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The map label for this gene is ppiB [H]

Identifier: 108811181

GI number: 108811181

Start: 1174940

End: 1175434

Strand: Reverse

Name: ppiB [H]

Synonym: YPN_1016

Alternate gene names: 108811181

Gene position: 1175434-1174940 (Counterclockwise)

Preceding gene: 108811184

Following gene: 108811180

Centisome position: 25.92

GC content: 46.67

Gene sequence:

>495_bases
ATGGTCACGTTTCATACTAATCACGGCGATATCGTCATTAATACCTTCGCTGATAAAGCGCCGGCTACCGTTGAAAATTT
CCTGAATTACTGCCGTAAAGGTTTCTATGATAACACTATTTTCCACCGTGTTATTGATGGTTTCATGATCCAGGGCGGCG
GTTTCGAACCCGGCATGAGCCAGAAAACAACGGATGCACCAATCAAAAACGAAGCCAACAACGGTCTGAAAAATACCCGT
GGCACGTTGGCAATGGCGCGTACCAATGATCCACACTCGGCTACCGCTCAGTTCTTCATTAACGTCGCTGACAATGATTT
TCTGAACTTCCGTTCAGAGCGCCCGGATGGCTGGGGTTACTGCGTATTTGCTGAAGTAACCGACGGTTTGGACGTAGTTG
ATAAAATCAAAAATGTTGCGACGGGCCGCAGTGGCATGCATCAAGATGTGCCAAAAGAAGATGTGATCATCAAAAGCGTC
ACTATTAGCGAGTAA

Upstream 100 bases:

>100_bases
GAACGAGTACTGACTCAATCTCAGAGATATGATATAAGAGCCGTCTAAAGAGTTACGACTCATTTGTGAATACACCTATT
ACACTAGCAGGAACATTATT

Downstream 100 bases:

>100_bases
TGACGGCTTAATGAGCACGCTTTTTATTGCAGATCTGCATCTCAGCGTTCAGGAACCGGCAATCACTGCCGGTTTTCTGC
ATTTTATACAGCGTGAGGCT

Product: peptidyl-prolyl cis-trans isomerase B (rotamase B)

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVTFHTNHGDIVINTFADKAPATVENFLNYCRKGFYDNTIFHRVIDGFMIQGGGFEPGMSQKTTDAPIKNEANNGLKNTR
GTLAMARTNDPHSATAQFFINVADNDFLNFRSERPDGWGYCVFAEVTDGLDVVDKIKNVATGRSGMHQDVPKEDVIIKSV
TISE

Sequences:

>Translated_164_residues
MVTFHTNHGDIVINTFADKAPATVENFLNYCRKGFYDNTIFHRVIDGFMIQGGGFEPGMSQKTTDAPIKNEANNGLKNTR
GTLAMARTNDPHSATAQFFINVADNDFLNFRSERPDGWGYCVFAEVTDGLDVVDKIKNVATGRSGMHQDVPKEDVIIKSV
TISE
>Mature_164_residues
MVTFHTNHGDIVINTFADKAPATVENFLNYCRKGFYDNTIFHRVIDGFMIQGGGFEPGMSQKTTDAPIKNEANNGLKNTR
GTLAMARTNDPHSATAQFFINVADNDFLNFRSERPDGWGYCVFAEVTDGLDVVDKIKNVATGRSGMHQDVPKEDVIIKSV
TISE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=34.9397590361446, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=35.3658536585366, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=35.3658536585366, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=35.3658536585366, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=35.5828220858896, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=36.9230769230769, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI5454154, Length=160, Percent_Identity=34.375, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=32.9268292682927, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=35.9712230215827, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI310129267, Length=139, Percent_Identity=35.2517985611511, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI310120620, Length=139, Percent_Identity=35.2517985611511, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI10863927, Length=139, Percent_Identity=34.5323741007194, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=84.7560975609756, Blast_Score=293, Evalue=3e-81,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=54.6583850931677, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=37.0629370629371, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=143, Percent_Identity=37.0629370629371, Blast_Score=87, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=180, Percent_Identity=34.4444444444444, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=160, Percent_Identity=31.875, Blast_Score=72, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=145, Percent_Identity=37.9310344827586, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17539496, Length=167, Percent_Identity=31.1377245508982, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=150, Percent_Identity=32, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=150, Percent_Identity=32, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17565860, Length=150, Percent_Identity=36, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=108, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320510, Length=168, Percent_Identity=37.5, Blast_Score=71, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=32.3741007194245, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=30.952380952381, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17986117, Length=145, Percent_Identity=32.4137931034483, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=32.7272727272727, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24652460, Length=166, Percent_Identity=31.3253012048193, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586038, Length=148, Percent_Identity=35.1351351351351, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45549139, Length=139, Percent_Identity=37.410071942446, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647301, Length=158, Percent_Identity=34.1772151898734, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18151; Mature: 18151

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTFHTNHGDIVINTFADKAPATVENFLNYCRKGFYDNTIFHRVIDGFMIQGGGFEPGMS
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCC
QKTTDAPIKNEANNGLKNTRGTLAMARTNDPHSATAQFFINVADNDFLNFRSERPDGWGY
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEE
CVFAEVTDGLDVVDKIKNVATGRSGMHQDVPKEDVIIKSVTISE
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MVTFHTNHGDIVINTFADKAPATVENFLNYCRKGFYDNTIFHRVIDGFMIQGGGFEPGMS
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCC
QKTTDAPIKNEANNGLKNTRGTLAMARTNDPHSATAQFFINVADNDFLNFRSERPDGWGY
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEE
CVFAEVTDGLDVVDKIKNVATGRSGMHQDVPKEDVIIKSVTISE
EEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]