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The map label for this gene is atsA [H]

Identifier: 108797996

GI number: 108797996

Start: 1124232

End: 1126583

Strand: Direct

Name: atsA [H]

Synonym: Mmcs_1023

Alternate gene names: 108797996

Gene position: 1124232-1126583 (Clockwise)

Preceding gene: 108797995

Following gene: 108797997

Centisome position: 19.7

GC content: 66.71

Gene sequence:

>2352_bases
GTGCGCACGGAATTCAACGGCAAGATCGAACTGGACATCCGCGATTCCGAGCCCGACTGGGGTCCGTACGCCGCGCCGAC
CGCACCCGAGGGCGCGCCCAATGTGCTGTACCTCGTGTGGGATGACACCGGTATCGCGACGTGGGACTGCTTCGGCGGCC
TGGTCGAGATGCCGGCGATGAGCCGTATCGCCGAACGCGGTGTGCGCCTGTCGCAGTTCCACACCACGGCGCTGTGCTCG
CCGACCCGTGCCTCCCTGCTCACCGGCCGCAACGCGACGACCGTCGGGATGGCCACCATCGAGGAGTTCACCGACGGCTT
CCCGAACTGCAGCGGCCGCATCCCGTTCGACACCGCGCTGATCTCGGAGGTCCTCGCGGAGAACGGCTACAACACCTACT
GCGTCGGCAAGTGGCACCTCACTCCGCTCGAGGAGTCGAATCTGGCTGCCACCAAACGACACTGGCCGCTGTCTCGTGGG
TTCGAACGGTTCTACGGCTTCATGGGCGGCGAAACCGACCAGTGGTATCCCGAACTCGTCTACGACAACCACCCGGTCGC
CCCGCCCGGCACCCCCGAGGACGGCTATCACCTGTCGAAGGACCTCGCGGACAAGACGATCGAGTTCATCCGCGACGCCA
AGGTGATCGCGCCCGACAAACCGTGGTTCTCCTACGTCTGCCCGGGTGCCGGCCACGCCCCACACCACGTGTTCAAGGAA
TGGGCCGACCGCTACGCGGGCCGCTTCGACATGGGCTACGAGGCCTACCGCGAGATCGTGCTGGAGAACCAGAAACGCCT
CGGCATCGTCCCGTCGGACACCGAACTCTCACCGATGAACCCGTACGCCGACGTCACCGGGCCCAACGGGGAGCCGTGGC
CCGTCCAGGACACGGTGCGGCCGTGGGATTCCCTGTCCGACAACGAGAAACGGCTCTTCTGCCGGATGGCGGAGGTCTTC
GCCGGATTCCTGTCCTACACCGATGCGCAGATCGGCCGGATCCTCGACTACCTGGAGGAGTCGGGTCAGCTCGACAACAC
GATCATCGTGGTGATCTCCGACAACGGGGCCAGCGGCGAAGGCGGACCCGACGGTTCGGTCAACGAGACGAAGTTCTTCA
ACGGCTACATCGACACCGCCGAGGAGGGGCTCAAGGTCATCGACGATCTCGGTGGCCCGCACACCTACAACCACTATCCG
ACCGGCTGGGCGATGGCGTTCAACACGCCCTACAAACTGTTCAAGCGCTACGCCTCCCATGAGGGGGGCATCGCCGACAC
CGCGATCATCTCGTGGCCCGACGGCATCGCCGCGCACGGTGAGGTGCGGGACAACTACGTCAACGTCTGCGACATCACCC
CGACGGTGTACGACCTGCTGGGGCTCACCGCCCCGGCCTCCGTGCGCGGGGTGCCGCAGAAACCGCTCGACGGTGTGAGT
TTCAAAGTGACACTGGACAATCCGACCGCGCCCACCGGCAAGGAGACGCAGTTCTACTCGATGCTCGGCACCCGGGGGAT
CTGGCACCAGGGCTGGTTCGCCAACACCGTGCACGCGGCGTCGCCGGCCGGCTGGTCGCATTTCGACGACGACCGCTGGG
AGTTGTTCCACATCGAGGCCGACCGCGCCCAGGTGCACGATCTGGCCGCCGAACACCCGGAGAAACTCGAGGAACTCAAG
GCGCTGTGGTTCAGCGAGGCCGCCAAGTACAACGGGCTGCCGCTCGGCGATCTCAACATCTTCGACACCATCGGGCGGTG
GCGGCCCAGCCTGTCGGGTGCGCGGGACGCCTACGTGTACTACCCGGGCACCGCGGATGTCGGAACCGGCGCCGTCGTCG
AGGTCCAGGGCCGCTCGTTCGTGGTGCTGGCCGAGGTCACCGTCGACGACGACACCGCACAGGGTGTGGTGTTCAAACAC
GGTGGCGCACACGGTGGTCACGTGATGTACGTGCAGGACGGCCGGCTGCACTACGCGTACAACTTCCTCGGCGAGACCGA
ACAGAAGATGGCGTCGTCGGTGCCGATCACCCCCGGCCGGCACACCTTCGGGATCGCCTACACCCGGACCGGCACCGTCG
AGGGCAGCCACACCCCCCTCGGTGACGCCGTGCTCTACGTCGACGACGACGCGGTCGCCTCCTACCCGGGCATGATGAGC
CACCCCGGGACGTTCGGACTGGCCGGCGCCACGCTCTCGGTGGGCCGCAACAGCGGATCCCCGGTCTCGCGGGCCTACCG
GCCGCCGTTCGAGTTCACCGGCGGCACCATCGCCCAGGTCTCGTTCGACGTCTCCGGCAAGCCCTACCTCGACCTGGAAC
GCGAGTTCGCCCGGGCCTTCGCGAAGGACTGA

