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The map label for this gene is lcfB [H]

Identifier: 108797718

GI number: 108797718

Start: 784714

End: 786312

Strand: Reverse

Name: lcfB [H]

Synonym: Mmcs_0739

Alternate gene names: 108797718

Gene position: 786312-784714 (Counterclockwise)

Preceding gene: 108797720

Following gene: 108797717

Centisome position: 13.78

GC content: 68.23

Gene sequence:

>1599_bases
ATGAGTGATCAGCTGCGGCATTTCCTGCACTCCGGCCACCTGACGGTCGGCGCACTGAAGCGCCACAAGGACCGGCCGGT
GCTCTTCCTGGGCGACACCACGATGACCGGCGGTGAGCTCGCCGACCGCATCAGCCAGTACATCCAGGCGTTCGAGGCGC
TCGGCGCGGGTACGGGCGCGGCCGTCGGCCTGCTCTCGCTCAACCGGCCCGAGGTGCTGATGATCATCGGCGCCGGCCAG
ACGCAGGGCTACCGCCGCACCGCACTACACCCTCTAGGCTCGCTGGACGATCACGCCTACGTGCTGTCCGACGCCGGGGT
GACGTCGCTGATCATCGATCCCAACCCGATGTTCGTCGAGCGGGCGCTGGGCCTGCTGGAGAAGGTTCCGTCGCTCAAGC
AGGTCCTCACGATCGGCCCGGTCCCGGAGGAGTTGTCCGAGGTCGCGGTCGATCTGAGCGCCGAGGCGGCCAAATACCCG
GCCAAACCCCTGGTGGCCGCGGATCTGCCGCCCGACCACATCGGCGGGCTGACCTACACCGGCGGCACCACCGGCAAACC
CAAGGGCGTCATCGGCACGACCCAGTCGATCACCACCATGACGACCGTCCAACTGGCCGAATGGGAGTGGCCGGAGAACC
CGCGGTTCCTGATGTGCACGCCGCTGTCGCACGCCGGTGCGGCGTTCTTCACCCCGGTCATCGTCAAGGGCGGCGAGCTG
ATCGTGCTGACGAAGTTCGACCCGGCCGAGGTGCTGCGCGTCATCGAGGAGCAGAAGATCACCGCGACGATGCTCGTGCC
GTCGATGATCTACGCGCTGATGGACCACCCGGATTCGCACACCCGCGACCTGTCGTCGCTGGAGACGGTGTACTACGGCG
CCTCGGCGATGAACCCGGTGCGCCTGAAGGAGGCGATCCGGCGGTTCGGCCCGATCTTCGCGCAGTACTACGGCCAGTCC
GAGGCGCCGATGGTGATCACCTACCTGTCGAAGAAGGAGCACGACGACAAGCGGCTGACGTCATGTGGCCGCCCGACGCT
CTTCGCGCGGGTGGCGCTGCTCGGCGAGGACGGGCAGCCGGTCCCGCAGGGCGAGGTCGGGGAGATCTGTGTCTCCGGTC
CGCTGCTGTCGGGCGGCTACTGGAACCTGCCCGACGCGACGGCCGAGACCTTCCGGGACGGCTGGATGCACACCGGTGAC
CTGGCACGCGAGGACGAGGACGGCTTCTACTTCATCGTCGACCGCACCAAGGACATGATCGTCACCGGCGGCTTCAACGT
CTTCCCGCGCGAGGTGGAGGACGTCGTCGCCGAACATCCCCTGGTCGCGCAGGTGTGCGTGATCGGCACCCCCGACGAGA
AGTGGGGTGAGGCCGTCACGGCCGTGGTGGTGCTGCGGCCCGACGCCGACTCCTCCGAAGAGTCCGTGGCGACGATGACC
GCCGAGATCCAGGCGGCAGTCAAGGAGCGCAAGGGTTCGGTGCACGTGCCCAAGCAGGTGGTCGTCGCCGAGTCGGTGCC
GATCACCGCGCTGGGCAAGCCCGACAAGAAGGCGGTGCGGGCGCAGTTCTGGGAGGGCGCAGGGCGAGCCGTCGGCTGA

Upstream 100 bases:

>100_bases
CCGCGCCGGGTGGTTGCGCGAACAGGGCCGCGCCCCGGCCCGGTTCTGAAATCGCGGGGACCGGCTGACTGGAATTGGAA
CACGTTCTAGTCTGTTGGCC

Downstream 100 bases:

>100_bases
TTCTCATCCGCGAGCAGACGCAAATGCTCCGCCTCGACGGCGTGTCGCGGGACATTTGCGTCTGCTCGGCAGAATGGGCC
CGTGGTTTCTGACATCCAGC

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 532; Mature: 531

Protein sequence:

>532_residues
MSDQLRHFLHSGHLTVGALKRHKDRPVLFLGDTTMTGGELADRISQYIQAFEALGAGTGAAVGLLSLNRPEVLMIIGAGQ
TQGYRRTALHPLGSLDDHAYVLSDAGVTSLIIDPNPMFVERALGLLEKVPSLKQVLTIGPVPEELSEVAVDLSAEAAKYP
AKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEWEWPENPRFLMCTPLSHAGAAFFTPVIVKGGEL
IVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLKEAIRRFGPIFAQYYGQS
EAPMVITYLSKKEHDDKRLTSCGRPTLFARVALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPDATAETFRDGWMHTGD
LAREDEDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPLVAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEESVATMT
AEIQAAVKERKGSVHVPKQVVVAESVPITALGKPDKKAVRAQFWEGAGRAVG

Sequences:

>Translated_532_residues
MSDQLRHFLHSGHLTVGALKRHKDRPVLFLGDTTMTGGELADRISQYIQAFEALGAGTGAAVGLLSLNRPEVLMIIGAGQ
TQGYRRTALHPLGSLDDHAYVLSDAGVTSLIIDPNPMFVERALGLLEKVPSLKQVLTIGPVPEELSEVAVDLSAEAAKYP
AKPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEWEWPENPRFLMCTPLSHAGAAFFTPVIVKGGEL
IVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLKEAIRRFGPIFAQYYGQS
EAPMVITYLSKKEHDDKRLTSCGRPTLFARVALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPDATAETFRDGWMHTGD
LAREDEDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPLVAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEESVATMT
AEIQAAVKERKGSVHVPKQVVVAESVPITALGKPDKKAVRAQFWEGAGRAVG
>Mature_531_residues
SDQLRHFLHSGHLTVGALKRHKDRPVLFLGDTTMTGGELADRISQYIQAFEALGAGTGAAVGLLSLNRPEVLMIIGAGQT
QGYRRTALHPLGSLDDHAYVLSDAGVTSLIIDPNPMFVERALGLLEKVPSLKQVLTIGPVPEELSEVAVDLSAEAAKYPA
KPLVAADLPPDHIGGLTYTGGTTGKPKGVIGTTQSITTMTTVQLAEWEWPENPRFLMCTPLSHAGAAFFTPVIVKGGELI
VLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPVRLKEAIRRFGPIFAQYYGQSE
APMVITYLSKKEHDDKRLTSCGRPTLFARVALLGEDGQPVPQGEVGEICVSGPLLSGGYWNLPDATAETFRDGWMHTGDL
AREDEDGFYFIVDRTKDMIVTGGFNVFPREVEDVVAEHPLVAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEESVATMTA
EIQAAVKERKGSVHVPKQVVVAESVPITALGKPDKKAVRAQFWEGAGRAVG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=529, Percent_Identity=25.7088846880907, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI187761345, Length=387, Percent_Identity=30.749354005168, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI187761343, Length=387, Percent_Identity=30.749354005168, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI42544132, Length=391, Percent_Identity=26.0869565217391, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI122937307, Length=269, Percent_Identity=29.368029739777, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI38505220, Length=358, Percent_Identity=28.2122905027933, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI157311624, Length=297, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI157311622, Length=297, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI58082049, Length=297, Percent_Identity=27.6094276094276, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI27477105, Length=519, Percent_Identity=24.8554913294798, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI115511026, Length=286, Percent_Identity=29.020979020979, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI28416953, Length=431, Percent_Identity=22.2737819025522, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI13375727, Length=372, Percent_Identity=23.9247311827957, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI8923896, Length=379, Percent_Identity=25.065963060686, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI253970489, Length=379, Percent_Identity=25.065963060686, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1788107, Length=537, Percent_Identity=27.9329608938547, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI145693145, Length=359, Percent_Identity=29.8050139275766, Blast_Score=148, Evalue=7e-37,
Organism=Escherichia coli, GI221142682, Length=491, Percent_Identity=24.847250509165, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI1786810, Length=378, Percent_Identity=25.9259259259259, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790505, Length=371, Percent_Identity=25.0673854447439, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1786529, Length=537, Percent_Identity=25.6983240223464, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788595, Length=348, Percent_Identity=25.5747126436782, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786801, Length=374, Percent_Identity=26.2032085561497, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=424, Percent_Identity=32.0754716981132, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17558820, Length=505, Percent_Identity=26.3366336633663, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17560308, Length=513, Percent_Identity=27.2904483430799, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=448, Percent_Identity=26.1160714285714, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71994690, Length=373, Percent_Identity=28.686327077748, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71994703, Length=373, Percent_Identity=28.686327077748, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71994694, Length=373, Percent_Identity=28.686327077748, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=26.9005847953216, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17560140, Length=321, Percent_Identity=28.9719626168224, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=498, Percent_Identity=26.3052208835341, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=525, Percent_Identity=25.9047619047619, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=362, Percent_Identity=27.6243093922652, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI25141359, Length=506, Percent_Identity=23.7154150197628, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=359, Percent_Identity=25.0696378830084, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17556552, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=25.2777777777778, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319264, Length=567, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=158, Percent_Identity=27.2151898734177, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24581924, Length=493, Percent_Identity=27.3833671399594, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI18859661, Length=371, Percent_Identity=30.4582210242588, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648255, Length=514, Percent_Identity=27.0428015564202, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24648253, Length=515, Percent_Identity=26.6019417475728, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21355181, Length=521, Percent_Identity=25.9117082533589, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21356441, Length=552, Percent_Identity=26.6304347826087, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI281365686, Length=360, Percent_Identity=26.9444444444444, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358303, Length=361, Percent_Identity=25.4847645429363, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI20130357, Length=361, Percent_Identity=27.1468144044321, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653035, Length=365, Percent_Identity=26.8493150684932, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24648257, Length=368, Percent_Identity=28.804347826087, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI21356947, Length=358, Percent_Identity=26.536312849162, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI161076582, Length=371, Percent_Identity=25.6064690026954, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24648260, Length=524, Percent_Identity=24.236641221374, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19922652, Length=522, Percent_Identity=23.9463601532567, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648676, Length=386, Percent_Identity=28.2383419689119, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656500, Length=508, Percent_Identity=23.0314960629921, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921316, Length=487, Percent_Identity=24.6406570841889, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI62472339, Length=380, Percent_Identity=25.7894736842105, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24667959, Length=380, Percent_Identity=25.7894736842105, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24667955, Length=380, Percent_Identity=25.7894736842105, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355225, Length=378, Percent_Identity=23.015873015873, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221329755, Length=386, Percent_Identity=20.4663212435233, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 57417; Mature: 57286

