGCCGCCTCGGTGACAAA
TCTCTGGGCGCAGGGGGGTTTTATGCCCCATGGCTTTCGTGGTTTGATCATGGCAATGGCGGTTATTATGTTCTCTTTTG
GCGGTCTGGAGATGGTAGGGATTACTGCAGCAGAAGCCGAAGATCCACGGAACAGTATTCCTAAAGCGACTAATCAGGTC
GTTTATCGCATTCTTATTTTTTATATTGGCTCACTGACGGTGCTTCTGTCTCTTTTCCCGTGGAACAATGTCGTCGAAGG
GGGAAGTCCTTTCGTGATGATTTTCGATGCGTTAGATAGCCCTTGGGTGGCAACAGCATTGAATGTGGTTGTCCTGACCG
CCGCCCTGTCGGTGTATAACAGTGGTGTGTATTGTAACAGTCGTATGCTTTTTGGGCTGGCATCACAGGGGAATGCGCCT
AAGTTGTTGACCAAGTTAAATAAGCGTGGTGTCCCCATCCGTTCAATTGCACTTTCAGCATTAGCGACTTCAGCTGGCGT
GGTGATTAACTATATTATGCCCGGCAAAGCCTTTGAATTACTTATGGCGTTGGTGGTTTCAACACTGGTAATCAACTGGG
TGATGATTTGCCTGGCGCATCTGAAGTTTCGCAAGGCTAAAGTTAAAGAGGGCGTTGTGCCTCGCTTCAAAGCACTCTGG
TACCCCTACGGCAATTATCTGTGCCTGGTCTTCCTCGCATTAATTCTCGTCATTATGTATCTCACCGAAGGGATTCGGAT
CTCTGTGTTGATGATGCCAGTATGGATAGCGTTACTTTGGTGTGGTTTTGTACTTACTCGGCGTAAGTGTCCAAAAACGG
TGACTAGCCTCTAA

Upstream 100 bases:

>100_bases
GATGCTGGCGGGTTTAAGTGTTAAAAAAACCGCCGCAGACTCATTTATGAAATGCGTTGTTTATTCACACCAGTGCGTAA
TCAGTGCAACAGAGGGTAGG

Downstream 100 bases:

>100_bases
TGCTTCCTGATTAGCAGGGCAGTAAAATGCCGCGCTTGGAAGGGTGCGGCTTGAGCTTATATCAATAGTGATTGTTTGAT
TATTGTACTTTATTGTTATT

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKV
AAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGFMPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQV
VYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAP
KLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALW
YPYGNYLCLVFLALILVIMYLTEGIRISVLMMPVWIALLWCGFVLTRRKCPKTVTSL

Sequences:

>Translated_457_residues
MEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKV
AAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGFMPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQV
VYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAP
KLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALW
YPYGNYLCLVFLALILVIMYLTEGIRISVLMMPVWIALLWCGFVLTRRKCPKTVTSL
>Mature_457_residues
MEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYWWPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKV
AAIIGMIVFGAYLLASGSGGPAASVTNLWAQGGFMPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQV
VYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYNSGVYCNSRMLFGLASQGNAP
KLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFELLMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALW
YPYGNYLCLVFLALILVIMYLTEGIRISVLMMPVWIALLWCGFVLTRRKCPKTVTSL

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=23.3802816901408, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258645169, Length=370, Percent_Identity=19.7297297297297, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI181337167, Length=281, Percent_Identity=24.9110320284698, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=70.3947368421053, Blast_Score=653, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=444, Percent_Identity=69.1441441441441, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=41.6279069767442, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=39.2543859649123, Blast_Score=346, Evalue=2e-96,
Organism=Escherichia coli, GI1786602, Length=447, Percent_Identity=43.8478747203579, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI87081915, Length=390, Percent_Identity=38.4615384615385, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI87081708, Length=460, Percent_Identity=34.3478260869565, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1789017, Length=437, Percent_Identity=36.1556064073227, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788480, Length=401, Percent_Identity=35.4114713216958, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081869, Length=173, Percent_Identity=27.1676300578035, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=444, Percent_Identity=34.4594594594595, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=34.4671201814059, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6322892, Length=401, Percent_Identity=33.4164588528678, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324924, Length=447, Percent_Identity=30.8724832214765, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=31.1111111111111, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6321053, Length=472, Percent_Identity=30.0847457627119, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320717, Length=469, Percent_Identity=28.3582089552239, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=30.6733167082294, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=32.4120603015075, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=446, Percent_Identity=33.4080717488789, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=475, Percent_Identity=28.4210526315789, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=449, Percent_Identity=30.2895322939866, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6319608, Length=450, Percent_Identity=28.8888888888889, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=30.0248138957816, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=402, Percent_Identity=30.0995024875622, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=27.3399014778325, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=431, Percent_Identity=27.8422273781903, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=27.3453093812375, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI221512776, Length=286, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666159, Length=286, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667468, Length=362, Percent_Identity=24.0331491712707, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24668806, Length=354, Percent_Identity=23.1638418079096, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356285, Length=354, Percent_Identity=23.1638418079096, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24668802, Length=354, Percent_Identity=23.1638418079096, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50054; Mature: 50054

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00024 HEMOPEXIN ; PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFL
CCCHHHHHHHHCCHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGG
CCCCCHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAASVTNLWAQGGFMPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQV
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
VYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLASQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFEL
CCCEECCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHH
LMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTEGIRISVLMMPVWIALLWCGFVLTRRKCPKTVTSL
HCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MEQQLQNSSLKRGLKNRHIQLIALGGAIGTGLFLGIAQTINMAGPSVILGYAIGGFIAFL
CCCHHHHHHHHCCHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGDFAGFLSGWNYWAMFILVGMAELTAVGIYIQYW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEEE
WPEIPTWVSAAVFFIIINAINLVNVRLYGETEFWFAIIKVAAIIGMIVFGAYLLASGSGG
CCCCCHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAASVTNLWAQGGFMPHGFRGLIMAMAVIMFSFGGLEMVGITAAEAEDPRNSIPKATNQV
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHH
VYRILIFYIGSLTVLLSLFPWNNVVEGGSPFVMIFDALDSPWVATALNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHC
SGVYCNSRMLFGLASQGNAPKLLTKLNKRGVPIRSIALSALATSAGVVINYIMPGKAFEL
CCCEECCEEEEEECCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHH
LMALVVSTLVINWVMICLAHLKFRKAKVKEGVVPRFKALWYPYGNYLCLVFLALILVIMY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHH
LTEGIRISVLMMPVWIALLWCGFVLTRRKCPKTVTSL
HCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]