| Definition | Yersinia pestis Nepal516, complete genome. |
|---|---|
| Accession | NC_008149 |
| Length | 4,534,590 |
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The map label for this gene is pbpC [H]
Identifier: 108811219
GI number: 108811219
Start: 1210939
End: 1213302
Strand: Reverse
Name: pbpC [H]
Synonym: YPN_1055
Alternate gene names: 108811219
Gene position: 1213302-1210939 (Counterclockwise)
Preceding gene: 108811221
Following gene: 108811217
Centisome position: 26.76
GC content: 52.54
Gene sequence:
>2364_bases ATGCGCATCCCAACCTTAATGGCAACCAAACGCCTGTTGCAAAATATCCTGATGGCCCTCTTTCTGTTGGCCCTCTTGGT CATCGGCTTTCGGCTGTGGCCACACCCGCCCTTGTCTCAGGGGCTCCCACTCTCTACGGCTTACTATGATCGGCACGGCA CGCTATTACGTCTTTCGCTGGCTAATGATGATCGTTATCGCCTGTGGACACCGTTGGAAGAGATCTCCCCATTGGTGATA CAGGGTATCCAACTGCATGAAGACCGCGGTTTCTATTATCATCCCGGTGTTAATCCCATTAGCCTGTTACGCGGGTTCTG GCAAAGCTATGTACAAGGCGGCAGGCAACAGGGCGGTTCAACCCTGACCATGCAGTTGGCACGGATGCACTGGCATCTCA ATACCCGTTCGCCAACAGGTAAATTGCGACAAATCGCCCGAGCTATCCAACTGGAACTGAGCTATTCCAAGCACGATATT TTAGAGGCTTACCTGAATTACGCCCCTTATGGCCGTAATATCGAAAGTATTGCCGCTGCCAGCCTGATTTATTTTGATAA AAAACCCCAGCAACTGACGCTGCCAGAAGCCCTGACATTGGCGGTATTGCCCCAATCGCCCAGTTACCGCATTGATCCCA CCACCGGTGTGCTGGGGAGCGCCCTGACCCAAGCCCGTAACCGGCTATTCGTTCGCTGGCAACAAACGTACCCCACCGAT AGCAGCCAAATGGCGCTATTCCAGTTACCGCTCAGCCTGCGTCAACCCGAAAAAATGCCCTATATCGCGCCACATTTTAT TGAACAGATCCGGCGGCAAAATCAACAACTGGCGAATACCCAGAGTCAGGTTGACACCACACTGGATGCCAATCTGCAAC AACTGGTAGAAAAACAGGTCGAGGCCTTTATCCGCCGTAATAACAGCCGGGGTATCCATAATGCGGCGGTATTATTGCTG GATACACGGGATATGGGCGTTCGGGCGCTGGTGGGGTCGGCAAATTATTATGACCGAGAAATTCAGGGGCAAGTTAACGG CACCAATGCCAAACGCTCCCCCGGTTCGACACTGAAACCCTTTATTTATGCTCTAGGGCTAGAACAGGGGATACTGCATC CGATGACCATCCTGAAAGATGTGCCCTCTTCTTTCGGGGCCTATGCGCCAGAGAATTTTGACCACCGTTTTCTGGGGCCA GTGACCGCCACGGACGCCTTGAATTTCAGCCGAAACATTCCTGCGGTGTATGTCGCATCCCGTTTAAGACAACCAACGCT ATACCAATTTTTACGTTTATCCGGTGTTACCAATATGGCCAGTGAAAACCATTACGGTTTATCACTGGTGCTGGGGGGCG GTGAAATTACCCTACAGGAGCTGGCGCGGCTCTATGCCATGTTGGCGAATCGCGGCACACTGCACCCCATACAAATGGTA CAAACAGATAAAACGCTGCCCTCCATTCGTCTGTTAAGCGAGGCGGCCAGTTTCATCACGCTTGATATGTTGCGTCAGCA CCGCCGCCCCGGTGATACCTTGGCACAAAGCCCCACCTCGCTACCGGTCTACTGGAAAACCGGGACCTCTTGGGGATTCA GAGATGCCTGGAGCGCAGGGATTTTTGGCCCTTATGTGTTAATCGTCTGGGAAGGCAACTTTGCGGGTAAGGGCAACAGC GCCTTTGTCGGTGCCGATGCCGCCGCACCGTTATTCTTTAATATTATTGACAGTATTCAGGCTAACTACCCAGCGCTGCG CGAGCCTAAACATCCTTGGCCGCCACAGTTAAAACGGGTGGCTATCTGTCTGGCCAGCGGCAACTTGCCCACGCCTTGGT GTCAGCAGCAAGGTAAAACCTGGTTTATTCCGGGGAAATCGCCGATCAAAGTCGATACGGTCTATCGCCCCGTCGTGATT GATATAAATAGTGGTCAGGCCGCTTGTCTACCTTATGACCGCAGCCAGACCCGTACTGAAGTTTTTGAGTTCTGGCCATC GGATCTGGCCAATGTATTTGCTCAAGCGGGCTTGCCGAAACGCCAACCACCTGACCGCTCTCACTGCAAAGAAGGGAATA CTCTCGCATCGGGTAATGCACCACGTATCACCTCACCGCTGCGCAATACCACCTACACCCTGCGCCAATCACAACAGGGC CGTGATCAGATTGTATTCAGCGCCACTCTTGATGCGGATAGCACCACCACTTACTGGTTTGTTGACGATATCTATCTAGG CAGCAGCACCAGTAAAAAATCCATCGATTGGCATCCGACCCGCAGCGGTCAATACCGCATTCGGGCAATTGATGATCATG GCCGCGCTGATAGTAGGCTAATTCGTGTTGAGAAAGTGGATTAA
Upstream 100 bases:
>100_bases GCTGAAAGCTTTACTGAACCCCCAGCCTAGCTGGGGGTTTTCTGGGCACAACAACGCGCCCCGCATCGCCGGGGCGCTAT CGGATTTCAGCCGTAACCAG
Downstream 100 bases:
>100_bases TGGCACACCTTACGGTTTCCATCCTTAGAGCGCCTGCTGTGCTTCTACGGGGTAATATATTGATATTGGTCAACGAGATG AGTAACCAGCAAACGGCCGG
Product: hypothetical protein
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 787; Mature: 787
Protein sequence:
>787_residues MRIPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVI QGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDI LEAYLNYAPYGRNIESIAAASLIYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTD SSQMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLL DTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGP VTATDALNFSRNIPAVYVASRLRQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMV QTDKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNS AFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVI DINSGQAACLPYDRSQTRTEVFEFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQG RDQIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD
Sequences:
>Translated_787_residues MRIPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVI QGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDI LEAYLNYAPYGRNIESIAAASLIYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTD SSQMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLL DTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGP VTATDALNFSRNIPAVYVASRLRQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMV QTDKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNS AFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVI DINSGQAACLPYDRSQTRTEVFEFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQG RDQIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD >Mature_787_residues MRIPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSLANDDRYRLWTPLEEISPLVI QGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGSTLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDI LEAYLNYAPYGRNIESIAAASLIYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTD SSQMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQVEAFIRRNNSRGIHNAAVLLL DTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKPFIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGP VTATDALNFSRNIPAVYVASRLRQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMV QTDKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAGIFGPYVLIVWEGNFAGKGNS AFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRVAICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVI DINSGQAACLPYDRSQTRTEVFEFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQG RDQIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRLIRVEKVD
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=804, Percent_Identity=32.089552238806, Blast_Score=320, Evalue=3e-88, Organism=Escherichia coli, GI1786343, Length=523, Percent_Identity=26.7686424474187, Blast_Score=112, Evalue=9e-26, Organism=Escherichia coli, GI87082258, Length=256, Percent_Identity=28.125, Blast_Score=95, Evalue=2e-20, Organism=Escherichia coli, GI1789601, Length=228, Percent_Identity=27.6315789473684, Blast_Score=69, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 88406; Mature: 88406
Theoretical pI: Translated: 9.92; Mature: 9.92
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRIPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSL CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEE ANDDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGS CCCCCEEEECCHHHCCHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCC TLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAA HHHHEEEHHHEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHH SLIYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTD HHEEECCCCCEEECCCEEEEEEECCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCCCCC SSQMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQV CCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EAFIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKP HHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHH FIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVAS HHHHHHHHCCCHHHHHHHHHCHHHHCCCCCCCCCCCEECCCHHHHHCCCCCCCCHHHHHH RLRQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMV HCCCHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCHHHEE QTDKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAG ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCHHCCCC IFGPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRV CCCCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEE AICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTE EEEEECCCCCCHHHHHCCCEEEECCCCCEEEEEEECEEEEEECCCCEEEECCCCCHHHHH VFEFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQG HHHHCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCEEEEHHCCCC RDQIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRL CCEEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEE IRVEKVD EEEEECC >Mature Secondary Structure MRIPTLMATKRLLQNILMALFLLALLVIGFRLWPHPPLSQGLPLSTAYYDRHGTLLRLSL CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEE ANDDRYRLWTPLEEISPLVIQGIQLHEDRGFYYHPGVNPISLLRGFWQSYVQGGRQQGGS CCCCCEEEECCHHHCCHHHHCCEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCC TLTMQLARMHWHLNTRSPTGKLRQIARAIQLELSYSKHDILEAYLNYAPYGRNIESIAAA HHHHEEEHHHEEECCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHHHHHH SLIYFDKKPQQLTLPEALTLAVLPQSPSYRIDPTTGVLGSALTQARNRLFVRWQQTYPTD HHEEECCCCCEEECCCEEEEEEECCCCCEEECCCHHHHHHHHHHHCCEEEEEEECCCCCC SSQMALFQLPLSLRQPEKMPYIAPHFIEQIRRQNQQLANTQSQVDTTLDANLQQLVEKQV CCCEEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EAFIRRNNSRGIHNAAVLLLDTRDMGVRALVGSANYYDREIQGQVNGTNAKRSPGSTLKP HHHHHCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCEEECCCCCCCCCCCCCCCHHH FIYALGLEQGILHPMTILKDVPSSFGAYAPENFDHRFLGPVTATDALNFSRNIPAVYVAS HHHHHHHHCCCHHHHHHHHHCHHHHCCCCCCCCCCCEECCCHHHHHCCCCCCCCHHHHHH RLRQPTLYQFLRLSGVTNMASENHYGLSLVLGGGEITLQELARLYAMLANRGTLHPIQMV HCCCHHHHHHHHHHCCHHHCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCHHHEE QTDKTLPSIRLLSEAASFITLDMLRQHRRPGDTLAQSPTSLPVYWKTGTSWGFRDAWSAG ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCEEEEECCCCCCCCHHCCCC IFGPYVLIVWEGNFAGKGNSAFVGADAAAPLFFNIIDSIQANYPALREPKHPWPPQLKRV CCCCEEEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHEE AICLASGNLPTPWCQQQGKTWFIPGKSPIKVDTVYRPVVIDINSGQAACLPYDRSQTRTE EEEEECCCCCCHHHHHCCCEEEECCCCCEEEEEEECEEEEEECCCCEEEECCCCCHHHHH VFEFWPSDLANVFAQAGLPKRQPPDRSHCKEGNTLASGNAPRITSPLRNTTYTLRQSQQG HHHHCHHHHHHHHHHCCCCCCCCCCHHHCCCCCEECCCCCCCCCCCCCCCEEEEHHCCCC RDQIVFSATLDADSTTTYWFVDDIYLGSSTSKKSIDWHPTRSGQYRIRAIDDHGRADSRL CCEEEEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEE IRVEKVD EEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]