Upstream 100 bases:

>100_bases
TCGAGAAGGCCAAGTAGCCACTTCGTCCACGACAGACCCCGACACGCACAGCGTGTCGGGGTCTTCGTTTTTCGGCCATC
CGCCCAGGTAGTCTCCGTGC

Downstream 100 bases:

>100_bases
CCCTCTACGCTGAAGAGATGCTGACCGAGCTGGTCGAACTGCCGGGCGGCACCTTCCGGATGGGCTCCACGCAGTTCTAT
CCGGAGGAAGTGCCGGTGCA

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 783; Mature: 783

Protein sequence:

>783_residues
MRTEFNGKIELDIRDSEPDWGPYAAPTAPEGAPNVLYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCS
PTRASLLTGRNATTVGMATIEEFTDGFPNCSGRIPFDTALISEVLAENGYNTYCVGKWHLTPLEESNLAATKRHWPLSRG
FERFYGFMGGETDQWYPELVYDNHPVAPPGTPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKE
WADRYAGRFDMGYEAYREIVLENQKRLGIVPSDTELSPMNPYADVTGPNGEPWPVQDTVRPWDSLSDNEKRLFCRMAEVF
AGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGEGGPDGSVNETKFFNGYIDTAEEGLKVIDDLGGPHTYNHYP
TGWAMAFNTPYKLFKRYASHEGGIADTAIISWPDGIAAHGEVRDNYVNVCDITPTVYDLLGLTAPASVRGVPQKPLDGVS
FKVTLDNPTAPTGKETQFYSMLGTRGIWHQGWFANTVHAASPAGWSHFDDDRWELFHIEADRAQVHDLAAEHPEKLEELK
ALWFSEAAKYNGLPLGDLNIFDTIGRWRPSLSGARDAYVYYPGTADVGTGAVVEVQGRSFVVLAEVTVDDDTAQGVVFKH
GGAHGGHVMYVQDGRLHYAYNFLGETEQKMASSVPITPGRHTFGIAYTRTGTVEGSHTPLGDAVLYVDDDAVASYPGMMS
HPGTFGLAGATLSVGRNSGSPVSRAYRPPFEFTGGTIAQVSFDVSGKPYLDLEREFARAFAKD

Sequences:

