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The map label for this gene is ndh [H]

Identifier: 108812174

GI number: 108812174

Start: 2275951

End: 2277255

Strand: Reverse

Name: ndh [H]

Synonym: YPN_2012

Alternate gene names: 108812174

Gene position: 2277255-2275951 (Counterclockwise)

Preceding gene: 108812175

Following gene: 108812173

Centisome position: 50.22

GC content: 48.28

Gene sequence:

>1305_bases
TTGACAACGCTGAAGAAAAAAATCGTTATTATTGGTGGTGGTGCAGGGGGTCTTGAGTTGGCAACCAGTCTCGGCCATAA
ACTCGGGCGCAGTAAAAAAGCAGATATAGTCCTGGTTGACCGTAACCATAGCCATCTGTGGAAACCACTGTTACATGAAG
TTGCTACAGGCTCTTTGGATGATGGTGTCGATGCGTTGAGCTATTTGGCGCATGCTCGTAATCACTATTTCAATTTCCAA
CTGGGTTCATTAACCGGTATTAACCGTGAAAACAAAACAATCAGCCTGGCTGAGATTTGTGATGAACACGGTGATGTACT
GGTGACTCAACGTGAGTTGTCCTATGACATTCTGGTGATGGCCTTGGGCAGTGTTTCTAACGATTTCGGGACACCGGGCG
TGAAGGATAACTGCATCTTCTTGGATAACCCTCATCAGGCGCATCGTTTCCATAATGAAATGCTCAACCTATTCCTGAAG
TATTCTGCTCAACCGGGTGAAAAAGGCAAAGTAGACATCGCTATCGTTGGCGGCGGGGCTACCGGTGTTGAGCTGTCTGC
AGAGTTACACAATGCGGTGAAGCAGTTGCACAGTTATGGTTTTGAGGGGTTAGATAACCACGCGCTGAATGTAACTTTGG
TTGAGGCGGGTGAACGTATTTTACCGGCGTTGCCACCACGTATCTCTTCAGCAGCCCATCAAGAACTGACTAAATTGGGT
GTGCGCGTATTGACCAAAACCATGGTGACCAGTGCTGATGAAAATGGCCTGAATACCAAAGAGGGTGAATTTATTCATGC
TGATTTGATGGTATGGGCGGCGGGTATCAAAGCGCCAGACTTTATGAAAGACATTGCCGGGCTGGAAACTAACCGTATTA
ATCAGTTGGTGGTTGAGCCAACGCTGCAAACGACCCGAGATCCAAATATCTTCGCTATTGGCGATTGTGCTTCTTGCCCG
CAACCGAGCGGTGGTTTTGTTCCTCCTCGCGCGCAGTCTGCACATCAGATGGCCAGCCGCTGCTACAGCAATATTCTGGC
CTTACTCAATGGGCAGAGCCTGAAACCATATATCTACAAAGATCATGGTTCACTGGTTTCGCTATCTAAGTTCAGCACCG
TCGGTAGCCTGATGGGGAACCTGATGCGTGGTTCAATGATGGTCGAAGGGCGTGTAGCACGCGTCGTTTATATCTCGTTG
TATCGTATGCATCAGGTCGCATTACATGGTTATACCAAGACAGGTCTGATGATGCTGGTGGGCGGGATTAATCGGGTGAT
TAGGCCACGGTTGAAGCTTCACTAA

Upstream 100 bases:

>100_bases
TGACCACAGTTTATTGATTTAATATTAGCGAACCCTATGTTATCTAAGGATATTATTTTTTACCCTTAGCTAACAATTGG
TTCACATTTAGGGGGGCATT

Downstream 100 bases:

>100_bases
ATTCCCCTTCGGCCTTGACGTTGCAGCGGCGTTAGCGGCGTTCACTCACCCGAATTGCTTACTGGTCGTTGACCTTAAAA
TCAATAGACTCATCGGGATT

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTTLKKKIVIIGGGAGGLELATSLGHKLGRSKKADIVLVDRNHSHLWKPLLHEVATGSLDDGVDALSYLAHARNHYFNFQ
LGSLTGINRENKTISLAEICDEHGDVLVTQRELSYDILVMALGSVSNDFGTPGVKDNCIFLDNPHQAHRFHNEMLNLFLK
YSAQPGEKGKVDIAIVGGGATGVELSAELHNAVKQLHSYGFEGLDNHALNVTLVEAGERILPALPPRISSAAHQELTKLG
VRVLTKTMVTSADENGLNTKEGEFIHADLMVWAAGIKAPDFMKDIAGLETNRINQLVVEPTLQTTRDPNIFAIGDCASCP
QPSGGFVPPRAQSAHQMASRCYSNILALLNGQSLKPYIYKDHGSLVSLSKFSTVGSLMGNLMRGSMMVEGRVARVVYISL
YRMHQVALHGYTKTGLMMLVGGINRVIRPRLKLH

Sequences:

>Translated_434_residues
MTTLKKKIVIIGGGAGGLELATSLGHKLGRSKKADIVLVDRNHSHLWKPLLHEVATGSLDDGVDALSYLAHARNHYFNFQ
LGSLTGINRENKTISLAEICDEHGDVLVTQRELSYDILVMALGSVSNDFGTPGVKDNCIFLDNPHQAHRFHNEMLNLFLK
YSAQPGEKGKVDIAIVGGGATGVELSAELHNAVKQLHSYGFEGLDNHALNVTLVEAGERILPALPPRISSAAHQELTKLG
VRVLTKTMVTSADENGLNTKEGEFIHADLMVWAAGIKAPDFMKDIAGLETNRINQLVVEPTLQTTRDPNIFAIGDCASCP
QPSGGFVPPRAQSAHQMASRCYSNILALLNGQSLKPYIYKDHGSLVSLSKFSTVGSLMGNLMRGSMMVEGRVARVVYISL
YRMHQVALHGYTKTGLMMLVGGINRVIRPRLKLH
>Mature_433_residues
TTLKKKIVIIGGGAGGLELATSLGHKLGRSKKADIVLVDRNHSHLWKPLLHEVATGSLDDGVDALSYLAHARNHYFNFQL
GSLTGINRENKTISLAEICDEHGDVLVTQRELSYDILVMALGSVSNDFGTPGVKDNCIFLDNPHQAHRFHNEMLNLFLKY
SAQPGEKGKVDIAIVGGGATGVELSAELHNAVKQLHSYGFEGLDNHALNVTLVEAGERILPALPPRISSAAHQELTKLGV
RVLTKTMVTSADENGLNTKEGEFIHADLMVWAAGIKAPDFMKDIAGLETNRINQLVVEPTLQTTRDPNIFAIGDCASCPQ
PSGGFVPPRAQSAHQMASRCYSNILALLNGQSLKPYIYKDHGSLVSLSKFSTVGSLMGNLMRGSMMVEGRVARVVYISLY
RMHQVALHGYTKTGLMMLVGGINRVIRPRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=434, Percent_Identity=82.258064516129, Blast_Score=727, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323794, Length=348, Percent_Identity=29.0229885057471, Blast_Score=89, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6323515, Length=448, Percent_Identity=26.1160714285714, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320118, Length=352, Percent_Identity=25.5681818181818, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47181; Mature: 47050

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLKKKIVIIGGGAGGLELATSLGHKLGRSKKADIVLVDRNHSHLWKPLLHEVATGSLD
CCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC
DGVDALSYLAHARNHYFNFQLGSLTGINRENKTISLAEICDEHGDVLVTQRELSYDILVM
CHHHHHHHHHHHHHCEEEEEECCEECCCCCCCEEEHHHHHHCCCCEEEEECCCCCEEEEE
ALGSVSNDFGTPGVKDNCIFLDNPHQAHRFHNEMLNLFLKYSAQPGEKGKVDIAIVGGGA
EHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
TGVELSAELHNAVKQLHSYGFEGLDNHALNVTLVEAGERILPALPPRISSAAHQELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHH
VRVLTKTMVTSADENGLNTKEGEFIHADLMVWAAGIKAPDFMKDIAGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECC
TLQTTRDPNIFAIGDCASCPQPSGGFVPPRAQSAHQMASRCYSNILALLNGQSLKPYIYK
CHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DHGSLVSLSKFSTVGSLMGNLMRGSMMVEGRVARVVYISLYRMHQVALHGYTKTGLMMLV
CCCCEEEHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GGINRVIRPRLKLH
HHHHHHHCCHHCCC
>Mature Secondary Structure 
TTLKKKIVIIGGGAGGLELATSLGHKLGRSKKADIVLVDRNHSHLWKPLLHEVATGSLD
CCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCC
DGVDALSYLAHARNHYFNFQLGSLTGINRENKTISLAEICDEHGDVLVTQRELSYDILVM
CHHHHHHHHHHHHHCEEEEEECCEECCCCCCCEEEHHHHHHCCCCEEEEECCCCCEEEEE
ALGSVSNDFGTPGVKDNCIFLDNPHQAHRFHNEMLNLFLKYSAQPGEKGKVDIAIVGGGA
EHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
TGVELSAELHNAVKQLHSYGFEGLDNHALNVTLVEAGERILPALPPRISSAAHQELTKLG
CCEEEHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCHHHHHHHHHHHHH
VRVLTKTMVTSADENGLNTKEGEFIHADLMVWAAGIKAPDFMKDIAGLETNRINQLVVEP
HHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHCCCCCCHHHHHHHHCCCCCCCCEEEECC
TLQTTRDPNIFAIGDCASCPQPSGGFVPPRAQSAHQMASRCYSNILALLNGQSLKPYIYK
CHHCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
DHGSLVSLSKFSTVGSLMGNLMRGSMMVEGRVARVVYISLYRMHQVALHGYTKTGLMMLV
CCCCEEEHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GGINRVIRPRLKLH
HHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]