Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 108811429

GI number: 108811429

Start: 1441717

End: 1443096

Strand: Reverse

Name: xseA

Synonym: YPN_1266

Alternate gene names: 108811429

Gene position: 1443096-1441717 (Counterclockwise)

Preceding gene: 108811433

Following gene: 108811416

Centisome position: 31.82

GC content: 52.25

Gene sequence:

>1380_bases
ATGTCGCAATCTTCCGCCTCCTCAATTTTTACTGTCAGCCGCCTGAATCAGACGGTACGAGAACTATTGGAAAGGGAAAT
GGGCCAGATTTGGCTCACTGCCGAGATTTCTAATTTCTCTCAGCCCGCTTCTGGGCACTGGTATTTCACGCTGAAAGATG
ATCGGGCGCAAGTGCGCTGTGCCATGTTTCGTAACAGCAACCGCCGCACCACTTTCCGTCCGCAGAATGGCCAACAAGTT
TTGGTCAGGGCATCAATTACCCTGTATGAACCCCGTGGTGATTATCAGTTAATTGCGGAAAGTATGCAGCCTGCCGGTGA
TGGGTTGCTGCAACAACAATTTGAACAGCTTAAGCAACAATTAGCGGCCGAAGGGCTGTTTGATCAAAGCCACAAACAGC
CACTCCCTCACCCCGCCAAACAAGTGGGCGTAATAACGTCTGCCAGTGGGGCTGCGCTGCATGATGTGCTGCATGTGTTA
CAGCGCCGTGATCCATCGCTTCCAGTAATTATTTATCCCACATCAGTACAGGGCGTTGATGCGCCATTGCAGATAGTCCG
TGCGATCCAGTTGGCGAACTTACGTGCTGAATGCGATGTATTGATTGTTGGCCGCGGTGGCGGATCGCTAGAAGATTTGT
GGAGTTTCAACGACGAACGGGTTGCCCGCGCTATCTTTAACAGCCATATCCCTATCGTCAGCGCTGTCGGCCATGAAACC
GATGTCACTATTGCCGATTTTGTTGCTGATTTACGCGCCCCAACCCCTTCGGCTGCCGCCGAGCTAGTCAGTCGCAATCA
GATTGAGCTCGTTCGTCAGATTCAAGGGCAACAGCAACGAATGGAAATGGCGATGGATTACTATCTGGCGCAACGCAACC
AGCAATTCACCCGCCTTGAACACCGTTTGCAGCAACAGCATCCGCATTTACGTTTAGCCCGTCAGCAAACATTGTTGCTG
AAATTACAACGTAGGCTGGAAGAGAGTGCACAAACACAGATCCGCTTATTAAGTAAACGTACCGAGCGGCTGCAACAGCG
TTTGCAGCAAGTGCAGCCTCAGGGGCAAATTCACCGGTATAACCAGCGGGTACAGCAGCAAGAATACCGTTTACGTCAAG
CTGTAGAGCGCCAGCTCAATGGCTATCGCCAACGCTTTGGTATCGCCTGCTCCCAGCTAGAGGCCGTGAGCCCACTGGCA
ACACTGGCCCGTGGCTACAGCGTGACACAGACGCCAGCAGGGGCGTTATTGAAGACCACCAAGCAAGTACAGGCCGGTGA
TAAACTGACCACCCGGTTGCAAGACGGTTGGGTGGAAAGTGAGATTACCCAAGTCACCGTAGCGAAGAAAAGCCGTCAGA
AAAAAGTAGTGACGCAGTGA

Upstream 100 bases:

>100_bases
GATTGCCTCCAGCACTTTCTCATAATATTTCTTGCCAACCAGTTTGAGGCAGGTAATATCGGTTAATTAAGTCCTTGTTT
TAAAATTTGATCCAGGTCAC

Downstream 100 bases:

>100_bases
CGCAGTGACGCAGTGACGCAGTGACGCAGTGATTATAGCGGCAAGGATGGGGCTGCCAGTAAAATCATCAGCCTCTAACA
CTCTTTCGTTGATCATTTCC

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSQSSASSIFTVSRLNQTVRELLEREMGQIWLTAEISNFSQPASGHWYFTLKDDRAQVRCAMFRNSNRRTTFRPQNGQQV
LVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQLAAEGLFDQSHKQPLPHPAKQVGVITSASGAALHDVLHVL
QRRDPSLPVIIYPTSVQGVDAPLQIVRAIQLANLRAECDVLIVGRGGGSLEDLWSFNDERVARAIFNSHIPIVSAVGHET
DVTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRNQQFTRLEHRLQQQHPHLRLARQQTLLL
KLQRRLEESAQTQIRLLSKRTERLQQRLQQVQPQGQIHRYNQRVQQQEYRLRQAVERQLNGYRQRFGIACSQLEAVSPLA
TLARGYSVTQTPAGALLKTTKQVQAGDKLTTRLQDGWVESEITQVTVAKKSRQKKVVTQ