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQLRHFLHSGHLTVGALKRHKDRPVLFLGDTTMTGGELADRISQYIQAFEALGAGTGA
CCHHHHHHHHCCCEEEEHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
AVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAGVTSLIIDPNPMFVE
EEEEEECCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCEEEEECCCCEEEEECCCHHHHH
RALGLLEKVPSLKQVLTIGPVPEELSEVAVDLSAEAAKYPAKPLVAADLPPDHIGGLTYT
HHHHHHHHCCCHHHHEECCCCHHHHHHHHHCCCHHHHCCCCCCEEECCCCCHHCCCEEEC
GGTTGKPKGVIGTTQSITTMTTVQLAEWEWPENPRFLMCTPLSHAGAAFFTPVIVKGGEL
CCCCCCCCCEEECCCCEEEEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHEECCCCE
IVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPV
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHH
RLKEAIRRFGPIFAQYYGQSEAPMVITYLSKKEHDDKRLTSCGRPTLFARVALLGEDGQP
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCHHEEEEEEECCCCCC
VPQGEVGEICVSGPLLSGGYWNLPDATAETFRDGWMHTGDLAREDEDGFYFIVDRTKDMI
CCCCCCCCEEECCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEE
VTGGFNVFPREVEDVVAEHPLVAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEESVATMT
EECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHCCEEEEEEEECCCCCCCCHHHHHHH
AEIQAAVKERKGSVHVPKQVVVAESVPITALGKPDKKAVRAQFWEGAGRAVG
HHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SDQLRHFLHSGHLTVGALKRHKDRPVLFLGDTTMTGGELADRISQYIQAFEALGAGTGA
CHHHHHHHHCCCEEEEHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
AVGLLSLNRPEVLMIIGAGQTQGYRRTALHPLGSLDDHAYVLSDAGVTSLIIDPNPMFVE
EEEEEECCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCEEEEECCCCEEEEECCCHHHHH
RALGLLEKVPSLKQVLTIGPVPEELSEVAVDLSAEAAKYPAKPLVAADLPPDHIGGLTYT
HHHHHHHHCCCHHHHEECCCCHHHHHHHHHCCCHHHHCCCCCCEEECCCCCHHCCCEEEC
GGTTGKPKGVIGTTQSITTMTTVQLAEWEWPENPRFLMCTPLSHAGAAFFTPVIVKGGEL
CCCCCCCCCEEECCCCEEEEEEEEEEECCCCCCCCEEEECCCCCCCHHHHHHHEECCCCE
IVLTKFDPAEVLRVIEEQKITATMLVPSMIYALMDHPDSHTRDLSSLETVYYGASAMNPV
EEEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHH
RLKEAIRRFGPIFAQYYGQSEAPMVITYLSKKEHDDKRLTSCGRPTLFARVALLGEDGQP
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHCCCCHHEEEEEEECCCCCC
VPQGEVGEICVSGPLLSGGYWNLPDATAETFRDGWMHTGDLAREDEDGFYFIVDRTKDMI
CCCCCCCCEEECCCEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEE
VTGGFNVFPREVEDVVAEHPLVAQVCVIGTPDEKWGEAVTAVVVLRPDADSSEESVATMT
EECCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHCCEEEEEEEECCCCCCCCHHHHHHH
AEIQAAVKERKGSVHVPKQVVVAESVPITALGKPDKKAVRAQFWEGAGRAVG
HHHHHHHHHCCCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]