>Translated_783_residues
MRTEFNGKIELDIRDSEPDWGPYAAPTAPEGAPNVLYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCS
PTRASLLTGRNATTVGMATIEEFTDGFPNCSGRIPFDTALISEVLAENGYNTYCVGKWHLTPLEESNLAATKRHWPLSRG
FERFYGFMGGETDQWYPELVYDNHPVAPPGTPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKE
WADRYAGRFDMGYEAYREIVLENQKRLGIVPSDTELSPMNPYADVTGPNGEPWPVQDTVRPWDSLSDNEKRLFCRMAEVF
AGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGEGGPDGSVNETKFFNGYIDTAEEGLKVIDDLGGPHTYNHYP
TGWAMAFNTPYKLFKRYASHEGGIADTAIISWPDGIAAHGEVRDNYVNVCDITPTVYDLLGLTAPASVRGVPQKPLDGVS
FKVTLDNPTAPTGKETQFYSMLGTRGIWHQGWFANTVHAASPAGWSHFDDDRWELFHIEADRAQVHDLAAEHPEKLEELK
ALWFSEAAKYNGLPLGDLNIFDTIGRWRPSLSGARDAYVYYPGTADVGTGAVVEVQGRSFVVLAEVTVDDDTAQGVVFKH
GGAHGGHVMYVQDGRLHYAYNFLGETEQKMASSVPITPGRHTFGIAYTRTGTVEGSHTPLGDAVLYVDDDAVASYPGMMS
HPGTFGLAGATLSVGRNSGSPVSRAYRPPFEFTGGTIAQVSFDVSGKPYLDLEREFARAFAKD
>Mature_783_residues
MRTEFNGKIELDIRDSEPDWGPYAAPTAPEGAPNVLYLVWDDTGIATWDCFGGLVEMPAMSRIAERGVRLSQFHTTALCS
PTRASLLTGRNATTVGMATIEEFTDGFPNCSGRIPFDTALISEVLAENGYNTYCVGKWHLTPLEESNLAATKRHWPLSRG
FERFYGFMGGETDQWYPELVYDNHPVAPPGTPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKE
WADRYAGRFDMGYEAYREIVLENQKRLGIVPSDTELSPMNPYADVTGPNGEPWPVQDTVRPWDSLSDNEKRLFCRMAEVF
AGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGEGGPDGSVNETKFFNGYIDTAEEGLKVIDDLGGPHTYNHYP
TGWAMAFNTPYKLFKRYASHEGGIADTAIISWPDGIAAHGEVRDNYVNVCDITPTVYDLLGLTAPASVRGVPQKPLDGVS
FKVTLDNPTAPTGKETQFYSMLGTRGIWHQGWFANTVHAASPAGWSHFDDDRWELFHIEADRAQVHDLAAEHPEKLEELK
ALWFSEAAKYNGLPLGDLNIFDTIGRWRPSLSGARDAYVYYPGTADVGTGAVVEVQGRSFVVLAEVTVDDDTAQGVVFKH
GGAHGGHVMYVQDGRLHYAYNFLGETEQKMASSVPITPGRHTFGIAYTRTGTVEGSHTPLGDAVLYVDDDAVASYPGMMS
HPGTFGLAGATLSVGRNSGSPVSRAYRPPFEFTGGTIAQVSFDVSGKPYLDLEREFARAFAKD

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI59797060, Length=237, Percent_Identity=28.6919831223629, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI38569405, Length=331, Percent_Identity=23.2628398791541, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI157266309, Length=161, Percent_Identity=36.6459627329193, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI109389362, Length=254, Percent_Identity=26.7716535433071, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI38569407, Length=222, Percent_Identity=28.8288288288288, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI71852584, Length=146, Percent_Identity=35.6164383561644, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI53831991, Length=137, Percent_Identity=35.7664233576642, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI71852586, Length=146, Percent_Identity=35.6164383561644, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI58743319, Length=142, Percent_Identity=35.2112676056338, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31742482, Length=150, Percent_Identity=31.3333333333333, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI146229331, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI146229329, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI6005990, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI146229324, Length=244, Percent_Identity=28.2786885245902, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI4503899, Length=242, Percent_Identity=29.3388429752066, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI87081924, Length=213, Percent_Identity=25.8215962441315, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI115533416, Length=159, Percent_Identity=32.0754716981132, Blast_Score=70, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17559078, Length=132, Percent_Identity=34.8484848484849, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281363223, Length=352, Percent_Identity=24.4318181818182, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666175, Length=454, Percent_Identity=23.1277533039648, Blast_Score=80, Evalue=8e-15,
Organism=Drosophila melanogaster, GI281366397, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366395, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24666163, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 86038; Mature: 86038

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2 ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTEFNGKIELDIRDSEPDWGPYAAPTAPEGAPNVLYLVWDDTGIATWDCFGGLVEMPAM
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHH
SRIAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMATIEEFTDGFPNCSGRIPFDTAL
HHHHHCCCEEEHHHHHHHCCCCHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHH
ISEVLAENGYNTYCVGKWHLTPLEESNLAATKRHWPLSRGFERFYGFMGGETDQWYPELV
HHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHE
YDNHPVAPPGTPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKE
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCEEECCCCCCCHHHHHHH
WADRYAGRFDMGYEAYREIVLENQKRLGIVPSDTELSPMNPYADVTGPNGEPWPVQDTVR
HHHHHCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PWDSLSDNEKRLFCRMAEVFAGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
GGPDGSVNETKFFNGYIDTAEEGLKVIDDLGGPHTYNHYPTGWAMAFNTPYKLFKRYASH
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHCC
EGGIADTAIISWPDGIAAHGEVRDNYVNVCDITPTVYDLLGLTAPASVRGVPQKPLDGVS
CCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCE
FKVTLDNPTAPTGKETQFYSMLGTRGIWHQGWFANTVHAASPAGWSHFDDDRWELFHIEA
EEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
DRAQVHDLAAEHPEKLEELKALWFSEAAKYNGLPLGDLNIFDTIGRWRPSLSGARDAYVY
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEE
YPGTADVGTGAVVEVQGRSFVVLAEVTVDDDTAQGVVFKHGGAHGGHVMYVQDGRLHYAY
ECCCCCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEECCCCCCCEEEEEECCCEEEEE
NFLGETEQKMASSVPITPGRHTFGIAYTRTGTVEGSHTPLGDAVLYVDDDAVASYPGMMS
ECCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCC
HPGTFGLAGATLSVGRNSGSPVSRAYRPPFEFTGGTIAQVSFDVSGKPYLDLEREFARAF
CCCCCEECCEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
AKD
HCC
>Mature Secondary Structure
MRTEFNGKIELDIRDSEPDWGPYAAPTAPEGAPNVLYLVWDDTGIATWDCFGGLVEMPAM
CCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHH
SRIAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMATIEEFTDGFPNCSGRIPFDTAL
HHHHHCCCEEEHHHHHHHCCCCHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHH
ISEVLAENGYNTYCVGKWHLTPLEESNLAATKRHWPLSRGFERFYGFMGGETDQWYPELV
HHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHE
YDNHPVAPPGTPEDGYHLSKDLADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKE
ECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCCCEEECCCCCCCHHHHHHH
WADRYAGRFDMGYEAYREIVLENQKRLGIVPSDTELSPMNPYADVTGPNGEPWPVQDTVR
HHHHHCCCCCCCHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PWDSLSDNEKRLFCRMAEVFAGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
GGPDGSVNETKFFNGYIDTAEEGLKVIDDLGGPHTYNHYPTGWAMAFNTPYKLFKRYASH
CCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHCC
EGGIADTAIISWPDGIAAHGEVRDNYVNVCDITPTVYDLLGLTAPASVRGVPQKPLDGVS
CCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCCCCCCE
FKVTLDNPTAPTGKETQFYSMLGTRGIWHQGWFANTVHAASPAGWSHFDDDRWELFHIEA
EEEEECCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEC
DRAQVHDLAAEHPEKLEELKALWFSEAAKYNGLPLGDLNIFDTIGRWRPSLSGARDAYVY
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEE
YPGTADVGTGAVVEVQGRSFVVLAEVTVDDDTAQGVVFKHGGAHGGHVMYVQDGRLHYAY
ECCCCCCCCCCEEEECCCEEEEEEEEEECCCCCCCEEEECCCCCCCEEEEEECCCEEEEE
NFLGETEQKMASSVPITPGRHTFGIAYTRTGTVEGSHTPLGDAVLYVDDDAVASYPGMMS
ECCCCHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCHHHCCCCCCC
HPGTFGLAGATLSVGRNSGSPVSRAYRPPFEFTGGTIAQVSFDVSGKPYLDLEREFARAF
CCCCCEECCEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHH
AKD
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7744061; 10984043 [H]