Sequences:

>Translated_459_residues
MSQSSASSIFTVSRLNQTVRELLEREMGQIWLTAEISNFSQPASGHWYFTLKDDRAQVRCAMFRNSNRRTTFRPQNGQQV
LVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQLAAEGLFDQSHKQPLPHPAKQVGVITSASGAALHDVLHVL
QRRDPSLPVIIYPTSVQGVDAPLQIVRAIQLANLRAECDVLIVGRGGGSLEDLWSFNDERVARAIFNSHIPIVSAVGHET
DVTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRNQQFTRLEHRLQQQHPHLRLARQQTLLL
KLQRRLEESAQTQIRLLSKRTERLQQRLQQVQPQGQIHRYNQRVQQQEYRLRQAVERQLNGYRQRFGIACSQLEAVSPLA
TLARGYSVTQTPAGALLKTTKQVQAGDKLTTRLQDGWVESEITQVTVAKKSRQKKVVTQ
>Mature_458_residues
SQSSASSIFTVSRLNQTVRELLEREMGQIWLTAEISNFSQPASGHWYFTLKDDRAQVRCAMFRNSNRRTTFRPQNGQQVL
VRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQLAAEGLFDQSHKQPLPHPAKQVGVITSASGAALHDVLHVLQ
RRDPSLPVIIYPTSVQGVDAPLQIVRAIQLANLRAECDVLIVGRGGGSLEDLWSFNDERVARAIFNSHIPIVSAVGHETD
VTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRNQQFTRLEHRLQQQHPHLRLARQQTLLLK
LQRRLEESAQTQIRLLSKRTERLQQRLQQVQPQGQIHRYNQRVQQQEYRLRQAVERQLNGYRQRFGIACSQLEAVSPLAT
LARGYSVTQTPAGALLKTTKQVQAGDKLTTRLQDGWVESEITQVTVAKKSRQKKVVTQ

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=454, Percent_Identity=71.8061674008811, Blast_Score=667, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_YERPA (Q1C5J4)

Other databases:

- EMBL:   CP000308
- RefSeq:   YP_652223.1
- STRING:   Q1C5J4
- GeneID:   4118182
- GenomeReviews:   CP000308_GR
- KEGG:   ypa:YPA_2313
- eggNOG:   COG1570
- HOGENOM:   HBG634411
- OMA:   EISNFTR
- ProtClustDB:   PRK00286
- BioCyc:   YPES360102:YPA_2313-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 52099; Mature: 51968

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSSASSIFTVSRLNQTVRELLEREMGQIWLTAEISNFSQPASGHWYFTLKDDRAQVRC
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHH
AMFRNSNRRTTFRPQNGQQVLVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQ
HHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LAAEGLFDQSHKQPLPHPAKQVGVITSASGAALHDVLHVLQRRDPSLPVIIYPTSVQGVD
HHHHCCCCCCCCCCCCCCHHHHCEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
APLQIVRAIQLANLRAECDVLIVGRGGGSLEDLWSFNDERVARAIFNSHIPIVSAVGHET
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCC
DVTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRNQQFTRLE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HRLQQQHPHLRLARQQTLLLKLQRRLEESAQTQIRLLSKRTERLQQRLQQVQPQGQIHRY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NQRVQQQEYRLRQAVERQLNGYRQRFGIACSQLEAVSPLATLARGYSVTQTPAGALLKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
KQVQAGDKLTTRLQDGWVESEITQVTVAKKSRQKKVVTQ
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SQSSASSIFTVSRLNQTVRELLEREMGQIWLTAEISNFSQPASGHWYFTLKDDRAQVRC
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCEEEEEEECCCHHHHH
AMFRNSNRRTTFRPQNGQQVLVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQ
HHHHCCCCCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
LAAEGLFDQSHKQPLPHPAKQVGVITSASGAALHDVLHVLQRRDPSLPVIIYPTSVQGVD
HHHHCCCCCCCCCCCCCCHHHHCEEECCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
APLQIVRAIQLANLRAECDVLIVGRGGGSLEDLWSFNDERVARAIFNSHIPIVSAVGHET
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCC
DVTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRNQQFTRLE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
HRLQQQHPHLRLARQQTLLLKLQRRLEESAQTQIRLLSKRTERLQQRLQQVQPQGQIHRY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
NQRVQQQEYRLRQAVERQLNGYRQRFGIACSQLEAVSPLATLARGYSVTQTPAGALLKTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
KQVQAGDKLTTRLQDGWVESEITQVTVAKKSRQKKVVTQ
HHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA