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The map label for this gene is nuoC

Identifier: 108812310

GI number: 108812310

Start: 2428941

End: 2430737

Strand: Reverse

Name: nuoC

Synonym: YPN_2148

Alternate gene names: 108812310

Gene position: 2430737-2428941 (Counterclockwise)

Preceding gene: 108812311

Following gene: 108812309

Centisome position: 53.6

GC content: 51.47

Gene sequence:

>1797_bases
ATGACTGATTTAACGACGTCCGACAGCTTACAGCCTGCATGGCAAACCCGTGATCATCTTGATGATCCGGTGATTGGTGA
ATTGTCGAACCGTTTTGGGCCAGAGGCCTTTGTTGTGCAAGCAACCCGTACCGGTATGCCCGTGGTATGGGTGAAGCGTG
AACAACTGCTGGAAGTAATGTCGTTTCTGAGAAAACAACCAAAGCCTTATGTCATGCTGTTCGATTTGCATGGCGTGGAT
GAGCGTCTACGTACCCACCGCCAGGGCCTCCCTGATGCGGACTTTTCTGTTTTCTATCATCTGCTTTCCATTGAACGTAA
CCGCGACATTATGCTGAAAGTGGCACTGTCTGAAAAAGACTTACATGTGTCCACAGCAACCAAAATTTTTCCCAATGCCA
ACTGGTATGAGCGGGAAACATGGGAGATGTTCGGTATTACCTTTGATGGTCACCCGCATCTGACGCGTATCATGATGCCG
CAGAGTTGGGAAGGTCATCCGCTGCGTAAAGATTACCCCGCCCGGGCGACCGAGTTCGATCCCTATGTGCTGACAAAGCA
GAAAGAAGATCTGGAAATGGAATCCCTGACCTTTAAGCCAGAAGATTGGGGCATGAAACGCGGGACTGAAAACGAGGACT
TCATGTTCCTTAACCTCGGCCCAAACCACCCCTCTTCACACGGTGCTTTCCGTATCGTGTTGCAGCTTGATGGTGAAGAA
ATTATCGACTGCGTACCGGATGTGGGTTACCACCACCGTGGTGCGGAGAAGATGGGCGAGCGCCAGTCCTGGCACAGCTA
CATTCCTTACACCGACCGTATCGAATACTTGGGCGGTTGTGTAAACGAAATGCCTTACGTGTTGGCGGTTGAAAAACTGG
CGGGCATCGTGGTGCCCGATCGCGTGAACACCATCCGGGTCATGCTGTCAGAATTATTCCGAATCAACAGTCACTTACTG
TATATCAGTACCTTTATTCAAGACGTCGGTGCCATGACGCCCGTGTTCTTTGCCTTTACTGACCGTCAGAAAGTGTACGA
CGTGATCGAGGCGATTACCGGGTTCCGTATGCACCCGGCCTGGTTCCGCATTGGTGGTGTGGCGCACGACCTGCCACGCG
GCTGGGAACGTTTGCTACGCGACTTCCTTGACTGGATGCCAAAACGTCTGGATTCCTACGTTAAAGCCGCTTTGCAGAAC
AGCATCCTGAAAGGGCGCTCCGTTGGTGTGGCCGCGTATAATGCGAAAGAGGCGTTAGAGTGGGGCGTCACCGGTGCGGG
CTTGCGTGCTACCGGGGTTGAATTTGACGTGCGCAAATGGCGTCCGTATTCCGGTTATGAGAACTTTGATTTTGAAGTGC
CTGTCGGTAACAACGGCGATTGCTATGACCGCGTGATGCTGAAAGTGGAAGAGTTACGTCAAAGCCTGCGTATTCTGGAG
CAATGTTATAAAAACATGCCAGAAGGACCATTCAAGGCTGATCATCCACTGACGACACCACCACCAAAAGAGCGCACGCT
TCAACATATCGAAACGCTAATCACTCACTTCCTGCAAGTGTCATGGGGGCCAGTGATGCCAGCGAACGAATCTTTCCAGA
TGATTGAAGCAACCAAAGGGATTAACAGCTATTACCTGACCAGTGACGGCAGCACCATGAGTTACCGCACCCGGATACGG
ACCCCAAGCTATGCCCATTTGCAGCAGATCCCATCGGTTATCCGTGGCAGTTTGGTATCTGACCTGATCGTCTATCTGGG
CAGTATCGATTTTGTAATGTCTGATGTGGACCGCTAA

Upstream 100 bases:

>100_bases
TTTTTGGAGAGAATGTAATTTTTTTCCGGGGCATGTATGCAGCAAATGACCACAAAATGACACATTCAGTGTGGTGAAAA
AACAGTGTGGTGAATAAATA

Downstream 100 bases:

>100_bases
TTATGAGTGATCAAAAAGAGACTCAGGCTCATAACGGAAGCCTTGATGTGGTGAATCTGGCAGTCAATGCGGCTGAACCA
GCGGCCATGCCAGACGCCTT

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MTDLTTSDSLQPAWQTRDHLDDPVIGELSNRFGPEAFVVQATRTGMPVVWVKREQLLEVMSFLRKQPKPYVMLFDLHGVD
ERLRTHRQGLPDADFSVFYHLLSIERNRDIMLKVALSEKDLHVSTATKIFPNANWYERETWEMFGITFDGHPHLTRIMMP
QSWEGHPLRKDYPARATEFDPYVLTKQKEDLEMESLTFKPEDWGMKRGTENEDFMFLNLGPNHPSSHGAFRIVLQLDGEE
IIDCVPDVGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIVVPDRVNTIRVMLSELFRINSHLL
YISTFIQDVGAMTPVFFAFTDRQKVYDVIEAITGFRMHPAWFRIGGVAHDLPRGWERLLRDFLDWMPKRLDSYVKAALQN
SILKGRSVGVAAYNAKEALEWGVTGAGLRATGVEFDVRKWRPYSGYENFDFEVPVGNNGDCYDRVMLKVEELRQSLRILE
QCYKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIR
TPSYAHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR

Sequences:

>Translated_598_residues
MTDLTTSDSLQPAWQTRDHLDDPVIGELSNRFGPEAFVVQATRTGMPVVWVKREQLLEVMSFLRKQPKPYVMLFDLHGVD
ERLRTHRQGLPDADFSVFYHLLSIERNRDIMLKVALSEKDLHVSTATKIFPNANWYERETWEMFGITFDGHPHLTRIMMP
QSWEGHPLRKDYPARATEFDPYVLTKQKEDLEMESLTFKPEDWGMKRGTENEDFMFLNLGPNHPSSHGAFRIVLQLDGEE
IIDCVPDVGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIVVPDRVNTIRVMLSELFRINSHLL
YISTFIQDVGAMTPVFFAFTDRQKVYDVIEAITGFRMHPAWFRIGGVAHDLPRGWERLLRDFLDWMPKRLDSYVKAALQN
SILKGRSVGVAAYNAKEALEWGVTGAGLRATGVEFDVRKWRPYSGYENFDFEVPVGNNGDCYDRVMLKVEELRQSLRILE
QCYKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIR
TPSYAHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
>Mature_597_residues
TDLTTSDSLQPAWQTRDHLDDPVIGELSNRFGPEAFVVQATRTGMPVVWVKREQLLEVMSFLRKQPKPYVMLFDLHGVDE
RLRTHRQGLPDADFSVFYHLLSIERNRDIMLKVALSEKDLHVSTATKIFPNANWYERETWEMFGITFDGHPHLTRIMMPQ
SWEGHPLRKDYPARATEFDPYVLTKQKEDLEMESLTFKPEDWGMKRGTENEDFMFLNLGPNHPSSHGAFRIVLQLDGEEI
IDCVPDVGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIVVPDRVNTIRVMLSELFRINSHLLY
ISTFIQDVGAMTPVFFAFTDRQKVYDVIEAITGFRMHPAWFRIGGVAHDLPRGWERLLRDFLDWMPKRLDSYVKAALQNS
ILKGRSVGVAAYNAKEALEWGVTGAGLRATGVEFDVRKWRPYSGYENFDFEVPVGNNGDCYDRVMLKVEELRQSLRILEQ
CYKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIRT
PSYAHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=382, Percent_Identity=40.3141361256544, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI260898743, Length=372, Percent_Identity=40.0537634408602, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI4758788, Length=126, Percent_Identity=38.0952380952381, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI145693162, Length=599, Percent_Identity=88.4808013355593, Blast_Score=1122, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=601, Percent_Identity=25.7903494176373, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788832, Length=584, Percent_Identity=26.3698630136986, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17555284, Length=427, Percent_Identity=40.5152224824356, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17568379, Length=427, Percent_Identity=39.5784543325527, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI71990788, Length=119, Percent_Identity=32.7731092436975, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32563621, Length=119, Percent_Identity=32.7731092436975, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=39.9477806788512, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24638644, Length=384, Percent_Identity=39.5833333333333, Blast_Score=320, Evalue=1e-87,
Organism=Drosophila melanogaster, GI24656494, Length=165, Percent_Identity=34.5454545454545, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_YERP3 (A7FGQ7)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400435.1
- ProteinModelPortal:   A7FGQ7
- STRING:   A7FGQ7
- GeneID:   5387257
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1456
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- ProtClustDB:   PRK11742
- BioCyc:   YPSE349747:YPSIP31758_1456-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR010218
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01961
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 68887; Mature: 68755

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLTTSDSLQPAWQTRDHLDDPVIGELSNRFGPEAFVVQATRTGMPVVWVKREQLLEVM
CCCCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECHHHHHHHH
SFLRKQPKPYVMLFDLHGVDERLRTHRQGLPDADFSVFYHLLSIERNRDIMLKVALSEKD
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCC
LHVSTATKIFPNANWYERETWEMFGITFDGHPHLTRIMMPQSWEGHPLRKDYPARATEFD
CEEEHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
PYVLTKQKEDLEMESLTFKPEDWGMKRGTENEDFMFLNLGPNHPSSHGAFRIVLQLDGEE
CEEEECCCCCCCHHHEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCHH
IIDCVPDVGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIVVPD
HHHHCCCCCCCCCCHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCEECCC
RVNTIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKVYDVIEAITGFRMHPA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCH
WFRIGGVAHDLPRGWERLLRDFLDWMPKRLDSYVKAALQNSILKGRSVGVAAYNAKEALE
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHH
WGVTGAGLRATGVEFDVRKWRPYSGYENFDFEVPVGNNGDCYDRVMLKVEELRQSLRILE
CCCCCCCCEECCCEEEHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
QCYKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKG
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
INSYYLTSDGSTMSYRTRIRTPSYAHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
CCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
TDLTTSDSLQPAWQTRDHLDDPVIGELSNRFGPEAFVVQATRTGMPVVWVKREQLLEVM
CCCCCCCCCCCCHHHHHCCCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECHHHHHHHH
SFLRKQPKPYVMLFDLHGVDERLRTHRQGLPDADFSVFYHLLSIERNRDIMLKVALSEKD
HHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCC
LHVSTATKIFPNANWYERETWEMFGITFDGHPHLTRIMMPQSWEGHPLRKDYPARATEFD
CEEEHHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
PYVLTKQKEDLEMESLTFKPEDWGMKRGTENEDFMFLNLGPNHPSSHGAFRIVLQLDGEE
CEEEECCCCCCCHHHEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEEEECCHH
IIDCVPDVGYHHRGAEKMGERQSWHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGIVVPD
HHHHCCCCCCCCCCHHHHCCHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCEECCC
RVNTIRVMLSELFRINSHLLYISTFIQDVGAMTPVFFAFTDRQKVYDVIEAITGFRMHPA
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCCCH
WFRIGGVAHDLPRGWERLLRDFLDWMPKRLDSYVKAALQNSILKGRSVGVAAYNAKEALE
HHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHH
WGVTGAGLRATGVEFDVRKWRPYSGYENFDFEVPVGNNGDCYDRVMLKVEELRQSLRILE
CCCCCCCCEECCCEEEHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
QCYKNMPEGPFKADHPLTTPPPKERTLQHIETLITHFLQVSWGPVMPANESFQMIEATKG
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCC
INSYYLTSDGSTMSYRTRIRTPSYAHLQQIPSVIRGSLVSDLIVYLGSIDFVMSDVDR
CCEEEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA